-
1
-
-
79951847989
-
Principles and current strategies for targeting autophagy for cancer treatment
-
Amaravadi RK, Lippincott-Schwartz J, Yin XM et al. (2011) Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 17:654-66
-
(2011)
Clin Cancer Res
, vol.17
, pp. 654-666
-
-
Amaravadi, R.K.1
Lippincott-Schwartz, J.2
Yin, X.M.3
-
2
-
-
33846794896
-
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
-
Amaravadi RK, Yu D, Lum JJ et al. (2007) Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 117:326-36
-
(2007)
J Clin Invest
, vol.117
, pp. 326-336
-
-
Amaravadi, R.K.1
Yu, D.2
Lum, J.J.3
-
3
-
-
20344387475
-
Autophagy: Dual roles in life and death
-
Baehrecke EH (2005) Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 6:505-10
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
4
-
-
0017729395
-
Intracellular protein degradation
-
Ballard FJ (1977) Intracellular protein degradation. Essays Biochem 13:1-37
-
(1977)
Essays Biochem
, vol.13
, pp. 1-37
-
-
Ballard, F.J.1
-
5
-
-
84868481873
-
Vemurafenib: The first drug approved for BRAF-mutant cancer
-
Bollag G, Tsai J, Zhang J et al. (2012) Vemurafenib: The first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov 11:873-86
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 873-886
-
-
Bollag, G.1
Tsai, J.2
Zhang, J.3
-
6
-
-
19944434059
-
Inhibition of macroautophagy triggers apoptosis
-
Boya P, Gonzalez-Polo RA, Casares N et al. (2005) Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 25:1025-40
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1025-1040
-
-
Boya, P.1
Gonzalez-Polo, R.A.2
Casares, N.3
-
7
-
-
33845711166
-
Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
-
Carreira S, Goodall J, Denat L et al. (2006) Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev 20:3426-39
-
(2006)
Genes Dev
, vol.20
, pp. 3426-3439
-
-
Carreira, S.1
Goodall, J.2
Denat, L.3
-
8
-
-
0032533594
-
Malignant melanoma: Modern black plague and genetic black box
-
Chin L, Merlino G, DePinho RA (1998) Malignant melanoma: Modern black plague and genetic black box. Genes Dev 12:3467-81
-
(1998)
Genes Dev
, vol.12
, pp. 3467-3481
-
-
Chin, L.1
Merlino, G.2
DePinho, R.A.3
-
9
-
-
58149511987
-
Mechanism of apoptosis induction by inhibition of the anti-Apoptotic BCL-2 proteins
-
Chipuk JE, Fisher JC, Dillon CP et al. (2008) Mechanism of apoptosis induction by inhibition of the anti-Apoptotic BCL-2 proteins. Proc Natl Acad Sci USA 105:20327-32
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 20327-20332
-
-
Chipuk, J.E.1
Fisher, J.C.2
Dillon, C.P.3
-
10
-
-
41149152733
-
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization
-
Chipuk JE, Green DR (2008) How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol 18:157-64
-
(2008)
Trends Cell Biol
, vol.18
, pp. 157-164
-
-
Chipuk, J.E.1
Green, D.R.2
-
12
-
-
51349112454
-
Chloroquine: Novel uses & manifestations
-
Cooper RG, Magwere T (2008) Chloroquine: Novel uses & manifestations. Indian J Med Res 127:305-16
-
(2008)
Indian J Med Res
, vol.127
, pp. 305-316
-
-
Cooper, R.G.1
Magwere, T.2
-
13
-
-
65649147543
-
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
-
Dankort D, Curley DP, Cartlidge RA et al. (2009) Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 41:544-52
-
(2009)
Nat Genet
, vol.41
, pp. 544-552
-
-
Dankort, D.1
Curley, D.P.2
Cartlidge, R.A.3
-
14
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-54
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
15
-
-
79958753992
-
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
-
Fricker M, O'Prey J, Tolkovsky AM et al. (2010) Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis 1:e59
-
(2010)
Cell Death Dis
, vol.1
-
-
Fricker, M.1
O'Prey, J.2
Tolkovsky, A.M.3
-
16
-
-
77952328364
-
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
-
Gomes NP, Espinosa JM (2010) Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev 24:1022-34
-
(2010)
Genes Dev
, vol.24
, pp. 1022-1034
-
-
Gomes, N.P.1
Espinosa, J.M.2
-
18
-
-
0036463405
-
A matter of life and death
-
Green DR, Evan GI (2002) A matter of life and death. Cancer Cell 1:19-30
-
(2002)
Cancer Cell
, vol.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
19
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R et al. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 25:460-70
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
-
21
-
-
84862957567
-
MEK'ing the most of p53 reactivation therapy in melanoma
-
Lee JT, Herlyn M (2012) MEK'ing the most of p53 reactivation therapy in melanoma. J Invest Dermatol 132:263-5
-
(2012)
J Invest Dermatol
, vol.132
, pp. 263-265
-
-
Lee, J.T.1
Herlyn, M.2
-
22
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132:27-42
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
23
-
-
84861893781
-
Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-Term tumor regression
-
Liang X, De Vera ME, Buchser WJ et al. (2012) Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-Term tumor regression. Cancer Res 72:2791-801
-
(2012)
Cancer Res
, vol.72
, pp. 2791-2801
-
-
Liang, X.1
De Vera, M.E.2
Buchser, W.J.3
-
24
-
-
79956028916
-
Ras, autophagy and glycolysis
-
Lock R, Debnath J (2011) Ras, autophagy and glycolysis. Cell Cycle 10:1516-7
-
(2011)
Cell Cycle
, vol.10
, pp. 1516-1517
-
-
Lock, R.1
Debnath, J.2
-
25
-
-
38149141767
-
Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
-
Maclean KH, Dorsey FC, Cleveland JL et al. (2008) Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118:79-88
-
(2008)
J Clin Invest
, vol.118
, pp. 79-88
-
-
Maclean, K.H.1
Dorsey, F.C.2
Cleveland, J.L.3
-
26
-
-
79953295757
-
Autophagy in Ras-induced malignant transformation: Fatal or vital
-
Marino G, Martins I, Kroemer G (2011) Autophagy in Ras-induced malignant transformation: Fatal or vital? Mol Cell 42:1-3
-
(2011)
Mol Cell
, vol.42
, pp. 1-3
-
-
Marino, G.1
Martins, I.2
Kroemer, G.3
-
27
-
-
0035265686
-
PUMA, anovel proapoptotic gene, is induced by p53
-
Nakano K, Vousden KH (2001) PUMA, anovel proapoptotic gene, is induced by p53. Mol Cell 7:683-94
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
29
-
-
0036097786
-
Keeping killers on a tight leash: Transcriptional and post-Translational control of the pro-Apoptotic activity of BH3-only proteins
-
Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: Transcriptional and post-Translational control of the pro-Apoptotic activity of BH3-only proteins. Cell Death Differ 9:505-12
-
(2002)
Cell Death Differ
, vol.9
, pp. 505-512
-
-
Puthalakath, H.1
Strasser, A.2
-
30
-
-
0030614915
-
Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
-
Sattler M, Liang H, Nettesheim D et al. (1997) Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis. Science 275:983-6
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Nettesheim, D.3
-
31
-
-
33750214678
-
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
-
Schumm K, Rocha S, Caamano J et al. (2006) Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. EMBO J 25:4820-32
-
(2006)
EMBO J
, vol.25
, pp. 4820-4832
-
-
Schumm, K.1
Rocha, S.2
Caamano, J.3
-
32
-
-
79955961530
-
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo
-
Sheen JH, Zoncu R, Kim D et al. (2011) Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell 19:613-28
-
(2011)
Cancer Cell
, vol.19
, pp. 613-628
-
-
Sheen, J.H.1
Zoncu, R.2
Kim, D.3
-
33
-
-
0035843169
-
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
-
Soengas MS, Capodieci P, Polsky D et al. (2001) Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409:207-11
-
(2001)
Nature
, vol.409
, pp. 207-211
-
-
Soengas, M.S.1
Capodieci, P.2
Polsky, D.3
-
34
-
-
84860389354
-
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
-
Strasser A, Cory S, Adams JM (2011) Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J 30:3667-83
-
(2011)
EMBO J
, vol.30
, pp. 3667-3683
-
-
Strasser, A.1
Cory, S.2
Adams, J.M.3
-
35
-
-
33845656738
-
Acetylation of the p53 DNA-binding domain regulates apoptosis induction
-
Sykes SM, Mellert HS, Holbert MA et al. (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell 24:841-51
-
(2006)
Mol Cell
, vol.24
, pp. 841-851
-
-
Sykes, S.M.1
Mellert, H.S.2
Holbert, M.A.3
-
36
-
-
33845668241
-
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
-
Tang Y, Luo J, Zhang W et al. (2006) Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell 24:827-39
-
(2006)
Mol Cell
, vol.24
, pp. 827-839
-
-
Tang, Y.1
Luo, J.2
Zhang, W.3
-
37
-
-
79951689086
-
Identification of aneuploidyselective antiproliferation compounds
-
Tang YC, Williams BR, Siegel JJ et al. (2011) Identification of aneuploidyselective antiproliferation compounds. Cell 144:499-512
-
(2011)
Cell
, vol.144
, pp. 499-512
-
-
Tang, Y.C.1
Williams, B.R.2
Siegel, J.J.3
-
38
-
-
33746108329
-
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
-
Tanida I, Minematsu-Ikeguchi N, Ueno T et al. (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1:84-91
-
(2005)
Autophagy
, vol.1
, pp. 84-91
-
-
Tanida, I.1
Minematsu-Ikeguchi, N.2
Ueno, T.3
-
39
-
-
67651152483
-
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells
-
Tormo D, Checinska A, Alonso-Curbelo D et al. (2009) Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells. Cancer Cell 16:103-14
-
(2009)
Cancer Cell
, vol.16
, pp. 103-114
-
-
Tormo, D.1
Checinska, A.2
Alonso-Curbelo, D.3
-
40
-
-
84861845490
-
Melanoma: From mutations to medicine
-
Tsao H, Chin L, Garraway LA et al. (2012) Melanoma: From mutations to medicine. Genes Dev 26:1131-55
-
(2012)
Genes Dev
, vol.26
, pp. 1131-1155
-
-
Tsao, H.1
Chin, L.2
Garraway, L.A.3
-
42
-
-
65349103899
-
Blinded by the light: The growing complexity of p53
-
Vousden KH, Prives C (2009) Blinded by the light: The growing complexity of p53. Cell 137:413-31
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
43
-
-
77951249136
-
Lysosome dysfunction triggers Atg7-dependent neural apoptosis
-
Walls KC, Ghosh AP, Franklin AV et al. (2010) Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 285:10497-507
-
(2010)
J Biol Chem
, vol.285
, pp. 10497-10507
-
-
Walls, K.C.1
Ghosh, A.P.2
Franklin, A.V.3
-
44
-
-
69049103034
-
PUMA is directly activated by NFkappaB and contributes to TNF-Alpha-induced apoptosis
-
Wang P, Qiu W, Dudgeon C et al. (2009) PUMA is directly activated by NFkappaB and contributes to TNF-Alpha-induced apoptosis. Cell Death Differ 16:1192-202
-
(2009)
Cell Death Differ
, vol.16
, pp. 1192-1202
-
-
Wang, P.1
Qiu, W.2
Dudgeon, C.3
-
45
-
-
0025852057
-
C-myc protein expression in untransformed fibroblasts
-
Waters CM, Littlewood TD, Hancock DC et al. (1991) c-myc protein expression in untransformed fibroblasts. Oncogene 6:797-805
-
(1991)
Oncogene
, vol.6
, pp. 797-805
-
-
Waters, C.M.1
Littlewood, T.D.2
Hancock, D.C.3
-
46
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
White E (2012) Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 12:401-10
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 401-410
-
-
White, E.1
-
47
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S, Wang X, Contino G et al. (2011) Pancreatic cancers require autophagy for tumor growth. Genes & Dev 25:717-29
-
(2011)
Genes & Dev
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
-
48
-
-
0035265823
-
PUMA induces the rapid apoptosis of colorectal cancer cells
-
Yu J, Zhang L, Hwang PM et al. (2001) PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7:673-82
-
(2001)
Mol Cell
, vol.7
, pp. 673-682
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
|