메뉴 건너뛰기




Volumn 34, Issue 6, 2013, Pages 822-836

Personalizing therapy in advanced non-small cell lung cancer

Author keywords

non small cell lung cancer; oncogenic driver mutations; personalized therapy

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AFATINIB; ANTINEOPLASTIC AGENT; BRIVANIB; BRIVANIB ALANINATE; CABOZANTINIB; CARBOPLATIN; CETUXIMAB; CH 5424802; CISPLATIN; CRIZOTINIB; DASATINIB; DOCETAXEL; ERLOTINIB; GANETESPIB; GEFITINIB; GEMCITABINE; LDK 378; LUMINESPIB; ONARTUZUMAB; PACLITAXEL; PEMETREXED; PONATINIB; RETASPIMYCIN; RIDAFOROLIMUS; SELUMETINIB; TIVANTINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VEMURAFENIB;

EID: 84884571733     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0033-1358552     Document Type: Article
Times cited : (18)

References (156)
  • 2
    • 0028963973 scopus 로고
    • Symptoms at presentation for treatment in patients with lung cancer: Implications for the evaluation of palliative treatment
    • The Medical Research Council (MRC) Lung Cancer Working Party.
    • Hopwood P., Stephens R. J.; The Medical Research Council (MRC) Lung Cancer Working Party. Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. Br J Cancer: 1995; 71 3 633 636
    • (1995) Br J Cancer , vol.71 , Issue.3 , pp. 633-636
    • Hopwood, P.1    Stephens, R.J.2
  • 3
    • 53749097825 scopus 로고    scopus 로고
    • Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data from 16 randomized controlled trials
    • et al; NSCLC Meta-Analyses Collaborative Group.
    • Burdett S., Stephens R., Stewart L., et al. NSCLC Meta-Analyses Collaborative Group. Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol: 2008; 26 28 4617 4625
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4617-4625
    • Burdett, S.1    Stephens, R.2    Stewart, L.3
  • 4
    • 18244390213 scopus 로고    scopus 로고
    • Chemotherapy in non-small cell lung cancer: An update of an individual patient data-based meta-analysis
    • author reply 1205-1206
    • Burdett S., Stewart L., Pignon J-P. Chemotherapy in non-small cell lung cancer: an update of an individual patient data-based meta-analysis. J Thorac Cardiovasc Surg: 2005; 129 5 1205, author reply 1205-1206
    • (2005) J Thorac Cardiovasc Surg , vol.129 , Issue.5 , pp. 1205
    • Burdett, S.1    Stewart, L.2    Pignon, J.-P.3
  • 5
    • 0023922084 scopus 로고
    • Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer report of a Canadian multicenter randomized trial
    • et al.
    • Rapp E., Pater J. L., Willan A., et al. Chemotherapy can prolong survival in patients with advanced non-small-cell lung cancer report of a Canadian multicenter randomized trial. J Clin Oncol: 1988; 6 4 633 641
    • (1988) J Clin Oncol , vol.6 , Issue.4 , pp. 633-641
    • Rapp, E.1    Pater, J.L.2    Willan, A.3
  • 6
    • 0028843552 scopus 로고
    • Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
    • Non-small Cell Lung Cancer Collaborative Group
    • Non-small Cell Lung Cancer Collaborative Group Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ: 1995; 311 7010 899 909
    • (1995) BMJ , vol.311 , Issue.7010 , pp. 899-909
  • 14
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • et al.
    • Kwak E. L., Bang Y. J., Camidge D. R., et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med: 2010; 363 18 1693 1703
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 15
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • et al.
    • Bergethon K., Shaw A. T., Ou S. H., et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol: 2012; 30 8 863 870
    • (2012) J Clin Oncol , vol.30 , Issue.8 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 16
    • 84883451574 scopus 로고    scopus 로고
    • Efficacy and safety of crizotinib in patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC) [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8032
    • Ou S. I., Bang Y., Camidge D. R., et al. Efficacy and safety of crizotinib in patients with advanced ROS1-rearranged non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8032
    • J Clin Oncol
    • Ou, S.I.1    Bang, Y.2    Camidge, D.R.3
  • 17
    • 84869224992 scopus 로고    scopus 로고
    • Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: Higher susceptibility of women to smoking-related KRAS-mutant cancers
    • et al.
    • Dogan S., Shen R., Ang D. C., et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res: 2012; 18 22 6169 6177
    • (2012) Clin Cancer Res , vol.18 , Issue.22 , pp. 6169-6177
    • Dogan, S.1    Shen, R.2    Ang, D.C.3
  • 18
    • 21244460046 scopus 로고    scopus 로고
    • Annual smoking-attributable mortality, years of potential life lost, and productivity losses United States, 1997-2001
    • Centers for Disease Control and Prevention (CDC)
    • Centers for Disease Control and Prevention (CDC) Annual smoking-attributable mortality, years of potential life lost, and productivity losses United States, 1997-2001. MMWR Morb Mortal Wkly Rep: 2005; 54 25 625 628
    • (2005) MMWR Morb Mortal Wkly Rep , vol.54 , Issue.25 , pp. 625-628
  • 21
    • 84884538692 scopus 로고    scopus 로고
    • A multicenter effort to identify driver mutations and employ targeted therapy in patients with lung adenocarcinomas: The Lung Cancer Mutation Consortium (LCMC) [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8019
    • Johnson B. E., Kris M. G., Berry L. D., et al. A multicenter effort to identify driver mutations and employ targeted therapy in patients with lung adenocarcinomas: The Lung Cancer Mutation Consortium (LCMC) [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8019
    • J Clin Oncol
    • Johnson, B.E.1    Kris, M.G.2    Berry, L.D.3
  • 23
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma S. V., Bell D. W., Settleman J., Haber D. A. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer: 2007; 7 3 169 181
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 24
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • et al.
    • Mok T. S., Wu Y. L., Thongprasert S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med: 2009; 361 10 947 957
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 25
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • et al; Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica.
    • Rosell R., Carcereny E., Gervais R., et al. Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol: 2012; 13 3 239 246
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 26
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • et al.
    • Zhou C., Wu Y. L., Chen G., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol: 2011; 12 8 735 742
    • (2011) Lancet Oncol , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 27
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • et al; North-East Japan Study Group.
    • Maemondo M., Inoue A., Kobayashi K., et al. North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med: 2010; 362 25 2380 2388
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 28
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • et al; West Japan Oncology Group.
    • Mitsudomi T., Morita S., Yatabe Y., et al. West Japan Oncology Group. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol: 2010; 11 2 121 128
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 29
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • et al.
    • Sequist L. V., Yang J. C., Yamamoto N., et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol: 2013; 31 27 3327 3334
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 30
    • 84884659258 scopus 로고    scopus 로고
    • LUX-Lung 6: A randomized, open-label, phase III study of afatinab (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8016
    • Wu Y. L., Zhou C., Hu C., et al. LUX-Lung 6: A randomized, open-label, phase III study of afatinab (A) versus gemcitabine/cisplatin (GC) as first-line treatment for Asian patients (pts) with EGFR mutation-positive (EGFR M+) advanced adenocarcinoma of the lung [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8016
    • J Clin Oncol
    • Wu, Y.L.1    Zhou, C.2    Hu, C.3
  • 31
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS)
    • et al.
    • Fukuoka M., Wu Y. L., Thongprasert S., et al. Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS). J Clin Oncol: 2011; 29 21 2866 2874
    • (2011) J Clin Oncol , vol.29 , Issue.21 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3
  • 32
    • 84871540705 scopus 로고    scopus 로고
    • Treating patients with EGFR-sensitizing mutations: First line or second line is there a difference
    • Mok T., Yang J. J., Lam K. C. Treating patients with EGFR-sensitizing mutations: first line or second line is there a difference? J Clin Oncol: 2013; 31 8 1081 1088
    • (2013) J Clin Oncol , vol.31 , Issue.8 , pp. 1081-1088
    • Mok, T.1    Yang, J.J.2    Lam, K.C.3
  • 33
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • et al.
    • Arcila M. E., Oxnard G. R., Nafa K., et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res: 2011; 17 5 1169 1180
    • (2011) Clin Cancer Res , vol.17 , Issue.5 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3
  • 34
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • et al.
    • Yu H. A., Arcila M. E., Rekhtman N., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res: 2013; 19 8 2240 2247
    • (2013) Clin Cancer Res , vol.19 , Issue.8 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3
  • 35
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • et al.
    • Miller V. A., Hirsh V., Cadranel J., et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol: 2012; 13 5 528 538
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3
  • 36
    • 70349684791 scopus 로고    scopus 로고
    • Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
    • et al.
    • Regales L., Gong Y., Shen R., et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest: 2009; 119 10 3000 3010
    • (2009) J Clin Invest , vol.119 , Issue.10 , pp. 3000-3010
    • Regales, L.1    Gong, Y.2    Shen, R.3
  • 37
    • 84867760241 scopus 로고    scopus 로고
    • HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
    • et al.
    • Takezawa K., Pirazzoli V., Arcila M. E., et al. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov: 2012; 2 10 922 933
    • (2012) Cancer Discov , vol.2 , Issue.10 , pp. 922-933
    • Takezawa, K.1    Pirazzoli, V.2    Arcila, M.E.3
  • 38
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • et al.
    • Ohashi K., Sequist L. V., Arcila M. E., et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A: 2012; 109 31 E2127 E2133
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.31
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 39
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • et al.
    • Sequist L. V., Waltman B. A., Dias-Santagata D., et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med: 2011; 3 75 75ra26
    • (2011) Sci Transl Med , vol.3 , Issue.75
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 40
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • et al.
    • Bean J., Brennan C., Shih J. Y., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A: 2007; 104 52 20932 20937
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.52 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3
  • 44
    • 70349342712 scopus 로고    scopus 로고
    • EML4-ALK: Honing in on a new target in non-small-cell lung cancer
    • Horn L., Pao W. EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol: 2009; 27 26 4232 4235
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4232-4235
    • Horn, L.1    Pao, W.2
  • 45
    • 78649973178 scopus 로고    scopus 로고
    • Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene
    • et al.
    • Chen Z., Sasaki T., Tan X., et al. Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene. Cancer Res: 2010; 70 23 9827 9836
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9827-9836
    • Chen, Z.1    Sasaki, T.2    Tan, X.3
  • 46
    • 44849126091 scopus 로고    scopus 로고
    • Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
    • et al.
    • McDermott U., Iafrate A. J., Gray N. S., et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res: 2008; 68 9 3389 3395
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3389-3395
    • McDermott, U.1    Iafrate, A.J.2    Gray, N.S.3
  • 47
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • et al.
    • Soda M., Takada S., Takeuchi K., et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci U S A: 2008; 105 50 19893 19897
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 48
    • 70349336416 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
    • et al.
    • Shaw A. T., Yeap B. Y., Mino-Kenudson M., et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol: 2009; 27 26 4247 4253
    • (2009) J Clin Oncol , vol.27 , Issue.26 , pp. 4247-4253
    • Shaw, A.T.1    Yeap, B.Y.2    Mino-Kenudson, M.3
  • 49
    • 65249095599 scopus 로고    scopus 로고
    • The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS
    • et al; University of Hong Kong Lung Cancer Study Group.
    • Wong D. W., Leung E. L., So K. K., et al. University of Hong Kong Lung Cancer Study Group. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer: 2009; 115 8 1723 1733
    • (2009) Cancer , vol.115 , Issue.8 , pp. 1723-1733
    • Wong, D.W.1    Leung, E.L.2    So, K.K.3
  • 50
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: Updated results from a phase 1 study
    • et al.
    • Camidge D. R., Bang Y. J., Kwak E. L., et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol: 2012; 13 10 1011 1019
    • (2012) Lancet Oncol , vol.13 , Issue.10 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 51
    • 84941627946 scopus 로고    scopus 로고
    • Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer [abstract]
    • 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7533
    • Kim D. W., Ahn M. J., Shi Y. Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer [abstract]. J Clin Oncol 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7533
    • J Clin Oncol
    • Kim, D.W.1    Ahn, M.J.2    Shi, Y.3
  • 52
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
    • et al.
    • Shaw A. T., Yeap B. Y., Solomon B. J., et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol: 2011; 12 11 1004 1012
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1004-1012
    • Shaw, A.T.1    Yeap, B.Y.2    Solomon, B.J.3
  • 53
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • et al.
    • Shaw A. T., Kim D. W., Nakagawa K., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med: 2013; 368 25 2385 2394
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 54
    • 78049426513 scopus 로고    scopus 로고
    • EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • et al; ALK Lung Cancer Study Group.
    • Choi Y. L., Soda M., Yamashita Y., et al. ALK Lung Cancer Study Group. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med: 2010; 363 18 1734 1739
    • (2010) N Engl J Med , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 55
    • 79956318797 scopus 로고    scopus 로고
    • Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
    • et al.
    • Katayama R., Khan T. M., Benes C., et al. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci U S A: 2011; 108 18 7535 7540
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.18 , pp. 7535-7540
    • Katayama, R.1    Khan, T.M.2    Benes, C.3
  • 56
    • 84857027931 scopus 로고    scopus 로고
    • Escaping ALK inhibition: Mechanisms of and strategies to overcome resistance
    • Lovly C. M., Pao W. Escaping ALK inhibition: mechanisms of and strategies to overcome resistance. Sci Transl Med: 2012; 4 120 ps2
    • (2012) Sci Transl Med , vol.4 , Issue.120
    • Lovly, C.M.1    Pao, W.2
  • 57
    • 84856990335 scopus 로고    scopus 로고
    • Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    • et al.
    • Doebele R. C., Pilling A. B., Aisner D. L., et al. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res: 2012; 18 5 1472 1482
    • (2012) Clin Cancer Res , vol.18 , Issue.5 , pp. 1472-1482
    • Doebele, R.C.1    Pilling, A.B.2    Aisner, D.L.3
  • 58
    • 84856999699 scopus 로고    scopus 로고
    • Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers
    • et al.
    • Katayama R., Shaw A. T., Khan T. M., et al. Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers. Sci Transl Med: 2012; 4 120 20ra17
    • (2012) Sci Transl Med , vol.4 , Issue.120
    • Katayama, R.1    Shaw, A.T.2    Khan, T.M.3
  • 59
    • 80052793410 scopus 로고    scopus 로고
    • A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors
    • et al.
    • Sasaki T., Koivunen J., Ogino A., et al. A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res: 2011; 71 18 6051 6060
    • (2011) Cancer Res , vol.71 , Issue.18 , pp. 6051-6060
    • Sasaki, T.1    Koivunen, J.2    Ogino, A.3
  • 60
    • 84884993118 scopus 로고    scopus 로고
    • Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8010
    • Shaw A. T., Mehra R., Kim D. W., et al. Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8010
    • J Clin Oncol
    • Shaw, A.T.1    Mehra, R.2    Kim, D.W.3
  • 61
    • 84975120588 scopus 로고    scopus 로고
    • A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: Updated safety and efficacy results from AF-001JP [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8033
    • Nakagawa K., Kiura K., Nishio M., et al. A phase I/II study with a highly selective ALK inhibitor CH5424802 in ALK-positive non-small cell lung cancer (NSCLC) patients: Updated safety and efficacy results from AF-001JP [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8033
    • J Clin Oncol
    • Nakagawa, K.1    Kiura, K.2    Nishio, M.3
  • 62
    • 84878971581 scopus 로고    scopus 로고
    • A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
    • et al.
    • Socinski M. A., Goldman J., El-Hariry I., et al. A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res: 2013; 19 11 3068 3077
    • (2013) Clin Cancer Res , vol.19 , Issue.11 , pp. 3068-3077
    • Socinski, M.A.1    Goldman, J.2    El-Hariry, I.3
  • 63
    • 84866382273 scopus 로고    scopus 로고
    • Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC) [abstract]
    • et al. 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7543
    • Garon E. B., Moran T., Barlesi F., et al. Phase II study of the HSP90 inhibitor AUY922 in patients with previously treated, advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7543
    • J Clin Oncol
    • Garon, E.B.1    Moran, T.2    Barlesi, F.3
  • 64
    • 79951885125 scopus 로고    scopus 로고
    • Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer
    • et al.
    • Sequist L. V., Gettinger S., Senzer N. N., et al. Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer. J Clin Oncol: 2010; 28 33 4953 4960
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4953-4960
    • Sequist, L.V.1    Gettinger, S.2    Senzer, N.N.3
  • 65
    • 84859794344 scopus 로고    scopus 로고
    • ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway
    • Ou S. H., Tan J., Yen Y., Soo R. A. ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway. Expert Rev Anticancer Ther: 2012; 12 4 447 456
    • (2012) Expert Rev Anticancer Ther , vol.12 , Issue.4 , pp. 447-456
    • Ou, S.H.1    Tan, J.2    Yen, Y.3    Soo, R.A.4
  • 66
    • 84865092224 scopus 로고    scopus 로고
    • Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement [abstract]
    • et al. 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7508
    • Shaw A. T., Camidge D. R., Engelman J. A., et al. Clinical activity of crizotinib in advanced non-small cell lung cancer (NSCLC) harboring ROS1 gene rearrangement [abstract]. J Clin Oncol 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7508
    • J Clin Oncol
    • Shaw, A.T.1    Camidge, D.R.2    Engelman, J.A.3
  • 67
    • 0025358375 scopus 로고
    • Characterization of ROS1 cDNA from a human glioblastoma cell line
    • Birchmeier C., O'Neill K., Riggs M., Wigler M. Characterization of ROS1 cDNA from a human glioblastoma cell line. Proc Natl Acad Sci U S A: 1990; 87 12 4799 4803
    • (1990) Proc Natl Acad Sci U S A , vol.87 , Issue.12 , pp. 4799-4803
    • Birchmeier, C.1    O'Neill, K.2    Riggs, M.3    Wigler, M.4
  • 68
    • 0023477402 scopus 로고
    • Expression and rearrangement of the ROS1 gene in human glioblastoma cells
    • Birchmeier C., Sharma S., Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proc Natl Acad Sci U S A: 1987; 84 24 9270 9274
    • (1987) Proc Natl Acad Sci U S A , vol.84 , Issue.24 , pp. 9270-9274
    • Birchmeier, C.1    Sharma, S.2    Wigler, M.3
  • 70
  • 71
    • 84867888741 scopus 로고    scopus 로고
    • Targeting ROS1 with anaplastic lymphoma kinase inhibitors: A promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer
    • Chin L. P., Soo R. A., Soong R., Ou S. H. Targeting ROS1 with anaplastic lymphoma kinase inhibitors: a promising therapeutic strategy for a newly defined molecular subset of non-small-cell lung cancer. J Thorac Oncol: 2012; 7 11 1625 1630
    • (2012) J Thorac Oncol , vol.7 , Issue.11 , pp. 1625-1630
    • Chin, L.P.1    Soo, R.A.2    Soong, R.3    Ou, S.H.4
  • 72
    • 84857985225 scopus 로고    scopus 로고
    • RET, ROS1 and ALK fusions in lung cancer
    • et al.
    • Takeuchi K., Soda M., Togashi Y., et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med: 2012; 18 3 378 381
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 378-381
    • Takeuchi, K.1    Soda, M.2    Togashi, Y.3
  • 73
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
    • et al.
    • Rimkunas V. M., Crosby K. E., Li D., et al. Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res: 2012; 18 16 4449 4457
    • (2012) Clin Cancer Res , vol.18 , Issue.16 , pp. 4449-4457
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3
  • 75
    • 67649652208 scopus 로고    scopus 로고
    • BRAF mutation in metastatic colorectal cancer
    • Tol J., Nagtegaal I. D., Punt C. JA. BRAF mutation in metastatic colorectal cancer. N Engl J Med: 2009; 361 1 98 99
    • (2009) N Engl J Med , vol.361 , Issue.1 , pp. 98-99
    • Tol, J.1    Nagtegaal, I.D.2    Punt, C.J.3
  • 76
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • et al.
    • De Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol: 2010; 11 8 753 762
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 77
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • et al.
    • Paik P. K., Arcila M. E., Fara M., et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol: 2011; 29 15 2046 2051
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 78
    • 84868481873 scopus 로고    scopus 로고
    • Vemurafenib: The first drug approved for BRAF-mutant cancer
    • et al.
    • Bollag G., Tsai J., Zhang J., et al. Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov: 2012; 11 11 873 886
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.11 , pp. 873-886
    • Bollag, G.1    Tsai, J.2    Zhang, J.3
  • 79
    • 84866595717 scopus 로고    scopus 로고
    • A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib
    • et al.
    • Gautschi O., Pauli C., Strobel K., et al. A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. J Thorac Oncol: 2012; 7 10 e23 e24
    • (2012) J Thorac Oncol , vol.7 , Issue.10
    • Gautschi, O.1    Pauli, C.2    Strobel, K.3
  • 80
    • 84883879311 scopus 로고    scopus 로고
    • Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma
    • [Epub ahead of print]
    • Peters S., Michielin O., Zimmermann S. Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma. J Clin Oncol: 2013; 31 20 e341 e344 [Epub ahead of print]
    • (2013) J Clin Oncol , vol.31 , Issue.20
    • Peters, S.1    Michielin, O.2    Zimmermann, S.3
  • 81
    • 84884999688 scopus 로고    scopus 로고
    • Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8009
    • Planchard D., Mazieres J., Riely G. J., et al. Interim results of phase II study BRF113928 of dabrafenib in BRAF V600E mutation-positive non-small cell lung cancer (NSCLC) patients. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8009
    • J Clin Oncol
    • Planchard, D.1    Mazieres, J.2    Riely, G.J.3
  • 82
    • 84876419277 scopus 로고    scopus 로고
    • Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer
    • Rudin C. M., Hong K., Streit M. Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. J Thorac Oncol: 2013; 8 5 e41 e42
    • (2013) J Thorac Oncol , vol.8 , Issue.5
    • Rudin, C.M.1    Hong, K.2    Streit, M.3
  • 83
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W., Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol: 2011; 12 2 175 180
    • (2011) Lancet Oncol , vol.12 , Issue.2 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 85
    • 84875914687 scopus 로고    scopus 로고
    • MET as a possible target for non-small-cell lung cancer
    • Sadiq A. A., Salgia R. MET as a possible target for non-small-cell lung cancer. J Clin Oncol: 2013; 31 8 1089 1096
    • (2013) J Clin Oncol , vol.31 , Issue.8 , pp. 1089-1096
    • Sadiq, A.A.1    Salgia, R.2
  • 88
    • 77951879838 scopus 로고    scopus 로고
    • Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
    • et al.
    • Onitsuka T., Uramoto H., Ono K., et al. Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status. J Thorac Oncol: 2010; 5 5 591 596
    • (2010) J Thorac Oncol , vol.5 , Issue.5 , pp. 591-596
    • Onitsuka, T.1    Uramoto, H.2    Ono, K.3
  • 89
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato R., Kosaka T., Kuwano H., Sekido Y., Yatabe Y., Mitsudomi T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol: 2009; 4 1 5 11
    • (2009) J Thorac Oncol , vol.4 , Issue.1 , pp. 5-11
    • Onozato, R.1    Kosaka, T.2    Kuwano, H.3    Sekido, Y.4    Yatabe, Y.5    Mitsudomi, T.6
  • 90
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]
    • et al. 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 29(15): 7505
    • Spigel D. R., Ervin T. J., Ramlau R., et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC [abstract]. J Clin Oncol 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 29(15): 7505
    • J Clin Oncol
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.3
  • 91
    • 84861733799 scopus 로고    scopus 로고
    • MET: A promising anticancer therapeutic target
    • Peters S., Adjei A. A. MET: a promising anticancer therapeutic target. Nat Rev Clin Oncol: 2012; 9 6 314 326
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.6 , pp. 314-326
    • Peters, S.1    Adjei, A.A.2
  • 92
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
    • et al.
    • Ou S. H., Kwak E. L., Siwak-Tapp C., et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol: 2011; 6 5 942 946
    • (2011) J Thorac Oncol , vol.6 , Issue.5 , pp. 942-946
    • Ou, S.H.1    Kwak, E.L.2    Siwak-Tapp, C.3
  • 93
    • 84862908734 scopus 로고    scopus 로고
    • Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor
    • et al.
    • Chi A. S., Batchelor T. T., Kwak E. L., et al. Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor. J Clin Oncol: 2012; 30 3 e30 e33
    • (2012) J Clin Oncol , vol.30 , Issue.3
    • Chi, A.S.1    Batchelor, T.T.2    Kwak, E.L.3
  • 94
    • 0032894774 scopus 로고    scopus 로고
    • RET proto-oncogene in the development of human cancer
    • Eng C. RET proto-oncogene in the development of human cancer. J Clin Oncol: 1999; 17 1 380 393 (Pubitemid 29022417)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.1 , pp. 380-393
    • Eng, C.1
  • 95
    • 78650412305 scopus 로고    scopus 로고
    • Targeting RET receptor tyrosine kinase activation in cancer
    • Phay J. E., Shah M. H. Targeting RET receptor tyrosine kinase activation in cancer. Clin Cancer Res: 2010; 16 24 5936 5941
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 5936-5941
    • Phay, J.E.1    Shah, M.H.2
  • 97
    • 0025022463 scopus 로고
    • PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas
    • et al.
    • Grieco M., Santoro M., Berlingieri M. T., et al. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell: 1990; 60 4 557 563
    • (1990) Cell , vol.60 , Issue.4 , pp. 557-563
    • Grieco, M.1    Santoro, M.2    Berlingieri, M.T.3
  • 99
    • 80053150200 scopus 로고    scopus 로고
    • Molecular genetics and diagnosis of thyroid cancer
    • Nikiforov Y. E., Nikiforova M. N. Molecular genetics and diagnosis of thyroid cancer. Nat Rev Endocrinol: 2011; 7 10 569 580
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.10 , pp. 569-580
    • Nikiforov, Y.E.1    Nikiforova, M.N.2
  • 100
    • 73149115248 scopus 로고    scopus 로고
    • Targeting the RET pathway in thyroid cancer
    • Wells S. A. Jr, Santoro M. Targeting the RET pathway in thyroid cancer. Clin Cancer Res: 2009; 15 23 7119 7123
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7119-7123
    • Wells Jr., S.A.1    Santoro, M.2
  • 101
    • 0034693757 scopus 로고    scopus 로고
    • The RET proto-oncogene in human cancers
    • Jhiang S. M. The RET proto-oncogene in human cancers. Oncogene: 2000; 19 49 5590 5597
    • (2000) Oncogene , vol.19 , Issue.49 , pp. 5590-5597
    • Jhiang, S.M.1
  • 102
    • 63949086127 scopus 로고    scopus 로고
    • KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
    • et al.
    • Takeuchi K., Choi Y. L., Togashi Y., et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res: 2009; 15 9 3143 3149
    • (2009) Clin Cancer Res , vol.15 , Issue.9 , pp. 3143-3149
    • Takeuchi, K.1    Choi, Y.L.2    Togashi, Y.3
  • 103
    • 84857929267 scopus 로고    scopus 로고
    • KIF5B-RET fusions in lung adenocarcinoma
    • et al.
    • Kohno T., Ichikawa H., Totoki Y., et al. KIF5B-RET fusions in lung adenocarcinoma. Nat Med: 2012; 18 3 375 377
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 375-377
    • Kohno, T.1    Ichikawa, H.2    Totoki, Y.3
  • 104
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • et al.
    • Wang R., Hu H., Pan Y., et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol: 2012; 30 35 4352 4359
    • (2012) J Clin Oncol , vol.30 , Issue.35 , pp. 4352-4359
    • Wang, R.1    Hu, H.2    Pan, Y.3
  • 105
    • 84876383602 scopus 로고    scopus 로고
    • A patient with lung adenocarcinoma and RET fusion treated with vandetanib
    • et al.
    • Gautschi O., Zander T., Keller F. A., et al. A patient with lung adenocarcinoma and RET fusion treated with vandetanib. J Thorac Oncol: 2013; 8 5 e43 e44
    • (2013) J Thorac Oncol , vol.8 , Issue.5
    • Gautschi, O.1    Zander, T.2    Keller, F.A.3
  • 106
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • Spector N. L., Blackwell K. L. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol: 2009; 27 34 5838 5847
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 107
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • et al.
    • Stephens P., Hunter C., Bignell G., et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature: 2004; 431 7008 525 526
    • (2004) Nature , vol.431 , Issue.7008 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 109
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • et al.
    • Arcila M. E., Chaft J. E., Nafa K., et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res: 2012; 18 18 4910 4918
    • (2012) Clin Cancer Res , vol.18 , Issue.18 , pp. 4910-4918
    • Arcila, M.E.1    Chaft, J.E.2    Nafa, K.3
  • 111
    • 80052558779 scopus 로고    scopus 로고
    • Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers
    • et al.
    • Tomizawa K., Suda K., Onozato R., et al. Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers. Lung Cancer: 2011; 74 1 139 144
    • (2011) Lung Cancer , vol.74 , Issue.1 , pp. 139-144
    • Tomizawa, K.1    Suda, K.2    Onozato, R.3
  • 112
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
    • et al.
    • Mazières J., Peters S., Lepage B., et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol: 2013; 31 16 1997 2003
    • (2013) J Clin Oncol , vol.31 , Issue.16 , pp. 1997-2003
    • Mazières, J.1    Peters, S.2    Lepage, B.3
  • 113
    • 84856823963 scopus 로고    scopus 로고
    • Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
    • et al.
    • Chaft J. E., Arcila M. E., Paik P. K., et al. Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling. Mol Cancer Ther: 2012; 11 2 485 491
    • (2012) Mol Cancer Ther , vol.11 , Issue.2 , pp. 485-491
    • Chaft, J.E.1    Arcila, M.E.2    Paik, P.K.3
  • 114
    • 84856071447 scopus 로고    scopus 로고
    • Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
    • et al.
    • Bendell J. C., Rodon J., Burris H. A., et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol: 2012; 30 3 282 290
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 282-290
    • Bendell, J.C.1    Rodon, J.2    Burris, H.A.3
  • 115
    • 76749171098 scopus 로고    scopus 로고
    • Phase i dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors [abstract]
    • et al. 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 27(15S): 3500
    • Shapiro G., Kwak E. L., Baselga J., et al. Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors [abstract]. J Clin Oncol 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 27(15S): 3500
    • J Clin Oncol
    • Shapiro, G.1    Kwak, E.L.2    Baselga, J.3
  • 116
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • et al.
    • Ding L., Getz G., Wheeler D. A., et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature: 2008; 455 7216 1069 1075
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 118
    • 83255162603 scopus 로고    scopus 로고
    • First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors
    • et al.
    • Yap T. A., Yan L., Patnaik A., et al. First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol: 2011; 29 35 4688 4695
    • (2011) J Clin Oncol , vol.29 , Issue.35 , pp. 4688-4695
    • Yap, T.A.1    Yan, L.2    Patnaik, A.3
  • 119
    • 48649107410 scopus 로고    scopus 로고
    • Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
    • et al.
    • Marks J. L., Gong Y., Chitale D., et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res: 2008; 68 14 5524 5528
    • (2008) Cancer Res , vol.68 , Issue.14 , pp. 5524-5528
    • Marks, J.L.1    Gong, Y.2    Chitale, D.3
  • 120
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
    • et al.
    • Jänne P. A., Shaw A. T., Pereira J. R., et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol: 2013; 14 1 38 47
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 38-47
    • Jänne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 121
    • 84894467946 scopus 로고    scopus 로고
    • Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with docetaxel in KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): A phase I/Ib trial [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8028
    • Gandara D., Hiret S., Blumenschein G. R., et al. Oral MEK1/MEK2 inhibitor trametinib (GSK1120212) in combination with docetaxel in KRAS-mutant and wild-type (WT) advanced non-small cell lung cancer (NSCLC): A phase I/Ib trial [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8028
    • J Clin Oncol
    • Gandara, D.1    Hiret, S.2    Blumenschein, G.R.3
  • 122
    • 84899072421 scopus 로고    scopus 로고
    • A five-arm, open-label, phase I/Ib study to access safety and tolerability of the oral MEK1/MEK2 inhibitor trametinib(GSK1120212) in combination with chemotherapy or erlotinib in patients with advanced solid tumors [abstract]
    • et al. 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 3023
    • Becerra C., Infante J. R., Garbo L. E., et al. A five-arm, open-label, phase I/Ib study to access safety and tolerability of the oral MEK1/MEK2 inhibitor trametinib(GSK1120212) in combination with chemotherapy or erlotinib in patients with advanced solid tumors [abstract]. J Clin Oncol 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 3023
    • J Clin Oncol
    • Becerra, C.1    Infante, J.R.2    Garbo, L.E.3
  • 123
    • 84884237434 scopus 로고    scopus 로고
    • NTRK1 gene fusions as a novel oncogene target in lung cancer [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8023
    • Doebele R. C., Vaishnavi A., Capelletti M., et al. NTRK1 gene fusions as a novel oncogene target in lung cancer [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8023
    • J Clin Oncol
    • Doebele, R.C.1    Vaishnavi, A.2    Capelletti, M.3
  • 124
    • 84877853271 scopus 로고    scopus 로고
    • Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
    • et al.
    • Mo M. L., Chen Z., Zhou H. M., et al. Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer. J Exp Clin Cancer Res: 2013; 32 29
    • (2013) J Exp Clin Cancer Res , vol.32 , pp. 29
    • Mo, M.L.1    Chen, Z.2    Zhou, H.M.3
  • 125
    • 84869049935 scopus 로고    scopus 로고
    • Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia
    • et al.
    • Bicocca V. T., Chang B. H., Masouleh B. K., et al. Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell: 2012; 22 5 656 667
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 656-667
    • Bicocca, V.T.1    Chang, B.H.2    Masouleh, B.K.3
  • 127
    • 0021347296 scopus 로고
    • Isolation of transforming sequences of two human lung carcinomas: Structural and functional analysis of the activated c-K-ras oncogenes
    • Nakano H., Yamamoto F., Neville C., Evans D., Mizuno T., Perucho M. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A: 1984; 81 1 71 75 (Pubitemid 14180829)
    • (1984) Proceedings of the National Academy of Sciences of the United States of America , vol.81 , Issue.1 , pp. 71-75
    • Nakano, H.1    Yamamoto, F.2    Neville, C.3
  • 128
    • 0021362206 scopus 로고
    • Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
    • Santos E., Martin-Zanca D., Reddy E. P., Pierotti M. A., Della Porta G., Barbacid M. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science: 1984; 223 4637 661 664 (Pubitemid 14186799)
    • (1984) Science , vol.223 , Issue.4637 , pp. 661-664
    • Santos, E.1    Martin Zanca, D.2    Reddy, E.P.3
  • 129
    • 65349107082 scopus 로고    scopus 로고
    • KRAS mutations in non-small cell lung cancer
    • Riely G. J., Marks J., Pao W. KRAS mutations in non-small cell lung cancer. Proc Am Thorac Soc: 2009; 6 2 201 205
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.2 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 131
    • 53249145767 scopus 로고    scopus 로고
    • Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
    • et al.
    • Riely G. J., Kris M. G., Rosenbaum D., et al. Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. Clin Cancer Res: 2008; 14 18 5731 5734
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5731-5734
    • Riely, G.J.1    Kris, M.G.2    Rosenbaum, D.3
  • 132
    • 84863116014 scopus 로고    scopus 로고
    • Effect of KRAS oncogene substitutions on protein behavior: Implications for signaling and clinical outcome
    • et al.
    • Ihle N. T., Byers L. A., Kim E. S., et al. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst: 2012; 104 3 228 239
    • (2012) J Natl Cancer Inst , vol.104 , Issue.3 , pp. 228-239
    • Ihle, N.T.1    Byers, L.A.2    Kim, E.S.3
  • 133
    • 84878545631 scopus 로고    scopus 로고
    • The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma
    • et al.
    • Villaruz L. C., Socinski M. A., Cunningham D. E., et al. The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma. Cancer: 2013; 119 12 2268 2274
    • (2013) Cancer , vol.119 , Issue.12 , pp. 2268-2274
    • Villaruz, L.C.1    Socinski, M.A.2    Cunningham, D.E.3
  • 134
    • 84888334527 scopus 로고    scopus 로고
    • Comparison of the characteristics and clinical course of 677 patients with metastatic lung cancers with mutations in KRAS codons 12 and 13 [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8025
    • Yu H. A., Sima C. S., Shen R., et al. Comparison of the characteristics and clinical course of 677 patients with metastatic lung cancers with mutations in KRAS codons 12 and 13 [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8025
    • J Clin Oncol
    • Yu, H.A.1    Sima, C.S.2    Shen, R.3
  • 135
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
    • et al.
    • Jänne P. A., Shaw A. T., Pereira J. R., et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol: 2013; 14 1 38 47
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 38-47
    • Jänne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 136
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • et al.
    • Sequist L. V., von Pawel J., Garmey E. G., et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol: 2011; 29 24 3307 3315
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3
  • 137
    • 84871391881 scopus 로고    scopus 로고
    • Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib
    • et al.
    • Acquaviva J., Smith D. L., Sang J., et al. Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib. Mol Cancer Ther: 2012; 11 12 2633 2643
    • (2012) Mol Cancer Ther , vol.11 , Issue.12 , pp. 2633-2643
    • Acquaviva, J.1    Smith, D.L.2    Sang, J.3
  • 138
    • 80052557069 scopus 로고    scopus 로고
    • Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors
    • et al.
    • De Raedt T., Walton Z., Yecies J. L., et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell: 2011; 20 3 400 413
    • (2011) Cancer Cell , vol.20 , Issue.3 , pp. 400-413
    • De Raedt, T.1    Walton, Z.2    Yecies, J.L.3
  • 139
    • 68949124435 scopus 로고    scopus 로고
    • Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study [abstract]
    • ASCO Meeting Abstracts
    • O'Byrne K. J., Bondarenko I., Barrios C., et al. Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study [abstract]. ASCO Meeting Abstracts 2009; J Clin Oncol 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 27(15S): 8007
    • (2009) J Clin Oncol 2009 ASCO Annual Meeting Proceedings (Post-Meeting Edition) , vol.27 , Issue.15 , pp. 8007
    • O'Byrne, K.J.1    Bondarenko, I.2    Et Al., B.C.3
  • 140
    • 84904720828 scopus 로고    scopus 로고
    • GALAXY-2 trial: A randomized phase III study of ganetespib in combination with docetaxel versus docetaxel alone in patients with advanced non-small cell lung adenocarcinoma [abstract]
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): TPS8126
    • Fennell D. A., Goss G. D., Socinski M. A., et al. GALAXY-2 trial: A randomized phase III study of ganetespib in combination with docetaxel versus docetaxel alone in patients with advanced non-small cell lung adenocarcinoma [abstract]. J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): TPS8126
    • J Clin Oncol
    • Fennell, D.A.1    Goss, G.D.2    Socinski, M.A.3
  • 141
    • 84866169938 scopus 로고    scopus 로고
    • A randomzied discontinuation phase II trial of ridaforolimus in non-small cell lung cancer (NSCLC) patients with KRAS mutations [abstract]
    • et al. 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7531
    • Riely G. J., Brahmer J. R., Planchard D., et al. A randomzied discontinuation phase II trial of ridaforolimus in non-small cell lung cancer (NSCLC) patients with KRAS mutations [abstract]. J Clin Oncol 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 30(15): 7531
    • J Clin Oncol
    • Riely, G.J.1    Brahmer, J.R.2    Planchard, D.3
  • 142
    • 84857087591 scopus 로고    scopus 로고
    • Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: Lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations
    • et al.
    • Rekhtman N., Paik P. K., Arcila M. E., et al. Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations. Clin Cancer Res: 2012; 18 4 1167 1176
    • (2012) Clin Cancer Res , vol.18 , Issue.4 , pp. 1167-1176
    • Rekhtman, N.1    Paik, P.K.2    Arcila, M.E.3
  • 143
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network Comprehensive genomic characterization of squamous cell lung cancers. Nature: 2012; 489 7417 519 525
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 144
    • 78650451788 scopus 로고    scopus 로고
    • Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer
    • et al.
    • Weiss J., Sos M. L., Seidel D., et al. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci Transl Med: 2010; 2 62 62ra93
    • (2010) Sci Transl Med , vol.2 , Issue.62
    • Weiss, J.1    Sos, M.L.2    Seidel, D.3
  • 145
    • 79958112619 scopus 로고    scopus 로고
    • Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
    • et al.
    • Dutt A., Ramos A. H., Hammerman P. S., et al. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer. PLoS ONE: 2011; 6 6 e20351
    • (2011) PLoS ONE , vol.6 , Issue.6
    • Dutt, A.1    Ramos, A.H.2    Hammerman, P.S.3
  • 146
    • 84865675174 scopus 로고    scopus 로고
    • Brivanib (BMS-582664) in advanced solid tumors (AST): Results of a phase II randomized discontinuation trial (RDT) [abstract]
    • et al. 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 29(15): 3079
    • Ratain M. J., Schwartz G. K., Oza A. M., et al. Brivanib (BMS-582664) in advanced solid tumors (AST): Results of a phase II randomized discontinuation trial (RDT) [abstract]. J Clin Oncol 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 29(15): 3079
    • J Clin Oncol
    • Ratain, M.J.1    Schwartz, G.K.2    Oza, A.M.3
  • 147
    • 84866709500 scopus 로고    scopus 로고
    • Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
    • et al.
    • Hammerman P. S., Sos M. L., Ramos A. H., et al. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov: 2011; 1 1 78 89
    • (2011) Cancer Discov , vol.1 , Issue.1 , pp. 78-89
    • Hammerman, P.S.1    Sos, M.L.2    Ramos, A.H.3
  • 150
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • DOI 10.1200/JCO.2004.02.141
    • Sansal I., Sellers W. R. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol: 2004; 22 14 2954 2963 (Pubitemid 41079915)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.14 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 152
    • 52049099853 scopus 로고    scopus 로고
    • PIK3CA mutations and copy number gains in human lung cancers
    • et al.
    • Yamamoto H., Shigematsu H., Nomura M., et al. PIK3CA mutations and copy number gains in human lung cancers. Cancer Res: 2008; 68 17 6913 6921
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 6913-6921
    • Yamamoto, H.1    Shigematsu, H.2    Nomura, M.3
  • 153
    • 34548485621 scopus 로고    scopus 로고
    • PIK3CA gene amplification in Japanese non-small cell lung cancer
    • DOI 10.1016/j.lungcan.2007.06.020, PII S0169500207003960
    • Kawano O., Sasaki H., Okuda K., et al. PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer: 2007; 58 1 159 160 (Pubitemid 47379973)
    • (2007) Lung Cancer , vol.58 , Issue.1 , pp. 159-160
    • Kawano, O.1    Sasaki, H.2    Okuda, K.3    Yukiue, H.4    Yokoyama, T.5    Yano, M.6    Fujii, Y.7
  • 154
    • 84895919657 scopus 로고    scopus 로고
    • Patterns of metastasis and survival in patients with PI3K pathway-driven stage IV squamous cell lung cancers (SQCLC)
    • et al. 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8022
    • Paik P. K., Moreira A. L., Wang L., et al. Patterns of metastasis and survival in patients with PI3K pathway-driven stage IV squamous cell lung cancers (SQCLC). J Clin Oncol 2013 ASCO Annual Meeting Proceedings (Post-Meeting Edition); 31(15): 8022
    • J Clin Oncol
    • Paik, P.K.1    Moreira, A.L.2    Wang, L.3
  • 155
    • 84871254065 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models
    • et al.
    • Spoerke J. M., O'Brien C., Huw L., et al. Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res: 2012; 18 24 6771 6783
    • (2012) Clin Cancer Res , vol.18 , Issue.24 , pp. 6771-6783
    • Spoerke, J.M.1    O'Brien, C.2    Huw, L.3
  • 156
    • 84861976809 scopus 로고    scopus 로고
    • First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • et al.
    • Han J. Y., Park K., Kim S. W., et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol: 2012; 30 10 1122 1128
    • (2012) J Clin Oncol , vol.30 , Issue.10 , pp. 1122-1128
    • Han, J.Y.1    Park, K.2    Kim, S.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.