Reduced systemic toxicity and preserved vestibular toxicity following co-treatment with nitriles and CYP2E1 inhibitors: A mouse model for hair cell loss

JARO - Journal of the Association for Research in Otolaryngology

Volumn 14, Issue 5, 2013, Pages 661-671

  Saldaña Ruíz, Sandra ^a,b   Boadas Vaello, Pere ^c   Sedó Cabezón, Lara ^a,b   Llorens, Jordi ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c UNIVERSITY OF GIRONA   (Spain)

Author keywords

allylnitrile; cis crotononitrile; hair cell ablation; mouse; ototoxicity; vestibular toxicity

Indexed keywords

1,2 DICHLOROETHYLENE; ALLYL CYANIDE; CROTONONITRILE; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; DIALLYLSULFIDE; NITRILE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL LOSS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HAIR CELL; MALE; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TOXICITY; UTRICLE; VESTIBULAR DISORDER; VESTIBULAR FUNCTION;

ALLYL COMPOUNDS; ANIMALS; BEHAVIOR, ANIMAL; CELL DEATH; CYTOCHROME P-450 CYP2E1; DEAFNESS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HAIR CELLS, VESTIBULAR; MALE; MICE; MICE, 129 STRAIN; MICROSCOPY, ELECTRON, SCANNING; NITRILES; SULFIDES; VESTIBULAR FUNCTION TESTS; VESTIBULE, LABYRINTH;

EID: 84884261959     PISSN: 15253961     EISSN: 14387573     Source Type: Journal    
DOI: 10.1007/s10162-013-0399-7     Document Type: Article

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