Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

Oncotarget

Volumn 4, Issue 7, 2013, Pages 1065-1074

  Beebe, Kristin ^a   Mollapour, Mehdi ^a,f   Scroggins, Bradley ^a   Prodromou, Chrisostomos ^b   Xu, Wanping ^a   Tokita, Mari ^a   Taldone, Tony ^c   Pullen, Lester ^d   Zierer, Bettina K ^e   Lee, Min Jung ^a   Trepel, Jane ^a   Buchner, Johannes ^e   Bolon, Daniel ^d   Chiosis, Gabriela ^c   Neckers, Leonard ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Drug binding; Hsp90; Hsp90 inhibitor; Phosphorylation; Posttranslational modification

Indexed keywords

ANSAMYCIN DERIVATIVE; ANTINEOPLASTIC AGENT; BENZOQUINONE; CHAPERONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; PU H71; PURINE DERIVATIVE; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; 9H PURINE 9 PROPANAMINE, 6 AMINO 8 ((6 IODO 1,3 BENZODIOXOL 5 YL)THIO) N (1 METHYLETHYL); 9H-PURINE-9-PROPANAMINE, 6-AMINO-8-((6-IODO-1,3-BENZODIOXOL-5-YL)THIO)-N-(1-METHYLETHYL)-; BENZOQUINONE DERIVATIVE; MACROCYCLIC LACTAM;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER SURVIVAL; DIMERIZATION; DRUG BINDING; DRUG POTENCY; DRUG TARGETING; HUMAN; HUMAN CELL; MOLECULAR LIBRARY; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; TUMOR CELL CULTURE; TUMOR CELL LINE;

BENZODIOXOLES; BENZOQUINONES; BINDING SITES; CELL LINE, TUMOR; HEK293 CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PURINES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 84884253288     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1099     Document Type: Article

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