Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

International Journal of Molecular Medicine

Volumn 29, Issue 4, 2012, Pages 649-655

  Gao, Feng Hou ^a   Liu, Feng ^a   Wei, Wei ^a   Liu, Li Bin ^b   Xu, Mang Hua ^a   Guo, Zhu Ying ^a   Li, Wei ^b   Jiang, Bin ^a   Wu, Ying Li ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Colorectal cancer; Hydrogen peroxide; Oridonin; Senescence

Indexed keywords

ACETYLCYSTEINE; BETA GALACTOSIDASE; GLUTATHIONE; HYDROGEN PEROXIDE; LIPOCORTIN 5; ORIDONIN; PROTEIN P16; PROTEIN P53; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL AGING; CELL DEATH; COLON ADENOCARCINOMA; DOWN REGULATION; ENZYME ACTIVITY; ONCOGENE C MYC; PRIORITY JOURNAL; UPREGULATION;

ACETYLCYSTEINE; ANNEXIN A5; APOPTOSIS; BETA-GALACTOSIDASE; CELL AGING; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DITERPENES, KAURANE; DOWN-REGULATION; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; NEOPLASM PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; REACTIVE OXYGEN SPECIES; THIOREDOXIN-DISULFIDE REDUCTASE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84863265308     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.895     Document Type: Article

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