Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats insight from the nmr structure of the wth complement type repeat domain alone and in complex with gentamicin

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 4424-4435

  Dagil, Robert ^a   O'Shea, Charlotte ^a   Nykjaer, Anders ^b   Bonvin, Alexandre M J J ^c   Kragelund, Birthe B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDES; BACTERIAL INFECTIONS; CALRETICULIN; LIGAND BINDING; MYCOBACTERIAL; NEGATIVELY CHARGED; NEPHROTOXICITY; NMR STRUCTURES; NMR TITRATION; OTOTOXICITY; SIDE-CHAINS; STRUCTURAL INFORMATION; STRUCTURE-BASED DESIGNS; THREE-DIMENSIONAL MODEL; THREE-DIMENSIONAL STRUCTURE;

LIGANDS;

THREE DIMENSIONAL;

GENTAMICIN; MEGALIN RECEPTOR; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CONTROLLED STUDY; DISULFIDE BOND; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; LIGAND BINDING; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMINO ACID MOTIFS; GENTAMICINS; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; MOLECULAR DOCKING SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPETITIVE SEQUENCES, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873671045     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.434159     Document Type: Article

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