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Volumn 73, Issue 13, 2013, Pages 1451-1462

Eplerenone: A review of its use in patients with chronic systolic heart failure and mild symptoms

Author keywords

[No Author keywords available]

Indexed keywords

ALFUZOSIN; AMIFOSTINE; ANGIOTENSIN RECEPTOR ANTAGONIST; BACLOFEN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATININE; CYCLOSPORIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; ERYTHROMYCIN; GLUCOCORTICOID; ITRACONAZOLE; KETOCONAZOLE; LITHIUM; MINERALOCORTICOID RECEPTOR; NELFINAVIR; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; POTASSIUM; POTASSIUM SPARING DIURETIC AGENT; PRAZOSIN; RITONAVIR; SAQUINAVIR; SPIRONOLACTONE; TACROLIMUS; TETRACOSACTIDE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMETHOPRIM; UNINDEXED DRUG;

EID: 84884618648     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.1007/s40265-013-0098-z     Document Type: Review
Times cited : (16)

References (72)
  • 1
    • 77954056940 scopus 로고    scopus 로고
    • Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: Current status
    • 20590619 10.1111/j.1476-5381.2010.00750.x 1:CAS:528:DC%2BC3cXht1Oit7zM
    • Ma TK, Kam KK, Yan BP, et al. Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status. Br J Pharmacol. 2010;160(6):1273-92.
    • (2010) Br J Pharmacol , vol.160 , Issue.6 , pp. 1273-1292
    • Ma, T.K.1    Kam, K.K.2    Yan, B.P.3
  • 2
    • 0038179527 scopus 로고    scopus 로고
    • Eplerenone: Cardiovascular protection
    • 12756192 10.1161/01.CIR.0000071081.35693.9A 1:CAS:528: DC%2BD3sXjs1antbo%3D
    • Brown NJ. Eplerenone: cardiovascular protection. Circulation. 2003;107(19):2512-8.
    • (2003) Circulation , vol.107 , Issue.19 , pp. 2512-2518
    • Brown, N.J.1
  • 3
    • 6444220362 scopus 로고    scopus 로고
    • The role of the renin-angiotensin-aldosterone system in heart failure
    • 15526242 10.3317/jraas.2004.024 1:CAS:528:DC%2BD2cXpslGhsrw%3D
    • Unger T, Li J. The role of the renin-angiotensin-aldosterone system in heart failure. J Renin Angiotensin Aldosterone Syst. 2004;5(1 Suppl):S7-10.
    • (2004) J Renin Angiotensin Aldosterone Syst , vol.5 , Issue.1 SUPPL.
    • Unger, T.1    Li, J.2
  • 4
    • 80055092820 scopus 로고    scopus 로고
    • Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure
    • 21731887 10.2147/VHRM.S13779 1:CAS:528:DC%2BC3MXns1yitrk%3D
    • Nappi JM, Sieg A. Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure. Vasc Health Risk Manag. 2011;7:353-63.
    • (2011) Vasc Health Risk Manag , vol.7 , pp. 353-363
    • Nappi, J.M.1    Sieg, A.2
  • 5
    • 0027245468 scopus 로고
    • Vasodilation to acetylcholine in primary and secondary forms of human hypertension
    • 8505103 10.1161/01.HYP.21.6.929 1:STN:280:DyaK3s3nvFOrug%3D%3D
    • Taddei S, Virdis A, Mattei P, et al. Vasodilation to acetylcholine in primary and secondary forms of human hypertension. Hypertension. 1993;21(6 Pt 2):929-33.
    • (1993) Hypertension , vol.21 , Issue.6 PART 2 , pp. 929-933
    • Taddei, S.1    Virdis, A.2    Mattei, P.3
  • 6
    • 0035108054 scopus 로고    scopus 로고
    • Arterial pressure, left ventricular mass, and aldosterone in essential hypertension
    • 11244006 10.1161/01.HYP.37.3.845 1:CAS:528:DC%2BD3MXitFegtLo%3D
    • El-Gharbawy AH, Nadig VS, Kotchen JM, et al. Arterial pressure, left ventricular mass, and aldosterone in essential hypertension. Hypertension. 2001;37(3):845-50.
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 845-850
    • El-Gharbawy, A.H.1    Nadig, V.S.2    Kotchen, J.M.3
  • 7
    • 33845687252 scopus 로고    scopus 로고
    • High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction
    • 17116769 10.1161/CIRCULATIONAHA.106.634626 1:CAS:528:DC%2BD28Xht1Ohu7zJ
    • Beygui F, Collet JP, Benoliel JJ, et al. High plasma aldosterone levels on admission are associated with death in patients presenting with acute ST-elevation myocardial infarction. Circulation. 2006;114(24):2604-10.
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2604-2610
    • Beygui, F.1    Collet, J.P.2    Benoliel, J.J.3
  • 8
    • 33845700523 scopus 로고    scopus 로고
    • Aldosterone and cardiovascular disease: Smoke and fire
    • 17159070 10.1161/CIRCULATIONAHA.106.668715
    • Calhoun DA. Aldosterone and cardiovascular disease: smoke and fire. Circulation. 2006;114(24):2572-4.
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2572-2574
    • Calhoun, D.A.1
  • 9
    • 0025088737 scopus 로고
    • Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group
    • 2225374 10.1161/01.CIR.82.5.1730 1:STN:280:DyaK3M%2FivF2juw%3D%3D
    • Swedberg K, Eneroth P, Kjekshus J, et al. Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group. Circulation. 1990;82(5):1730-6.
    • (1990) Circulation , vol.82 , Issue.5 , pp. 1730-1736
    • Swedberg, K.1    Eneroth, P.2    Kjekshus, J.3
  • 10
    • 0031406824 scopus 로고    scopus 로고
    • Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension
    • 9443767 10.1016/S0895-7061(97)00301-4 1:CAS:528:DyaK1cXktFeitA%3D%3D
    • Blacher J, Amah G, Girerd X, et al. Association between increased plasma levels of aldosterone and decreased systemic arterial compliance in subjects with essential hypertension. Am J Hypertens. 1997;10(12 Pt 1):1326-34.
    • (1997) Am J Hypertens , vol.10 , Issue.12 PART 1 , pp. 1326-1334
    • Blacher, J.1    Amah, G.2    Girerd, X.3
  • 11
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
    • 10673249 10.1161/01.CIR.101.6.594 1:CAS:528:DC%2BD3cXhtlGntL4%3D
    • Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation. 2000;101(6):594-7.
    • (2000) Circulation , vol.101 , Issue.6 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 12
    • 0019865836 scopus 로고
    • Rise in plasma concentration of aldosterone during long-term angiotensin II suppression
    • 7035596 10.1677/joe.0.0910457 1:CAS:528:DyaL38XhtFGlurw%3D
    • Staessen J, Lijnen P, Fagard R, et al. Rise in plasma concentration of aldosterone during long-term angiotensin II suppression. J Endocrinol. 1981;91(3):457-65.
    • (1981) J Endocrinol , vol.91 , Issue.3 , pp. 457-465
    • Staessen, J.1    Lijnen, P.2    Fagard, R.3
  • 13
    • 0033533456 scopus 로고    scopus 로고
    • Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators
    • 10477530 10.1161/01.CIR.100.10.1056 1:CAS:528:DyaK1MXmt1Whs7w%3D
    • McKelvie RS, Yusuf S, Pericak D, et al. Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study Investigators. Circulation. 1999;100(10):1056-64.
    • (1999) Circulation , vol.100 , Issue.10 , pp. 1056-1064
    • McKelvie, R.S.1    Yusuf, S.2    Pericak, D.3
  • 14
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • 10471456 10.1056/NEJM199909023411001 1:CAS:528:DyaK1MXmtVyrurk%3D
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med. 1999;341(10):709-17.
    • (1999) N Engl J Med , vol.341 , Issue.10 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 15
    • 21244485814 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis
    • 15947888 10.1007/s10741-005-2345-1 1:CAS:528:DC%2BD2MXltFGqsr0%3D
    • Sica DA. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Fail Rev. 2005;10(1):23-9.
    • (2005) Heart Fail Rev , vol.10 , Issue.1 , pp. 23-29
    • Sica, D.A.1
  • 16
    • 42349101107 scopus 로고    scopus 로고
    • A comparison of the aldosterone-blocking agents eplerenone and spironolactone
    • 18404673 10.1002/clc.20324
    • Struthers A, Krum H, Williams GH. A comparison of the aldosterone-blocking agents eplerenone and spironolactone. Clin Cardiol. 2008;31(4):153-8.
    • (2008) Clin Cardiol , vol.31 , Issue.4 , pp. 153-158
    • Struthers, A.1    Krum, H.2    Williams, G.H.3
  • 17
    • 77952118055 scopus 로고    scopus 로고
    • Pfizer Ltd. Accessed 1 Mar 2013
    • Pfizer Ltd. Inspra (eplerenone): UK summary of product characteristics. 2012. http://www.medicines.org.uk/EMC/medicine/16746/SPC/ Inspra+25mg+%26+50+mg+film-coated+tablets/. Accessed 1 Mar 2013.
    • (2012) Inspra (Eplerenone): UK Summary of Product Characteristics
  • 19
    • 10444281707 scopus 로고    scopus 로고
    • Eplerenone: A review of its use in left ventricular systolic dysfunction and heart failure after acute myocardial infarction
    • 15537370 10.2165/00003495-200464230-00005 1:CAS:528: DC%2BD2MXks1Whuw%3D%3D
    • Keating GM, Plosker GL. Eplerenone: a review of its use in left ventricular systolic dysfunction and heart failure after acute myocardial infarction. Drugs. 2004;64(23):2689-707.
    • (2004) Drugs. , vol.64 , Issue.23 , pp. 2689-2707
    • Keating, G.M.1    Plosker, G.L.2
  • 20
    • 0037488488 scopus 로고    scopus 로고
    • Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure
    • 12791709 10.1161/01.RES.0000080521.15238.E5 1:CAS:528: DC%2BD3sXltVGrs74%3D
    • Qin W, Rudolph AE, Bond BR, et al. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ Res. 2003;93(1):69-76.
    • (2003) Circ Res , vol.93 , Issue.1 , pp. 69-76
    • Qin, W.1    Rudolph, A.E.2    Bond, B.R.3
  • 21
    • 0242543981 scopus 로고    scopus 로고
    • Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction
    • 14607457 10.1016/j.jacc.2003.05.003 1:CAS:528:DC%2BD3sXpsVCqu7s%3D
    • Fraccarollo D, Galuppo P, Hildemann S, et al. Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction. J Am Coll Cardiol. 2003;42(9):1666-73.
    • (2003) J Am Coll Cardiol , vol.42 , Issue.9 , pp. 1666-1673
    • Fraccarollo, D.1    Galuppo, P.2    Hildemann, S.3
  • 22
    • 0036893647 scopus 로고    scopus 로고
    • Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart
    • 12446610 10.1210/en.2002-220120 1:CAS:528:DC%2BD38Xpt1eltLs%3D
    • Rocha R, Martin-Berger CL, Yang P, et al. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology. 2002;143(12):4828-36.
    • (2002) Endocrinology , vol.143 , Issue.12 , pp. 4828-4836
    • Rocha, R.1    Martin-Berger, C.L.2    Yang, P.3
  • 23
    • 0036838616 scopus 로고    scopus 로고
    • Aldosterone induces a vascular inflammatory phenotype in the rat heart
    • 12384457 1:CAS:528:DC%2BD38XovVOmt74%3D
    • Rocha R, Rudolph AE, Frierdich GE, et al. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am J Physiol Heart Circ Physiol. 2002;283(5):H1802-10.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283 , Issue.5
    • Rocha, R.1    Rudolph, A.E.2    Frierdich, G.E.3
  • 24
    • 0037016007 scopus 로고    scopus 로고
    • Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure
    • 12460880 10.1161/01.CIR.0000039104.56479.42 1:CAS:528: DC%2BD38XovVeltrc%3D
    • Suzuki G, Morita H, Mishima T, et al. Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure. Circulation. 2002;106(23):2967-72.
    • (2002) Circulation , vol.106 , Issue.23 , pp. 2967-2972
    • Suzuki, G.1    Morita, H.2    Mishima, T.3
  • 25
    • 36849077592 scopus 로고    scopus 로고
    • Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure
    • 17940859 10.1007/s10557-007-6057-8 1:CAS:528:DC%2BD2sXhtl2ks7zK
    • Rastogi S, Mishra S, Zaca V, et al. Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure. Cardiovasc Drugs Ther. 2007;21(6):415-22.
    • (2007) Cardiovasc Drugs Ther , vol.21 , Issue.6 , pp. 415-422
    • Rastogi, S.1    Mishra, S.2    Zaca, V.3
  • 26
    • 33745172144 scopus 로고    scopus 로고
    • Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart
    • 17083072 10.3317/jraas.2006.005
    • De Mello WC. Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart. J Renin Angiotensin Aldosterone Syst. 2006;7(1):40-6.
    • (2006) J Renin Angiotensin Aldosterone Syst , vol.7 , Issue.1 , pp. 40-46
    • De Mello, W.C.1
  • 27
    • 56549084712 scopus 로고    scopus 로고
    • Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart: On the presence of an intracrine renin angiotensin aldosterone system
    • 18585409 10.1016/j.regpep.2008.06.003
    • De Mello WC, Gerena Y. Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart: on the presence of an intracrine renin angiotensin aldosterone system. Regul Pept. 2008;151(1-3):54-60.
    • (2008) Regul Pept , vol.151 , Issue.1-3 , pp. 54-60
    • De Mello, W.C.1    Gerena, Y.2
  • 28
    • 0038206805 scopus 로고    scopus 로고
    • Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: Effect on endothelial dysfunction
    • 12798439 10.1016/S0008-6363(03)00333-X 1:CAS:528:DC%2BD3sXksVOrtrc%3D
    • Schafer A, Fraccarollo D, Hildemann SK, et al. Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction. Cardiovasc Res. 2003;58(3):655-62.
    • (2003) Cardiovasc Res , vol.58 , Issue.3 , pp. 655-662
    • Schafer, A.1    Fraccarollo, D.2    Hildemann, S.K.3
  • 29
    • 0038150601 scopus 로고    scopus 로고
    • Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition
    • 12783115
    • Schafer A, Fraccarollo D, Hildemann S, et al. Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition. Thromb Haemost. 2003;89(6):1024-30.
    • (2003) Thromb Haemost , vol.89 , Issue.6 , pp. 1024-1030
    • Schafer, A.1    Fraccarollo, D.2    Hildemann, S.3
  • 30
    • 84865627923 scopus 로고    scopus 로고
    • Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure
    • 22645059 10.1177/1470320312447650
    • Jung C, Florvaag A, Oberle V, et al. Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure. J Renin Angiotensin Aldosterone Syst. 2012;13(3):401-6.
    • (2012) J Renin Angiotensin Aldosterone Syst , vol.13 , Issue.3 , pp. 401-406
    • Jung, C.1    Florvaag, A.2    Oberle, V.3
  • 31
    • 47849118484 scopus 로고    scopus 로고
    • A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis
    • 18657667 10.1016/j.ahj.2008.03.012 1:CAS:528:DC%2BD1cXovFyqt7k%3D
    • Stewart RAH, Kerr AJ, Cowan BR, et al. A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis. Am Heart J. 2008;156(2):348-55.
    • (2008) Am Heart J , vol.156 , Issue.2 , pp. 348-355
    • Stewart, R.A.H.1    Kerr, A.J.2    Cowan, B.R.3
  • 32
    • 33745662138 scopus 로고    scopus 로고
    • Eplerenone inhibits tumour necrosis factor alpha shedding process by tumour necrosis factor alpha converting enzyme in monocytes from patients with congestive heart failure
    • 16775109 10.1136/hrt.2005.071829 1:CAS:528:DC%2BD28Xntl2ltLs%3D
    • Satoh M, Ishikawa Y, Minami Y, et al. Eplerenone inhibits tumour necrosis factor alpha shedding process by tumour necrosis factor alpha converting enzyme in monocytes from patients with congestive heart failure. Heart. 2006;92(7):979-80.
    • (2006) Heart , vol.92 , Issue.7 , pp. 979-980
    • Satoh, M.1    Ishikawa, Y.2    Minami, Y.3
  • 33
    • 85081791995 scopus 로고    scopus 로고
    • Effect of low dose eplerenone on endothelial function in patients with stable coronary artery disease [abstract no. P2609]
    • Sudano I, Flammer AJ, Roas S, et al. Effect of low dose eplerenone on endothelial function in patients with stable coronary artery disease [abstract no. P2609]. Eur Heart J. 2012;33 Suppl 1:442.
    • (2012) Eur Heart J. , vol.331 , pp. 442
    • Sudano, I.1    Flammer, A.J.2    Roas, S.3
  • 34
    • 77954739690 scopus 로고    scopus 로고
    • Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction
    • 20299607 1:CAS:528:DC%2BC3cXot1eiurY%3D
    • Udelson JE, Feldman AM, Greenberg B, et al. Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction. Circulation. 2010;3(3):347-53.
    • (2010) Circulation , vol.3 , Issue.3 , pp. 347-353
    • Udelson, J.E.1    Feldman, A.M.2    Greenberg, B.3
  • 35
    • 78649370678 scopus 로고    scopus 로고
    • 1c levels in patients with chronic heart failure
    • 21095280 10.1016/j.ahj.2010.04.024 1:CAS:528:DC%2BC3cXhsVGitbnI
    • 1c levels in patients with chronic heart failure. Am Heart J. 2010;160(5):915-21.
    • (2010) Am Heart J , vol.160 , Issue.5 , pp. 915-921
    • Yamaji, M.1    Tsutamoto, T.2    Kawahara, C.3
  • 36
    • 85081800195 scopus 로고    scopus 로고
    • Aldosterone antagonism with eplerenone does not adversely affect plasma glucose levels in patients with diabetes mellitus: Findings from a post hoc analysis of the EPHESUS trial [abstract no. P2456]
    • Deedwania P, Pitt B, Desai R, et al. Aldosterone antagonism with eplerenone does not adversely affect plasma glucose levels in patients with diabetes mellitus: findings from a post hoc analysis of the EPHESUS trial [abstract no. P2456]. Eur Heart J. 2010;31 Suppl 1:423-4.
    • (2010) Eur Heart J , vol.311 , pp. 423-424
    • Deedwania, P.1    Pitt, B.2    Desai, R.3
  • 37
    • 0023117413 scopus 로고
    • Three new epoxy-spirolactone derivatives: Characterization in vivo and in vitro
    • 2949071
    • de Gasparo M, Joss U, Ramjoue HP, et al. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J Pharmacol Exp Ther. 1987;240(2):650-6.
    • (1987) J Pharmacol Exp Ther , vol.240 , Issue.2 , pp. 650-656
    • De Gasparo, M.1    Joss, U.2    Ramjoue, H.P.3
  • 38
    • 2342592636 scopus 로고    scopus 로고
    • The evolution of aldosterone antagonists
    • 15134797 10.1016/j.mce.2003.10.005 1:CAS:528:DC%2BD2cXjvVeqtbw%3D
    • Garthwaite SM, McMahon EG. The evolution of aldosterone antagonists. Mol Cell Endocrinol. 2004;217(1-2):27-31.
    • (2004) Mol Cell Endocrinol , vol.217 , Issue.1-2 , pp. 27-31
    • Garthwaite, S.M.1    McMahon, E.G.2
  • 39
    • 0035997359 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
    • 12160194 10.1016/S0895-7061(02)02957-6 1:CAS:528:DC%2BD38Xms1aisLw%3D
    • Weinberger MH, Roniker B, Krause SL, et al. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens. 2002;15(8):709-16.
    • (2002) Am J Hypertens , vol.15 , Issue.8 , pp. 709-716
    • Weinberger, M.H.1    Roniker, B.2    Krause, S.L.3
  • 40
    • 42049101473 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research [NDA 21-437] Accessed 22 Apr 2013
    • Center for Drug Evaluation and Research. Clinical pharmacology and biopharmaceutical review(s) [NDA 21-437]. 2003. http://www.accessdata.fda.gov/ drugsatfda-docs/nda/2002/21-437-Inspra-BioPharmr-P3.pdf. Accessed 22 Apr 2013.
    • (2003) Clinical Pharmacology and Biopharmaceutical Review(s)
  • 41
    • 42049101473 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research Accessed 22 Apr 2013
    • Center for Drug Evaluation and Research. Clinical pharmacology and biopharmaceutics review (21-437/S-002). 2003. http://www.accessdata.fda.gov/ drugsatfda-docs/nda/2003/21-437S002-Inspra-BioPharmr.pdf. Accessed 22 Apr 2013.
    • (2003) Clinical Pharmacology and Biopharmaceutics Review (21-437/S-002)
  • 42
    • 0142180980 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans
    • 14570778 10.1124/dmd.31.11.1448 1:CAS:528:DC%2BD3sXosV2qu70%3D
    • Cook CS, Berry LM, Bible RH, et al. Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans. Drug Metab Dispos. 2003;31(11):1448-55.
    • (2003) Drug Metab Dispos , vol.31 , Issue.11 , pp. 1448-1455
    • Cook, C.S.1    Berry, L.M.2    Bible, R.H.3
  • 43
    • 78650399880 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms
    • 21073363 10.1056/NEJMoa1009492 1:CAS:528:DC%2BC3MXisValuw%3D%3D
    • Zannad F, McMurray JJV, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2011;364(1):11-21.
    • (2011) N Engl J Med , vol.364 , Issue.1 , pp. 11-21
    • Zannad, F.1    McMurray, J.J.V.2    Krum, H.3
  • 45
    • 77952962152 scopus 로고    scopus 로고
    • Rationale and design of the Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF)
    • 20388647 10.1093/eurjhf/hfq049 1:CAS:528:DC%2BC3cXmvVSqsL4%3D
    • Zannad F, McMurray JJV, Drexler H, et al. Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF). Eur J Heart Fail. 2010;12(6):617-22.
    • (2010) Eur J Heart Fail , vol.12 , Issue.6 , pp. 617-622
    • Zannad, F.1    McMurray, J.J.V.2    Drexler, H.3
  • 46
    • 84884644195 scopus 로고    scopus 로고
    • Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: Analysis of the EMPHASIS-HF Study
    • 10.1161/CIRCHEARTFAILURE.112.000173
    • Krum H, Shi H, Pitt B, et al. Clinical benefit of eplerenone in patients with mild symptoms of systolic heart failure already receiving optimal best practice background drug therapy: analysis of the EMPHASIS-HF Study. Circ Heart Fail. 2013. doi: 10.1161/CIRCHEARTFAILURE.112.000173.
    • (2013) Circ Heart Fail
    • Krum, H.1    Shi, H.2    Pitt, B.3
  • 47
    • 79952565084 scopus 로고    scopus 로고
    • Hypokalemia and sudden cardiac death
    • 21264075
    • Kjeldsen K. Hypokalemia and sudden cardiac death. Exp Clin Cardiol. 2010;15(4):e96-9.
    • (2010) Exp Clin Cardiol , vol.15 , Issue.4
    • Kjeldsen, K.1
  • 48
    • 0023598475 scopus 로고
    • Mortality in heart failure: Clinical variables of prognostic value
    • 2447925 10.1136/hrt.58.6.572 1:STN:280:DyaL1c7gslaksQ%3D%3D
    • Cleland JG, Dargie HJ, Ford I. Mortality in heart failure: clinical variables of prognostic value. Br Heart J. 1987;58(6):572-82.
    • (1987) Br Heart J , vol.58 , Issue.6 , pp. 572-582
    • Cleland, J.G.1    Dargie, H.J.2    Ford, I.3
  • 49
    • 35948988073 scopus 로고    scopus 로고
    • Management of atrial fibrillation in patients with heart failure
    • 17855740 10.1093/eurheartj/ehm341 1:CAS:528:DC%2BD1cXisV2i
    • Neuberger HR, Mewis C, van Veldhuisen DJ, et al. Management of atrial fibrillation in patients with heart failure. Eur Heart J. 2007;28(21):2568-77.
    • (2007) Eur Heart J , vol.28 , Issue.21 , pp. 2568-2577
    • Neuberger, H.R.1    Mewis, C.2    Van Veldhuisen, D.J.3
  • 50
    • 0025779484 scopus 로고
    • Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
    • 1866765 10.1161/01.STR.22.8.983 1:STN:280:DyaK3Mzislektg%3D%3D
    • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22(8):983-8.
    • (1991) Stroke , vol.22 , Issue.8 , pp. 983-988
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 51
    • 77950245742 scopus 로고    scopus 로고
    • Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation
    • 20388187 10.1111/j.1476-5381.2010.00675.x 1:CAS:528:DC%2BC3cXks1Ojs7g%3D
    • Lendeckel U, Dobrev D, Goette A. Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation. Br J Pharmacol. 2010;159(8):1581-3.
    • (2010) Br J Pharmacol , vol.159 , Issue.8 , pp. 1581-1583
    • Lendeckel, U.1    Dobrev, D.2    Goette, A.3
  • 52
    • 76449091669 scopus 로고    scopus 로고
    • Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation
    • 20170814 10.1016/j.jacc.2009.09.045 1:CAS:528:DC%2BC3cXjvF2ltbY%3D
    • Tsai CT, Chiang FT, Tseng CD, et al. Increased expression of mineralocorticoid receptor in human atrial fibrillation and a cellular model of atrial fibrillation. J Am Coll Cardiol. 2010;55(8):758-70.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.8 , pp. 758-770
    • Tsai, C.T.1    Chiang, F.T.2    Tseng, C.D.3
  • 53
    • 77950228107 scopus 로고    scopus 로고
    • Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing
    • 20082611 10.1111/j.1476-5381.2009.00551.x 1:CAS:528:DC%2BC3cXks1Ojs7k%3D
    • Zhao J, Li J, Li W, et al. Effects of spironolactone on atrial structural remodelling in a canine model of atrial fibrillation produced by prolonged atrial pacing. Br J Pharmacol. 2010;159(8):1584-94.
    • (2010) Br J Pharmacol , vol.159 , Issue.8 , pp. 1584-1594
    • Zhao, J.1    Li, J.2    Li, W.3
  • 54
    • 20344396863 scopus 로고    scopus 로고
    • Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: A meta-analysis
    • 15936615 10.1016/j.jacc.2004.11.070 1:CAS:528:DC%2BD2MXpsVCqt7s%3D
    • Healey JS, Baranchuk A, Crystal E, et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol. 2005;45(11):1832-9.
    • (2005) J Am Coll Cardiol , vol.45 , Issue.11 , pp. 1832-1839
    • Healey, J.S.1    Baranchuk, A.2    Crystal, E.3
  • 55
    • 34547646848 scopus 로고    scopus 로고
    • Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: A meta-analysis
    • 17289748 10.1093/eurheartj/ehl484 1:CAS:528:DC%2BD2sXksFWmtrw%3D
    • Nasr IA, Bouzamondo A, Hulot JS, et al. Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis. Eur Heart J. 2007;28(4):457-62.
    • (2007) Eur Heart J , vol.28 , Issue.4 , pp. 457-462
    • Nasr, I.A.1    Bouzamondo, A.2    Hulot, J.S.3
  • 56
    • 84860309326 scopus 로고    scopus 로고
    • Eplerenone and atrial fibrillation in mild systolic heart failure: Results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization and SurvIval Study in Heart Failure) study
    • 22538330 10.1016/j.jacc.2011.11.063 1:CAS:528:DC%2BC38Xmt1Cgs7s%3D
    • Swedberg K, Zannad F, McMurray JJV, et al. Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study. J Am Coll Cardiol. 2012;59(18):1598-603.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.18 , pp. 1598-1603
    • Swedberg, K.1    Zannad, F.2    McMurray, J.J.V.3
  • 57
    • 44449146547 scopus 로고    scopus 로고
    • Diabetes, left ventricular systolic dysfunction, and chronic heart failure
    • 18424786 10.1093/eurheartj/ehn156 1:CAS:528:DC%2BD1cXntF2gsL4%3D
    • MacDonald MR, Petrie MC, Hawkins NM, et al. Diabetes, left ventricular systolic dysfunction, and chronic heart failure. Eur Heart J. 2008;29(10):1224-40.
    • (2008) Eur Heart J , vol.29 , Issue.10 , pp. 1224-1240
    • Macdonald, M.R.1    Petrie, M.C.2    Hawkins, N.M.3
  • 58
    • 33846294746 scopus 로고    scopus 로고
    • Incident diabetes in clinical trials of antihypertensive drugs: A network meta-analysis
    • 17240286 10.1016/S0140-6736(07)60108-1 1:CAS:528:DC%2BD2sXntlCnsA%3D%3D
    • Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet. 2007;369(9557):201-7.
    • (2007) Lancet , vol.369 , Issue.9557 , pp. 201-207
    • Elliott, W.J.1    Meyer, P.M.2
  • 59
    • 84864433114 scopus 로고    scopus 로고
    • Eplerenone and new-onset diabetes in patients with mild heart failure: Results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF)
    • 22611047 10.1093/eurjhf/hfs067 1:CAS:528:DC%2BC38XhtFCrsrbM
    • Preiss D, van Veldhuisen DJ, Sattar N, et al. Eplerenone and new-onset diabetes in patients with mild heart failure: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Eur J Heart Fail. 2012;14(8):909-15.
    • (2012) Eur J Heart Fail , vol.14 , Issue.8 , pp. 909-915
    • Preiss, D.1    Van Veldhuisen, D.J.2    Sattar, N.3
  • 60
    • 84868597662 scopus 로고    scopus 로고
    • Eplerenone in patients with systolic heart failure and mild symptoms: Analysis of repeat hospitalizations
    • 23042980 10.1161/CIRCULATIONAHA.112.110536 1:CAS:528:DC%2BC38Xhs1Wlu7vJ
    • Rogers JK, McMurray JJV, Pocock SJ, et al. Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations. Circulation. 2012;126(19):2317-23.
    • (2012) Circulation , vol.126 , Issue.19 , pp. 2317-2323
    • Rogers, J.K.1    McMurray, J.J.V.2    Pocock, S.J.3
  • 61
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction [erratum appears in N Engl J Med. 2003;348(22):2271]
    • 12668699 10.1056/NEJMoa030207 1:CAS:528:DC%2BD3sXis1ehurY%3D
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction [erratum appears in N Engl J Med. 2003;348(22):2271]. N Engl J Med. 2003;348(14):1309-21.
    • (2003) N Engl J Med , vol.348 , Issue.14 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 62
    • 53249090182 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology
    • 18799522 10.1093/eurheartj/ehn309 1:CAS:528:DC%2BD1cXhtlGisbvO
    • Dickstein K, Cohen-Solal A, Filippatos G, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) [errata appear in Eur Heart J. 2010;31(5):624 and Eur Heart J. 2010;12(4):416]. Eur Heart J. 2008;29(19):2388-442.
    • (2008) Eur Heart J. , vol.29 , Issue.19 , pp. 2388-2442
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 63
    • 24044508284 scopus 로고    scopus 로고
    • The risks and benefits of aldosterone antagonists
    • 16036053 10.1007/s11897-005-0011-5 1:CAS:528:DC%2BD2MXhtFSkt7vE
    • Sica DA. The risks and benefits of aldosterone antagonists. Curr Heart Fail Rep. 2005;2(2):65-71.
    • (2005) Curr Heart Fail Rep , vol.2 , Issue.2 , pp. 65-71
    • Sica, D.A.1
  • 64
    • 77649106201 scopus 로고    scopus 로고
    • Aldosterone receptor antagonists: Effective but often forgotten
    • 20177008 10.1161/CIRCULATIONAHA.109.895235
    • Maron BA, Leopold JA. Aldosterone receptor antagonists: effective but often forgotten. Circulation. 2010;121(7):934-9.
    • (2010) Circulation , vol.121 , Issue.7 , pp. 934-939
    • Maron, B.A.1    Leopold, J.A.2
  • 65
    • 84864493727 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
    • 22611136 10.1093/eurheartj/ehs104
    • McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012;33(14):1787-847.
    • (2012) Eur Heart J , vol.33 , Issue.14 , pp. 1787-1847
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3
  • 66
    • 78650886292 scopus 로고    scopus 로고
    • Aldosterone antagonists-last man standing?
    • 21073364 10.1056/NEJMe1012547 1:CAS:528:DC%2BC3MXisVChsQ%3D%3D
    • Armstrong PW. Aldosterone antagonists-last man standing? N Engl J Med. 2011;364(1):79-80.
    • (2011) N Engl J Med , vol.364 , Issue.1 , pp. 79-80
    • Armstrong, P.W.1
  • 67
    • 84877290231 scopus 로고    scopus 로고
    • Association of spironolactone use with all-cause mortality in heart failure: A propensity scored cohort study
    • 23386667 10.1161/CIRCHEARTFAILURE.112.000115 1:CAS:528: DC%2BC3sXntVOqsL8%3D
    • Lund LH, Svennblad B, Melhus H, et al. Association of spironolactone use with all-cause mortality in heart failure: a propensity scored cohort study. Circ Heart Fail. 2013;6(2):174-83.
    • (2013) Circ Heart Fail , vol.6 , Issue.2 , pp. 174-183
    • Lund, L.H.1    Svennblad, B.2    Melhus, H.3
  • 68
    • 84859098439 scopus 로고    scopus 로고
    • Eplerenone: Is it time to add this drug to current heart failure therapy?
    • 23251764 10.1177/2040622311429891 1:CAS:528:DC%2BC38XivVymt7o%3D
    • Pitt B, Zannad F. Eplerenone: is it time to add this drug to current heart failure therapy? Ther Adv Chronic Dis. 2012;3(1):5-9.
    • (2012) Ther Adv Chronic Dis , vol.3 , Issue.1 , pp. 5-9
    • Pitt, B.1    Zannad, F.2
  • 69
    • 11144344961 scopus 로고    scopus 로고
    • Spironolactone impairs endothelial function and heart rate variability in patients with type 2 diabetes
    • 15365622 10.1007/s00125-004-1510-8 1:CAS:528:DC%2BD2cXpsFKrtrc%3D
    • Davies JI, Band M, Morris A, et al. Spironolactone impairs endothelial function and heart rate variability in patients with type 2 diabetes. Diabetologia. 2004;47(10):1687-94.
    • (2004) Diabetologia , vol.47 , Issue.10 , pp. 1687-1694
    • Davies, J.I.1    Band, M.2    Morris, A.3
  • 70
    • 77952118055 scopus 로고    scopus 로고
    • Pharmacia Ltd. Accessed 8 May 2013
    • Pharmacia Ltd. Aldactone: UK summary of product characteristics. 2012. http://www.medicines.org.uk/emc/medicine/9136/SPC/Aldactone+25mg+Tablets/. Accessed 8 May 2013.
    • (2012) Aldactone: UK Summary of Product Characteristics
  • 72
    • 84882415231 scopus 로고    scopus 로고
    • Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: A randomized, double-blind trial
    • 10.1093/eurheartj/eht187
    • Pitt B, Kober L, Ponikowski P, et al. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. Eur Heart J. 2013. doi: 10.1093/eurheartj/ eht187.
    • (2013) Eur Heart J.
    • Pitt, B.1    Kober, L.2    Ponikowski, P.3


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