Mutation breeding of acetoin high producing Bacillus subtilis blocked in 2,3-butanediol dehydrogenase

World Journal of Microbiology and Biotechnology

Volumn 29, Issue 10, 2013, Pages 1783-1789

  Zhang, Xian ^a   Zhang, Rongzhen ^a   Yang, Taowei ^a   Zhang, Jing ^a   Xu, Meijuan ^a   Li, Huazhong ^a   Xu, Zhenghong ^a   Rao, Zhiming ^a  

^a JIANGNAN UNIVERSITY   (China)

Author keywords

2,3 Butanediol dehydrogenase; Acetoin; Acetoin reductase; Bacillus subtilis; Mutagenesis

Indexed keywords

2 ,3-BUTANEDIOL; 2 ,3-BUTANEDIOL DEHYDROGENASE; ACETOIN; BACILLUS SUBTILIS; BATCH FERMENTATION; DIETHYL SULFATE; MUTATION BREEDING; QUALITATIVE IDENTIFICATION;

BYPRODUCTS; FERMENTATION; MUTAGENESIS;

GENE ENCODING;

BACILLUS SUBTILIS;

2,3 BUTYLENE GLYCOL; 2,3-BUTYLENE GLYCOL; ACETOIN; ALCOHOL DEHYDROGENASE; BUTANEDIOL; BUTANEDIOL DEHYDROGENASE; MUTAGENIC AGENT; MUTANT PROTEIN;

ARTICLE; BACILLUS SUBTILIS; DRUG EFFECT; GENE INACTIVATION; GENETICS; METABOLIC ENGINEERING; METABOLISM; METHODOLOGY; MUTAGENESIS; RADIATION EXPOSURE; STOP CODON; ULTRAVIOLET RADIATION;

ACETOIN; ALCOHOL OXIDOREDUCTASES; BACILLUS SUBTILIS; BUTYLENE GLYCOLS; CODON, NONSENSE; GENE KNOCKOUT TECHNIQUES; METABOLIC ENGINEERING; MUTAGENESIS; MUTAGENS; MUTANT PROTEINS; ULTRAVIOLET RAYS;

EID: 84884813430     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-013-1339-8     Document Type: Article

References (23)

1. Dettwiler B, Dunn IJ, Heinzle E, Prenosil JE (1993) A simulation model for the continuous production of acetoin and butanediol using Bacillus subtilis with integrated pervaporation separation. Biotechnol Bioeng 41(8): 791-800.
2. Horie K, Oba T, Motomura S, Isogai A, Yoshimura T, Tsuge K, Koganemaru K, Kobayashi G, Kitagaki H (2010) Breeding of a low pyruvate-producing sake yeast by isolation of a mutant resistant to ethyl alpha-transcyanocinnamate, an inhibitor of mitochondrial pyruvate transport. Biosci Biotechnol Biochem 74(4): 843-847. doi: 10. 1271/Bbb. 90373.
3. Ji XJ, Huang H, Li S, Du J, Lian M (2008) Enhanced 2, 3-butanediol production by altering the mixed acid fermentation pathway in Klebsiella oxytoca. Biotechnol Lett 30(4): 731-734. doi: 10. 1007/s10529-007-9599-8.
4. Jung HK, Park CD, Bae DH, Hong JH (2008) Isolation of alcohol-tolerant amylolytic Saccharomyces cerevisiae and its application to alcohol fermentation. Food Sci Biotechnol 17(6): 1160-1164.
5. Lopez J, Thoms B, Fortnagel P (1973) Mutants of Bacillus subtilis blocked in acetoin reductase. Eur J Biochem 40(2): 479-483.
6. Muehlbauer FJ, Cho S, Sarker A, McPhee KE, Coyne CJ, Rajesh PN, Ford R (2006) Application of biotechnology in breeding lentil for resistance to biotic and abiotic stress. Euphytica 147(1-2): 149-165. doi: 10. 1007/s10681-006-7108-0.
7. Nicholson WL (2008) The Bacillus subtilisydjL (bdhA) gene encodes acetoin reductase/2, 3-butanediol dehydrogenase. Appl Environ Microbiol 74(22): 6832-6838.
8. Perkins JB, Sloma A, Hermann T, Theriault K, Zachgo E, Erdenberger T, Hannett N, Chatterjee NP, Williams IIV, Rufo GA Jr, Hatch R, Pero J (1999) Genetic engineering of Bacillus subtilis for the commercial production of riboflavin. J Ind Microbiol Biotechnol 22(1): 8-18. doi: 10. 1038/sj. jim. 2900587.
9. Phalip V, Schmitt P, Diviès C (1994) A method for screening diacetyl and acetoin-producing bacteria on agar plates. J Basic Microbiol 34(4): 277-280. doi: 10. 1002/jobm. 3620340412.
10. Qin JY, Xiao ZJ, Ma CQ, Xie NZ, Liu PH, Xu P (2006) Production of 2, 3-butanediol by Klebsiella pneumoniae using glucose and ammonium phosphate. Chin J Chem Eng 14(1): 132-136.
11. Setlow B, Cabrera-Hernandez A, Cabrera-Martinez RM, Setlow P (2004) Identification of aryl-phospho-beta-D-glucosidases in Bacillus subtilis. Arch Microbiol 181(1): 60-67. doi: 10. 1007/s00203-003-0628-2.
12. Song H, Chen XC, Cao JM, Fang T, Bai JX, Xiong JA, Ying HJ (2010) Directed breeding of an Arthrobacter mutant for high-yield production of cyclic adenosine monophosphate by N + ion implantation. Radiat Phys Chem 79(8): 826-830. doi: 10. 1016/j. radphyschem. 2010. 03. 005.
13. Su CX, Zhou W, Fan YH, Wang L, Zhao SG, Yu ZL (2006) Mutation breeding of chitosanase-producing strain Bacillus sp S65 by low-energy ion implantation. J Ind Microbiol Biotechnol 33(12): 1037-1042. doi: 10. 1007/s10295-006-0155-7.
14. Sun JN, Zhang LY, Rao B, Han YB, Chu J, Zhu JW, Shen YL, Wei DZ (2012) Enhanced acetoin production by Serratia marcescens H32 using statistical optimization and a two-stage agitation speed control strategy. Biotechnol Bioprocess Eng 17(3): 598-605. doi: 10. 1007/s12257-011-0587-4.
15. Wang M, Fu J, Zhang XY, Chen T (2012) Metabolic engineering of Bacillus subtilis for enhanced production of acetoin. Biotechnol Lett 34(10): 1877-1885. doi: 10. 1007/s10529-012-0981-9.
16. Weenink XO, Punt PJ, van den Hondel CAMJJ, Ram AFJ (2006) A new method for screening and isolation of hypersecretion mutants in Aspergillus niger. Appl Microbiol Biotechnol 69(6): 711-717. doi: 10. 1007/s00253-005-0013-y.
17. Winkelman JW, Clark DP (1984) Proton suicide: general method for direct selection of sugar transport- and fermentation-defective mutants. J Bacteriol 160(2): 687-690.
18. Xiao ZJ, Xu P (2007) Acetoin metabolism in bacteria. Crit Rev Microbiol 33(2): 127-140. doi: 10. 1080/10408410701364604.
19. Xiao ZJ, Liu PH, Qin JY, Xu P (2007) Statistical optimization of medium components for enhanced acetoin production from molasses and soybean meal hydrolysate. Appl Microbiol Biotechnol 74(1): 61-68.
20. Xu H, Jia SR, Liu JJ (2011) Development of a mutant strain of Bacillus subtilis showing enhanced production of acetoin. Afr J Biotechnol 10(5): 779-788.
21. Yu EK, Saddler JN (1983) Fed-batch approach to production of 2, 3-butanediol by Klebsiella pneumoniae grown on high substrate concentrations. Appl Environ Microbiol 46(3): 630-635.
22. Zhang X, Yang TW, Lin Q, Xu MJ, Xia HF, Xu ZH, Li HZ, Rao ZM (2011) Isolation and identification of an acetoin high production bacterium that can reverse transform 2, 3-butanediol to acetoin at the decline phase of fermentation. World J Microbiol Biotechnol 27(12): 2785-2790.
23. Zhang L, Chen S, Xie H, Tian Y, Hu K (2012) Efficient acetoin production by optimization of medium components and oxygen supply control using a newly isolated Paenibacillus polymyxa CS107. J Chem Technol Biotechnol: n/a-n/a.