Chemical composition, antioxidant and antigenotoxic activities of different fractions of gentiana asclepiadea l. Roots extract

EXCLI Journal

Volumn 12, Issue , 2013, Pages 807-823

  Mihailović, Vladimir ^a   Matić, Sanja ^a   Mišić, Danijela ^b   Solujić, Slavica ^a   Stanić, Snežana ^a   Katanić, Jelena ^a   Mladenović, Milan ^a   Stanković, Nevena ^a  

^a UNIVERSITY OF KRAGUJEVAC   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Antigenotoxicity; Antioxidant activity; Gentiana asclepiadea L.; Gentiopicrine; Phenolic contents; Secoiridoids

Indexed keywords

ACETIC ACID ETHYL ESTER; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BUTANOL; BUTYLCRESOL; CHLOROFORM; FLAVONOID; FLAVONOL DERIVATIVE; GALLIC ACID; GENTIANA ASCLEPIADEA EXTRACT; GENTIOPICRINE; MESYLIC ACID ETHYL ESTER; PHENOL DERIVATIVE; PLANT EXTRACT; SECOIRIDOID; SWEROSIDE; SWERTIAMARIN; TANNIN; UNCLASSIFIED DRUG;

ALKYLATION; ANTIGENOTOXIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DNA DAMAGE; DROSOPHILA MELANOGASTER; DRUG ACTIVITY; GENE MUTATION; GENTIAN; GENTIANA ASCLEPIADEA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; PLANT ROOT;

EID: 84884570902     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (64)

1. Aaronson S. Important vegetable supplements. In: Kiple KF, Ornelas KC (ed): The Cambridge world history food (pp 231-249). New York: Cambridge University Press, 2000.
2. Aberham A, Pieri V, Croom Jr EM, Ellmer-er E, Stuppner H. Analysis of iridoids, se-coiridoids and xanthones in Centaurium er-ythraea, Frasera caroliniensis and Gentia-na lutea using LC-MS and RP-HPLC. J Pharm Biomed Anal 2011;54:517-525.
3. Alekperov UK. Plant antimutagens and their mixtures in inhibition of genotoxic effects of xenobiotics and aging processes. Eur J Cancer Prev 2002;11:8-11.
4. Alpsoy L, Sahin H, Karaman S. Anti-oxidative and anti-genotoxic effects of me-thanolic extract of Mentha pulegium on human lymphocyte culture. Toxicol Ind Health 2011;27:647-654.
5. Bate-Smith EC. Astringent tannins of Acer species. Phytochemistry 1977;16:1421-1426.
6. Brighente IMC, Dias M, Verdi LG, Pizzo-latti MG. Antioxidant activity and total phenolic content of some Brazilian species. Pharm Biol 2007;45:156-161.
7. Dastmalchi K, Dorman HJD, Kosar M, Hil-tunen R. Chemical composition and in vitro antioxidant evaluation of a water soluble Moldavian balm (Dracocephalum moldavi-ca L.) extract. LWT - Food Sc Technol 2007;40:239-248.
8. De Flora S. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat Res 1998;402:151-158.
9. De Flora S, Ferguson LR. Overview of mechanisms of cancer chemopreventive agents. Mutat Res 2005;591:8-15.
10. Dević M, Momčilović I, Krstić D, Maksi-mović V, Konjević R. In vitro multiplication of willow getian Gentiana asclepiadea L. and the production of getiopicrine and mangiferin. Phyton 2006;46:45-54.
11. Edenharder R, Grunhage D. Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cu-mene hydroperoxide in Salmonella typhi-murium TA102. Mutat Res 2003;540:1-18.
12. El Hamss R, Idaomar M, Alonso-Moraga A, Muñoz-Serrano A. Antimutagenic properties of bell and black pepper. Food Chem Toxicol 2003;41:41-47.
13. Fedeli D, Berrettini M, Gabryelak T, Fal-cioni G. The effect of some tannins on trout erythrocytes exposed to oxidative stress. Mutat Res 2004;563:89-96.
14. Fürst P. Basics in clinical nutrition: Role of antioxidants in nutritional support. ESPEN J 2009;4:e105-e107.
15. Gülçin I. Antioxidant activity of L-adre-naline: A structure-activity insight. Chem-Biol Interact 2009;179:71-80.
16. Haslam E. Galloyl esters in the Aceraceae. Phytochemistry 1965;4:495-498.
17. Hsouna AB, Trigui M, Culioli G, Blache Y, Jaoua S. Antioxidant constituents from Lawsonia inermis leaves: Isolation, structure elucidation and antioxidative capacity. Food Chem 2011;125:193-200.
18. Hsu CK, Chiang BH, Chen YS, Yang JH, Liu CL. Improving the antioxidant activity of buckwheat (Fagopyrum tataricm Gaertn) sprout with trace element water. Food Chem 2008;108:633-641.
19. Hudecová A, Hasplova K, Miadokova E, Magdolenova Z, Rinna A, Galova E et al. Cytotoxic and genotoxic effect of meth-anolic flower extract from Gentiana ascle-piadea on COS 1 cells. Neuroendocrinol Lett 2010;31:21-25.
20. Hudecová A, Hašplová K, Miadoková E, Magdolenová Z, Rinna A, Collins AR et al. Gentiana asclepiadea protects human cells against oxidation DNA lesions. Cell Bio-chem Funct 2012a;30:101-107.
21. Hudecová A, Hasplova K, Kellovska L, Ikreniova M, Miadokova E, Galova E et al. Gentiana asclepiadea and Armoracia rusti-cana can modulate the adaptive response induced by zeocin in human lymphocytes. Neoplasma 2012b;59:62-69.
22. Hung YH, Wang YJ, Chou CC. Antimuta-genic activity of Aspergillus awamori-fermented black soyabean response to stimulated digestive juice treatments and its an-timutagenic mechanisms. LWT - Food Sc Technol 2009;42:56-62.
23. Inatani R, Nakatani N, Fuwa H. Antioxida-tive effect of the constituents of rosemary (Rosemarinus officinalis L.) and their derivatives. Agr Biol Chem 1983;47:521-528.
24. Janković T, Krstić D, Aljančić I, Šavikin-Fodulović K, Menković N, Vajs V et al. Xanthones and C-glycosides from the aerial parts of four species of Gentianella from Serbia and Montenegro. Biochem Sys Ecol 2005;33:729-735.
25. Jensen SR, Schripsema J. Chemotaxonomy and pharmacology of Gentianaceae. In: Albert VA (ed): Gentianaceae-systematics and natural history (pp 573-631). New York: Cambridge University Press, 2002.
26. Jiang RW, Wong KL, Chan YM, Xu HX, But PPH, Shaw PC. Isolation of iridoid and secoiridoid glycosides and comparative study on Radix gentianae and related adulterants by HPLC analysis. Phytochemistry 2005;66:2674-2680.
27. Josifović M. Flora SR Srbije V. Beograd, Serbia: SANU, 1973.
28. Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. J Nutr Bio-chem 2008;19:347-61.
29. Kaina B, Christmann M. DNA repair in resistance to alkylating anticancer drugs. Int J Clin Pharm Ther 2002;40:354-367.
30. Kaisoon O, Siriamornpun S, Weerapreeya-kul N, Meeso N. Phenolic compounds and antioxidant activities of edible flowers from Thailand. J Func Foods 2011;3:88-89.
31. Karawita R, Siriwardhana N, Lee KW, Heo MS, Yeo IK, Lee YD et al. Reactive oxygen species scavenging, metal chelating, reducing power and lipid peroxidation inhibition properties of different solvent fractions from Hizikia fusiformis. Eur Food Res Technol 2005;220:363-371.
32. Kim IS, Yang M, Lee OH, Kang SN. The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts. LWT - Food Sc Technol 2011;44: 1328-1332.
33. Kitanov G, Spassov S. A naphthodipyra-nodione from Gentiana asclepiadea. Phyto-chemistry 1992;31:1067-1068.
34. Ko FN, Chu CC, Lin CN, Chang CC, Tehg CM. Isoorientin-6"-O-glucoside, a water-soluble antioxidant isolated from Gentiana arisanensis. Biochim Biophys Acta 1998; 1389:81-90.
35. Krishnaiah D, Sarbatly R, Nithyanandam R. A review of the antioxidant potential of medicinal plant species. Food Bioprod Process 2011;89:217-233.
36. Krstić D, Janković T, Aljančić I, Šavikin-Fodulović K, Menković N, Milosavljević S. Phytochemical investigation of Gentiana dinarica. Biochem Syst Ecol 2004;32:937-941.
37. Kumarasamy Y, Byres M, Cox PJ, Jaspars M, Nahar L, Sarker SD. Screening seeds of some Scottish plants for free-radical scavenging activity. Phytother Res 2007;21: 615-621.
38. Kuroda Y, Shima N, Yazawa K, Kaji K. Desmutagenic and bio-antimutagenic activity of docosahexaenoic acid and eicosa-pentaenoic acid in cultured Chinese hamster V79 cells. Mutat Res 2001;497:123-130.
39. Kušar A, Zupančič A, Šentjurc M, Baričevič D. Free radical scavenging activities of yellow gentian (Gentiana lutea L.) measured by electron spin resonance. Hum Exp Toxicol 2006;25:599-604.
40. Lewis EB, Bacher F. Method of feeding ethyl methanesulfonate (EMS) to Drosophi-la males. Drosoph Inf Serv 1968;43:193.
41. 6-alkylguanine-DNA alkyltransferase: role in carcinogenicity and chemotherapy. Bio-essays 2002;24:255-266.
42. Marinova EM, Yanishlieva NV. Antioxida-tive activity of extracts from selected species of the family Lamiaceae in sunflower oil. Food Chem 1997;58:245-248.
43. Menković N, Šavikin K, Tasić S, Zbunić G, Stešević S, Milosavljević S et al. Ethnobo-tanical study on traditional uses of wild medicinal plants in Prokletije Mountains (Montenegro). J Ethnopharmacol 2011;133: 97-107.
44. Mihailović V, Mihailović M, Uskoković A, Arambašić J, Mišić D, Stanković V et al. Hepatoprotective effects of Gentiana ascle-piadea L. extracts against carbon tetrachloride induced liver injury in rats. Food Chem Toxicol 2013;52:83-90.
45. Mpondo EM, Chulia AJ. 6-O-P-D-Glu-cosyl gentiopicroside: A new secoiridoid from Gentiana asclepiadea. Planta Med 1988;54:185-186.
46. Nićiforović N, Mihailović V, Mašković P, Solujić S, Stojković A, Pavlović-Muratspahić D. Antioxidant activity of selected plant species; potential new sources of natural antioxidants. Food Chem Toxicol 2010;48:3125-3130.
47. Oyaizu M. Antioxidative activities of browning reaction prepared from glucosamine. Jpn J Nutr 1986;44:307-315.
48. Petz B. Basic statistical method for non-mathematical use. Croatia: SNL Zagreb, 1985.
49. Prieto P, Pineda M, Aguilar M. Spectropho-tometric quantitation of antioxidant capacity through the formation of a phosphomo-lybdenum complex: Specific application to the determination of vitamin E1. Anal Bio-chem 1999;269:337-341.
50. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Rad-ic Biol Med 1996;20:933-956.
51. Romero-Jiménez M, Campos-Sánchez J, Analla M, Muñoz-Serrano A, Alonso-Mo-raga A. Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat Res 2005;585:147-155.
52. Sarić M. Lekovite biljke SR Srbije. Beo-grad, Serbia: SANU, 1989.
53. Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent oxi-dants and antioxidants. Meth Enzymol 1999;299:152-178.
54. Siriwardhana N, Lee KW, Jeon YJ, Kim SH, Haw WJ. Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition. Food Sci Technol Int 2003;9:339-346.
55. Stephanou G, Vlastos D, Vlachodimitro-poulos D, Demopoulos NA. A comparative study on the effect of MNU on human lymphocyte cultures in vitro evaluated by 06-mdG formation, micronuclei and sister chromatid exchanges induction. Cancer Lett 1996;109:109-114.
56. Szücs Z, Ddnos B, Nyiredy SZ. Comparative analysis of the underground parts of Gentiana species by HPLC with diode-array and mass spectrometric detection. Chroma-tographia 2002;56:19-23.
57. Takao T, Watanabe N, Yagi I, Sakata K. A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Biosci Biotechnol Biochem 1994; 58:1780-1783.
58. Terpinc P, Čeh B, Ulrih PN, Abramovič H. Studies of the correlation between antioxi-dant properties and the total phenolic content of different oil cake extracts. Ind Crop Prod 2012;39:210-217.
59. Wolfender JL, Hamburger M, Hostettmann K. Search for bitter principles in Chironia species by lc-ms and isolation of a new se-coiridoid diglycoside from Chironia kreb-sii. J Nat Prod 1993;56:682-689.
60. Würgler FE, Graf U. Mutagenicity testing with Drosophila melanogaster. In: Mu-hammed A, Von Borster RC (eds): Basic and applied mutagenesis (pp 343-372). New York: Plenum Press, 1985.
61. Yao LH, Jiang YM, Shi J, Tomás-Barberán FA, Datta N, Singanusong R et al. Flavo-noids in food and their health benefits. Plant Food Hum Nutr 2004;59:113-22.
62. Yermakov AI, Arasimov VV, Yarosh NP. Methods of biochemical analysis of plants. Leningrad: Agropromizdat (in Russian), 1987.
63. Zhao J. Nutraceuticals, nutritional therapy, phytonutrients, and phytotherapy for improvement of human health: A perspective on plant biotechnology application. Recent Pat Biotechnol 2007;1:75-97.
64. Zhao ZL, Dorje G, Wang ZT. Identification of medicinal plants used as Tibetan traditional medicine Jie-Ji. J Ethnopharmacol 2010;132:122-126.