The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class a module to mediate receptor activation

Journal of Biological Chemistry

Volumn 288, Issue 39, 2013, Pages 28138-28151

  Kong, Roy C K ^a,b   Petrie, Emma J ^b,c   Mohanty, Biswaranjan ^d   Ling, Jason ^b,c   Lee, Jeremy C Y ^b,c   Gooley, Paul R ^b,c   Bathgate, Ross A D ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS A; DRUG DEVELOPMENT; HYDROPHOBIC MOIETIES; LOW DENSITY LIPOPROTEINS; N TERMINUS; N-TERMINALS; RECEPTOR ACTIVATION; SIDE-CHAINS;

BIOCHEMISTRY; BIOLOGY;

HYDROPHOBICITY;

G PROTEIN COUPLED RECEPTOR; LEUCINE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LYSINE; RELAXIN FAMILY PEPTIDE RECEPTOR 1; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRAIN HEK293; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIGAND BINDING; LOSS OF FUNCTION MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

G PROTEIN-COUPLED RECEPTORS (GPCR); NMR; PEPTIDE HORMONES; PEPTIDES; PROTEIN STRUCTURE; RELAXIN; RXFP1;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; CELL MEMBRANE; GENES, REPORTER; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, LDL; RECEPTORS, PEPTIDE; RELAXIN; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84884756868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.499640     Document Type: Article

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