Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction

Molecular Oncology

Volumn 7, Issue 5, 2013, Pages 907-916

  Wang, Ji Ying ^a   Yu, Pei ^a   Chen, Shuying ^a   Xing, Haiyan ^a   Chen, Yirui ^a   Wang, Min ^a   Tang, Kejing ^a   Tian, Zheng ^a   Rao, Qing ^a   Wang, Jianxiang ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Bone marrow microenvironment; Chemotherapy resistance; Leukemia; Migration; Quiescence; Rho GTPase

Indexed keywords

CD34 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1C; PROTEIN P21; PROTEIN P27; RAC1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER PATIENT; CELL CYCLE; CELL HOMING; CELL MIGRATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; MYELOID LEUKEMIA; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REDUCTION; STEM CELL NICHE; TUMOR MICROENVIRONMENT;

BONE MARROW MICROENVIRONMENT; CHEMOTHERAPY RESISTANCE; LEUKEMIA; MIGRATION; QUIESCENCE; RHO GTPASE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELLS, CULTURED; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKEMIA; MICE; MICE, SCID; RAC1 GTP-BINDING PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84884287297     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2013.05.001     Document Type: Article

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