Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair

Carcinogenesis

Volumn 26, Issue 11, 2005, Pages 2010-2018

  Parker, Antony R ^a,e   Sieber, Oliver M ^d   Shi, Chanjuan ^a   Hua, Li ^a   Takao, Masashi ^c   Tomlinson, Ian P ^d   Eshleman, James R ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c TOHOKU UNIVERSITY   (Japan)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e Binding Site Group Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA GLYCOSYLASE MUTY; HETERODUPLEX; HYDROGEN PEROXIDE; MENADIONE; MUTANT PROTEIN; OLIGONUCLEOTIDE;

ARTICLE; BASE MISPAIRING; CELL LINE; CELL SURVIVAL; COLON CARCINOGENESIS; COLON POLYPOSIS; COLORECTAL CANCER; DNA BINDING; DNA DAMAGE; DNA REPAIR; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSFECTION; HIGH RISK PATIENT; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; RISK ASSESSMENT; WILD TYPE;

ADENOMATOUS POLYPOSIS COLI; ALLELES; ANTIFIBRINOLYTIC AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; COLORECTAL NEOPLASMS; DEOXYGUANOSINE; DNA DAMAGE; DNA GLYCOSYLASES; DNA REPAIR; GLYCOSYLATION; HUMANS; HYDROGEN PEROXIDE; IMMUNOPRECIPITATION; MUTATION; OXIDANTS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; VITAMIN K 3;

EID: 27744462223     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi166     Document Type: Article

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