Different muscarinic receptor subtypes modulate proliferation of primary human detrusor smooth muscle cells via Akt/PI3K and map kinases

Pharmacological Research

Volumn 74, Issue , 2013, Pages 1-6

  Arrighi, Nicola ^c   Bodei, Serena ^a   Zani, Danilo ^a,c   Michel, Martin C ^b   Simeone, Claudio ^a   Cosciani Cunico, Sergio ^a   Spano, Pierfranco ^a   Sigala, Sandra ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Istituto Clinico Citta di Brescia   (Italy)

Author keywords

Human detrusor smooth; Muscarinic receptors; Muscle cell; Proliferation

Indexed keywords

1,4 DIAMINO 2,3 DICYANO 1,4 BIS[2 AMINOPHENYLTHIO]BUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ATROPINE; CARBACHOL; DARIFENACIN; MITOGEN ACTIVATED PROTEIN KINASE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; OTENZEPAD; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; QUINUCLIDINYL BENZILATE H3; RADIOLIGAND; THYMIDINE H 3; U 126; UNCLASSIFIED DRUG;

AGED; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG POTENCY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRACELLULAR SIGNALING; LIGAND BINDING; MALE; MUSCLE CONTRACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

HUMAN DETRUSOR SMOOTH; MUSCARINIC RECEPTORS; MUSCLE CELL; PROLIFERATION;

AGED; ATROPINE; BENZOFURANS; CARBACHOL; CELL PROLIFERATION; CELLS, CULTURED; CHOLINERGIC AGONISTS; GENE EXPRESSION; HUMANS; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCARINIC ANTAGONISTS; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PIPERIDINES; PIRENZEPINE; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINES; RECEPTORS, MUSCARINIC; RNA, MESSENGER; URINARY BLADDER;

EID: 84884775956     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.04.007     Document Type: Article

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