Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 1, 2011, Pages

  Pires, Paulo W ^a   Rogers, Curt T ^a   Mcclain, Jonathon L ^a   Garver, Hannah S ^a   Fink, Gregory D ^a   Dorrance, Anne M ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Hypertension; Middle cerebral artery; Vascular remodeling

Indexed keywords

COLLAGEN; DOXYCYCLINE; ELASTIN; GELATINASE A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY RESISTANCE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL INJURY; BLOOD VESSEL REMODELING; BLOOD VESSEL WALL; BRAIN DAMAGE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; HEART RATE; HEMISPHERE; MALE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MIDDLE CEREBRAL ARTERY; MYOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; BLOTTING, WESTERN; BODY WEIGHT; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DOXYCYCLINE; HEART; KIDNEY; LASER-DOPPLER FLOWMETRY; MALE; MATRIX METALLOPROTEINASES; MESENTERIC ARTERIES; MIDDLE CEREBRAL ARTERY; ORGAN SIZE; PROTEASE INHIBITORS; RATS; RATS, INBRED SHR; STROKE; VASCULAR RESISTANCE;

EID: 79959901572     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01206.2010     Document Type: Article

References (49)

1. Bassiouny HS, Song RH, Hong XF, Singh A, Kocharyan H, Glagov S. Flow regulation of 72-kD collagenase IV (MMP-2) after experimentalarterial injury. Circulation 98: 157-163, 1998.
2. Baumbach GL, Ghoneim S. Vascular remodeling in hypertension. ScanningMicrosc 7: 137-142, 1993.
3. Baumbach GL, Hajdu MA. Mechanics and composition of cerebralarterioles in renal and spontaneously hypertensive rats. Hypertension 21:816-826, 1993.
4. Castro MM, Rizzi E, Figueiredo-Lopes L, Fernandes K, Bendhack LM, Pitol DL, Gerlach RF, Tanus-Santos JE. Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in reno vascular hypertensive rats. Atherosclerosis 198: 320-331, 2008.
5. Castro MM, Rizzi E, Prado CM, Rossi MA, Tanus-Santos JE, Gerlach RF. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling. Matrix Biol 29:194-201, 2010.
6. Castro MM, Rizzi E, Rodrigues GJ, Ceron CS, Bendhack LM, Gerlach RF, Tanus-Santos JE. Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension. Free Radic Biol Med 46: 1298-1307, 2009.
7. Chesler NC, Ku DN, Galis ZS. Trans mural pressure induces matrix degrading activity in porcine arteries ex vivo. Am J Physiol Heart CircPhysiol 277: H2002-H2009, 1999.
8. Cipolla MJ, Curry AB. Middle cerebral artery function after stroke: the threshold duration of reperfusion for myogenic activity. Stroke 33: 2094-2099, 2002.
9. Cipolla MJ, Lessov N, Hammer ES, Curry AB. Threshold duration of ischemia for myogenic tone in middle cerebral arteries: effect on vascularsmooth muscle actin. Stroke 32: 1658-1664, 2001.
10. Cipolla MJ, McCall AL, Lessov N, Porter JM. Reperfusion decreasesmyogenic reactivity and alters middle cerebral artery function after focalcerebral ischemia in rats. Stroke 28: 176-180, 1997.
11. Coyle P, Heistad DD. Blood flow through cerebral collateral vessels in hypertensive and normotensive rats. Hypertension 8: II 67-71, 1986.
12. Deutsch C, Portik-Dobos V, Smith AD, Ergul A, Dorrance AM. Diet-induced obesity causes cerebral vessel remodeling and increasesthe damage caused by ischemic stroke. Microvasc Res 78: 100-106, 2009.
13. Dorrance AM, Pollock DM, Romanko OP, Stepp DW. A high-potassiumdiet reduces infarct size and improves vascular structure in hypertensive rats. Am J Physiol Regul Integr Comp Physiol 292: R415-R422,2007.
14. Dorrance AM, Rupp NC, Nogueira EF. Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia. Hypertension 47: 590-595, 2006.
15. English AR. Apha-6-deoxyocytetracycline. 3. Total and unbound anti bioticserum concentrations after oral administration to mice. Proc Soc Exp Biol Med 126: 487-491, 1967.
16. Fagan SC, Waller JL, Nichols FT, Edwards DJ, Pettigrew LC, Clark WM, Hall CE, Switzer JA, Ergul A, Hess DC. Minocycline to improveneurologic outcome in stroke (MINOS). A dose-finding study. Stroke 41:2283-2287, 2010.
17. Feihl F, Liaudet L, Levy BI, Waeber B. Hypertension and micro vascular remodelling. Cardiovasc Res 78: 274-285, 2008.
18. Fitchett D. Results of the ONTARGET and TRANSCEND studies: an update and discussion. Vasc Health Risk Manag 5: 21-29, 2009.
19. Flamant M, Placier S, Dubroca C, Esposito B, Lopes I, Chatziantoniou C, Tedgui A, Dussaule JC, Lehoux S. Role of matrix metalloproteinasesin early hypertensive vascular remodeling. Hypertension 50:212-218, 2007.
20. Folkow B, Grimby G, Thulesius O. Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance. Acta Physiol Scand 44: 255-272, 1958.
21. Galis ZS, Khatri JJ. Matrix metallo proteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 90: 251-262,2002.
22. Hajdu MA, Baumbach GL. Mechanics of large and small cerebralarteries in chronic hypertension. Am J Physiol Heart Circ Physiol 266:H1027-H1033, 1994.
23. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension 21: 391-397, 1993.
24. Intengan HD, Schiffrin EL. Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis. Hypertension 38: 581-587, 2001.
25. Izzard AS, Graham D, Burnham MP, Heerkens EH, Dominiczak AF, Heagerty AM. Myogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat. Am J Physiol HeartCirc Physiol 285: H1489-H1494, 2003.
26. Izzard AS, Rizzoni D, Agabiti-Rosei E, Heagerty AM. Small artery structure and hypertension: adaptive changes and target organ damage. J Hypertens 23: 247-250, 2005.
27. Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 87: 779-789, 2010.
28. Junqueira LC, Bignolas G, Brentani RR. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11: 447-455, 1979.
29. Junquiera LC, Junqueira LC, Brentani RR. A simple and sensitive method for the quantitative estimation of collagen. Anal Biochem 94:96-99, 1979.
30. King AJ, Osborn JW, Fink GD. Splanchnic circulation is a critical neural target in angiotensin II salt hypertension in rats. Hypertension 50:547-556, 2007.
31. Lee CZ, Xue Z, Zhu Y, Yang GY, Young WL. Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage. Stroke 38: 2563-2568, 2007.
32. Lee RM. Morphology of cerebral arteries. Pharmacol Ther 66: 149-173, 1995.
33. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84-91,1989.
34. Marchesi C, Ebrahimian T, Angulo O, Paradis P, Schiffrin EL. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 54: 1384-1392, 2009.
35. Marrelli SP, Khorovets A, Johnson TD, Childres WF, Bryan RM Jr. P2 purinoceptor-mediated dilations in the rat middle cerebral artery after is chemia-reperfusion. Am J Physiol Heart Circ Physiol 276: H33-H41,1999.
36. Mulvany MJ. Vascular remodelling of resistance vessels: can we define this? Cardiovasc Res 41: 9-13, 1999.
37. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinasesand TIMPs. Cardiovasc Res 69: 562-573, 2006.
38. Osmond JM, Dorrance AM. 11beta-hydroxysteroid dehydrogenase typeII inhibition causes cerebrovascular remodeling and increases infarct size after cerebral ischemia. Endocrinology 150: 713-719, 2009.
39. Osmond JM, Mintz JD, Dalton B, Stepp DW. Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat. Hypertension 53: 381-386, 2009.
40. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol 75: 346-359, 2008.
41. Rigsby CS, Pollock DM, Dorrance AM. Dietary potassium supplementation improves vascular structure and ameliorates the damage caused by cerebral ischemia in normotensive rats. Nutr Metab (Lond)5: 3, 2008.
42. Rigsby CS, Pollock DM, Dorrance AM. Spironolactone improvesstructure and increases tone in the cerebral vasculature of male spontaneouslyhypertensive stroke-prone rats. Microvasc Res 73: 198-205,2007.
43. Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases andTIMPs are associated with blood-brain barrier opening after reperfusion inrat brain. Stroke 29: 2189-2195, 1998.
44. Rosenberg GA, Yang Y. Vasogenic edema due to tight junction disruption bymatrix metalloproteinases in cerebral ischemia. Neurosurg Focus 22: E4, 2007.
45. Ruddy JM, Jones JA, Stroud RE, Mukherjee R, Spinale FG, Ikonomidis JS. Differential effects of mechanical and biological stimuli onmatrix metalloproteinase promoter activation in the thoracic aorta. Circulation120: S262-S268, 2009.
46. Sakurada M, Yoshimoto T, Sekizawa N, Hirono Y, Suzuki N, Hirata Y. Vasculoprotective effect of cilostazol in aldosterone-induced hypertensiverats. Hypertens Res 33: 229-235, 2009.
47. Short D. Morphology of the intestinal arterioles in chronic human hypertension.Br Heart J 28: 184-192, 1966.
48. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C,Sharp FR. A semiautomated method for measuring brain infarct volume.J Cereb Blood Flow Metab 10: 290-293, 1990.
49. Touyz RM. Reactive oxygen species and angiotensin II signaling invascular cells-implications in cardiovascular disease. Braz J Med Biol Res37: 1263-1273, 2004.