-
1
-
-
84884855179
-
-
WHO website, Available:. Accessed 2013 Aug 27
-
WHO website, Available: http://www.who.int/features/factfiles/obesity/en/.Accessed 2013 Aug 27.
-
-
-
-
2
-
-
3242876199
-
Obesity as a disease: no lightweight matter
-
Conway B, Rene A, (2004) Obesity as a disease: no lightweight matter. Obes Rev 5: 145-151.
-
(2004)
Obes Rev
, vol.5
, pp. 145-151
-
-
Conway, B.1
Rene, A.2
-
3
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
-
4
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL, (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
5
-
-
0030977992
-
Crystal structure of the obese protein leptin-E100
-
Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, et al. (1997) Crystal structure of the obese protein leptin-E100. Nature 387: 206-209.
-
(1997)
Nature
, vol.387
, pp. 206-209
-
-
Zhang, F.1
Basinski, M.B.2
Beals, J.M.3
Briggs, S.L.4
Churgay, L.M.5
-
6
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, et al. (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387: 903-908.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
Soos, M.A.4
Rau, H.5
-
7
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD, (1998) A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 18: 213-215.
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
8
-
-
77954461979
-
A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness
-
Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, et al. (2010) A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab 95: 2836-2840.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2836-2840
-
-
Fischer-Posovszky, P.1
von Schnurbein, J.2
Moepps, B.3
Lahr, G.4
Strauss, G.5
-
9
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392: 398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
Cabrol, S.4
Pelloux, V.5
-
10
-
-
0036800760
-
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
-
Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, et al. (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110: 1093-1103.
-
(2002)
J Clin Invest
, vol.110
, pp. 1093-1103
-
-
Farooqi, I.S.1
Matarese, G.2
Lord, G.M.3
Keogh, J.M.4
Lawrence, E.5
-
11
-
-
54549091125
-
Systems biology: Metabonomics
-
Nicholson JK, Lindon JC, (2008) Systems biology: Metabonomics. Nature 455: 1054-1056.
-
(2008)
Nature
, vol.455
, pp. 1054-1056
-
-
Nicholson, J.K.1
Lindon, J.C.2
-
12
-
-
77952339975
-
Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes
-
Connor SC, Hansen MK, Corner A, Smith RF, Ryan TE, (2010) Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Mol Biosyst 6: 909-921.
-
(2010)
Mol Biosyst
, vol.6
, pp. 909-921
-
-
Connor, S.C.1
Hansen, M.K.2
Corner, A.3
Smith, R.F.4
Ryan, T.E.5
-
13
-
-
59449097019
-
Clinical applications of metabolomics in oncology: a review
-
Spratlin JL, Serkova NJ, Eckhardt SG, (2009) Clinical applications of metabolomics in oncology: a review. Clin Cancer Res 15: 431-440.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 431-440
-
-
Spratlin, J.L.1
Serkova, N.J.2
Eckhardt, S.G.3
-
14
-
-
38349078772
-
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model
-
Martin FP, Wang Y, Sprenger N, Yap IK, Lundstedt T, et al. (2008) Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol 4: 157.
-
(2008)
Mol Syst Biol
, vol.4
, pp. 157
-
-
Martin, F.P.1
Wang, Y.2
Sprenger, N.3
Yap, I.K.4
Lundstedt, T.5
-
15
-
-
33645804032
-
Metabolic profiling of livers and blood from obese Zucker rats
-
Serkova NJ, Jackman M, Brown JL, Liu T, Hirose R, et al. (2006) Metabolic profiling of livers and blood from obese Zucker rats. J Hepatol 44: 956-962.
-
(2006)
J Hepatol
, vol.44
, pp. 956-962
-
-
Serkova, N.J.1
Jackman, M.2
Brown, J.L.3
Liu, T.4
Hirose, R.5
-
16
-
-
66749118301
-
Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents
-
Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, et al. (2009) Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents. J Proteome Res 8: 2361-2375.
-
(2009)
J Proteome Res
, vol.8
, pp. 2361-2375
-
-
Waldram, A.1
Holmes, E.2
Wang, Y.3
Rantalainen, M.4
Wilson, I.D.5
-
17
-
-
78349279992
-
A metabonomic comparison of urinary changes in Zucker and GK rats
-
Zhao LC, Zhang XD, Liao SX, Gao HC, Wang HY, et al. (2010) A metabonomic comparison of urinary changes in Zucker and GK rats. J Biomed Biotechnol 2010: 431894.
-
(2010)
J Biomed Biotechnol
, vol.2010
, pp. 431894
-
-
Zhao, L.C.1
Zhang, X.D.2
Liao, S.X.3
Gao, H.C.4
Wang, H.Y.5
-
18
-
-
50649120799
-
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study
-
Schirra HJ, Anderson CG, Wilson WJ, Kerr L, Craik DJ, et al. (2008) Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study. PLoS One 3: e2764.
-
(2008)
PLoS One
, vol.3
-
-
Schirra, H.J.1
Anderson, C.G.2
Wilson, W.J.3
Kerr, L.4
Craik, D.J.5
-
19
-
-
79956076012
-
Metabolomic response to exercise training in lean and diet-induced obese mice
-
Duggan GE, Hittel DS, Sensen CW, Weljie AM, Vogel HJ, et al. (2011) Metabolomic response to exercise training in lean and diet-induced obese mice. J Appl Physiol 110: 1311-1318.
-
(2011)
J Appl Physiol
, vol.110
, pp. 1311-1318
-
-
Duggan, G.E.1
Hittel, D.S.2
Sensen, C.W.3
Weljie, A.M.4
Vogel, H.J.5
-
20
-
-
52249095319
-
Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse
-
Shearer J, Duggan G, Weljie A, Hittel DS, Wasserman DH, et al. (2008) Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab 10: 950-958.
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 950-958
-
-
Shearer, J.1
Duggan, G.2
Weljie, A.3
Hittel, D.S.4
Wasserman, D.H.5
-
21
-
-
58149382045
-
Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet
-
Li H, Xie Z, Lin J, Song H, Wang Q, et al. (2008) Transcriptomic and metabonomic profiling of obesity-prone and obesity-resistant rats under high fat diet. J Proteome Res 7: 4775-4783.
-
(2008)
J Proteome Res
, vol.7
, pp. 4775-4783
-
-
Li, H.1
Xie, Z.2
Lin, J.3
Song, H.4
Wang, Q.5
-
23
-
-
84856609425
-
Multi- and megavariate data analysis
-
Umetrics AB
-
Eriksson L, Johansson E, Kettaneh-Wold N, Trygg J, Wikström C, et al. (2006) Multi- and megavariate data analysis. Basic Principles and Applications.: Umetrics AB.
-
(2006)
Basic Principles and Applications
-
-
Eriksson, L.1
Johansson, E.2
Kettaneh-Wold, N.3
Trygg, J.4
Wikström, C.5
-
24
-
-
77954256613
-
MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
-
Xia J, Wishart DS, (2010) MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res 38: W71-77.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Xia, J.1
Wishart, D.S.2
-
25
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, et al. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
Hecht, R.4
Winters, D.5
-
26
-
-
0022531052
-
Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations
-
Golay A, Swislocki AL, Chen YD, Jaspan JB, Reaven GM, (1986) Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations. J Clin Endocrinol Metab 63: 481-484.
-
(1986)
J Clin Endocrinol Metab
, vol.63
, pp. 481-484
-
-
Golay, A.1
Swislocki, A.L.2
Chen, Y.D.3
Jaspan, J.B.4
Reaven, G.M.5
-
28
-
-
77950341375
-
Creatine metabolism and the urea cycle
-
Brosnan JT, Brosnan ME, (2010) Creatine metabolism and the urea cycle. Mol Genet Metab 100Suppl 1: S49-52.
-
(2010)
Mol Genet Metab
, vol.100
-
-
Brosnan, J.T.1
Brosnan, M.E.2
-
29
-
-
65649099171
-
Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology
-
Zyromski NJ, Mathur A, Gowda GA, Murphy C, Swartz-Basile DA, et al. (2009) Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology. Pancreatology 9: 410-419.
-
(2009)
Pancreatology
, vol.9
, pp. 410-419
-
-
Zyromski, N.J.1
Mathur, A.2
Gowda, G.A.3
Murphy, C.4
Swartz-Basile, D.A.5
-
30
-
-
52649149131
-
Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes
-
Gipson GT, Tatsuoka KS, Ball RJ, Sokhansanj BA, Hansen MK, et al. (2008) Multi-platform investigation of the metabolome in a leptin receptor defective murine model of type 2 diabetes. Mol Biosyst 4: 1015-1023.
-
(2008)
Mol Biosyst
, vol.4
, pp. 1015-1023
-
-
Gipson, G.T.1
Tatsuoka, K.S.2
Ball, R.J.3
Sokhansanj, B.A.4
Hansen, M.K.5
-
31
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N, (2004) Upstream and downstream of mTOR. Genes Dev 18: 1926-1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
33
-
-
0016410664
-
Muscle amino acid metabolism and gluconeogenesis
-
Ruderman NB, (1975) Muscle amino acid metabolism and gluconeogenesis. Annu Rev Med 26: 245-258.
-
(1975)
Annu Rev Med
, vol.26
, pp. 245-258
-
-
Ruderman, N.B.1
-
34
-
-
0035140455
-
The BCAA-BCKA cycle: its relation to alanine and glutamine synthesis and protein balance
-
Holecek M, (2001) The BCAA-BCKA cycle: its relation to alanine and glutamine synthesis and protein balance. Nutrition 17: 70.
-
(2001)
Nutrition
, vol.17
, pp. 70
-
-
Holecek, M.1
-
35
-
-
31544440119
-
Potential importance of leucine in treatment of obesity and the metabolic syndrome
-
Layman DK, Walker DA, (2006) Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 136: 319S-323S.
-
(2006)
J Nutr
, vol.136
-
-
Layman, D.K.1
Walker, D.A.2
-
36
-
-
0035094978
-
Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies
-
Lynch CJ, (2001) Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr 131: 861S-865S.
-
(2001)
J Nutr
, vol.131
-
-
Lynch, C.J.1
-
37
-
-
0021278228
-
The plasma amino acid response to cafeteria feeding in the rat: influence of hyperphagia, sucrose intake, and exercise
-
Calles-Escandon J, Cunningham J, Felig P, (1984) The plasma amino acid response to cafeteria feeding in the rat: influence of hyperphagia, sucrose intake, and exercise. Metabolism 33: 364-368.
-
(1984)
Metabolism
, vol.33
, pp. 364-368
-
-
Calles-Escandon, J.1
Cunningham, J.2
Felig, P.3
-
38
-
-
34247397544
-
Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers
-
van Doorn M, Vogels J, Tas A, van Hoogdalem EJ, Burggraaf J, et al. (2007) Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers. Br J Clin Pharmacol 63: 562-574.
-
(2007)
Br J Clin Pharmacol
, vol.63
, pp. 562-574
-
-
van Doorn, M.1
Vogels, J.2
Tas, A.3
van Hoogdalem, E.J.4
Burggraaf, J.5
-
39
-
-
20344376194
-
The role of leucine in the regulation of protein metabolism
-
Garlick PJ, (2005) The role of leucine in the regulation of protein metabolism. J Nutr 135: 1553S-1556S.
-
(2005)
J Nutr
, vol.135
-
-
Garlick, P.J.1
-
40
-
-
84862287116
-
Investigating potential mechanisms of obesity by metabolomics
-
Xie B, Waters MJ, Schirra HJ, (2012) Investigating potential mechanisms of obesity by metabolomics. J Biomed Biotechnol 2012: 805683.
-
(2012)
J Biomed Biotechnol
, vol.2012
, pp. 805683
-
-
Xie, B.1
Waters, M.J.2
Schirra, H.J.3
-
41
-
-
78751535748
-
Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model
-
Sishi B, Loos B, Ellis B, Smith W, du Toit EF, et al. (2011) Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp Physiol 96: 179-193.
-
(2011)
Exp Physiol
, vol.96
, pp. 179-193
-
-
Sishi, B.1
Loos, B.2
Ellis, B.3
Smith, W.4
du Toit, E.F.5
-
42
-
-
79959453305
-
Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism
-
Macotela Y, Emanuelli B, Bang AM, Espinoza DO, Boucher J, et al. (2011) Dietary leucine-an environmental modifier of insulin resistance acting on multiple levels of metabolism. PLoS One 6: e21187.
-
(2011)
PLoS One
, vol.6
-
-
Macotela, Y.1
Emanuelli, B.2
Bang, A.M.3
Espinoza, D.O.4
Boucher, J.5
-
43
-
-
10044219517
-
Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
-
Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E, (2004) Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J 18: 1894-1896.
-
(2004)
FASEB J
, vol.18
, pp. 1894-1896
-
-
Hinault, C.1
Mothe-Satney, I.2
Gautier, N.3
Lawrence Jr., J.C.4
Van Obberghen, E.5
-
44
-
-
16244412330
-
Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats
-
Fu WJ, Haynes TE, Kohli R, Hu J, Shi W, et al. (2005) Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats. J Nutr 135: 714-721.
-
(2005)
J Nutr
, vol.135
, pp. 714-721
-
-
Fu, W.J.1
Haynes, T.E.2
Kohli, R.3
Hu, J.4
Shi, W.5
-
45
-
-
77956501826
-
Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health
-
McKnight JR, Satterfield MC, Jobgen WS, Smith SB, Spencer TE, et al. (2010) Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids 39: 349-357.
-
(2010)
Amino Acids
, vol.39
, pp. 349-357
-
-
McKnight, J.R.1
Satterfield, M.C.2
Jobgen, W.S.3
Smith, S.B.4
Spencer, T.E.5
-
46
-
-
60249098019
-
Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats
-
Jobgen W, Meininger CJ, Jobgen SC, Li P, Lee MJ, et al. (2009) Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats. J Nutr 139: 230-237.
-
(2009)
J Nutr
, vol.139
, pp. 230-237
-
-
Jobgen, W.1
Meininger, C.J.2
Jobgen, S.C.3
Li, P.4
Lee, M.J.5
-
47
-
-
67349147426
-
Arginine metabolism and nutrition in growth, health and disease
-
Wu G, Bazer FW, Davis TA, Kim SW, Li P, et al. (2009) Arginine metabolism and nutrition in growth, health and disease. Amino Acids 37: 153-168.
-
(2009)
Amino Acids
, vol.37
, pp. 153-168
-
-
Wu, G.1
Bazer, F.W.2
Davis, T.A.3
Kim, S.W.4
Li, P.5
-
48
-
-
80053921608
-
Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes
-
Oberbach A, Bluher M, Wirth H, Till H, Kovacs P, et al. (2011) Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes. J Proteome Res 10: 4769-4788.
-
(2011)
J Proteome Res
, vol.10
, pp. 4769-4788
-
-
Oberbach, A.1
Bluher, M.2
Wirth, H.3
Till, H.4
Kovacs, P.5
-
49
-
-
0016805132
-
Amino acid pattern in plasma before and after jejuno-ileal shunt operation for obesity
-
Backman L, Hallberg D, Kallner A, (1975) Amino acid pattern in plasma before and after jejuno-ileal shunt operation for obesity. Scand J Gastroenterol 10: 811-816.
-
(1975)
Scand J Gastroenterol
, vol.10
, pp. 811-816
-
-
Backman, L.1
Hallberg, D.2
Kallner, A.3
-
50
-
-
0041965831
-
Insulin effects on acetate metabolism
-
Piloquet H, Ferchaud-Roucher V, Duengler F, Zair Y, Maugere P, et al. (2003) Insulin effects on acetate metabolism. Am J Physiol Endocrinol Metab 285: E561-565.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Piloquet, H.1
Ferchaud-Roucher, V.2
Duengler, F.3
Zair, Y.4
Maugere, P.5
-
51
-
-
0013907843
-
Citrate metabolism in diabetes. I. Plasma citrate in alloxan-diabetic rats and in clinical diabetes
-
DeVilliers DC Jr, Dixit PK, Lazarow A, (1966) Citrate metabolism in diabetes. I. Plasma citrate in alloxan-diabetic rats and in clinical diabetes. Metabolism 15: 458-465.
-
(1966)
Metabolism
, vol.15
, pp. 458-465
-
-
DeVilliers Jr., D.C.1
Dixit, P.K.2
Lazarow, A.3
-
52
-
-
0032452225
-
Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years
-
Randle PJ, (1998) Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 14: 263-283.
-
(1998)
Diabetes Metab Rev
, vol.14
, pp. 263-283
-
-
Randle, P.J.1
-
53
-
-
46049100453
-
Effects of L-carnitine on obesity, diabetes, and as an ergogenic aid
-
Cha YS, (2008) Effects of L-carnitine on obesity, diabetes, and as an ergogenic aid. Asia Pac J Clin Nutr 17Suppl 1: 306-308.
-
(2008)
Asia Pac J Clin Nutr
, vol.17
, pp. 306-308
-
-
Cha, Y.S.1
-
54
-
-
79955433960
-
Metabolomic analysis of livers and serum from high-fat diet induced obese mice
-
Kim HJ, Kim JH, Noh S, Hur HJ, Sung MJ, et al. (2011) Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J Proteome Res 10: 722-731.
-
(2011)
J Proteome Res
, vol.10
, pp. 722-731
-
-
Kim, H.J.1
Kim, J.H.2
Noh, S.3
Hur, H.J.4
Sung, M.J.5
-
55
-
-
77956299196
-
Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS)
-
Kim JY, Park JY, Kim OY, Ham BM, Kim HJ, et al. (2010) Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 9: 4368-4375.
-
(2010)
J Proteome Res
, vol.9
, pp. 4368-4375
-
-
Kim, J.Y.1
Park, J.Y.2
Kim, O.Y.3
Ham, B.M.4
Kim, H.J.5
-
56
-
-
78651134314
-
Metabolic control of creatine biosynthesis. II. Restoration of transamidinase activity following creatine repression
-
Walker JB, (1961) Metabolic control of creatine biosynthesis. II. Restoration of transamidinase activity following creatine repression. J Biol Chem 236: 493-498.
-
(1961)
J Biol Chem
, vol.236
, pp. 493-498
-
-
Walker, J.B.1
-
57
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027-1031.
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
-
58
-
-
80054913827
-
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
-
Delzenne NM, Neyrinck AM, Backhed F, Cani PD, (2011) Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 7: 639-646.
-
(2011)
Nat Rev Endocrinol
, vol.7
, pp. 639-646
-
-
Delzenne, N.M.1
Neyrinck, A.M.2
Backhed, F.3
Cani, P.D.4
-
59
-
-
84866596616
-
1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode
-
Jung JY, Kim IY, Kim YN, Kim JS, Shin JH, et al. (2012) 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode. BMB Rep 45: 419-424.
-
(2012)
BMB Rep
, vol.45
, pp. 419-424
-
-
Jung, J.Y.1
Kim, I.Y.2
Kim, Y.N.3
Kim, J.S.4
Shin, J.H.5
-
60
-
-
33747618036
-
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
-
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, et al. (2006) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A 103: 12511-12516.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 12511-12516
-
-
Dumas, M.E.1
Barton, R.H.2
Toye, A.3
Cloarec, O.4
Blancher, C.5
-
61
-
-
84877331372
-
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
-
Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, et al. (2013) Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19: 576-585.
-
(2013)
Nat Med
, vol.19
, pp. 576-585
-
-
Koeth, R.A.1
Wang, Z.2
Levison, B.S.3
Buffa, J.A.4
Org, E.5
-
62
-
-
17844404232
-
Gut microorganisms, mammalian metabolism and personalized health care
-
Nicholson JK, Holmes E, Wilson ID, (2005) Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 3: 431-438.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 431-438
-
-
Nicholson, J.K.1
Holmes, E.2
Wilson, I.D.3
-
64
-
-
19544374744
-
A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats
-
Williams RE, Lenz EM, Evans JA, Wilson ID, Granger JH, et al. (2005) A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats. J Pharm Biomed Anal 38: 465-471.
-
(2005)
J Pharm Biomed Anal
, vol.38
, pp. 465-471
-
-
Williams, R.E.1
Lenz, E.M.2
Evans, J.A.3
Wilson, I.D.4
Granger, J.H.5
-
65
-
-
34247842731
-
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human
-
Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, et al. (2007) A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics 29: 99-108.
-
(2007)
Physiol Genomics
, vol.29
, pp. 99-108
-
-
Salek, R.M.1
Maguire, M.L.2
Bentley, E.3
Rubtsov, D.V.4
Hough, T.5
-
66
-
-
77953611756
-
Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype
-
Calvani R, Miccheli A, Capuani G, Tomassini Miccheli A, Puccetti C, et al. (2010) Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype. Int J Obes (Lond) 34: 1095-1098.
-
(2010)
Int J Obes (Lond)
, vol.34
, pp. 1095-1098
-
-
Calvani, R.1
Miccheli, A.2
Capuani, G.3
Tomassini Miccheli, A.4
Puccetti, C.5
-
67
-
-
0029847006
-
Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism
-
Smith EA, Macfarlane GT, (1996) Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J Appl Bacteriol 81: 288-302.
-
(1996)
J Appl Bacteriol
, vol.81
, pp. 288-302
-
-
Smith, E.A.1
Macfarlane, G.T.2
-
68
-
-
0026652318
-
Estimation of short-chain fatty acid production from protein by human intestinal bacteria based on branched-chain fatty acid measurements
-
Macfarlane GT, Gibson GR, Beatty E, Cummings JH, (1992) Estimation of short-chain fatty acid production from protein by human intestinal bacteria based on branched-chain fatty acid measurements. FEMS Microbiology Letters 101: 81-88.
-
(1992)
FEMS Microbiology Letters
, vol.101
, pp. 81-88
-
-
Macfarlane, G.T.1
Gibson, G.R.2
Beatty, E.3
Cummings, J.H.4
-
69
-
-
41149099000
-
Symbiotic gut microbes modulate human metabolic phenotypes
-
Li M, Wang B, Zhang M, Rantalainen M, Wang S, et al. (2008) Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 105: 2117-2122.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2117-2122
-
-
Li, M.1
Wang, B.2
Zhang, M.3
Rantalainen, M.4
Wang, S.5
-
70
-
-
48749108374
-
Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS
-
Sun J, Schnackenberg LK, Holland RD, Schmitt TC, Cantor GH, et al. (2008) Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J Chromatogr B Analyt Technol Biomed Life Sci 871: 328-340.
-
(2008)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.871
, pp. 328-340
-
-
Sun, J.1
Schnackenberg, L.K.2
Holland, R.D.3
Schmitt, T.C.4
Cantor, G.H.5
-
71
-
-
0028062027
-
Cardioprotective actions of taurine against intracellular and extracellular calcium-induced effects
-
Satoh H, (1994) Cardioprotective actions of taurine against intracellular and extracellular calcium-induced effects. Adv Exp Med Biol 359: 181-196.
-
(1994)
Adv Exp Med Biol
, vol.359
, pp. 181-196
-
-
Satoh, H.1
-
72
-
-
3042519102
-
Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects
-
Zhang M, Bi LF, Fang JH, Su XL, Da GL, et al. (2004) Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects. Amino Acids 26: 267-271.
-
(2004)
Amino Acids
, vol.26
, pp. 267-271
-
-
Zhang, M.1
Bi, L.F.2
Fang, J.H.3
Su, X.L.4
Da, G.L.5
-
73
-
-
33646475134
-
Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics
-
Kochhar S, Jacobs DM, Ramadan Z, Berruex F, Fuerholz A, et al. (2006) Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics. Anal Biochem 352: 274-281.
-
(2006)
Anal Biochem
, vol.352
, pp. 274-281
-
-
Kochhar, S.1
Jacobs, D.M.2
Ramadan, Z.3
Berruex, F.4
Fuerholz, A.5
-
74
-
-
0036135892
-
Estrogen replacement increased the citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis
-
Dey J, Creighton A, Lindberg JS, Fuselier HA, Kok DJ, et al. (2002) Estrogen replacement increased the citrate and calcium excretion rates in postmenopausal women with recurrent urolithiasis. J Urol 167: 169-171.
-
(2002)
J Urol
, vol.167
, pp. 169-171
-
-
Dey, J.1
Creighton, A.2
Lindberg, J.S.3
Fuselier, H.A.4
Kok, D.J.5
-
75
-
-
0036255631
-
The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise
-
D'Eon T, Braun B, (2002) The roles of estrogen and progesterone in regulating carbohydrate and fat utilization at rest and during exercise. J Womens Health Gend Based Med 11: 225-237.
-
(2002)
J Womens Health Gend Based Med
, vol.11
, pp. 225-237
-
-
D'Eon, T.1
Braun, B.2
-
76
-
-
2342644814
-
Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
-
Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, et al. (2004) Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 27: 1036-1041.
-
(2004)
Diabetes Care
, vol.27
, pp. 1036-1041
-
-
Laaksonen, D.E.1
Niskanen, L.2
Punnonen, K.3
Nyyssonen, K.4
Tuomainen, T.P.5
-
77
-
-
0034106347
-
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study
-
Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB, (2000) Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 23: 490-494.
-
(2000)
Diabetes Care
, vol.23
, pp. 490-494
-
-
Stellato, R.K.1
Feldman, H.A.2
Hamdy, O.3
Horton, E.S.4
McKinlay, J.B.5
-
78
-
-
43249128538
-
Low testosterone levels are common and associated with insulin resistance in men with diabetes
-
Grossmann M, Thomas MC, Panagiotopoulos S, Sharpe K, Macisaac RJ, et al. (2008) Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 93: 1834-1840.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 1834-1840
-
-
Grossmann, M.1
Thomas, M.C.2
Panagiotopoulos, S.3
Sharpe, K.4
Macisaac, R.J.5
-
80
-
-
84860863051
-
Correlation between sex hormone levels and obesity in the elderly male
-
Cao J, Chen TM, Hao WJ, Li J, Liu L, et al. (2012) Correlation between sex hormone levels and obesity in the elderly male. Aging Male 15: 85-89.
-
(2012)
Aging Male
, vol.15
, pp. 85-89
-
-
Cao, J.1
Chen, T.M.2
Hao, W.J.3
Li, J.4
Liu, L.5
-
81
-
-
0041845178
-
Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences
-
Plumb R, Granger J, Stumpf C, Wilson ID, Evans JA, et al. (2003) Metabonomic analysis of mouse urine by liquid-chromatography-time of flight mass spectrometry (LC-TOFMS): detection of strain, diurnal and gender differences. Analyst 128: 819-823.
-
(2003)
Analyst
, vol.128
, pp. 819-823
-
-
Plumb, R.1
Granger, J.2
Stumpf, C.3
Wilson, I.D.4
Evans, J.A.5
-
82
-
-
34548730771
-
Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles
-
Slupsky CM, Rankin KN, Wagner J, Fu H, Chang D, et al. (2007) Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles. Anal Chem 79: 6995-7004.
-
(2007)
Anal Chem
, vol.79
, pp. 6995-7004
-
-
Slupsky, C.M.1
Rankin, K.N.2
Wagner, J.3
Fu, H.4
Chang, D.5
-
83
-
-
84872321275
-
Involvement of protein tyrosine phosphatases in adipogenesis: new anti-obesity targets?
-
Bae KH, Kim WK, Lee SC, (2012) Involvement of protein tyrosine phosphatases in adipogenesis: new anti-obesity targets? BMB Rep 45: 700-706.
-
(2012)
BMB Rep
, vol.45
, pp. 700-706
-
-
Bae, K.H.1
Kim, W.K.2
Lee, S.C.3
|