The role of leucine in the regulation of protein metabolism

Journal of Nutrition

Volumn 135, Issue 6 SUPPL., 2005, Pages

  Garlick, Peter J ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Branched chain amino acids; Insulin; Isoleucine; Leucine; Muscle; Protein synthesis; Valine

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUCOSE; INSULIN; ISOLEUCINE; LEUCINE; MUSCLE PROTEIN; PROTEIN; VALINE;

CONFERENCE PAPER; DOSE RESPONSE; HUMAN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

EID: 20344376194     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/135.6.1553s     Document Type: Conference Paper

References (26)

1. Fulks, R. H., Li, J. B. & Goldberg, A. L. (1975) Effects of insulin, glucose and amino acids on protein turnover in rat diaphragms. J. Biol. Chem. 250: 290-298.
2. Buse, M. G. & Reid, S. S. (1975) Leucine: a possible regulator of protein turnover in muscle. J. Clin. Invest. 56: 1250-1261.
3. Li, J. B. & Jefferson, L. S. (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochim. Biophys. Acta. 544: 351-359.
4. Morgan, H. E., Earl, D.C.N., Broadus, E. B., Giger, K. E., & Jefferson, L. S. (1971) Regulation of protein synthesis in heart muscle. I. Effect of amino acid levels on protein synthesis. J. Biol. Chem. 246: 2152-2162.
5. Rannels, D. E., Hjalmarson, A. C. & Morgan, H. E. (1974) Effects of noncarbohydrate substances on protein synthesis in muscle. Am J. Physiol. 226: 528-539.
6. Sherwin, R. S. (1978) Effect of starvation on the turnover and metabolic response to leucine. J. Clin. Invest. 61: 1471-1481.
7. Sapir, D. G. & Walser, M. (1977) Nitrogen sparing induced in starvation by infusion of branched chain ketoacids. Metab. Clin. Exp. 26: 301-308.
8. Mitch, W. E., Walser, M. & Sapir, D. G. (1981) Nitrogen sparing induced by leucine compared with that induced by its keto analogue, α-ketoisocaproate, in fasting obese man. J. Clin. Invest. 67: 553-562.
9. Hagenfeldt, L., Eriksson, S. & Wahren, J. (1980) Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. Clin. Sci. 59: 173-181.
10. Buse, M. G., Atwell, R. & Mancusi, V. (1979) In vitro effect of branched chain amino acids on the ribosomal cycle in muscles of fasted rats. Horm. Metab. Res. 11: 289292.
11. McNurlan, M. A., Fern, E. B. & Garlick, P. J. (1982) Failure of leucine to stimulate protein synthesis in vivo. Biochem. J. 204: 831-838.
12. 3H)phenylalanine. Biochem. J. 192: 719-723.
13. Preedy, V. R. & Garlick, P. J. (1986) The response of muscle protein synthesis to nutrient intake in postabsorptive rats: the role of insulin and amino acids. Biosci. Rep. 6: 177-183.
14. Garlick, P. J., Fern, M. & Preedy, V. R. (1983) The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats. Biochem. J. 210: 669-676.
15. Garlick, P. J. & Grant, I. (1988) Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Biochem J. 254: 579-584.
16. Dardevet, D., Sornet, C., Bayle, G., Prugnaud, J., Pouyet, C., & Grizard, J. (2002) Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal. J. Nutr. 132: 95-100.
17. Rieu, J., Sornet, C., Bayle, G., Prugnaud, J., Pouyet, C., Balage, M., Papet, I., Grizard, J. & Dardevet, D. (2003) Leucine-supplemented meal feeding for ten days beneficially affects postprandial muscle protein synthesis in old rats. J. Nutr. 133: 1198-1205.
18. Anthony, J. C., Anthony, T. G., & Layman, D. K. (1999) Leucine supplementation enhances skeletal muscle recovery in rats following exercise. J. Nutr. 129: 1102-1106.
19. Anthony, J. C., Lang, C. H., Crozier, S. J., Anthony, T. G., MacLean, D. A., Kimball, S. R. & Jefferson, L. S. (2002) Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am. J. Physiol. Endocrinol. Metab. 282: E1092-E1101.
20. Anthony, J. C., Reiter, A. K., Anthony, T. G., Crozier, S. J., Lang, C. H., MacLean, D. A., Kimball, S. R. & Jefferson, L. S. (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes 51: 928-936.
21. Bolster, D. R., Vary, T. C., Kimball, S. R., & Jefferson, L. S. (2004) Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J. Nutr. 134: 1704-1710.
22. Kimball, S. R. & Jefferson, L. S. (2004) Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin. Curr. Opin. Clin. Nutr. Metab. Care 7: 39-44.
23. Kadowaki, M. & Kanazawa, T. (2003) Amino acids as regulators of proteolysis. J. Nutr. 133: 2052S-2056S.
24. Anthony, T. G., Antony, J. C., Yoshizawa, F., Kimball, S. R. & Jefferson, L. S. (2001) Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in liver of rats. J. Nutr. 131: 1171-1176.
25. Mortimore, G. E. & Pösö, A. R. (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Ann. Rev. Nutr. 7: 539-564.
26. Layman, D. K. & Baum, J. I. (2004) Dietary protein impact on glycemic control during weight loss. J Nutr. 134: 968S-973S.