Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls

European Journal of Cell Biology

Volumn 81, Issue 3, 2002, Pages 153-160

  Loots, Miriam A M ^a   Kenter, Susan B ^a   Au, Fung L ^a   Van Galen, W J M ^a   Middelkoop, Esther ^b   Bos, Jan D ^a   Mekkes, Jan R ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Dutch Burns Foundation   (Netherlands)

Author keywords

Cell culture; Chronic diabetic wounds; Growth factors; Human fibroblasts; Wound healing

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR AB; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC FOOT; DNA SYNTHESIS; DRUG RESPONSE; FEMALE; FIBROBLAST; GROWTH ACCELERATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOGENESIS; PRIORITY JOURNAL; STIMULUS RESPONSE; WOUND HEALING;

EID: 0036226795     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00228     Document Type: Article

References (34)

1. Proliferation and mitogenic response to PDGF-BB of fibroblasts isolated from chronic venous leg ulcers is ulcer-age dependent
2. Comparing groups-continuous data
3. Diabetic foot ulcers in a multidisciplinary setting. An economic analysis of primary healing with amputation
4. Growth factors and wound healing: Part II. Role in normal and chronic wound healing
5. PDGF-AB and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
6. A factor in the serum of diabetic patients inhibits microtubule formation
7. Regulation of insulin-like growth factor (IGF) binding protein-2 synthesis and degradation by platelet-derived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells
8. Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
9. Proliferation and collagen synthesis by human dermal fibroblasts cultured from different body sites
10. Growth factors and diabetic complications
11. Characterisation of insulin-like growth factor-binding proteins produced by cultured fibroblasts from patients with noninsulin-dependent diabetes mellitus, insulin-dependent diabetes mellitus or obesity
12. Wound healing and the diabetic patient
13. Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo
14. Extracellular matrix and growth factors: An integrated interplay controlling tissue repair and progression to disease
15. Growth factors and repair of diabetic wounds
16. Cultured fibroblasts from chronic diabetic wounds on the lower extremity (non-insulin-dependent diabetes mellitus) show disturbed proliferation
17. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds
18. The effects of short-term application of a combination of platelet-derived and insulin-like growth factors on periodontal wound healing
19. Role of platelet-derived growth factor in wound healing: Synergistic effects with other growth factors
20. Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds
21. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence
22. Effects of IGF-I and glucose on protein and proteoglycan synthesis by human fetal mesangial cells in culture
23. The effect of epidermal growth factor on wound healing in mice
24. Growth factor responsiveness of cultured human fibroblasts declines with age
25. Effect of donor age on epidermal growth factor processing in man
26. Lower extremity foot ulcers and amputations in diabetes
27. Abnormalities in proliferation and protein synthesis in skin fibroblast cultures from patients with diabetes mellitus
28. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells
29. Cutaneous wound healing. Mechanisms of disease
30. Effects of growth factors in vivo. Cell ingrowth into porous subcutaneous chambers
31. Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors
32. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers
33. Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice
34. Restricted replicative life-span of diabetic fibroblasts in vitro: Its relation to microangiopathy