Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder

Pharmacology Biochemistry and Behavior

Volumn 111, Issue , 2013, Pages 120-127

  Liput, Daniel J ^a   Hammell, Dana C ^b   Stinchcomb, Audra L ^b,c   Nixon, Kimberly ^a  

^a University of Kentucky   (United States)

^b AllTranz Inc   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Alcoholism; Cannabidiol; Ethanol; Neuroprotection; Neurotoxicity; Transdermal

Indexed keywords

ALCOHOL; CANNABIDIOL;

ALCOHOL INTOXICATION; ALCOHOL USE DISORDER; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; BINGE DRINKING; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG FORMULATION; ENTORHINAL CORTEX; GEL; MALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHTING REFLEX;

RODENTIA;

ALCOHOLISM; CANNABIDIOL; ETHANOL; NEUROPROTECTION; NEUROTOXICITY; TRANSDERMAL;

ADMINISTRATION, CUTANEOUS; ALCOHOL-RELATED DISORDERS; ANIMALS; CANNABIDIOL; DISEASE MODELS, ANIMAL; MALE; NEURODEGENERATIVE DISEASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84884619769     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2013.08.013     Document Type: Article

References (55)

1. S. Agurell, S. Carlsson, J.E. Lindgren, A. Ohlsson, H. Gillespie, and L. Hollister Interactions of delta 1-tetrahydrocannabinol with cannabinol and cannabidiol following oral administration in man. Assay of cannabinol and cannabidiol by mass fragmentography Experientia 37 1981 1090 1092 (Pubitemid 12179489)
2. T. Bisogno, L. Hanus, L. De Petrocellis, S. Tchilibon, D.E. Ponde, and I. Brandi Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide Br J Pharmacol 134 2001 845 852 (Pubitemid 33016156)
3. R.M. Brand, and J.L. Jendrzejewski Chronic ethanol ingestion alters xenobiotic absorption through the skin: potential role of oxidative stress Food Chem Toxicol 46 2008 1940 1948
4. A. Castillo, M.R. Tolon, J. Fernandez-Ruiz, J. Romero, and J. Martinez-Orgado The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors Neurobiol Dis 37 2010 434 440
5. A. Cippitelli, R. Damadzic, K. Frankola, A. Goldstein, A. Thorsell, and E. Singley Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation Biol Psychiatry 67 2010 823 830
6. A. Cippitelli, R. Damadzic, C. Hamelink, M. Brunnquell, A. Thorsell, and M. Heilig Binge-like ethanol consumption increases corticosterone levels and neurodegeneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective Addict Biol 2012 10.1111/j.1369-1600.2012.00451. x
7. M.A. Collins, T.D. Corso, and E.J. Neafsey Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics Alcohol Clin Exp Res 20 1996 284 292
8. F.T. Crews Alcohol and neurodegeneration CNS Drug Rev 5 1999 379 394 (Pubitemid 30126739)
9. F.T. Crews, and K. Nixon Mechanisms of neurodegeneration and regeneration in alcoholism Alcohol Alcohol 44 2009 115 127
10. F.T. Crews, C.J. Braun, B. Hoplight, R.C. Switzer 3rd, and D.J. Knapp Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats Alcohol Clin Exp Res 24 2000 1712 1723
11. F. Crews, K. Nixon, D. Kim, J. Joseph, B. Shukitt-Hale, and L. Qin BHT blocks NF-kappaB activation and ethanol-induced brain damage Alcohol Clin Exp Res 30 2006 1938 1949 (Pubitemid 44630098)
12. J.M. Cunha, E.A. Carlini, A.E. Pereira, O.L. Ramos, C. Pimentel, and R. Gagliardi Chronic administration of cannabidiol to healthy volunteers and epileptic patients Pharmacology 21 1980 175 185 (Pubitemid 10039764)
13. S. Deiana, A. Watanabe, Y. Yamasaki, N. Amada, M. Arthur, and S. Fleming Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), delta(9)-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour Psychopharmacology (Berl) 219 2012 859 873
14. T. Demirakca, G. Ende, N. Kammerer, H. Welzel-Marquez, D. Hermann, and A. Heinz Effects of alcoholism and continued abstinence on brain volumes in both genders Alcohol Clin Exp Res 35 2011 1678 1685
15. F.S. Guimaraes, T.M. Chiaretti, F.G. Graeff, and A.W. Zuardi Antianxiety effect of cannabidiol in the elevated plus-maze Psychopharmacology (Berl) 100 1990 558 559 (Pubitemid 20102368)
16. C. Hamelink, A. Hampson, D.A. Wink, L.E. Eiden, and R.L. Eskay Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity J Pharmacol Exp Ther 314 2005 780 788 (Pubitemid 41043862)
17. A.J. Hampson, M. Grimaldi, J. Axelrod, and D. Wink Cannabidiol and (-)delta9-tetrahydrocannabinol are neuroprotective antioxidants Proc Natl Acad Sci U S A 95 1998 8268 8273 (Pubitemid 28326102)
18. C. Harper, and J. Kril Patterns of neuronal loss in the cerebral cortex in chronic alcoholic patients J Neurol Sci 92 1989 81 89 (Pubitemid 19217348)
19. D.J. Harvey Absorption, distribution, and biotransformation of the cannabinoids G.G. Nahas, K.M. Sutin, D.J. Harvey, S. Aqurell, Marihuana and medicine 1999 Humana Press Inc. New Jersey 91 103
20. D.S. Hasin, F.S. Stinson, E. Ogburn, and B.F. Grant Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions Arch Gen Psychiatry 64 2007 830 842 (Pubitemid 47026379)
21. D.M. Hayes, M.A. Deeny, C.A. Shaner, and K. Nixon Determining the threshold for alcohol-induced brain damage: new evidence with gliosis markers Alcohol Clin Exp Res 37 2013 425 434
22. D.A. Karanian, Q.B. Brown, A. Makriyannis, T.A. Kosten, and B.A. Bahr Dual modulation of endocannabinoid transport and fatty acid amide hydrolase protects against excitotoxicity J Neurosci 25 2005 7813 7820 (Pubitemid 41208653)
23. M.L. Kelso, D.J. Liput, D.W. Eaves, and K. Nixon Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder Neuroscience 197 2011 381 393
24. G.F. Koob, and M. Le Moal Drug abuse: hedonic homeostatic dysregulation Science 278 1997 52 58 (Pubitemid 27446270)
25. J.J. Kril, G.M. Halliday, M.D. Svoboda, and H. Cartwright The cerebral cortex is damaged in chronic alcoholics Neuroscience 79 1997 983 998 (Pubitemid 27293752)
26. J.L. Leasure, and K. Nixon Exercise neuroprotection in a rat model of binge alcohol consumption Alcohol Clin Exp Res 34 2010 404 414
27. C.S. Lieber Ethanol metabolism, cirrhosis and alcoholism Clin Chim Acta 257 1997 59 84 (Pubitemid 27055895)
28. R.Z. Litten, M. Egli, M. Heilig, C. Cui, J.B. Fertig, and M.L. Ryan Medications development to treat alcohol dependence: a vision for the next decade Addict Biol 17 2012 513 527
29. E. Majchrowicz Induction of physical dependence upon ethanol and the associated behavioral changes in rats Psychopharmacologia 43 1975 245 254
30. A.M. Malfait, R. Gallily, P.F. Sumariwalla, A.S. Malik, E. Andreakos, and R. Mechoulam The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis Proc Natl Acad Sci U S A 97 2000 9561 9566 (Pubitemid 30650815)
31. R. Mechoulam, L.A. Parker, and R. Gallily Cannabidiol: an overview of some pharmacological aspects J Clin Pharmacol 42 2002 11S 19S (Pubitemid 35205041)
32. S. Mechtcheriakov, C. Brenneis, K. Egger, F. Koppelstaetter, M. Schocke, and J. Marksteiner A widespread distinct pattern of cerebral atrophy in patients with alcohol addiction revealed by voxel-based morphometry J Neurol Neurosurg Psychiatry 78 2007 610 614 (Pubitemid 46853896)
33. K. Mishima, K. Hayakawa, K. Abe, T. Ikeda, N. Egashira, and K. Iwasaki Cannabidiol prevents cerebral infarction via a serotonergic 5- hydroxytryptamine1A receptor-dependent mechanism Stroke 36 2005 1077 1082
34. S.A. Morris, M.L. Kelso, D.J. Liput, S.A. Marshall, and K. Nixon Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence Alcoho 44 2010 89 98
35. M. Muzzi, R. Felici, L. Cavone, E. Gerace, A. Minassi, and G. Appendino Ischemic neuroprotection by TRPV1 receptor-induced hypothermia J Cereb Blood Flow Metab 32 2012 978 982
36. National Research Council (NRC) Guide for the care and use of laboratory animals 1996 The National Academies Press Washington, D.C.
37. K. Nixon, J.D. Pandya, T.R. Butler, D.J. Liput, S.A. Morris, and M.A. Prendergast Binge ethanol impairs neuronal mitochondrial bioenergetics - reversal by antioxidants and uncouplers Alcohol Clin Exp Res 33 2009 [supplement]
38. J.A. Obernier, T.W. Bouldin, and F.T. Crews Binge ethanol exposure in adult rats causes necrotic cell death Alcohol Clin Exp Res 26 2002 547 557 (Pubitemid 34408721)
39. A. Ohlsson, J.E. Lindgren, S. Andersson, S. Agurell, H. Gillespie, and L.E. Hollister Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration Biomed Environ Mass Spectrom 13 1986 77 83 (Pubitemid 16130554)
40. K.S. Paudel, D.C. Hammell, R.U. Agu, S. Valiveti, and A.L. Stinchcomb Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers Drug Dev Ind Pharm 36 2010 1088 1097
41. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates, Compact 6th edition 2009 Academic Press New York
42. R.G. Pertwee The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9- tetrahydrocannabivarin Br J Pharmacol 153 2008 199 215
43. A. Pfefferbaum, K.O. Lim, R.B. Zipursky, D.H. Mathalon, M.J. Rosenbloom, and B. Lane Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study Alcohol Clin Exp Res 16 1992 1078 1089 (Pubitemid 23005150)
44. A. Pfefferbaum, E.V. Sullivan, D.H. Mathalon, and K.O. Lim Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics Alcohol Clin Exp Res 21 1997 521 529 (Pubitemid 27217197)
45. L. Qin, and F.T. Crews NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration J Neuroinflammation 9 2012 5
46. K. Rando, K.I. Hong, Z. Bhagwagar, C.S. Li, K. Bergquist, and J. Guarnaccia Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study Am J Psychiatry 168 2011 183 192
47. Y. Ren, J. Whittard, A. Higuera-Matas, C.V. Morris, and Y.L. Hurd Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances J Neurosci 29 2009 14764 14769
48. L.C. Schmued, and K.J. Hopkins Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration Brain Res 874 2000 123 130
49. C. Scuderi, D.D. Filippis, T. Iuvone, A. Blasio, A. Steardo, and G. Esposito Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders Phytother Res 23 2009 597 602
50. K. Stavro, J. Pelletier, and S. Potvin Widespread and sustained cognitive deficits in alcoholism: a meta-analysis Addict Biol 18 2012 203 213
51. E.V. Sullivan, and A. Pfefferbaum Neurocircuitry in alcoholism: a substrate of disruption and repair Psychopharmacology (Berl) 180 2005 583 594 (Pubitemid 41317855)
52. E.V. Sullivan, L. Marsh, D.H. Mathalon, K.O. Lim, and A. Pfefferbaum Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics Alcohol Clin Exp Res 19 1995 110 122
53. R. Swift, D.W. Oslin, M. Alexander, and R. Forman Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review J Stud Alcohol Drugs 72 2011 1012 1018
54. T. Urso, J.S. Gavaler, and D.H. Van Thiel Blood ethanol levels in sober alcohol users seen in an emergency room Life Sci 28 1981 1053 1056 (Pubitemid 11110091)
55. R. Weathermon, and D.W. Crabb Alcohol and medication interactions Alcohol Res Health 23 1999 40 54