Inhibition of protein kinases by balanol: Specificity within the serine/threonine protein kinase subfamily

Molecular Pharmacology

Volumn 56, Issue 2, 1999, Pages 370-376

  Setyawan, Juliana ^a   Koide, Kazunori ^a   Diller, Thomas C ^a   Bunnage, Mark E ^a,b   Taylor, Susan S ^a   Nicolaou, K C ^a,b   Brunton, Laurence L ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BALANOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN SERINE KINASE; THREONINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE;

EID: 0032801142     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.2.370     Document Type: Article

References (23)

1. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 72:248-254.
2. Criss WE, Yamamoto M, Takai Y, Nishizuka Y and Morris HP (1978) Requirement of polycations for the enzymatic activity of a new protein kinase-substrate complex from Morris hepatoma 3924A. Cancer Res 38:3532-3539.
3. Dessauer CW and Gilman AG (1997) The catalytic mechanism of mammalian adenylyl cyclase. J Biol Chem 272:27787-27795.
4. Gustafsson ÅB and Brunton LL (1999) Differential and selective inhibition of PKA and PKC in intact cells by balanol congeners. Mol Pharmacol 56:377-382.
5. Hanks SK and Quinn AM (1991) Protein kinase catalytic domain sequence data base: Identification of conserved features of primary structure and classification of family members. Methods Enzymol 200:38-81.
6. Hanks SK, Quinn AM and Hunter T (1988) The protein kinase family: Conserved features and deduced phylogeny of the catalytic domains. Science (Wash DC) 241:42-52.
7. Hardie G and Hanks SK (1995) The Protein Kinase Facts Book. Academic Press, San Diego, CA.
8. Hilal-Dandan R, Ramirez MT, Villegas S, Gonzalez A, Endo-Mochizuki Y, Brown JH and Brunton LL (1997) Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathways. Am J Physiol 272:H130-H137.
9. Hunenberger PH, Helms V, Narayana N, Taylor SS and McCammon JA (1999) Determinants of ligand binding to cAMP-dependent protein kinase. Biochemistry 38:2358-2366.
10. Koide K, Bunnage ME, Paloma GL, Kanter JK, Taylor SS, Brunton LL and Nicolaou KC (1995) Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chem Biol 2:601-608.
11. Kulanthaivel P, Hallock YF, Boros C, Hamilton SM, Janzen WP, Ballas LM, Loomis CR, Juang JB, Katz B, Steiner JR and Clardy J (1993) Balanol: A novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. J Am Chem Soc 115:6452-6453.
12. Mendoza JS, Jagdmann GE Jr and Gosnell PA (1995) Synthesis and biological evaluation of conformationally constrained bicyclic and tricyclic balanol analogues as inhibitors of protein kinase C. Bioorg Med Chem Lett 5:2211-2216.
13. Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong N-H, Ten Eyck LF and Taylor SS (1999) Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry 38:2367-2376.
14. Nicolaou KC, Bunnage ME and Koide K (1994) Total synthesis of balanol. J Am Chem Soc 116:8402-8403.
15. Salomon Y, Londos C and Rodbell M (1974) A highly sensitive adenylate cyclase assay. Analyt Biochem 58:541-548.
16. Sanghera JS, Paddon HB, Bader SA and Pelech SL (1990) Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes. J Biol Chem 265:52-57.
17. b, cGMP-dependent protein kinaae. Mol Pharmacol 42:103-108.
18. 20 phosphorylation in skinned smooth muscle. Am J Physiol 262:C1437-C1445.
19. Taylor SS, Knighton D, Zheng J, Ten Eyck LF and Sowadski J (1992a) Structural framework for the protein kinase family. Annu Rev Cell Biol 8:429-462.
20. Taylor SS, Knighton D, Zheng J, Ten Eyck LF and Sowadski J (1992b) cAMP-dependent protein kinase and the protein kinase family. Faraday Discuss 93:143-152.
21. Taylor SS and Radzio-Andzelm E (1994) Three protein kinase structures define a common motif. Structure 2:345-355.
22. Wilson KP, McCaffrey PG, Hsiao K, Pazhanisamy S, Galullo V, Bemis GW, Fitzgibbon MJ, Caron PR, Murko MA and Su MSS (1997) The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem Biol 4:423-431.
23. Zheng J, Knighton DE, Ten Eyck LF, Karlsson R, Xuong N, Taylor SS and Sowadski JM (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32:2154-2161.