db/db mice exhibit severe wound-healing impairments compared with other murine diabetic strains in a silicone-splinted excisional wound model

Wound Repair and Regeneration

Volumn 15, Issue 5, 2007, Pages 665-670

  Michaels, Joseph ^a   Churgin, Samara S ^a   Blechman, Keith M ^a   Greives, Matthew R ^a   Aarabi, Shahram ^b   Galiano, Robert D ^a   Gurtner, Geoffrey C ^b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SILICON; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; EPITHELIZATION; FEMALE; GRANULATION TISSUE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES; VASCULARIZATION; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

ANIMALS; ANTIGENS, CD31; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED STRAINS; SILICONES; SPLINTS; WOUND HEALING;

EID: 34848870970     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2007.00273.x     Document Type: Article

References (23)

1. Animal Models of Diabetic Complications Consortium. Low-dose streptozotocin induction protocol (mouse) [accessed September 23, 2005]. Available at :.
2. Reiber GE, Lipsky BA, Gibbons GW. The burden of diabetic foot ulcers. Am J Surg 1998 176 (Suppl. 2A) : 5S 10S.
3. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 2005 366 : 1736 43.
4. Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA 2005 293 : 217 28.
5. Ramsey SD, Newton K, Blough D, McCulloch DK, Sandhu N, Reiber GE, Wagner EH. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care 1999 22 : 382 7.
6. Abbott CA, Garrow AP, Carrington AL, Morris J, Van Ross ER, Boulton AJ. Foot ulcer risk is lower in South-Asian and African-Caribbean compared with European diabetic patients in the U.K.: the North-West diabetes foot care study. Diabetes Care 2005 28 : 1869 75.
7. Gordois A, Scuffham P, Shearer A, Oglesby A, Tobian JA. The health care costs of diabetic peripheral neuropathy in the US. Diabetes Care 2003 26 : 1790 5.
8. Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med 2005 22 : 359 70.
9. Plum L, Wunderlich F, Baudler S, Krone W, Bruning J. Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives. Physiology (Bethesda) 2005 20 : 152 61.
10. Keswani SG, Katz AB, Lim FY, Zoltick P, Radu A, Alaee D, Herlyn M, Crombleholme TM. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen 2004 12 : 497 504.
11. Luo JD, Wang YY, Fu WL, Wu J, Chen AF. Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation 2004 110 : 2484 93.
12. Galiano RD, Tepper OM, Pelo CR, Bhatt KA, Callaghan M, Bastidas N, Bunting S, Steinmetz HG, Gurtner GC. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004 164 : 1935 47.
13. Sullivan SR, Underwood RA, Gibran NS, Sigle RO, Usui ML, Carter WG, Olerud JE. Validation of a model for the study of multiple wounds in the diabetic mouse (db/db). Plast Reconstr Surg 2004 113 : 953 60.
14. Sivan-Loukianova E, Awad OA, Stepanovic V, Bickenbach J, Schatteman GC. CD34+ blood cells accelerate vascularization and healing of diabetic mouse skin wounds. J Vasc Res 2003 40 : 368 77.
15. Galiano RD, Michaels J, Dobryansky M, Levine JP, Gurtner GC. Quantitative and reproducible murine model of excisional wound healing. Wound Repair Regen 2004 12 : 485 92.
16. Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 1997 46 : 887 94.
17. Michaels J, Dobryansky M, Galiano RD, Bhatt KA, Ashinoff R, Ceradini DJ, Gurtner GC. Topical vascular endothelial growth factor reverses delayed wound healing secondary to angiogenesis inhibitor administration. Wound Repair Regen 2005 13 : 506 12.
18. Greenhalgh DG. Wound healing and diabetes mellitus. Clin Plast Surg 2003 30 : 37 45.
19. Goodson WH III., Hung TK. Studies of wound healing in experimental diabetes mellitus. J Surg Res 1977 22 : 221 7.
20. Greenwald DP, Shumway S, Zachary LS, LaBarbera M, Albear P, Temaner M, Gottlieb LJ. Endogenous versus toxin-induced diabetes in rats: a mechanical comparison of two skin wound-healing models. Plast Reconstr Surg 1993 91 : 1087 93.
21. Verhofstad MH, Hendriks T. Diabetes impairs the development of early strength, but not the accumulation of collagen, during intestinal anastomotic healing in the rat. Br J Surg 1994 81 : 1040 5.
22. Spanheimer RG, Umpierrez GE, Stumpf V. Decreased collagen production in diabetic rats. Diabetes 1988 37 : 371 6.
23. Covington DS, Xue H, Pizzini R, Lally KP, Andrassy RJ. Streptozotocin and alloxan are comparable agents in the diabetic model of impaired wound healing. Diabetes Res 1993 23 : 47 53.