메뉴 건너뛰기




Volumn 106, Issue , 2012, Pages 173-196

From Bench to Beside to Cure Spinal Cord Injury: Lost in Translation?

Author keywords

Regeneration clinical trial; Remyelination axon; Spinal cord injury

Indexed keywords

11C7 ANTIBODY; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 7B12 ANTIBODY; ATI355 ANTIBODY; BA 210; CYCLIN DEPENDENT KINASE INHIBITOR 1; EXOENZYME C3; FASUDIL; IN 1 ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 11C7; MONOCLONAL ANTIBODY 7B12; MYELIN; NEP1-40 PEPTIDE; NOGO A ANTIBODY; PEPTIDE; PROTEIN NOGO A; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TACROLIMUS; UNCLASSIFIED DRUG; MYELIN PROTEIN; PROTEIN NOGO;

EID: 84884312397     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-407178-0.00008-9     Document Type: Chapter
Times cited : (22)

References (76)
  • 2
    • 69449094846 scopus 로고    scopus 로고
    • Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    • Alto L.T., Havton L.A., Conner J.M., et al. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neuroscience 2009, 12:1106-1113.
    • (2009) Nature Neuroscience , vol.12 , pp. 1106-1113
    • Alto, L.T.1    Havton, L.A.2    Conner, J.M.3
  • 3
    • 7244242234 scopus 로고    scopus 로고
    • Targeting recovery: Priorities of the spinal cord-injured population
    • Anderson K.D. Targeting recovery: Priorities of the spinal cord-injured population. Journal of Neurotrauma 2004, 21:1371-1383.
    • (2004) Journal of Neurotrauma , vol.21 , pp. 1371-1383
    • Anderson, K.D.1
  • 4
    • 23944498068 scopus 로고    scopus 로고
    • Recommended guidelines for studies of human subjects with spinal cord injury
    • Anderson D.K., Beattie M., Blesch A., et al. Recommended guidelines for studies of human subjects with spinal cord injury. Spinal Cord 2005, 43:453-458.
    • (2005) Spinal Cord , vol.43 , pp. 453-458
    • Anderson, D.K.1    Beattie, M.2    Blesch, A.3
  • 5
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. Journal of Neurotrauma 1995, 12:1-21.
    • (1995) Journal of Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 6
    • 58149512333 scopus 로고    scopus 로고
    • Spinal cord injury: Plasticity, regeneration and the challenge of translational drug development
    • Blesch A., Tuszynski M.H. Spinal cord injury: Plasticity, regeneration and the challenge of translational drug development. Trends in Neurosciences 2009, 32:41-47.
    • (2009) Trends in Neurosciences , vol.32 , pp. 41-47
    • Blesch, A.1    Tuszynski, M.H.2
  • 7
    • 0642309623 scopus 로고    scopus 로고
    • Features of skin-coincubated macrophages that promote recovery from spinal cord injury
    • Bomstein Y., Marder J.B., Vitner K., et al. Features of skin-coincubated macrophages that promote recovery from spinal cord injury. Journal of Neuroimmunology 2003, 142:10-16.
    • (2003) Journal of Neuroimmunology , vol.142 , pp. 10-16
    • Bomstein, Y.1    Marder, J.B.2    Vitner, K.3
  • 9
    • 0028867947 scopus 로고
    • Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
    • Bregman B.S., Kunkel-Bagden E., Schnell L., et al. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 1995, 378:498-501.
    • (1995) Nature , vol.378 , pp. 498-501
    • Bregman, B.S.1    Kunkel-Bagden, E.2    Schnell, L.3
  • 10
    • 34147151105 scopus 로고    scopus 로고
    • Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199
    • Cafferty W.B., Kim J.E., Lee J.K., et al. Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron 2007, 54:195-199.
    • (2007) Neuron , vol.54 , pp. 195-199
    • Cafferty, W.B.1    Kim, J.E.2    Lee, J.K.3
  • 11
    • 0023967246 scopus 로고
    • Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
    • Caroni P., Schwab M.E. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1988, 1:85-96.
    • (1988) Neuron , vol.1 , pp. 85-96
    • Caroni, P.1    Schwab, M.E.2
  • 12
    • 27744532683 scopus 로고    scopus 로고
    • Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury
    • Chan C.C., Khodarahmi K., Liu J., et al. Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury. Experimental Neurology 2005, 196:352-364.
    • (2005) Experimental Neurology , vol.196 , pp. 352-364
    • Chan, C.C.1    Khodarahmi, K.2    Liu, J.3
  • 13
    • 0034719513 scopus 로고    scopus 로고
    • Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    • Chen M.S., Huber A.B., van der Haar M.E., et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000, 403:434-439.
    • (2000) Nature , vol.403 , pp. 434-439
    • Chen, M.S.1    Huber, A.B.2    van der Haar, M.E.3
  • 14
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Crowe M.J., Bresnahan J.C., Shuman S.L., et al. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nature Medicine 1997, 3:73-76.
    • (1997) Nature Medicine , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3
  • 15
    • 0842329858 scopus 로고    scopus 로고
    • Providing the clinical basis for new interventional therapies: Refined diagnosis and assessment of recovery after spinal cord injury
    • Curt A., Schwab M.E., Dietz V. Providing the clinical basis for new interventional therapies: Refined diagnosis and assessment of recovery after spinal cord injury. Spinal Cord 2004, 42:1-6.
    • (2004) Spinal Cord , vol.42 , pp. 1-6
    • Curt, A.1    Schwab, M.E.2    Dietz, V.3
  • 18
    • 18444379933 scopus 로고    scopus 로고
    • Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth
    • Domeniconi M., Cao Z., Spencer T., et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 2002, 35:283-290.
    • (2002) Neuron , vol.35 , pp. 283-290
    • Domeniconi, M.1    Cao, Z.2    Spencer, T.3
  • 19
    • 33847391178 scopus 로고    scopus 로고
    • Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: Spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials
    • Fawcett J.W., Curt A., Steeves J.D., et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: Spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007, 45:190-205.
    • (2007) Spinal Cord , vol.45 , pp. 190-205
    • Fawcett, J.W.1    Curt, A.2    Steeves, J.D.3
  • 20
    • 79955961172 scopus 로고    scopus 로고
    • A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury
    • Fehlings M.G., Theodore N., Harrop J., et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. Journal of Neurotrauma 2011, 28:787-796.
    • (2011) Journal of Neurotrauma , vol.28 , pp. 787-796
    • Fehlings, M.G.1    Theodore, N.2    Harrop, J.3
  • 21
    • 0141499228 scopus 로고    scopus 로고
    • Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
    • Filbin M.T. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nature Reviews. Neuroscience 2003, 4:703-713.
    • (2003) Nature Reviews. Neuroscience , vol.4 , pp. 703-713
    • Filbin, M.T.1
  • 22
    • 8144228423 scopus 로고    scopus 로고
    • Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1
    • Fouad K., Klusman I., Schwab M.E. Regenerating corticospinal fibers in the Marmoset (Callitrix jacchus) after spinal cord lesion and treatment with the anti-Nogo-A antibody IN-1. The European Journal of Neuroscience 2004, 20:2479-2482.
    • (2004) The European Journal of Neuroscience , vol.20 , pp. 2479-2482
    • Fouad, K.1    Klusman, I.2    Schwab, M.E.3
  • 23
    • 0035905799 scopus 로고    scopus 로고
    • Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
    • Fournier A.E., Grandpre T., Strittmatter S.M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 2001, 409:341-346.
    • (2001) Nature , vol.409 , pp. 341-346
    • Fournier, A.E.1    Grandpre, T.2    Strittmatter, S.M.3
  • 24
    • 33745879440 scopus 로고    scopus 로고
    • Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
    • Freund P., Schmidlin E., Wannier T., et al. Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates. Nature Medicine 2006, 12:790-792.
    • (2006) Nature Medicine , vol.12 , pp. 790-792
    • Freund, P.1    Schmidlin, E.2    Wannier, T.3
  • 25
    • 69449093524 scopus 로고    scopus 로고
    • Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
    • Garcia-Alias G., Barkhuysen S., Buckle M., et al. Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nature Neuroscience 2009, 12:1145-1151.
    • (2009) Nature Neuroscience , vol.12 , pp. 1145-1151
    • Garcia-Alias, G.1    Barkhuysen, S.2    Buckle, M.3
  • 26
    • 0015590730 scopus 로고
    • Demyelination and remyelination after acute spinal cord compression
    • Gledhill R.F., Harrison B.M., McDonald W.I. Demyelination and remyelination after acute spinal cord compression. Experimental Neurology 1973, 38:472-487.
    • (1973) Experimental Neurology , vol.38 , pp. 472-487
    • Gledhill, R.F.1    Harrison, B.M.2    McDonald, W.I.3
  • 27
    • 0037198689 scopus 로고    scopus 로고
    • Nogo-66 receptor antagonist peptide promotes axonal regeneration
    • Grandpre T., Li S., Strittmatter S.M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 2002, 417:547-551.
    • (2002) Nature , vol.417 , pp. 547-551
    • Grandpre, T.1    Li, S.2    Strittmatter, S.M.3
  • 28
    • 0034719371 scopus 로고    scopus 로고
    • Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein
    • Grandpre T., Nakamura F., Vartanian T., et al. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403:439-444.
    • (2000) Nature , vol.403 , pp. 439-444
    • Grandpre, T.1    Nakamura, F.2    Vartanian, T.3
  • 29
    • 0036904245 scopus 로고    scopus 로고
    • Recent advances in pathophysiology and treatment of spinal cord injury
    • Hulsebosch C.E. Recent advances in pathophysiology and treatment of spinal cord injury. Advances in Physiology Education 2002, 26:238-255.
    • (2002) Advances in Physiology Education , vol.26 , pp. 238-255
    • Hulsebosch, C.E.1
  • 30
    • 84859594040 scopus 로고    scopus 로고
    • Central nervous system regeneration does not occur
    • Illis L.S. Central nervous system regeneration does not occur. Spinal Cord 2012, 50:259-263.
    • (2012) Spinal Cord , vol.50 , pp. 259-263
    • Illis, L.S.1
  • 31
    • 82255195568 scopus 로고    scopus 로고
    • Embryonic stem cells. Researchers mull impact of Geron's sudden exit from field
    • Kaiser J. Embryonic stem cells. Researchers mull impact of Geron's sudden exit from field. Science 2011, 334:1043.
    • (2011) Science , vol.334 , pp. 1043
    • Kaiser, J.1
  • 32
    • 0033139737 scopus 로고    scopus 로고
    • A review of the neuropathology of human spinal cord injury with emphasis on special features
    • Kakulas B.A. A review of the neuropathology of human spinal cord injury with emphasis on special features. The Journal of Spinal Cord Medicine 1999, 22:119-124.
    • (1999) The Journal of Spinal Cord Medicine , vol.22 , pp. 119-124
    • Kakulas, B.A.1
  • 33
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead H.S., Nistor G., Bernal G., et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2005, 25:4694-4705.
    • (2005) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3
  • 34
    • 0038076001 scopus 로고    scopus 로고
    • Axon regeneration in young adult mice lacking Nogo-A/B
    • Kim J.E., Li S., Grandpre T., et al. Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 2003, 38:187-199.
    • (2003) Neuron , vol.38 , pp. 187-199
    • Kim, J.E.1    Li, S.2    Grandpre, T.3
  • 35
    • 7044246002 scopus 로고    scopus 로고
    • Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury
    • Kim J.E., Liu B.P., Park J.H., et al. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron 2004, 44:439-451.
    • (2004) Neuron , vol.44 , pp. 439-451
    • Kim, J.E.1    Liu, B.P.2    Park, J.H.3
  • 36
    • 27244435547 scopus 로고    scopus 로고
    • Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results
    • Knoller N., Auerbach G., Fulga V., et al. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results. Journal of Neurosurgery. Spine 2005, 3:173-181.
    • (2005) Journal of Neurosurgery. Spine , vol.3 , pp. 173-181
    • Knoller, N.1    Auerbach, G.2    Fulga, V.3
  • 37
    • 76349111372 scopus 로고    scopus 로고
    • Translational research in spinal cord injury: A survey of opinion from the SCI community
    • Kwon B.K., Hillyer J., Tetzlaff W. Translational research in spinal cord injury: A survey of opinion from the SCI community. Journal of Neurotrauma 2010, 27:21-33.
    • (2010) Journal of Neurotrauma , vol.27 , pp. 21-33
    • Kwon, B.K.1    Hillyer, J.2    Tetzlaff, W.3
  • 38
    • 84866512164 scopus 로고    scopus 로고
    • Autologous incubated macrophage therapy in acute, complete spinal cord injury: Results of the phase 2 randomized controlled multicenter trial
    • Lammertse D.P., Jones L.A., Charlifue S.B., et al. Autologous incubated macrophage therapy in acute, complete spinal cord injury: Results of the phase 2 randomized controlled multicenter trial. Spinal Cord 2012, 50:661-671.
    • (2012) Spinal Cord , vol.50 , pp. 661-671
    • Lammertse, D.P.1    Jones, L.A.2    Charlifue, S.B.3
  • 40
    • 0032763125 scopus 로고    scopus 로고
    • Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination
    • Levine J.M., Reynolds R. Activation and proliferation of endogenous oligodendrocyte precursor cells during ethidium bromide-induced demyelination. Experimental Neurology 1999, 160:333-347.
    • (1999) Experimental Neurology , vol.160 , pp. 333-347
    • Levine, J.M.1    Reynolds, R.2
  • 41
    • 20844439022 scopus 로고    scopus 로고
    • Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury
    • Li S., Liu B.P., Budel S., et al. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2004, 24:10511-10520.
    • (2004) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.24 , pp. 10511-10520
    • Li, S.1    Liu, B.P.2    Budel, S.3
  • 43
    • 27644507789 scopus 로고    scopus 로고
    • Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats
    • Liebscher T., Schnell L., Schnell D., et al. Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Annals of Neurology 2005, 58:706-719.
    • (2005) Annals of Neurology , vol.58 , pp. 706-719
    • Liebscher, T.1    Schnell, L.2    Schnell, D.3
  • 44
    • 0037119581 scopus 로고    scopus 로고
    • Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor
    • Liu B.P., Fournier A., Grandpre T., et al. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 2002, 297:1190-1193.
    • (2002) Science , vol.297 , pp. 1190-1193
    • Liu, B.P.1    Fournier, A.2    Grandpre, T.3
  • 45
    • 57349179914 scopus 로고    scopus 로고
    • Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury
    • Lord-Fontaine S., Yang F., Diep Q., et al. Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury. Journal of Neurotrauma 2008, 25:1309-1322.
    • (2008) Journal of Neurotrauma , vol.25 , pp. 1309-1322
    • Lord-Fontaine, S.1    Yang, F.2    Diep, Q.3
  • 46
    • 84866392805 scopus 로고    scopus 로고
    • Long-distance growth and connectivity of neural stem cells after severe spinal cord injury
    • Lu P., Wang Y., Graham L., et al. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell 2012, 150:1264-1273.
    • (2012) Cell , vol.150 , pp. 1264-1273
    • Lu, P.1    Wang, Y.2    Graham, L.3
  • 47
    • 67649388365 scopus 로고    scopus 로고
    • Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury
    • Maier I.C., Ichiyama R.M., Courtine G., et al. Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury. Brain: A Journal of Neurology 2009, 132:1426-1440.
    • (2009) Brain: A Journal of Neurology , vol.132 , pp. 1426-1440
    • Maier, I.C.1    Ichiyama, R.M.2    Courtine, G.3
  • 48
    • 77957934921 scopus 로고    scopus 로고
    • First patient enters trial to test safety of stem cells in spinal injury
    • Mayor S. First patient enters trial to test safety of stem cells in spinal injury. BMJ 2010, 341:c5724.
    • (2010) BMJ , vol.341
    • Mayor, S.1
  • 49
    • 0035873174 scopus 로고    scopus 로고
    • Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A
    • Merkler D., Metz G.A., Raineteau O., et al. Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 2001, 21:3665-3673.
    • (2001) The Journal of Neuroscience: The Official Journal of the Society for Neuroscience , vol.21 , pp. 3665-3673
    • Merkler, D.1    Metz, G.A.2    Raineteau, O.3
  • 50
    • 33746286637 scopus 로고    scopus 로고
    • Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats
    • Nishio Y., Koda M., Kitajo K., et al. Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats. Experimental Neurology 2006, 200:392-397.
    • (2006) Experimental Neurology , vol.200 , pp. 392-397
    • Nishio, Y.1    Koda, M.2    Kitajo, K.3
  • 51
    • 49449094589 scopus 로고    scopus 로고
    • A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury
    • Pinzon A., Marcillo A., Pabon D., et al. A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. Experimental Neurology 2008, 213:129-136.
    • (2008) Experimental Neurology , vol.213 , pp. 129-136
    • Pinzon, A.1    Marcillo, A.2    Pabon, D.3
  • 52
    • 0031849511 scopus 로고    scopus 로고
    • Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats
    • Rapalino O., Lazarov-Spiegler O., Agranov E., et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nature Medicine 1998, 4:814-821.
    • (1998) Nature Medicine , vol.4 , pp. 814-821
    • Rapalino, O.1    Lazarov-Spiegler, O.2    Agranov, E.3
  • 53
    • 0018908523 scopus 로고
    • Axons from CNS neurons regenerate into PNS grafts
    • Richardson P.M., McGuinness U.M., Aguayo A.J. Axons from CNS neurons regenerate into PNS grafts. Nature 1980, 284:264-265.
    • (1980) Nature , vol.284 , pp. 264-265
    • Richardson, P.M.1    McGuinness, U.M.2    Aguayo, A.J.3
  • 54
    • 85052609949 scopus 로고    scopus 로고
    • Neuroprosthetics of the upper extremity-Clinical application in spinal cord injury and challenges for the future
    • Rupp R., Gerner H.J. Neuroprosthetics of the upper extremity-Clinical application in spinal cord injury and challenges for the future. Acta Neurochirurgica. Supplement 2007, 97:419-426.
    • (2007) Acta Neurochirurgica. Supplement , vol.97 , pp. 419-426
    • Rupp, R.1    Gerner, H.J.2
  • 55
    • 0025017637 scopus 로고
    • Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
    • Schnell L., Schwab M.E. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 1990, 343:269-272.
    • (1990) Nature , vol.343 , pp. 269-272
    • Schnell, L.1    Schwab, M.E.2
  • 56
    • 84857333220 scopus 로고    scopus 로고
    • Computer implementation of the international standards for neurological classification of spinal cord injury for consistent and efficient derivation of its subscores including handling of data from not testable segments
    • Schuld C., Wiese J., Hug A., et al. Computer implementation of the international standards for neurological classification of spinal cord injury for consistent and efficient derivation of its subscores including handling of data from not testable segments. Journal of Neurotrauma 2012, 29:453-461.
    • (2012) Journal of Neurotrauma , vol.29 , pp. 453-461
    • Schuld, C.1    Wiese, J.2    Hug, A.3
  • 58
    • 75349113016 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury
    • Sharp J., Frame J., Siegenthaler M., et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells 2010, 28:152-163.
    • (2010) Stem Cells , vol.28 , pp. 152-163
    • Sharp, J.1    Frame, J.2    Siegenthaler, M.3
  • 59
    • 0026639037 scopus 로고
    • Evidence of subclinical brain influence in clinically complete spinal cord injury: Discomplete SCI
    • Sherwood A.M., Dimitrijevic M.R., McKay W.B. Evidence of subclinical brain influence in clinically complete spinal cord injury: Discomplete SCI. Journal of the Neurological Sciences 1992, 110:90-98.
    • (1992) Journal of the Neurological Sciences , vol.110 , pp. 90-98
    • Sherwood, A.M.1    Dimitrijevic, M.R.2    McKay, W.B.3
  • 60
    • 0038076000 scopus 로고    scopus 로고
    • Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    • Simonen M., Pedersen V., Weinmann O., et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 2003, 38:201-211.
    • (2003) Neuron , vol.38 , pp. 201-211
    • Simonen, M.1    Pedersen, V.2    Weinmann, O.3
  • 61
    • 75449117162 scopus 로고    scopus 로고
    • Conversion in ASIA impairment scale during the first year after traumatic spinal cord injury
    • Spiess M.R., Muller R.M., Rupp R., et al. Conversion in ASIA impairment scale during the first year after traumatic spinal cord injury. Journal of Neurotrauma 2009, 26:2027-2036.
    • (2009) Journal of Neurotrauma , vol.26 , pp. 2027-2036
    • Spiess, M.R.1    Muller, R.M.2    Rupp, R.3
  • 62
    • 33645949401 scopus 로고    scopus 로고
    • A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats
    • Steward O., Sharp K., Selvan G., et al. A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Experimental Neurology 2006, 198:483-499.
    • (2006) Experimental Neurology , vol.198 , pp. 483-499
    • Steward, O.1    Sharp, K.2    Selvan, G.3
  • 63
    • 38649105790 scopus 로고    scopus 로고
    • A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice
    • Steward O., Sharp K., Yee K.M., et al. A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Experimental Neurology 2008, 209:446-468.
    • (2008) Experimental Neurology , vol.209 , pp. 446-468
    • Steward, O.1    Sharp, K.2    Yee, K.M.3
  • 64
    • 0037414673 scopus 로고    scopus 로고
    • A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat
    • Sung J.K., Miao L., Calvert J.W., et al. A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat. Brain Research 2003, 959:29-38.
    • (2003) Brain Research , vol.959 , pp. 29-38
    • Sung, J.K.1    Miao, L.2    Calvert, J.W.3
  • 65
    • 3042552705 scopus 로고    scopus 로고
    • Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats
    • Tanaka H., Yamashita T., Yachi K., et al. Cytoplasmic p21(Cip1/WAF1) enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 2004, 127:155-164.
    • (2004) Neuroscience , vol.127 , pp. 155-164
    • Tanaka, H.1    Yamashita, T.2    Yachi, K.3
  • 66
    • 0032082502 scopus 로고    scopus 로고
    • Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
    • Thallmair M., Metz G.A., Z'Graggen W.J., et al. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions. Nature Neuroscience 1998, 1:124-131.
    • (1998) Nature Neuroscience , vol.1 , pp. 124-131
    • Thallmair, M.1    Metz, G.A.2    Z'Graggen, W.J.3
  • 67
    • 84858668549 scopus 로고    scopus 로고
    • ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration
    • Tonges L., Koch J.C., Bahr M., et al. ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration. Frontiers in Molecular Neuroscience 2011, 4:39.
    • (2011) Frontiers in Molecular Neuroscience , vol.4 , pp. 39
    • Tonges, L.1    Koch, J.C.2    Bahr, M.3
  • 68
    • 0037038435 scopus 로고    scopus 로고
    • P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    • Wang K.C., Kim J.A., Sivasankaran R., et al. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420:74-78.
    • (2002) Nature , vol.420 , pp. 74-78
    • Wang, K.C.1    Kim, J.A.2    Sivasankaran, R.3
  • 69
    • 0037182860 scopus 로고    scopus 로고
    • Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth
    • Wang K.C., Koprivica V., Kim J.A., et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 2002, 417:941-944.
    • (2002) Nature , vol.417 , pp. 941-944
    • Wang, K.C.1    Koprivica, V.2    Kim, J.A.3
  • 70
    • 33745907828 scopus 로고    scopus 로고
    • In vivo high-resolution MR imaging of neuropathologic changes in the injured rat spinal cord
    • Weber T., Vroemen M., Behr V., et al. In vivo high-resolution MR imaging of neuropathologic changes in the injured rat spinal cord. American Journal of Neuroradiology 2006, 27:598-604.
    • (2006) American Journal of Neuroradiology , vol.27 , pp. 598-604
    • Weber, T.1    Vroemen, M.2    Behr, V.3
  • 72
    • 0036897583 scopus 로고    scopus 로고
    • A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
    • Wong S.T., Henley J.R., Kanning K.C., et al. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nature Neuroscience 2002, 5:1302-1308.
    • (2002) Nature Neuroscience , vol.5 , pp. 1302-1308
    • Wong, S.T.1    Henley, J.R.2    Kanning, K.C.3
  • 73
    • 0037071537 scopus 로고    scopus 로고
    • The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho
    • Yamashita T., Higuchi H., Tohyama M. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. The Journal of Cell Biology 2002, 157:565-570.
    • (2002) The Journal of Cell Biology , vol.157 , pp. 565-570
    • Yamashita, T.1    Higuchi, H.2    Tohyama, M.3
  • 74
    • 12844272145 scopus 로고    scopus 로고
    • Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo
    • Zheng B., Atwal J., Ho C., et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:1205-1210.
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , pp. 1205-1210
    • Zheng, B.1    Atwal, J.2    Ho, C.3
  • 75
    • 0038414519 scopus 로고    scopus 로고
    • Lack of enhanced spinal regeneration in Nogo-deficient mice
    • Zheng B., Ho C., Li S., et al. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 2003, 38:213-224.
    • (2003) Neuron , vol.38 , pp. 213-224
    • Zheng, B.1    Ho, C.2    Li, S.3
  • 76
    • 77954912826 scopus 로고    scopus 로고
    • Anti-Nogo on the go: From animal models to a clinical trial
    • Zorner B., Schwab M.E. Anti-Nogo on the go: From animal models to a clinical trial. Annals of the New York Academy of Sciences 2010, 1198(Suppl. 1):E22-E34.
    • (2010) Annals of the New York Academy of Sciences , vol.1198 , Issue.SUPPL. 1
    • Zorner, B.1    Schwab, M.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.