RhEGF-loaded PLGA-Alginate microspheres enhance the healing of full-thickness excisional wounds in diabetised Wistar rats

European Journal of Pharmaceutical Sciences

Volumn 50, Issue 3-4, 2013, Pages 243-252

  Gainza, Garazi ^a,b   Aguirre, José Javier ^c   Pedraz, José Luis ^a,b   Hernández, Rosa María ^a,b   Igartua, Manoli ^a,b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c HOSPITAL TXAGORRITXU   (Spain)

Author keywords

Alginate; Poly Lactic co Glycolic Acid (PLGA); Recombinant human epidermal growth factor (rhEGF); Tissue engineering; Wound healing

Indexed keywords

ALGINIC ACID; GLUCOSE; MICROSPHERE; POLYLACTIC ACID; RECOMBINANT EPIDERMAL GROWTH FACTOR; RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BODY WEIGHT; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DIABETIC FOOT; DRUG FORMULATION; DRUG RELEASE; EMULSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING;

ALGINATE; POLY-LACTIC-CO-GLYCOLIC-ACID (PLGA); RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR (RHEGF); TISSUE ENGINEERING; WOUND HEALING;

3T3 CELLS; ALGINATES; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; EPIDERMAL GROWTH FACTOR; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; LACTIC ACID; MALE; MICE; MICROSPHERES; POLYGLYCOLIC ACID; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; WOUND HEALING;

EID: 84884484103     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.07.003     Document Type: Article

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