Use of zebrafish apoptosis assays for preclinical drug discovery

Expert Opinion on Drug Discovery

Volumn 8, Issue 10, 2013, Pages 1191-1202

  McGrath, Patricia ^a   Seng, Wen Lin ^a  

^a Phylonix Pharmaceuticals Inc   (United States)

Author keywords

Acridine orange; Apoptosis; Caspase; Cell death; Microplate; TUNEL; Zebrafish

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; 3 INDOLEMETHANOL; ACETYLCYSTEINE; ACRIDINE ORANGE; AMIFOSTINE; ANTIOXIDANT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BUTHIONINE SULFOXIMINE; CASPASE; CASPASE 3; CASPASE 7; CYTOCHROME C; DEFEROXAMINE; HYDROXYBENZOIC ACID; METHIONINE; N(G) NITROARGININE METHYL ESTER; NEUROPROTECTIVE AGENT; RADIOPROTECTIVE AGENT; SELEGILINE; STAUROSPORINE; THIOCTIC ACID;

ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; APOPTOSIS; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG RESEARCH; DRUG SCREENING; FALSE POSITIVE RESULT; FLUORESCENCE MICROSCOPY; MORPHOMETRICS; NICK END LABELING; NONHUMAN; ORGANOGENESIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; ZEBRA FISH;

ANIMALS; APOPTOSIS; CASPASES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; RADIATION-PROTECTIVE AGENTS; ZEBRAFISH;

EID: 84884638842     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2013.825244     Document Type: Review

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