Loss of MUTYH function in human cells leads to accumulation of oxidative damage and genetic instability

Oncogene

Volumn 32, Issue 38, 2013, Pages 4500-4508

  Ruggieri, V ^a   Pin, E ^b   Russo, M T ^a   Barone, F ^a   Degan, P ^c   Sanchez, M ^a   Quaia, M ^b   Minoprio, A ^a   Turco, E ^a   Mazzei, F ^a   Viel, A ^b   Bignami, M ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

8 oxodG; DNA glycosylase activity; MUTYH variants; MUTYH associated polyposis; PIG A

Indexed keywords

8 HYDROXYGUANINE; DNA GLYCOSYLASE MUTY;

ADENOMATOUS POLYP; ARTICLE; CELL DAMAGE; CELL POPULATION; CONTROLLED STUDY; DNA SEQUENCE; ELECTROCHEMICAL DETECTION; FAMILY HISTORY; GENE EXPRESSION; GENETIC DRIFT; GENETIC VARIABILITY; GENOMIC INSTABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LOSS OF FUNCTION MUTATION; LYMPHOBLASTOID CELL LINE; LYMPHOCYTE; MISSENSE MUTATION; MUTAGENESIS; MUTAGENIC ACTIVITY; MUTATION RATE; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; WESTERN BLOTTING; WILD TYPE;

ADENOMATOUS POLYPOSIS COLI; ADULT; CELL LINE; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENOMIC INSTABILITY; HETEROZYGOTE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; MUTATION RATE; OXIDATIVE STRESS; PHENOTYPE;

ESCHERICHIA COLI;

EID: 84884588531     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.479     Document Type: Article

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