Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 13, Issue 3, 2012, Pages 401-406

  Jung, Christian ^a   Florvaag, Anna ^a   Oberle, Volker ^a   Fritzenwanger, Michael ^a   Kretschmar, Daniel ^a   Kuethe, Friedhelm ^a   Betge, Stefan ^a   Goebel, Bjoern ^a   Franz, Marcus ^a   Barz, Dagmar ^a   Ferrari, Markus ^a   Figulla, Hans R ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

apoptosis; Endothelial progenitor cells; eplerenone; heart failure; vascular diseases

Indexed keywords

CD133 ANTIGEN; CD34 ANTIGEN; EPLERENONE;

ADULT; AGED; APOPTOSIS; ARTICLE; BODY MASS; CD34 SELECTION; CELL COUNT; CONTROLLED STUDY; DISEASE CLASSIFICATION; DRUG EFFECT; ECHOCARDIOGRAPHY; ENDOTHELIAL PROGENITOR CELL; FLOW CYTOMETRY; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HUMAN; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; SPIROMETRY; VASCULAR DISEASE;

EID: 84865627923     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320312447650     Document Type: Article

References (30)

1. Urbich C, Dimmeler S. Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res. 2004 ; 95: 343-353 (Pubitemid 39100452)
2. Jujo K, Ii M, Losordo DW. Endothelial progenitor cells in neovascularization of infarcted myocardium. J Mol Cell Cardiol. 2008 ; 45: 530-544
3. Hill JM, Zalos G, Halcox JPJ, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003 ; 348: 593-600 (Pubitemid 36204953)
4. Schmidt-Lucke C, Rossig L, Fichtlscherer S, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: Proof of concept for the clinical importance of endogenous vascular repair. Circulation. 2005 ; 111: 2981-2987 (Pubitemid 40814192)
5. Humpert PM, Eichler H, Lammert A, et al. Adult vascular progenitor cells and tissue regeneration in metabolic syndrome. Vasa. 2005 ; 34: 73-78
6. Imanishi T, Moriwaki C, Hano T, et al. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens. 2005 ; 23: 1831-1837 (Pubitemid 41830423)
7. George J, Herz I, Goldstein E, et al. Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis. Arterioscler Thromb Vasc Biol. 2003 ; 23: e57 - e60
8. Jung C, Rafnsson A, Shemyakin A, et al. Different subpopulations of endothelial progenitor cells and circulating apoptotic progenitor cells in patients with vascular disease and diabetes. Int J Cardiol. 2010 ; 3: 368-372
9. Chen JZ, Zhang FR, Tao QM, et al. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond). 2004 ; 107: 273-280 (Pubitemid 39243886)
10. Kissel CK, Lehmann R, Assmus B, et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol. 2007 ; 49: 2341-2349 (Pubitemid 46891715)
11. Nonaka-Sarukawa M, Yamamoto K, Aoki H, et al. Circulating endothelial progenitor cells in congestive heart failure. Int J Cardiol. 2007 ; 119: 344-348 (Pubitemid 46921266)
12. Valgimigli M, Rigolin GM, Fucili A, et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation. 2004 ; 110: 1209-1212 (Pubitemid 39202334)
13. Fritzenwanger M, Lorenz F, Jung C, et al. Differential number of CD34+, CD133+ and CD34+/CD133+ cells in peripheral blood of patients with congestive heart failure. European Journal of Medical Research. 2009 ; 14: 113-117
14. Pelliccia F, Pasceri V, Cianfrocca C, et al. Endothelial progenitor cells in patients with coronary artery disease and left ventricular dysfunction. Coron Artery Dis. 2009 ; 20: 303-308
15. Schachinger V, Assmus B, Britten MB, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: Final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol. 2004 ; 44: 1690-1699 (Pubitemid 39369805)
16. Van Craenenbroeck EM, Conraads VM. Endothelial progenitor cells in vascular health: Focus on lifestyle. Microvasc Res. 2010 ; 79: 184-192
17. Pelliccia F, Pasceri V, Cianfrocca C, et al. Angiotensin II receptor antagonism with telmisartan increases number of endothelial progenitor cells in normotensive patients with coronary artery disease: a randomized, double-blind, placebo-controlled study. Atherosclerosis. 2010 ; 210: 510-515
18. Erbs S, Beck EB, Linke A, et al. High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling-results from a randomized, double-blind, and placebo-controlled study. Int J Cardiol. 2011 ; 146: 56-63
19. Thum T, Schmitter K, Fleissner F, et al. Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans. Eur Heart J. 2010 ; 32: 1275-1286
20. Zannad F, McMurray JJ, Krum H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med. 2010 ; 364: 11-21
21. Ladage D, Schutzeberg N, Dartsch T, et al. Hyperaldosteronism is associated with a decrease in number and altered growth factor expression of endothelial progenitor cells in rats. Int J Cardiol. 2011 ; 149: 152-156
22. Fadini GP, Miorin M, Facco M, et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol. 2005 ; 45: 1449-1457 (Pubitemid 40615617)
23. Jung C, Fischer N, Fritzenwanger M, et al. Endothelial progenitor cells in adolescents: Impact of overweight, age, smoking, sport and cytokines in younger age. Clin Res Cardiol. 2009 ; 98: 179-188
24. Funder JW. Reconsidering the roles of the mineralocorticoid receptor. Hypertension. 2009 ; 53: 286-290
25. Iraqi W, Rossignol P, Angioi M, et al. Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: Insights from the Eplerenone Post-acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study. Circulation. 2009 ; 119: 2471-2479
26. Kobayashi N, Fukushima H, Takeshima H, et al. Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb. Am J Hypertens. 2010 ; 23: 1007-1013
27. Michowitz Y, Goldstein E, Wexler D, et al. Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure. Heart. 2007 ; 93: 1046-1050 (Pubitemid 47310980)
28. Leone AM, Valgimigli M, Giannico MB, et al. From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells. Eur Heart J. 2009 ; 30: 890-899
29. Tousoulis D, Andreou I, Tsiatas M, et al. Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: The impact of inflammatory process and oxidative stress. Atherosclerosis. 2011 ; 214: 151-157
30. Maceneaney OJ, Kushner EJ, Van Guilder GP, et al. Endothelial progenitor cell number and colony-forming capacity in overweight and obese adults. Int J Obes (Lond). 2009 ; 33: 219-225