Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma L929 by enhancing reactive oxygen species generation

Journal of Pharmacological Sciences

Volumn 108, Issue 1, 2008, Pages 32-39

  Wu, Jin Nan ^a   Huang, Jian ^a   Yang, Jia ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bcl 2; L929; Oridonin; Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE INHIBITOR; LACTATE DEHYDROGENASE; ORIDONIN; PHOSPHOPROTEIN 53; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ASSAY; ENZYME INHIBITION; FIBROSARCOMA; GROWTH INHIBITION; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RABDOSIA; RABDOSIA RUBESCENCES;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL DEATH; CELL LINE; DITERPENES, KAURANE; ENZYME INHIBITORS; FIBROBLASTS; GENES, BCL-2; INDICATORS AND REAGENTS; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MICE; MITOCHONDRIAL MEMBRANES; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 52949092696     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0072079     Document Type: Article

References (26)

1. Meier P, Finch A, Evan G. Apoptosis in development. Nature. 2000;407:796-801.
2. Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: A link between cancer genetics and chemotherapy. Cell. 2002;108: 153-164.
3. Gougeon ML. Programmed cell death in HIV infection: dysregulation of Bcl-2 and Fas pathway and contribution to AIDS. Psychoneuroendocrinology. 1997;22:33-39.
4. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med. 1997;3:614-619.
5. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1311.
6. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995;80: 293-299.
7. Lukianova NI, Kulik GL, Chehun VF. Role of the p53 and bcl-2 genes in apoptosis and drug resistance of tumors. Vopr Onkol. 2000;46:121-128.
8. Schuler M, Bossy-Wetzel E, Goldstein JC, Fitzgerald P, Green DR. P53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem. 2000;275: 7337-7342.
9. Kajimoto S, Takanashi N, Kajimoto T, Xu M, Cao J, Masuda Y, et al. Sophoranone, extracted from a tradional Chineses medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores. Int J Cancer. 2002;99:879-890.
10. Li XT, Lin C, Li PY. Characteristics of cytostatic effect of oridonin in vitro. Acta Pharmacol Sin. 1986;7:361-363.
11. Fuji K, Node M, Ito N, Fujita E, Takeda S, Unemi N. Antitumor activity of diterpenoids from Rabdosia shikokiana var. occidentails. Chem Pharm Bull. 1989;33:1038-1042.
12. Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K, Itokawa H, et al. Antibacteria trichorabdal diterpenes from Rabdosia trichocarpa. Phytochemistry. 1994;36:1287-1291.
13. Vercanmmen D, Beyaert R, Denecker G. Inhibition of caspases increase the sensitivity of L929 cells to necrosis mediated by Tumor Necrosis Factor. J Exp Med. 1998;187:1477-1485.
14. Goossens V, Stange G, Moens K, Pipeleers D, Grooten J. Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I. Antioxid Redox Signa. 1999;1:285-295.
15. Zhang CL, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. Biol Pharm Bull. 2004;27:1527-1531.
16. Huang J, Wu LJ, Tashiro S, Onodera S, Ikejima T. The augmentation of TNFα-induced cell death in murine L929 fibrosarcoma by the pan-caspas inhibitor z-vad-fmk through pre-mitochondrial and MAPK-dependent pathways. Acta Media Okayama. 2005;53:253-260.
17. Huang J, Wu LJ, Tashiro S, Onodera S, Ikejima T. Fibroblast growth factor-2 suppresses oridonin-Induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinosiotol 3-kinase-independent Pathway. J Pharmacol Sci. 2006;102:305-313.
18. Fujia E, Nagao Y, Kohno T, Matsuda M, Ozaki M. Antitumor activity of acylated oridonin. Chen Pharm Bull. 1981;29:3208-3213.
19. Villa P, Kaufmann SH, Earnshaw WC. Caspase and caspase inhibitors. Trend Biochem Sci. 1997;22:388-393.
20. Prabhakaran K, Li L, Borowitz JL, Isom GE. Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation. Toxicol Appl Pharmacol. 2004;195:194-202.
21. Nakamura T, Sakamoto K. Reactive oxygen species up-regulates cyclooxygenase-2, p53, and Bax mRNA expression in bovine luteal cells. Biochem Biophys Res Commun. 2001;284:203-210.
22. Tan S, Sagara Y, Liu YB, Maher P, Schubert D. The regulation of reactive oxygen species production during programmed cell death. J Cell Biol. 1998;14:1423-1432.
23. Mcneill-Blue C, Wetmore BA, Sanchez JF, Freed WJ, Merrick BA. Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine. Brain Res. 2006;1112:1-15.
24. Yamaguchi T, Miki Y, Yoshida K. Protein kinase Cδ activates IκB-kinase α to induce the p53 tumor suppressor in response to oxidative stress. Cell Signal. 2007;19:2088-2097.
25. Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A, et al. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell. 2002;13:978-988.
26. Wang KK. Calpain and caspase: can you tell the difference? Trends Neurosci. 2000;23:20-26.