Influence of the 48867A>C (Asp358Ala) IL6R polymorphism on response to a lifestyle modification intervention in individuals with metabolic syndrome

Genetics and Molecular Research

Volumn 12, Issue 3, 2013, Pages 3983-3991

  Vargas, V R A ^a,b   Bonatto, S L ^a   Macagnan, F E ^a   Feoli, A M P ^a   Alho, C S ^a   Santos, N D V ^a   Schmitt, V M ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b DEPARTMENT OF FOOD ENGINEERING   (Brazil)

Author keywords

Exercise; Genetic risk factor; Nutritional intervention; Obesity

Indexed keywords

GLUCOSE; INTERLEUKIN 6 RECEPTOR; TRIACYLGLYCEROL;

ADULT; ARTICLE; CONTROLLED STUDY; DIET THERAPY; DISEASE SEVERITY; EXERCISE; FEMALE; GENETIC RISK; GENOTYPE; HUMAN; INTERLEUKIN 6 RECEPTOR GENE; LIFESTYLE MODIFICATION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE;

ADULT; ALLELES; BLOOD GLUCOSE; BLOOD PRESSURE; BRAZIL; CHOLESTEROL, HDL; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENOTYPE; HUMANS; INTERVENTION STUDIES; LIFE STYLE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-6; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84884836081     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2013.February.28.8     Document Type: Article

References (39)

1. Akintunde AA, Ayodele OE, Akinwusi PO and Opadijo GO (2011). Metabolic syndrome: comparison of occurrence using three definitions in hypertensive patients. Clin. Med. Res. 9: 26-31.
2. Busnello FM, Bodanese LC, Pellanda LC and Santos ZE (2011). Nutritional intervention and the impact on adherence to treatment in patients with metabolic syndrome. Arq. Bras. Cardiol. 97: 217-224.
3. Casella-Filho A, Chagas AC, Maranhão RC, Trombetta IC, et al. (2011). Effect of exercise training on plasma levels and functional properties of high-density lipoprotein cholesterol in the metabolic syndrome. Am. J. Cardiol. 107: 1168-1172.
4. Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, et al. (2008). The metabolic syndrome. Endocr. Rev. 29: 777-822.
5. Dalle GR, Calugi S, Centis E, Marzocchi R, et al. (2010). Lifestyle modification in the management of the metabolic syndrome: achievements and challenges. Diabetes Metab. Syndr. Obes. 3: 373-385.
6. Das SK and Elbein SC (2006). The genetic basis of type 2 diabetes. Cellscience 2: 100-131.
7. De Luca C and Olefsky JM (2006). Stressed out about obesity and insulin resistance. Nat. Med. 12: 41-42.
8. Duvnjak L and Duvnjak M (2009). The metabolic syndrome-an ongoing story. J. Physiol. Pharmacol. 60 Suppl 7: 19-24.
9. Esteve E, Villuendas G, Mallolas J, Vendrell J, et al. (2006). Polymorphisms in the interleukin-6 receptor gene are associated with body mass index and with characteristics of the metabolic syndrome. Clin. Endocrinol. 65: 88-91.
10. Fernández-Real JM and Ricart W (2003). Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr. Rev. 24: 278-301.
11. Galicia JC, Tai H, Komatsu Y, Shimada Y, et al. (2004). Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. Genes Immun. 5: 513-516.
12. Grundy SM, Cleeman JI, Daniels SR, Donato KA, et al. (2005). Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112: 2735-2752.
13. Gupta A and Gupta V (2010). Metabolic syndrome: what are the risks for humans? Biosci. Trends 4: 204-212.
14. Hamid YH, Rose CS, Urhammer SA, Glumer C, et al. (2005). Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes. Diabetologia 48: 251-260.
15. Heinrich PC, Behrmann I, Haan S, Hermanns HM, et al. (2003). Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374: 1-20.
16. IDF Clinical Guidelines Task Force (2006). Global guideline for type 2 diabetes: recommendations for standard, comprehensive, and minimal care. Diabet. Med. 23: 579-593.
17. Jones SA, Horiuchi S, Topley N, Yamamoto N, et al. (2001). The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 15: 43-58.
18. Kim LH, Lee HS, Kim YJ, Jung JH, et al. (2003). Identification of novel SNPs in the interleukin 6 receptor gene (IL6R). Hum. Mutat. 21: 450-451.
19. Lahiri DK and Nurnberger JI Jr. (1991). A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19: 5444.
20. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, et al. (2002). The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288: 2709-2716.
21. Lazar MA (2006). The humoral side of insulin resistance. Nat. Med. 12: 43-44.
22. Meshkani R and Adeli K (2009). Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin. Biochem. 42: 1331-1346.
23. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, et al. (1997). Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J. Clin. Endocrinol. Metab. 82: 4196-4200.
24. Monteiro R and Azevedo I (2010). Chronic inflammation in obesity and the metabolic syndrome. Mediators. Inflamm. 2010.
25. Ordovas JM and Shen J (2008). Gene-environment interactions and susceptibility to metabolic syndrome and other chronic diseases. J. Periodontol. 79: 1508-1513.
26. Pimentel GD, Arimura ST, de Moura BM, Silva ME, et al. (2010). Short-term nutritional counseling reduces body mass index, waist circumference, triceps skinfold and triglycerides in women with metabolic syndrome. Diabetol. Metab. Syndr. 2: 13.
27. Qi L, Rifai N and Hu FB (2007). Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women. Diabetes 56: 3075-3081.
28. Rafiq S, Frayling TM, Murray A, Hurst A, et al. (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun. 8: 552-559.
29. Ren J, Zhu W, Dai H, Chen Z, et al. (2007). Nutritional intervention in the metabolic syndrome. Asia Pac. J. Clin. Nutr. (Suppl 16) 1: 418-421.
30. Santer FR, Malinowska K, Culig Z and Cavarretta IT (2010). Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr. Relat. Cancer 17: 241-253.
31. Sherry ST, Ward MH, Kholodov M, Baker J, et al. (2001). dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 29: 308-311.
32. Sociedade Brasileira de Cardiologia (2005). I Diretriz Brasileira de Diagnóstico e Tratamento da Síndrome Metabólica. Arq. Bras. Cardiol. 84 (Suppl I): 1-28.
33. Villareal DT, Miller BV 3rd, Banks M, Fontana L, et al. (2006). Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am. J. Clin. Nutr. 84: 1317-1323.
34. Wang H, Zhang Z, Chu W, Hale T, et al. (2005). Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. J. Clin. Endocrinol. Metab. 90: 1123-1129.
35. Wang X, Hsu FC, Isom S, Walkup MP, et al. (2012). Effects of a 12-month physical activity intervention on prevalence of metabolic syndrome in elderly men and women. J. Gerontol. A Biol. Sci. Med. Sci. 67: 417-424.
36. Wellen KE and Hotamisligil GS (2005). Inflammation, stress, and diabetes. J. Clin. Invest. 115: 1111-1119.
37. Wolford JK, Colligan PB, Gruber JD and Bogardus C (2003). Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol. Genet. Metab. 80: 338-343.
38. Yamada Y, Kato K, Hibino T, Yokoi K, et al. (2007). Prediction of genetic risk for metabolic syndrome. Atherosclerosis 191: 298-304.
39. Yu Z, Ye X, Wang J, Qi Q, et al. (2009). Associations of physical activity with inflammatory factors, adipocytokines, and metabolic syndrome in middle-aged and older chinese people. Circulation 119: 2969-2977.