DNA damage in alzheimer disease lymphocytes and its relation to premature centromere division

Neurodegenerative Diseases

Volumn 12, Issue 3, 2013, Pages 156-163

  Živković, Lada ^a   Spremo Potparević, Biljana ^a   Siedlak, Sandra L ^c   Perry, George ^c   Plećaš Solarović, Bosiljka ^a   Milićević, Zorana ^b   Bajić, Vladan P ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA damage; Peripheral blood lymphocytes; Premature centromere division; Sporadic Alzheimer disease

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CENTROMERE; CHROMOSOMAL INSTABILITY; CLINICAL ARTICLE; COMET ASSAY; CONTROLLED STUDY; CYTOGENETICS; DNA DAMAGE; FEMALE; HUMAN; HUMAN CELL; MALE; PERIPHERAL LYMPHOCYTE; PREMATURE CENTROMERE DIVISION; PRIORITY JOURNAL; SEX DIFFERENCE; X CHROMOSOME; BLOOD SAMPLING; LYMPHOCYTE; MAJOR CLINICAL STUDY; MELTING POINT; PATHOGENESIS; SYSTEMIC DISEASE; YOUNG ADULT;

DNA;

EID: 84884289680     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000346114     Document Type: Article

References (57)

1. Spremo-Potparevic B, Zivkovic L, Plecas-Solarovic B, Bajic V: Chromosome instability in Alzheimer's disease. Arch Biol Sci 2011; 63: 603-608.
2. Potter H: Review and hypothesis: Alzheimer disease and Down syndrome-chromosome 21 nondisjunction may underlie both disorders. Am J Hum Genet 1991; 48: 1192-1200.
3. Iourov IY, Liehr T, Vorsanova SG, Kolotii AD, Yurov YB: Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB). Chromosome Res 2006; 14: 223-229.
4. Iourov IY, Vorsanova SG, Liehr T, Yurov YB: Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning. Neurobiol Dis 2009; 34: 212-220.
5. Spremo-Potparevic B, Zivkovic L, Djelic N, Plecas-Solarovic B, Smith MA, Bajic V: Premature centromere division of the X chromosome in neurons in Alzheimer's disease. J Neurochem 2008; 106: 2218-2223.
6. Spremo-Potparevic B, Zivkovic L, Djelic N, Bajic V: Analysis of premature centromere division (PCD) of the X chromosome in Alzheimer patients through the cell cycle. Exp Gerontol 2004; 39: 849-854.
7. Zivkovic L, Spremo-Potparevic B, Plecas-Solarovic B, Djelic N, Ocic G, Smiljkovic P, Siedlak SL, Smith MA, Bajic V: Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age. J Gerontol A Biol Sci Med Sci 2010; 65: 1269-1274.
8. Migliore L, Testa A, Scarpato R, Pavese N, Petrozzi L, Bonuccelli U: Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease. Hum Genet 1997; 101: 299-305.
9. Geller LN, Potter H: Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease. Neurobiol Dis 1999; 6: 167-179.
10. Arendt T: Cell cycle activation and aneuploid neurons in Alzheimer's disease. Mol Neurobiol 2012; 46: 125-135.
11. Granic A, Padmanabhan J, Norden M, Potter H: Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP. Mol Biol Cell 2010; 21: 511-520.
12. Kormann-Bortolotto MH, de Arruda Cardoso Smith M, Toniolo Neto J: Alzheimer's disease and ageing: a chromosomal approach. Gerontology 1993; 39: 1-6.
13. Zekanowski C, Wojda U: Aneuploidy, chromosomal missegregation, and cell cycle reentry in Alzheimer's disease. Acta Neurobiol Exp 2009; 69: 232-253.
14. Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T: Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci 2007; 27: 6859-6867.
15. Thomas P, Fenech M: Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis 2008; 23: 57-65.
16. Migliore L, Botto N, Scarpato R, Petrozzi L, Cipriani G, Bonuccelli U: Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients. Cytogenet Cell Genet 1999; 87: 41-46.
17. Boeras DI, Granic A, Padmanabhan J, Crespo NC, Rojiani AM, Potter H: Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy. Neurobiol Aging 2008; 29: 319-328.
18. Borysov SI, Granic A, Padmanabhan J, Walczak CE, Potter H: Alzheimer A disrupts the mitotic spindle and directly inhibits mitotic microtubule motors. Cell Cycle 2011; 10: 1397-1410.
19. Zivkovic L, Spremo-Potparevic B, Djelic N, Bajic V: Analysis of premature centromere division (PCD) of the chromosome 18 in peripheral blood lymphocytes in Alzheimer disease patients. Mech Ageing Dev 2006; 127: 892-896.
20. Fitzgerald PH, Archer SA, Morris CM: Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD). Hum Genet 1986; 72: 58-62.
21. Mehes K, Buhler EM: Premature centromere division: a possible manifestation of chromosome instability. Am J Med Genet 1995; 56: 76-79.
22. Bajic VP, Spremo-Potparevic B, Zivkovic L, Djelic N, Smith MA: Is the time dimension of the cell cycle re-entry in AB regulated by centromere cohesion dynamics? Biosci Hypotheses 2008; 1: 156-161.
23. Bajic VP, Spremo-Potparevic B, Zivkovic L, Bonda DJ, Siedlak SL, Casadesus G, Lee HG, Smith MA: The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging? Med Hypotheses 2009; 73: 917-920.
24. Bajic VP, Bonda DJ, Zivkovic L, Milicevic Z, Plecas-Solarovic B, Zhu X, Spremo-Potparevic B: The role of centromere cohesion and associated proteins in Alzheimer's disease: a relation to aneuploidy? In: de Rossi S, Bianchi F (eds): Aneuploidy: Etiology, Disorders and Risk Factors. New York: Nova Science Publishers, Inc. 2012.
25. Smith MA: Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss! J Alzheimers Dis 2006; 9: 305-308.
26. Cecchi C, Fiorillo C, Sorbi S, Latorraca S, Nacmias B, Bagnoli S, Nassi P, Liguri G: Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic Biol Med 2002; 33: 1372-1379.
27. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA: Mitochondrial abnormalities in Alzheimer's disease. J Neurosci 2001; 21: 3017-3023.
28. Migliore L, Fontana I, Trippi F, Colognato R, Coppede F, Tognoni G, Nucciarone B, Siciliano G: Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients. Neurobiol Aging 2005; 26: 567-573.
29. Kadioglu E, Sardas S, Aslan S, Isik E, Esat Karakaya A: Detection of oxidative DNA damage in lymphocytes of patients with Alzheimer's disease. Biomarkers 2004; 9: 203-209.
30. Pratico D: Peripheral biomarkers of oxidative damage in Alzheimer's disease: the road ahead. Neurobiol Aging 2005; 26: 581-583.
31. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
32. Singh NP, McCoy MT, Tice RR, Schneider EL: A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-191.
33. Anderson D, Yu TW, Phillips BJ, Schmezer P: The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay . Mutat Res 1994; 307: 261-271.
34. Retana-Ugalde R, Altamirano-Lozano M, Mendoza-Núnez VM: Is there a similarity between DNA damage in adults with chronic alcoholism and community-dwelling healthy older adults? Alcohol 2007; 42: 64-69.
35. Evans HJ, O'Riordan ML: Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests. Mutat Res 1975; 31: 135-148.
36. Fitzgerald PH: A mechanism of X chromosome aneuploidy in lymphocytes of aging women. Human Genetics 1975; 28: 153-158.
37. Migliore L, Coppede F: Genetic and environmental factors in cancer and neurodegenerative diseases. Mutat Res 2002; 512: 135-153.
38. Turker MS: Somatic cell mutations: can they provide a link between aging and cancer? Mech Ageing Dev 2000; 117: 1-19.
39. Bonda DJ, Bajic VP, Spremo-Potparevic B, Casadesus G, Zhu X, Smith MA, Lee HG: Review: cell cycle aberrations and neurodegeneration. Neuropathol Appl Neurobiol 2010; 36: 157-163.
40. Brasnjevic I, Hof PR, Steinbusch HW, Schmitz C: Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair 2008; 7: 1087-1097.
41. Mladinic M, Kopjar N, Milic M, Dasovic AB, Huzak M, Zeljezic D: Genomic instability in a healthy elderly population: a pilot study of possible cytogenetic markers related to ageing. Mutagenesis 2010; 25: 455-462.
42. Zhu X, Lee HG, Perry G, Smith MA: Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 2007; 1772: 494-502.
43. Heintz N: Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem Sci 1993; 18: 157-159.
44. Feddersen RM, Ehlenfeldt R, Yunis WS, Clark HB, Orr HT: Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice. Neuron 1992; 9: 955-966.
45. Moh C, Kubiak JZ, Bajic VP, Zhu X, Smith MA, Lee HG: Cell cycle deregulation in the neurons of Alzheimer's disease. Results Probl Cell Differ 2011; 53: 565-576.
46. Westra JW, Barral S, Chun J: A reevaluation of tetraploidy in the Alzheimer's disease brain. Neurodegener Dis 2009; 6: 221-229.
47. Bergman M, Salman H, Beloosesky Y, Djaldetti M, Bessler H: Are peripheral blood cells from patients with Alzheimer disease more sensitive to apoptotic stimuli? Alzheimer Dis Assoc Disord 2002; 16: 156-160.
48. Gabbita SP, Lovell MA, Markesbery WR: Increased nuclear DNA oxidation in the brain in Alzheimer's disease. J Neurochem 1998; 71: 2034-2040.
49. Lovell MA, Gabbita SP, Markesbery WR: Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF. J Neurochem 1999; 72: 771-776.
50. Mecocci P, Polidori MC, Ingegni T, Cherubini A, Chionne F, Cecchetti R, Senin U: Oxidative damage to DNA in lymphocytes from AD patients. Neurology 1998; 51: 1014-1017.
51. Migliore L, Coppede F, Fenech M, Thomas P: Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis 2011; 26: 85-92.
52. Coppede F, Migliore L: DNA repair in premature aging disorders and neurodegeneration. Curr Aging Sci 2010; 3: 3-19.
53. Humphreys V, Martin RM, Ratcliffe B, Duthie S, Wood S, Gunnell D, Collins AR: Age-related increases in DNA repair and antioxidant protection: a comparison of the Boyd Orr Cohort of elderly subjects with a younger population sample. Age Ageing 2007; 36: 521-526.
54. Mecocci P, MacGarvey U, Beal MF: Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 1994; 36: 747-751.
55. Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF: Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol 2002; 59: 794-798.
56. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 2001; 60: 759-767.
57. Morocz M, Kalman J, Juhasz A, Sinko I, Mc- Glynn AP, Downes CS, Janka Z, Rasko I: Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease. Neurobiol Aging 2002; 23: 47-53.