Cooperative binding of insulin-like peptide 3 to a dimeric relaxin family peptide receptor 2

Endocrinology

Volumn 149, Issue 3, 2008, Pages 1113-1120

  Svendsen, Angela Manegold ^a   Vrecl, Milka ^b   Ellis, Tina M ^a,f   Heding, Anders ^c   Kristensen, Jesper Bøggild ^d   Wade, John D ^e   Bathgate, Ross A D ^e   De Meyts, Pierre ^a   Nøhr, Jane ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c 7TM Pharma A S   (Denmark)

^d NOVO NORDISK A S   (Denmark)

^e UNIVERSITY OF MELBOURNE   (Australia)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN LIKE PEPTIDE 3; PEPTIDE HORMONE; RELAXIN FAMILY PEPTIDE RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONTROLLED STUDY; DIMERIZATION; DOSE RESPONSE; HUMAN; HUMAN CELL; INSULIN BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; TEMPERATURE DEPENDENCE;

CELL LINE; DIMERIZATION; HUMANS; INSULIN; LUMINESCENT MEASUREMENTS; PROTEIN BINDING; PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; TEMPERATURE; TRANSFECTION;

EID: 40849119953     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0412     Document Type: Article

References (48)

1. Roche PJ, Butkus A, Wintour EM, Tregear GW 1996 Structure and expression of Leydig insulin-like peptide mRNA in the sheep. Mol Cell Endocrinol 121:171-177
2. Wilkinson TN, Speed TP, Tregear GW, Bathgate RA 2005 Evolution of the relaxin-like peptide family. BMC Evol Biol 5:14
3. Bathgate RAD, Samuel CS, Burazin TC, Gundlach AL, Tregear GW 2003 Relaxin: new peptides, receptors and novel actions. Trends Endocrinol Metab 14:207-213
4. Bathgate RAD, Hsuch AJW, Sherwood OD 2005 Physiology and molecular biology of the relaxin peptide family. In: Neill J, Wassarmann P, eds. Knobil and Neill Physiology of reproduction. Philadelphia: Elsevier; 679-768
5. Adham IM, Burkhardt-Goettges E, Engel W 1996 The Leydig insulin-like peptide. J Anim Breed Genet 113:229-235
6. De Meyts P 2004 Insulin and its receptor: structure, function and evolution. Bioessays 26:1351-1362
7. Buellesbach EE, Yang S, Schwabe C 1992 The receptor-binding site of human relaxin II: a dual prong-binding mechanism. J Biol Chem 267:22957-22960
8. Buellesbach EE, Schwabe C 1995 A novel Leydig cell cDNA-derived protein is a relaxin-like factor. J Biol Chem 270:16011-16015
9. Buellesbach EE, Schwabe C 1994 Functional importance of the A chain loop in relaxin and insulin. J Biol Chem 269:13124-13128
10. Claasz AA, Bond CP, Bathgate RAD, Otvos L, Dawson NF, Summers RJ, Tregear GW, Wade JD 2002 Relaxin-like bioactivity of ovine insulin 3 (INSL3) analogues. Eur J Biochem 269:6287-6293
11. Rosengren KJ, Zhang S, Lin F, Daly NL, Scott DJ, Hughes RA, Bathgate RAD, Craik DJ, Wade JD 2006 Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. J Biol Chem 281:28287-28295
12. Halls ML, Bond CP, Sudo S, Kumagai J, Ferraro T, Layfield S, Bathgate RAD, Summers RJ 2005 Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8). J Pharmacol Exp Ther 313:677-687
13. Hsu SYT, Semyonov J, Park JI, Chang CL 2005 Evolution of the signaling system in relaxin-family peptides. Ann NY Acad Sci 1041:520-529
14. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ 2003 H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 278:7855-7862
15. Halls ML, Bathgate RAD, Sudo S, Kumagai J, Bond CP, Summers RJ 2005 Identification of binding sites with differing affinity and potency for relaxin analogues on LGR7 and LGR8 Receptors. Ann NY Acad Sci 1041:17-21
16. De Meyts P, Roth J, Neville Jr DM, Gavin JR, Lesniak MA 1973 Insulin interactions with its receptors, experimental evidence for negative cooperativity. Biochem Biophys Res Commun 55:154-161
17. De Meyts P, Bianco AR, Roth J 1976 Site site interactions among insulin receptors. Characterization of the negative cooperativity. J Biol Chem 251:1877-1888
18. Koshland DE Jr., Hamadani K 2002 Proteomics and models for enzyme cooperativity. J Biol Chem 277:46841-46844
19. Koshland Jr DE 1996 The structural basis of negative cooperativity: receptors and enzymes. Curr Opin Struct Biol 6:757-761
20. Limbird LE, De Meyts P, Lefkowitz RJ 1975 β-Adrenergic receptors: evidence for negative cooperativity. Biochem Biophys Res Commun 64:1160-1168
21. De Meyts P 1976 Cooperative properties of hormone receptors in cell membranes. J Supramol Struct 4:241-258
22. Powell-Jones CH, Thomas Jr CG, Nayfeh SN 1979 Contribution of negative cooperativity to the thyrotropin-receptor interaction in normal human thyroid: kinetic evaluation. Proc Natl Acad Sci USA 76:705-709
23. Pollet RJ, Standaert ML, Haase BA 1980 Hormone-receptor interactions are noncooperative: application to the β-adrenergic receptor. Proc Natl Acad Sci USA 77:4340-4344
24. Springael JY, Urizar E, Costagliola S, Vassart G, Parmentier M 2007 Allosteric properties of G protein-coupled receptor oligomers. Pharmacol Ther 115:410-418
25. Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, Bouvier M 2000 Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci USA 97:3684-3689
26. Urizar E, Montanelli L, Loy T, Bonomi M, Swillens S, Gales C, Bouvier M, Smits G, Vassart G, Costagliola S 2005 Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO J 24:1954-1964
27. Bathgate RAD, Lin F, Hanson NF, Otvos L, Guidolin A, Giannakis C, Bastiras S, Layfield SL, Ferraro T, Ma S, Zhao CX, Gundlach AL, Samuel CS, Tregear GW, Wade JD 2006 Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry 45:1043-1053
28. Wolven A, Okamura H, Rosenblatt Y, Resh MD 1997 Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association. Mol Biol Cell 8:1159-1173
29. Hancock JF, Cadwallader K, Paterson H, Marshall CJ 1991 A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J 10:4033-4039
30. Roth J 1975 Methods for assessing immunologic and biologic properties of iodinated peptide hormones. Methods Enzymol 37(Pt B):223-233
31. Buellesbach EE, Schwabe C 1999 Specific, high affinity relaxin-like factor receptors. J Biol Chem 274:22354-22358
32. Gavin JR, Gorden P, Roth J, Archer JA, Buell DN 1973 Characteristics of the human lymphocyte insulin receptor. J Biol Chem 248:2202-2207
33. Vrecl M, Drinovec L, Elling C, Heding A 2006 Opsin oligomerization in a heterologous cell system. J Recept Signal Transduct Res 26:505-526
34. Vrecl M, Joergensen R, Pogacnik A, Heding A 2004 Development of a BRET2 screening assay using β-arrestin 2 mutants. J Biomol Screen 9:322-333
35. Heding A 2004 Use of the BRET 7TM receptor/β-arrestin assay in drug discovery and screening. Expert Rev Mol Diagn 4:403-411
36. Vrecl M, Anderson L, Hanyaloglu A, McGregor AM, Groarke AD, Milligan G, Taylor PL, Eidne KA 1998 Agonist-induced endocytosis and recycling of the gonadotropin-releasing hormone receptor: effect of β-arrestin on internalization kinetics. Mol Endocrinol 12:1818-1829
37. Limbird LE, Lefkowitz RJ 1976 Negative cooperativity among β-adrenergic receptors in frog erythrocyte membranes. J Biol Chem 251:5007-5014
38. De Meyts P, Whittaker J 2002 Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 1:769-783
39. De Meyts P 1994 The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37:S135-S148
40. Ji I, Lee C, Song Y, Conn PM, Ji TH 2002 Cis- and trans-activation of hormone receptors: the LH receptor. Mol Endocrinol 16:1299-1308
41. James JR, Oliveira MI, Carmo AM, Iaboni A, Davis SJ 2006 A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer. Nat Methods 3:1001-1006
42. Mercier JF, Salahpour A, Angers S, Breit A, Bouvier M 2002 Quantitative assessment of β1- and β2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 277:44925-44931
43. Springael JY, Le Minh PN, Urizar E, Costagliola S, Vassart G, Parmentier M 2006 Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers. Mol Pharmacol 69:1652-1661
44. Ji I, Lee C, Jeoung M, Koo Y, Sievert GA, Ji TH 2004 Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals. Mol Endocrinol 18:968-978
45. Fan QR, Hendrickson WA 2005 Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433:269-277
46. Moyle WR, Lin W, Myers RV, Cao D, Kerrigan JE, Bernard MP 2005 Models of glycoprotein hormone receptor interaction. Endocrine 26:189-205
47. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A 2003 Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278:21655-21662
48. Ivell R, Bathgate RA Neohormone systems as exciting targets for drug development. Trends Endocrinol Metab 17:123