Polymorphisms, de novo lipogenesis, and plasma triglyceride response following fish oil supplementation

Journal of Lipid Research

Volumn 54, Issue 10, 2013, Pages 2866-2873

  Bouchard Mercier, Annie ^a,b   Rudkowska, Iwona ^a,b   Lemieux, Simone ^a   Couture, Patrick ^a,b   Vohl, Marie Claude ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

ACACA; ACLY; Fatty acid biosynthesis; Interindividual variability; Omega 3 polyunsaturated fatty acids; SREBF1

Indexed keywords

CHOLESTEROL; DOCOSAHEXAENOIC ACID; FISH OIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; TRIACYLGLYCEROL;

ACACA GENE; ACLY GENE; ADULT; AGED; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; GENE; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; LIPOGENESIS; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SREBF1 GENE;

ACACA; ACLY; FATTY ACID BIOSYNTHESIS; INTERINDIVIDUAL VARIABILITY; OMEGA-3 POLYUNSATURATED FATTY ACIDS; SREBF1;

ACETYL-COA CARBOXYLASE; ADULT; ATP CITRATE (PRO-S)-LYASE; CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FEMALE; FISH OILS; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LIPOGENESIS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TREATMENT OUTCOME; TRIGLYCERIDES; YOUNG ADULT;

EID: 84884125362     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M041590     Document Type: Article

References (46)

1. Statistics Canada. Leading Causes of Death in Canada. 2009. Accessed November 23, 2012. http://www.statcan.gc.ca/pub/84-215-x/2012001/hl-fs-eng.htm.
2. Morrison, A., and J. E. Hokanson. 2009. The independent relationship between triglycerides and coronary heart disease. Vasc. Health Risk Manag. 5: 89-95.
3. Ninomiya, J. K., G. L'Italien, M. H. Criqui, J. L. Whyte, A. Gamst, and R. S.Chen. 2004. Association of the metabolic syndrome with history of myocardial infarction and stroke in the Third National Health and Nutrition Examination Survey. Circulation. 109: 42-46.
4. Di Angelantonio, A. E., N. Sarwar, P. Perry, S. Kaptoge, K. K. Ray, A. Thompson, A. M. Wood, S. Lewington, N. Sattar, C. J. Packard, et al. 2009. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 302: 1993-2000.
5. Singh, A., A. Schwartzbard, E. Gianos, J. S. Berger, and H. Weintraub. 2013. What should we do about hypertriglyceridemia in coronary artery disease patients? Curr. Treat. Options Cardiovasc. Med. 15: 104-117.
6. Madden, J., C. M. Williams, P. C. Calder, G. Lietz, E. A. Miles, H. Cordell, J. C. Mathers, and A. M. Minihane. 2011. The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. Annu. Rev. Nutr. 31: 203-234.
7. Caslake, M. J., E. A. Miles, B. M. Kofler, G. Lietz, P. Curtis, C. K. Armah, A. C. Kimber, J. P. Grew, L. Farrell, J. Stannard, et al. 2008. Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Am. J. Clin. Nutr. 88: 618-629.
8. Cormier, H., I. Rudkowska, A. M. Paradis, E. Thifault, V. Garneau, S. Lemieux, P. Couture, and M. C. Vohl. 2012. Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation. Nutrients. 4: 1026-1041.
9. Eberle, D., B. Hegarty, P. Bossard, P. Ferre, and F. Foufelle. 2004. SREBP transcription factors: master regulators of lipid homeostasis. Biochimie. 86: 839-848.
10. Xu, J., M. Teran-Garcia, J. H. Park, M. T. Nakamura, and S. D. Clarke. 2001. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J. Biol. Chem. 276: 9800-9807.
11. Tanaka, N., X. Zhang, E. Sugiyama, H. Kono, A. Horiuchi, T. Nakajima, H. Kanbe, E. Tanaka, F. J. Gonzalez, and T. Aoyama. 2010. Eicosapentaenoic acid improves hepatic steatosis independent of PPARalpha activation through inhibition of SREBP-1 maturation in mice. Biochem. Pharmacol. 80: 1601-1612.
12. Chypre, M., N. Zaidi, and K. Smans. 2012. ATP-citrate lyase: a minireview. Biochem. Biophys. Res. Commun. 422: 1-4.
13. Wakil, S. J., J. K. Stoops, and V. C. Joshi. 1983. Fatty acid synthesis and its regulation. Annu. Rev. Biochem. 52: 537-579.
14. Eberle, D., K. Clement, D. Meyre, M. Sahbatou, M. Vaxillaire, G. A. Le, P. Ferre, A. Basdevant, P. Froguel, and F. Foufelle. 2004. SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes. 53: 2153-2157.
15. Zhang, Z., R. R. Gong, J. Du, L. Y. Xiao, W. Duan, X. D. Zhou, and D. Z. Fang. 2011. Associations of the SREBP-1c gene polymorphism with gender-specific changes in serum lipids induced by a high-carbohydrate diet in healthy Chinese youth. Appl. Physiol. Nutr. Metab. 36: 226-232.
16. Grarup, N., K. L. Stender-Petersen, E. A. Andersson, T. Jorgensen, K. Borch-Johnsen, A. Sandbaek, T. Lauritzen, O. Schmitz, T. Hansen, and O. Pedersen. 2008. Association of variants in the sterol regulatory element-binding factor 1 (SREBF1) gene with type 2 diabetes, glycemia, and insulin resistance: a study of 15,734 Danish subjects. Diabetes. 57: 1136-1142.
17. Diaz, F. J., A. Meary, M. J. Arranz, G. Ruano, A. Windemuth, and J. de. Leon. 2009. Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels. Schizophr. Res. 115: 136-140.
18. Goulet, J., G. Nadeau, A. Lapointe, B. Lamarche, and S. Lemieux. 2004. Validity and reproducibility of an interviewer-administered food frequency questionnaire for healthy French-Canadian men and women. Nutr. J. 3: 13-22.
19. Callaway, C. W., W. C. Chumlea, C. Bouchard, J. H. Himes, T. G. Lohman, A. D. Martin, C. D. Mitchell, W. H. Mueller, A. F. Roche, and V. D. Seefeldt. 1988. Standardization of anthropometric measurements. In The Airlie (VA) Consensus Conference. T. Lohman, A. Roche, and R. Martorel, editors. Human Kinetics Publishers, Champaign, IL. 39-80.
20. McNamara, J. R., and E. J. Schaefer. 1987. Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions. Clin. Chim. Acta. 166: 1-8.
21. Burstein, M., and J. Samaille. 1960. On a rapid determination of the cholesterol bound to the serum alpha- and beta-lipoproteins. Clin. Chim. Acta. 5: 609.
22. Albers, J. J., G. R. Warnick, D. Wiebe, P. King, P. Steiner, L. Smith, C. Breckenridge, A. Chow, K. Kuba, S. Weidman, et al. 1978. Multilaboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin. Chem. 24: 853-856.
23. Friedewald, W. T., R. I. Levy, and D. S. Fredrickson. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502.
24. Laurell, C. B. 1966. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal. Biochem. 15: 45-52.
25. Shaikh, N. A., and E. Downar. 1981. Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis. Circ. Res. 49: 316-325.
26. Kroger, E., R. Verreault, P. H. Carmichael, J. Lindsay, P. Julien, E. Dewailly, P. Ayotte, and D. Laurin. 2009. Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging. Am. J. Clin. Nutr. 90: 184-192.
27. Livak, K. J. 1999. Allelic discrimination using fluorogenic probes and the 5 ' nuclease assay. Genet. Anal. 14: 143-149.
28. Reese, M. G., F. H. Eeckman, D. Kulp, and D. Haussler. 1997. Improved splice site detection in Genie. J. Comput. Biol. 4: 311-323.
29. Shapiro, M. B., and P. Senapathy. 1987. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. 15: 7155-7174.
30. Desmet, F. O., D. Hamroun, M. Lalande, G. Collod-Beroud, M. Claustres, and C. Beroud. 2009. Human Splicing Finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res. 37: e67.
31. Yuan, H. Y., J. J. Chiou, W. H. Tseng, C. H. Liu, C. K. Liu, Y. J. Lin, H. H. Wang, A. Yao, Y. T. Chen, and C. N. Hsu. 2006. FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res. 34: W635 - W641.
32. Gao, X., J. Starmer, and E. R. Martin. 2008. A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms. Genet. Epidemiol. 32: 361-369.
33. National Cholesterol Education Program (NCEP) Expert Panel. 2002. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 106: 3143-3421.
34. Rudkowska, I., A. M. Paradis, E. Thifault, P. Julien, O. Barbier, P. Couture, S. Lemieux, and M. C. Vohl. 2012. Differences in metabolomic and transcriptomic profiles between responders and non-responders to an n-3 polyunsaturated fatty acids (PUFAs) supplementation. Genes Nutr. 8: 411-423.
35. Fabbrini, E., B. S. Mohammed, F. Magkos, K. M. Korenblat, B. W. Patterson, and S. Klein. 2008. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology. 134: 424-431.
36. Diraison, F., P. Moulin, and M. Beylot. 2003. Contribution of hepatic de novo lipogenesis and reesterification of plasma non esterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease. Diabetes Metab. 29: 478-485.
37. Vedala, A., W. Wang, R. A. Neese, M. P. Christiansen, and M. K. Hellerstein. 2006. Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans. J. Lipid Res. 47: 2562-2574.
38. Gibbons, G. F., S. M. Bartlett, C. E. Sparks, and J. D. Sparks. 1992. Extracellular fatty acids are not utilized directly for the synthesis of very-low-density lipoprotein in primary cultures of rat hepatocytes. Biochem. J. 287: 749-753.
39. Gibbons, G. F., D. Wiggins, A. M. Brown, and A. M. Hebbachi. 2004. Synthesis and function of hepatic very-low-density lipoprotein. Biochem. Soc. Trans. 32: 59-64.
40. Jump, D. B. 2008. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr. Opin. Lipidol. 19: 242-247.
41. Laudes, M., I. Barroso, J. Luan, M. A. Soos, G. Yeo, A. Meirhaeghe, L. Logie, A. Vidal-Puig, A. J. Schafer, N. J. Wareham, et al. 2004. Genetic variants in human sterol regulatory element binding protein- 1c in syndromes of severe insulin resistance and type 2 diabetes. Diabetes. 53: 842-846.
42. Liu, J. X., J. Liu, P. Q. Li, X. D. Xie, Q. Guo, L. M. Tian, X. Q. Ma, J. P. Zhang, J. Liu, and J. Y. Gao. 2008. Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population. Diabetes Res. Clin. Pract. 82: 42-47.
43. Yin, H. Q., M. Kim, J. H. Kim, G. Kong, K. S. Kang, H. L. Kim, B. I. Yoon, M. O. Lee, and B. H. Lee. 2007. Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol. Appl. Pharmacol. 223: 225-233.
44. NCBI. dbSNP Short Genetic Variations. 2012. Accessed December 11, 2012. http://www.ncbi.nlm.nih.gov/projects/SNP/snpref.cgi?rs=1293329.
45. de Leon, J., J. C. Correa, G. Ruano, A. Windemuth, M. J. Arranz, and F. J. Diaz. 2008. Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophr. Res. 98: 40-46.
46. Harris, W. S., and D. Bulchandani. 2006. Why do omega-3 fatty acids lower serum triglycerides? Curr. Opin. Lipidol. 17: 387-393.