Phosphorylation accelerates geldanamycin-induced Akt degradation

Archives of Biochemistry and Biophysics

Volumn 536, Issue 1, 2013, Pages 6-11

  Su, Chih Hao ^a   Lan, Keng Hsin ^a   Li, Chung Pin ^a   Chao, Yee ^a   Lin, Han Chieh ^a   Lee, Shou Dong ^a   Lee, Wei Ping ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Akt; CHIP; Hsp90 inhibitor; Phosphorylation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PROTEIN KINASE B; UBIQUITIN PROTEIN LIGASE E3; ANTINEOPLASTIC ANTIBIOTIC; BENZOQUINONE DERIVATIVE; HEAT SHOCK PROTEIN 90 INHIBITOR; MACROCYCLIC LACTAM; STUB1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HELA CELL; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; UBIQUITINATION; AKT; ANIMAL; CELL STRAIN HEK293; CHIP; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; MOUSE; PHOSPHORYLATION; POINT MUTATION;

AKT; CHIP; HSP90 INHIBITOR; PHOSPHORYLATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; ENZYME ACTIVATION; HEK293 CELLS; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; PHOSPHORYLATION; POINT MUTATION; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84884487041     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2013.04.015     Document Type: Article

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