Pathology of the rat vestibular sensory epithelia during subchronic 3,3′-iminodipropionitrile exposure: Hair cells may not be the primary target of toxicity

Acta Neuropathologica

Volumn 102, Issue 4, 2001, Pages 339-348

  Seoane, A ^a   Dememes D ^b   Llorens, J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSERM   (France)

Author keywords

Axonopathy; Cell death; Nerve terminals; Nitriles; Ototoxicity

Indexed keywords

3,3' IMINODIPROPIONITRILE; DRINKING WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SWELLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; HAIR CELL; INTERCELLULAR SPACE; LONG TERM EXPOSURE; MALE; NERVE ENDING; NEUROEPITHELIUM; NEUROTOXICITY; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT; RAT STRAIN; SENSORY NERVE; TARGET CELL; UTRICLE; VESTIBULE;

EID: 0034832209     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010100387     Document Type: Article

References (27)

1. Intermediate filaments in the newborn inner ear of the mouse
2. Cytoskeletal organization of the human inner ear
3. The iminodipropionitrile (IDPN)-induced dyskinetic syndrome: Behavioral and biochemical pharmacology
4. Axonal lesions and waltzing syndrome after IDPN administration in rats. With a concept - "Axostasis"
5. The axonal pathology in chronic IDPN intoxication
6. Neurofilament proteins form an annular superstructure in guinea-pig type I vestibular hair cells
7. Action de l'amino-dipropionitrile sur le comportement moteur de la souris blanche
8. Sodium transfer from endolymph through a luminal amiloride-sensitive channel
9. The pathophysiology of proximal neurofilamentous giant axonal swellings: Implications for the pathogenesis of amyotrophic lateral sclerosis
10. Slow axonal transport of neurofilament proteins: Impairment by β,β′-iminodipropionitrile administration
11. Cochlear innervation in the developing rat: An immunocytochemical study of neuro-filament and spectrin proteins
12. Development of degenerative muscle weakness by chronic administration of β,β′-iminodipropionitrile in the drinking water to rats: A model for motorneuropathy
13. Ultrastructural changes of the vestibular sensory organs after streptomycin application on the lateral canal
14. Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear
15. Hair cell degeneration resulting from 3,3′-iminodipropionitrile toxicity in the rat vestibular epithelia
16. 3,3′-Iminodipropionitrile induces neurofilament accumulations in the perikarya of rat vestibular ganglion neurons
17. Comparison of behavioral, vestibular, and axonal effects of subchronic IDPN in the rat
18. The behavioral syndrome caused by 3,3′-iminodipropionitrile and related nitriles in the rat is associated with degeneration of the vestibular sensory hair cells
19. Behavioral disturbances and vestibular pathology following crotonitrile exposure in rats
20. Apoptosis, oncosis, and necrosis. An overview of cell death
21. The neurofilament infrastructure of a developing presynaptic calyx
22. Neurofilament accumulation induced in synapses by leupeptin
23. Lathyrism
24. Glutamatergic receptors regulate expression, phosphorylation and accumulation of neurofilaments in spinal cord neurons
25. Cytoskeletal proteins at the cholinergic synapse: Distribution of desmin, actin, fodrin, neurofilaments, and tubulin in Torpedo electric organ
26. Morphology of the vestibular sense organ
27. Studies on the ocular changes of experimental lathyrism: Electron microscopic observations on epithelial, stromal and endothelial cells of β,β′-iminodipropionitrile (IDPN)-treated rat cornea