-
1
-
-
0033024863
-
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
-
10561265 1:CAS:528:DyaK1MXkvVSmur4%3D
-
Atkins MB, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999;17(7):2105-16.
-
(1999)
J Clin Oncol
, vol.17
, Issue.7
, pp. 2105-2116
-
-
Atkins, M.B.1
Lotze, M.T.2
Dutcher, J.P.3
-
2
-
-
0034124656
-
Dacarbazine-based chemotherapy for metastatic melanoma: Thirty-year experience overview
-
10840932 1:CAS:528:DC%2BD3cXjsVekt7o%3D
-
Serrone L, Zeuli M, Sega FM, Cognetti F. Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res. 2000;19(1):21-34.
-
(2000)
J Exp Clin Cancer Res
, vol.19
, Issue.1
, pp. 21-34
-
-
Serrone, L.1
Zeuli, M.2
Sega, F.M.3
Cognetti, F.4
-
3
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
This was the first phase III study to demonstrate an overall survival benefit with therapy in metastatic melanoma
-
•• Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-23. This was the first phase III study to demonstrate an overall survival benefit with therapy in metastatic melanoma.
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
4
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
This is a phase III study showing improved overall survival with ipilimumab plus dacarbazine compared with a previous standard of care, dacarbazine
-
•• Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-26. This is a phase III study showing improved overall survival with ipilimumab plus dacarbazine compared with a previous standard of care, dacarbazine.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
-
5
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
This is a phase III trial establishing vemurafenib as a standard of care for metastatic melanoma patients harboring the V600E BRAF mutation
-
•• Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-16. This is a phase III trial establishing vemurafenib as a standard of care for metastatic melanoma patients harboring the V600E BRAF mutation.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
6
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
This is a sentinel phase I trial demonstrating safety and clinical activity for PD-1 blockade
-
•• Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443-54. This is a sentinel phase I trial demonstrating safety and clinical activity for PD-1 blockade.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
7
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
This is a sentinel phase I trial demonstrating safety and clinical activity for PD-L1 blockade
-
•• Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455-65. This is a sentinel phase I trial demonstrating safety and clinical activity for PD-L1 blockade.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
8
-
-
0027417437
-
The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology
-
8433390 10.1093/jnci/85.5.365 1:STN:280:DyaK3s7msVarsQ%3D%3D
-
Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-76.
-
(1993)
J Natl Cancer Inst
, vol.85
, Issue.5
, pp. 365-376
-
-
Aaronson, N.K.1
Ahmedzai, S.2
Bergman, B.3
-
9
-
-
84862172613
-
Health related quality of life outcomes for unresectable stage III or IV melanoma patients receiving ipilimumab treatment
-
10.1186/1477-7525-10-66
-
Revicki DA, van den Eertwegh AJ, Lorigan P, et al. Health related quality of life outcomes for unresectable stage III or IV melanoma patients receiving ipilimumab treatment. Health Qual Life Outcome. 2012;10:66.
-
(2012)
Health Qual Life Outcome
, vol.10
, pp. 66
-
-
Revicki, D.A.1
Van Den Eertwegh, A.J.2
Lorigan, P.3
-
10
-
-
84859393995
-
CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic melanoma
-
22271879 10.1158/1078-0432.CCR-11-1823 1:CAS:528:DC%2BC38XkvFOlsrk%3D
-
Prieto PA, Yang JC, Sherry RM, et al. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res. 2012;18(7):2039-47.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.7
, pp. 2039-2047
-
-
Prieto, P.A.1
Yang, J.C.2
Sherry, R.M.3
-
11
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
12826605 10.1073/pnas.1533209100 1:CAS:528:DC%2BD3sXlsFGnt7c%3D
-
Phan GQ, Yang JC, Sherry RM, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A. 2003;100(14):8372-7.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.14
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
-
12
-
-
27844458057
-
Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: A phase I/II study
-
16283570 10.1245/ASO.2005.03.536
-
Maker AV, Phan GQ, Attia P, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol. 2005;12(12):1005-16.
-
(2005)
Ann Surg Oncol
, vol.12
, Issue.12
, pp. 1005-1016
-
-
Maker, A.V.1
Phan, G.Q.2
Attia, P.3
-
13
-
-
33747878218
-
Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma
-
16799341 10.1097/01.cji.0000208259.73167.58 1:CAS:528: DC%2BD28XmtFegsL0%3D
-
Maker AV, Yang JC, Sherry RM, et al. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. J Immunother. 2006;29(4):455-63.
-
(2006)
J Immunother
, vol.29
, Issue.4
, pp. 455-463
-
-
Maker, A.V.1
Yang, J.C.2
Sherry, R.M.3
-
14
-
-
84859414476
-
The antitumor immunity of ipilimumab: (T-cell) memories to last a lifetime?
-
22338019 10.1158/1078-0432.CCR-12-0409 1:CAS:528:DC%2BC38XkvFOmur8%3D
-
Postow MA, Callahan MK, Wolchok JD. The antitumor immunity of ipilimumab: (T-cell) memories to last a lifetime? Clin Cancer Res. 2012;18(7):1821-3.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.7
, pp. 1821-1823
-
-
Postow, M.A.1
Callahan, M.K.2
Wolchok, J.D.3
-
15
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
20004617 10.1016/S1470-2045(09)70334-1 1:CAS:528:DC%2BC3cXhtlGgtbY%3D
-
Wolchok JD, Neyns B, Linette G, et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 2010;11(2):155-64.
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 155-164
-
-
Wolchok, J.D.1
Neyns, B.2
Linette, G.3
-
16
-
-
84877093633
-
Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
-
23444228 10.1158/1078-0432.CCR-12-3080 1:CAS:528:DC%2BC3sXlvFyjtr4%3D
-
Robert C, Schadendorf D, Messina M, et al. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res. 2013;19(8):2232-9.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.8
, pp. 2232-2239
-
-
Robert, C.1
Schadendorf, D.2
Messina, M.3
-
17
-
-
84884594580
-
Outcomes of patients with malignant melanoma treated with immunotherapy prior to or after vemurafenib
-
Jun 1-5; Chicago
-
Ackerman A, McDermott D, Lawrence D, et al. Outcomes of patients with malignant melanoma treated with immunotherapy prior to or after vemurafenib. Paper presented at: 2012 ASCO Annual Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Ackerman, A.1
McDermott, D.2
Lawrence, D.3
-
18
-
-
84865553349
-
How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma
-
22918923 10.1093/annonc/mds258
-
Wolchok J. How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma. Ann Oncol. 2012;23 Suppl 8:viii15-21.
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 8
, pp. 15-21
-
-
Wolchok, J.1
-
19
-
-
77954373338
-
Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
-
20551059 10.1158/0008-5472.CAN-10-0118 1:CAS:528:DC%2BC3cXot1WlurY%3D
-
Boni A, Cogdill AP, Dang P, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res. 2010;70(13):5213-9.
-
(2010)
Cancer Res
, vol.70
, Issue.13
, pp. 5213-5219
-
-
Boni, A.1
Cogdill, A.P.2
Dang, P.3
-
20
-
-
78650391890
-
The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations
-
21169256 10.1158/1078-0432.CCR-10-1911 1:CAS:528:DC%2BC3cXhsFOjtr7O
-
Comin-Anduix B, Chodon T, Sazegar H, et al. The oncogenic BRAF kinase inhibitor PLX4032/RG7204 does not affect the viability or function of human lymphocytes across a wide range of concentrations. Clin Cancer Res. 2010;16(24):6040-8.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.24
, pp. 6040-6048
-
-
Comin-Anduix, B.1
Chodon, T.2
Sazegar, H.3
-
21
-
-
84863393623
-
Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
-
22156613 10.1158/1078-0432.CCR-11-2479 1:CAS:528:DC%2BC38Xjt1Wlur8%3D
-
Wilmott JS, Long GV, Howle JR, et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res. 2012;18(5):1386-94.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1386-1394
-
-
Wilmott, J.S.1
Long, G.V.2
Howle, J.R.3
-
22
-
-
84858760109
-
Combining immunotherapy and targeted therapies in cancer treatment
-
22437869 10.1038/nrc3237 1:CAS:528:DC%2BC38XksVehtrg%3D
-
Vanneman M, Dranoff G. Combining immunotherapy and targeted therapies in cancer treatment. Nat Rev Cancer. 2012;12(4):237-51.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 237-251
-
-
Vanneman, M.1
Dranoff, G.2
-
23
-
-
61649125595
-
The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
-
18922577 10.1016/j.leukres.2008.09.006 1:CAS:528:DC%2BD1MXivVWqu7Y%3D
-
Yang DH, Park JS, Jin CJ, et al. The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res. 2009;33(5):665-70.
-
(2009)
Leuk Res
, vol.33
, Issue.5
, pp. 665-670
-
-
Yang, D.H.1
Park, J.S.2
Jin, C.J.3
-
24
-
-
84875785905
-
Hepatotoxicity with combination of vemurafenib and ipilimumab
-
23550685 10.1056/NEJMc1302338 1:CAS:528:DC%2BC3sXls1aktbg%3D
-
Ribas A, Hodi FS, Callahan M, et al. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med. 2013;368(14):1365-6.
-
(2013)
N Engl J Med
, vol.368
, Issue.14
, pp. 1365-1366
-
-
Ribas, A.1
Hodi, F.S.2
Callahan, M.3
-
25
-
-
84857871490
-
Vemurafenib sensitivity skin reaction after ipilimumab
-
22375995 10.1056/NEJMc1114329 1:CAS:528:DC%2BC38XjsFSjsrs%3D
-
Harding JJ, Pulitzer M, Chapman PB. Vemurafenib sensitivity skin reaction after ipilimumab. N Engl J Med. 2012;366(9):866-8.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 866-868
-
-
Harding, J.J.1
Pulitzer, M.2
Chapman, P.B.3
-
26
-
-
4344609724
-
The treatment of brain metastases in melanoma patients
-
15325032 10.1016/j.ctrv.2004.05.001 1:CAS:528:DC%2BD2cXmvFCltr0%3D
-
Bafaloukos D, Gogas H. The treatment of brain metastases in melanoma patients. Cancer Treat Rev. 2004;30(6):515-20.
-
(2004)
Cancer Treat Rev
, vol.30
, Issue.6
, pp. 515-520
-
-
Bafaloukos, D.1
Gogas, H.2
-
27
-
-
0029086370
-
Prognostic factors in 1,521 melanoma patients with distant metastases
-
7670677 1:STN:280:DyaK2MvgtVGgtg%3D%3D
-
Barth A, Wanek LA, Morton DL. Prognostic factors in 1,521 melanoma patients with distant metastases. J Am Coll Surg. 1995;181(3):193-201.
-
(1995)
J Am Coll Surg
, vol.181
, Issue.3
, pp. 193-201
-
-
Barth, A.1
Wanek, L.A.2
Morton, D.L.3
-
28
-
-
84860446616
-
Ipilimumab in patients with melanoma and brain metastases: An open-label, phase 2 trial
-
22456429 10.1016/S1470-2045(12)70090-6 1:CAS:528:DC%2BC38Xmslyhsb4%3D
-
Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol. 2012;13(5):459-65.
-
(2012)
Lancet Oncol
, vol.13
, Issue.5
, pp. 459-465
-
-
Margolin, K.1
Ernstoff, M.S.2
Hamid, O.3
-
29
-
-
37549032137
-
Immunological aspects of cancer chemotherapy
-
18097448 10.1038/nri2216 1:CAS:528:DC%2BD2sXhsVKrsLnP
-
Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol. 2008;8(1):59-73.
-
(2008)
Nat Rev Immunol
, vol.8
, Issue.1
, pp. 59-73
-
-
Zitvogel, L.1
Apetoh, L.2
Ghiringhelli, F.3
Kroemer, G.4
-
30
-
-
2542421791
-
Cellular immunity in breast cancer patients completing taxane treatment
-
15161695 10.1158/1078-0432.CCR-1016-03 1:CAS:528:DC%2BD2cXkt1GhsLk%3D
-
Carson 3rd WE, Shapiro CL, Crespin TR, et al. Cellular immunity in breast cancer patients completing taxane treatment. Clin Cancer Res. 2004;10(10):3401-9.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.10
, pp. 3401-3409
-
-
Carson III, W.E.1
Shapiro, C.L.2
Crespin, T.R.3
-
31
-
-
25144466458
-
Gemcitabine selectively eliminates splenic Gr-1+/CD11b + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
-
16166452 10.1158/1078-0432.CCR-05-0883 1:CAS:528:DC%2BD2MXhtVShsb3O
-
Suzuki E, Kapoor V, Jassar AS, et al. Gemcitabine selectively eliminates splenic Gr-1+/CD11b + myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11(18):6713-21.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.18
, pp. 6713-6721
-
-
Suzuki, E.1
Kapoor, V.2
Jassar, A.S.3
-
32
-
-
79955581263
-
A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma
-
20082117 10.1007/s10637-009-9376-8 1:CAS:528:DC%2BC3MXkvVSqurg%3D
-
Hersh EM, O'Day SJ, Powderly J, et al. A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naive patients with advanced melanoma. Invest New Drugs. 2011;29(3):489-98.
-
(2011)
Invest New Drugs
, vol.29
, Issue.3
, pp. 489-498
-
-
Hersh, E.M.1
O'Day, S.J.2
Powderly, J.3
-
33
-
-
1842562211
-
Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: A phase III study
-
15020614 10.1200/JCO.2004.04.165 1:CAS:528:DC%2BD2cXptlCku7Y%3D
-
Avril MF, Aamdal S, Grob JJ, et al. Fotemustine compared with dacarbazine in patients with disseminated malignant melanoma: a phase III study. J Clin Oncol. 2004;22(6):1118-25.
-
(2004)
J Clin Oncol
, vol.22
, Issue.6
, pp. 1118-1125
-
-
Avril, M.F.1
Aamdal, S.2
Grob, J.J.3
-
34
-
-
84865567547
-
Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): An open-label, single-arm phase 2 trial
-
22894884 10.1016/S1470-2045(12)70324-8
-
Di Giacomo AM, Ascierto PA, Pilla L, et al. Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial. Lancet Oncol. 2012;13(9):879-86.
-
(2012)
Lancet Oncol
, vol.13
, Issue.9
, pp. 879-886
-
-
Di Giacomo, A.M.1
Ascierto, P.A.2
Pilla, L.3
-
35
-
-
84884588292
-
Development of brain metastases in patients with metastatic melanoma treated with ipilimumab plus temozolomide
-
Jun 1-5; Chicago
-
Wang J, Patel SG, Hwu WJ, et al. Development of brain metastases in patients with metastatic melanoma treated with ipilimumab plus temozolomide. Paper presented at: 2012 Annual ASCO Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 Annual ASCO Meeting
-
-
Wang, J.1
Patel, S.G.2
Hwu, W.J.3
-
36
-
-
84884586428
-
Phase II study of the frontline combination of ipilimumab and temozolomide in patients with metastatic melanoma
-
Jun 1-5; Chicago
-
Patel SP, Hwu WJ, Kim KB, et al. Phase II study of the frontline combination of ipilimumab and temozolomide in patients with metastatic melanoma. Paper presented at: 2012 Annual ASCO Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 Annual ASCO Meeting
-
-
Patel, S.P.1
Hwu, W.J.2
Kim, K.B.3
-
37
-
-
0016816906
-
An interesting case of possible abscopal effect in malignant melanoma
-
811297 10.1259/0007-1285-48-574-863 1:STN:280:DyaE28%2FmtlWqsw%3D%3D
-
Kingsley DP. An interesting case of possible abscopal effect in malignant melanoma. Br J Radiol. 1975;48(574):863-6.
-
(1975)
Br J Radiol
, vol.48
, Issue.574
, pp. 863-866
-
-
Kingsley, D.P.1
-
38
-
-
84872202826
-
The abscopal effect associated with a systemic anti-melanoma immune response
-
This is a case report demonstrating immune correlates of the abscopal effect in a patient treated with ipilimumab and external beam radiotherapy
-
• Stamell EF, Wolchok JD, Gnjatic S, et al. The abscopal effect associated with a systemic anti-melanoma immune response. Int J Radiat Oncol Biol Phys. 2013;85(2):293-5. This is a case report demonstrating immune correlates of the abscopal effect in a patient treated with ipilimumab and external beam radiotherapy.
-
(2013)
Int J Radiat Oncol Biol Phys
, vol.85
, Issue.2
, pp. 293-295
-
-
Stamell, E.F.1
Wolchok, J.D.2
Gnjatic, S.3
-
39
-
-
84857815877
-
Immunologic correlates of the abscopal effect in a patient with melanoma
-
22397654 10.1056/NEJMoa1112824 1:CAS:528:DC%2BC38XktFOgurw%3D
-
Postow MA, Callahan MK, Barker CA, et al. Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med. 2012;366(10):925-31.
-
(2012)
N Engl J Med
, vol.366
, Issue.10
, pp. 925-931
-
-
Postow, M.A.1
Callahan, M.K.2
Barker, C.A.3
-
40
-
-
84862124594
-
Phase 1 study of stereotactic body radiotherapy and interleukin-2 - Tumor and immunological responses
-
22674552 10.1126/scitranslmed.3003649 1:CAS:528:DC%2BC3sXptVelsw%3D%3D
-
Seung SK, Curti BD, Crittenden M, et al. Phase 1 study of stereotactic body radiotherapy and interleukin-2 - tumor and immunological responses. Sci Transl Med. 2012;4(137):137ra74.
-
(2012)
Sci Transl Med
, vol.4
, Issue.137
-
-
Seung, S.K.1
Curti, B.D.2
Crittenden, M.3
-
41
-
-
69949085196
-
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
-
19706802 10.1158/1078-0432.CCR-09-0265 1:CAS:528:DC%2BD1MXhtVOntrjP
-
Dewan MZ, Galloway AE, Kawashima N, et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res. 2009;15(17):5379-88.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.17
, pp. 5379-5388
-
-
Dewan, M.Z.1
Galloway, A.E.2
Kawashima, N.3
-
42
-
-
67349216128
-
Effectiveness of treatments for metastatic uveal melanoma
-
19375060 10.1016/j.ajo.2009.01.023
-
Augsburger JJ, Correa ZM, Shaikh AH. Effectiveness of treatments for metastatic uveal melanoma. Am J Ophthalmol. 2009;148(1):119-27.
-
(2009)
Am J Ophthalmol
, vol.148
, Issue.1
, pp. 119-127
-
-
Augsburger, J.J.1
Correa, Z.M.2
Shaikh, A.H.3
-
43
-
-
78651446131
-
Mutations in GNA11 in uveal melanoma
-
21083380 10.1056/NEJMoa1000584
-
Van Raamsdonk CD, Griewank KG, Crosby MB, et al. Mutations in GNA11 in uveal melanoma. N Engl J Med. 2010;363(23):2191-9.
-
(2010)
N Engl J Med
, vol.363
, Issue.23
, pp. 2191-2199
-
-
Van Raamsdonk, C.D.1
Griewank, K.G.2
Crosby, M.B.3
-
44
-
-
84885452509
-
Ipilimumab in the treatment of uveal melanoma: The Memorial Sloan-Kettering Cancer Center experience
-
Jun 1-5; Chicago
-
Khan S, Callahan M, Postow MA, et al. Ipilimumab in the treatment of uveal melanoma: The Memorial Sloan-Kettering Cancer Center experience. Paper presented at: 2012 ASCO Annual Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Khan, S.1
Callahan, M.2
Postow, M.A.3
-
45
-
-
84872085988
-
Ipilimumab activity in advanced uveal melanoma
-
23211837 10.1097/CMR.0b013e32835b554f 1:CAS:528:DC%2BC38XhvFSns7jM
-
Khattak MA, Fisher R, Hughes P, et al. Ipilimumab activity in advanced uveal melanoma. Melanoma Res. 2013;23(1):79-81.
-
(2013)
Melanoma Res
, vol.23
, Issue.1
, pp. 79-81
-
-
Khattak, M.A.1
Fisher, R.2
Hughes, P.3
-
46
-
-
84856739604
-
Ipilimumab in pretreated patients with metastatic uveal melanoma: Safety and clinical efficacy
-
21833591 10.1007/s00262-011-1089-0 1:CAS:528:DC%2BC38Xkt1WhsQ%3D%3D
-
Danielli R, Ridolfi R, Chiarion-Sileni V, et al. Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy. Cancer Immunol Immunother. 2012;61(1):41-8.
-
(2012)
Cancer Immunol Immunother
, vol.61
, Issue.1
, pp. 41-48
-
-
Danielli, R.1
Ridolfi, R.2
Chiarion-Sileni, V.3
-
47
-
-
79958066836
-
KIT as a therapeutic target in metastatic melanoma
-
21642685 10.1001/jama.2011.746 1:CAS:528:DC%2BC3MXntlOnsrY%3D
-
Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011;305(22):2327-34.
-
(2011)
JAMA
, vol.305
, Issue.22
, pp. 2327-2334
-
-
Carvajal, R.D.1
Antonescu, C.R.2
Wolchok, J.D.3
-
48
-
-
84882941100
-
Efficacy and safety of ipilimumab in patients with pretreated, mucosal melanoma: Experience from Italian clinics participating in the European expanded access programme (EAP)
-
Sep 28-October 2; Vienna
-
Del Vecchio M, Simeone E, Chiarion Sileni V, et al. Efficacy and safety of ipilimumab in patients with pretreated, mucosal melanoma: experience from Italian clinics participating in the European expanded access programme (EAP). Paper presented at: ESMO 2012 Congress; 2012 Sep 28-October 2; Vienna.
-
(2012)
ESMO 2012 Congress
-
-
Del Vecchio, M.1
Simeone, E.2
Chiarion Sileni, V.3
-
49
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
20086001 10.1158/1078-0432.CCR-09-2033 1:CAS:528:DC%2BC3cXhs1aru70%3D
-
Kirkwood JM, Lorigan P, Hersey P, et al. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res. 2010;16(3):1042-8.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
-
50
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
23295794 10.1200/JCO.2012.44.6112 1:CAS:528:DC%2BC3sXjvVart74%3D
-
Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013;31(5):616-22.
-
(2013)
J Clin Oncol
, vol.31
, Issue.5
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
-
51
-
-
84856069688
-
Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma
-
22184371 10.1200/JCO.2011.37.5394 1:CAS:528:DC%2BC38XjsFCitL0%3D
-
Tarhini AA, Cherian J, Moschos SJ, et al. Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol. 2012;30(3):322-8.
-
(2012)
J Clin Oncol
, vol.30
, Issue.3
, pp. 322-328
-
-
Tarhini, A.A.1
Cherian, J.2
Moschos, S.J.3
-
52
-
-
77950258677
-
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
-
20143434 10.1002/cncr.24951 1:CAS:528:DC%2BC3cXkvFOns7g%3D
-
Ku GY, Yuan J, Page DB, et al. Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer. 2010;116(7):1767-75.
-
(2010)
Cancer
, vol.116
, Issue.7
, pp. 1767-1775
-
-
Ku, G.Y.1
Yuan, J.2
Page, D.B.3
-
53
-
-
84884588553
-
Evaluation of the absolute lymphocyte count as a biomarker for melanoma patients treated with the commercially available dose of ipilimumab (3mg/kg)
-
Jun 1-5; Chicago
-
Postow MA, Yuan J, Panageas KS,et al. Evaluation of the absolute lymphocyte count as a biomarker for melanoma patients treated with the commercially available dose of ipilimumab (3mg/kg). Paper presented at: 2012 ASCO Annual Meeting. 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Postow, M.A.1
Yuan, J.2
Panageas, K.S.3
-
54
-
-
77952337834
-
Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
-
20460488 10.1158/1078-0432.CCR-10-0569 1:CAS:528:DC%2BC3cXlvF2hsrY%3D
-
Carthon BC, Wolchok JD, Yuan J, et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 2010;16(10):2861-71.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.10
, pp. 2861-2871
-
-
Carthon, B.C.1
Wolchok, J.D.2
Yuan, J.3
-
55
-
-
80053648839
-
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
-
21933959 10.1073/pnas.1110814108 1:CAS:528:DC%2BC3MXhtlWksrbK
-
Yuan J, Adamow M, Ginsberg BA, et al. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci U S A. 2011;108(40):16723- 8.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.40
, pp. 16723-16728
-
-
Yuan, J.1
Adamow, M.2
Ginsberg, B.A.3
-
56
-
-
79960895501
-
+ T cells in prevaccinated patients with melanoma: Three cases
-
21465316 10.1007/s00262-011-1011-9 1:CAS:528:DC%2BC3MXpt1OqsbY%3D
-
+ T cells in prevaccinated patients with melanoma: three cases. Cancer Immunol Immunother. 2011;60(8):1137-46.
-
(2011)
Cancer Immunol Immunother
, vol.60
, Issue.8
, pp. 1137-1146
-
-
Yuan, J.1
Ginsberg, B.2
Page, D.3
-
57
-
-
82155168544
-
A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
-
22123319 10.1186/1479-5876-9-204 1:CAS:528:DC%2BC38Xms1Cquw%3D%3D
-
Hamid O, Schmidt H, Nissan A, et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med. 2011;9:204.
-
(2011)
J Transl Med
, vol.9
, pp. 204
-
-
Hamid, O.1
Schmidt, H.2
Nissan, A.3
-
58
-
-
84862769116
-
An immune-active tumor microenvironment favors clinical response to ipilimumab
-
22146893 10.1007/s00262-011-1172-6 1:CAS:528:DC%2BC38XptVGnu7w%3D
-
Ji RR, Chasalow SD, Wang L, et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother. 2012;61(7):1019-31.
-
(2012)
Cancer Immunol Immunother
, vol.61
, Issue.7
, pp. 1019-1031
-
-
Ji, R.R.1
Chasalow, S.D.2
Wang, L.3
-
59
-
-
84871514990
-
Myeloid-derived suppressor cell quantity prior to treatment with ipilimumab at 10mg/kg to predict for overall survival in patients with metastatic melanoma
-
Jun 1-5; Chicago
-
Kitano S, Postow MA, Cortez C, et al. Myeloid-derived suppressor cell quantity prior to treatment with ipilimumab at 10mg/kg to predict for overall survival in patients with metastatic melanoma. Paper presented at: 2012 ASCO Annual Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Kitano, S.1
Postow, M.A.2
Cortez, C.3
-
60
-
-
84884590296
-
Biomarker for benefit from ipilimumab: Correlation of breadth of humor tumor-antigen-specific immunity with outcome
-
Jun 1-5; Chicago
-
Ellis SG, Wheater M, Tier K, et al. Biomarker for benefit from ipilimumab: correlation of breadth of humor tumor-antigen-specific immunity with outcome. Paper presented at: 2012 ASCO Annual Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Ellis, S.G.1
Wheater, M.2
Tier, K.3
-
61
-
-
84884597023
-
Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-mediated gastrointestinal adverse events
-
Jun 1-5; Chicago
-
Shahabi V, Berman D, Chasalow SD, et al. Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-mediated gastrointestinal adverse events. Paper presented at: 2012 ASCO Annual Meeting; 2012 Jun 1-5; Chicago.
-
(2012)
2012 ASCO Annual Meeting
-
-
Shahabi, V.1
Berman, D.2
Chasalow, S.D.3
-
62
-
-
84859158384
-
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
-
22236695 10.1016/j.coi.2011.12.009 1:CAS:528:DC%2BC38XltValu7o%3D
-
Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol. 2012;24(2):207-12.
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.2
, pp. 207-212
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
63
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
11015443 10.1084/jem.192.7.1027 1:CAS:528:DC%2BD3cXntFSlt7o%3D
-
Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000;192(7):1027-34.
-
(2000)
J Exp Med
, vol.192
, Issue.7
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
-
64
-
-
84884596647
-
Anti-programmed death-1 (PD-1) (BMS-936558/MDX-1106/ONO-4538) in patients with advanced solid tumors: Clinical activity, safety, and molecular markers
-
Sep 28-Oct 2; Vienna
-
Topalian SL, Brahmer JR, Hodi FS, et al. Anti-programmed death-1 (PD-1) (BMS-936558/MDX-1106/ONO-4538) in patients with advanced solid tumors: clinical activity, safety, and molecular markers. Paper presented at: ESMO 2012 Congress; 2012 Sep 28-Oct 2; Vienna.
-
(2012)
ESMO 2012 Congress
-
-
Topalian, S.L.1
Brahmer, J.R.2
Hodi, F.S.3
-
65
-
-
84872514622
-
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
-
Lipson EJ, Sharfman WH, Drake CG, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res. 2013.
-
(2013)
Clin Cancer Res.
-
-
Lipson, E.J.1
Sharfman, W.H.2
Drake, C.G.3
-
66
-
-
84864052441
-
Management of immune-related adverse events and kinetics of response with ipilimumab
-
22614989 10.1200/JCO.2012.41.6750 1:CAS:528:DC%2BC38Xht1ygsr%2FK
-
Weber JS, Kahler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol. 2012;30(21):2691-7.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2691-2697
-
-
Weber, J.S.1
Kahler, K.C.2
Hauschild, A.3
-
67
-
-
84884595490
-
Preliminary clinical efficacy and safety of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced melanoma
-
10.1111/pcmr.12023
-
Hamid O, Daud A, Robert C, et al. Preliminary clinical efficacy and safety of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced melanoma. Pigment Cell Melanoma Res. 2012;25(6):836-903.
-
(2012)
Pigment Cell Melanoma Res
, vol.25
, Issue.6
, pp. 836-903
-
-
Hamid, O.1
Daud, A.2
Robert, C.3
-
68
-
-
77956496386
-
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance
-
20472828 10.1182/blood-2010-01-265975 1:CAS:528:DC%2BC3cXhtFersbbP
-
Park JJ, Omiya R, Matsumura Y, et al. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood. 2010;116(8):1291-8.
-
(2010)
Blood
, vol.116
, Issue.8
, pp. 1291-1298
-
-
Park, J.J.1
Omiya, R.2
Matsumura, Y.3
-
69
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
-
19934295 10.1158/1078-0432.CCR-09-1624 1:CAS:528:DC%2BD1MXhsFSnu7vN
-
Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15(23):7412-20.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.23
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
-
70
-
-
84874889330
-
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
-
23460531 10.1158/1078-0432.CCR-12-2214 1:CAS:528:DC%2BC3sXjsFektbs%3D
-
Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer Res. 2013;19(5):997-1008.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 997-1008
-
-
Melero, I.1
Grimaldi, A.M.2
Perez-Gracia, J.L.3
Ascierto, P.A.4
-
71
-
-
79955785050
-
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production
-
21559358 10.1371/journal.pone.0019499 1:CAS:528:DC%2BC3MXlsl2gtLc%3D
-
Curran MA, Kim M, Montalvo W, et al. Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production. PLoS One. 2011;6(4):e19499.
-
(2011)
PLoS One
, vol.6
, Issue.4
, pp. 19499
-
-
Curran, M.A.1
Kim, M.2
Montalvo, W.3
-
72
-
-
84863393290
-
+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
-
22205715 10.1158/0008-5472.CAN-11-2637 1:CAS:528:DC%2BC38XitlGit7o%3D
-
+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res. 2012;72(4):887-96.
-
(2012)
Cancer Res
, vol.72
, Issue.4
, pp. 887-896
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
-
73
-
-
79956103042
-
Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors
-
21430066 10.1158/0008-5472.CAN-11-0096 1:CAS:528:DC%2BC3MXmtVGlt7s%3D
-
Ngiow SF, von Scheidt B, Akiba H, et al. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res. 2011;71(10):3540-51.
-
(2011)
Cancer Res
, vol.71
, Issue.10
, pp. 3540-3551
-
-
Ngiow, S.F.1
Von Scheidt, B.2
Akiba, H.3
-
74
-
-
53949108399
-
Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): A trial coordinated by the Eastern Cooperative Oncology Group
-
19001327 10.1200/JCO.2008.17.5448 1:CAS:528:DC%2BD1MXotFemtQ%3D%3D
-
Atkins MB, Hsu J, Lee S, et al. Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol. 2008;26(35):5748-54.
-
(2008)
J Clin Oncol
, vol.26
, Issue.35
, pp. 5748-5754
-
-
Atkins, M.B.1
Hsu, J.2
Lee, S.3
-
75
-
-
79955624415
-
Vaccine therapy for metastatic melanoma: Systematic review and meta-analysis of clinical trials
-
21537143 10.1097/CMR.0b013e328346554d 1:CAS:528:DC%2BC3MXlsV2lsrY%3D
-
Chi M, Dudek AZ. Vaccine therapy for metastatic melanoma: systematic review and meta-analysis of clinical trials. Melanoma Res. 2011;21(3):165-74.
-
(2011)
Melanoma Res
, vol.21
, Issue.3
, pp. 165-174
-
-
Chi, M.1
Dudek, A.Z.2
-
76
-
-
84859393998
-
Advances in the treatment of metastatic melanoma: Adoptive T-cell therapy
-
22484193 10.1053/j.seminoncol.2012.01.006 1:CAS:528:DC%2BC38Xltlagtbk%3D
-
Bernatchez C, Radvanyi LG, Hwu P. Advances in the treatment of metastatic melanoma: adoptive T-cell therapy. Semin Oncol. 2012;39(2):215-26.
-
(2012)
Semin Oncol
, vol.39
, Issue.2
, pp. 215-226
-
-
Bernatchez, C.1
Radvanyi, L.G.2
Hwu, P.3
|