-
1
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes
-
Weyer C., Bogardus C., Mott D.M., and Pratley R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes. J. Clin. Invest. 104 (1999) 787-794
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
2
-
-
0036224883
-
Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity
-
Sinha R., Dufour S., Petersen K.F., LeBon V., Enoksson S., Ma Y.Z., et al. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51 (2002) 1022-1027
-
(2002)
Diabetes
, vol.51
, pp. 1022-1027
-
-
Sinha, R.1
Dufour, S.2
Petersen, K.F.3
LeBon, V.4
Enoksson, S.5
Ma, Y.Z.6
-
3
-
-
0036318319
-
Diabetes: lipotoxicity in human pancreatic islets and the protective effect of metformin
-
Lupi R., Del Guerra S., Fierabracci V., Marselli L., Novelli M., Patanè G., et al. Diabetes: lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 51 Suppl. 1 (2002) S117-S134
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Lupi, R.1
Del Guerra, S.2
Fierabracci, V.3
Marselli, L.4
Novelli, M.5
Patanè, G.6
-
4
-
-
0037303077
-
Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites
-
Lam T.K., van de Werve G., and Giacca A. Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am. J. Physiol. Endocrinol. Metab. 284 (2003) E281-E290
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Lam, T.K.1
van de Werve, G.2
Giacca, A.3
-
5
-
-
0036251153
-
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109 (2002) 1125-1131
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
6
-
-
0036711553
-
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c
-
Foufelle F., and Ferré P. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem. J. 366 (2002) 377-391
-
(2002)
Biochem. J.
, vol.366
, pp. 377-391
-
-
Foufelle, F.1
Ferré, P.2
-
7
-
-
0028960739
-
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
-
Hua X., Wu J., Goldstein J.L., Brown M.S., and Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics 25 (1995) 667-673
-
(1995)
Genomics
, vol.25
, pp. 667-673
-
-
Hua, X.1
Wu, J.2
Goldstein, J.L.3
Brown, M.S.4
Hobbs, H.H.5
-
8
-
-
0031568872
-
Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)
-
Miserez A.R., Cao G., Probst L.C., and Hobbs H.H. Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2). Genomics 40 (1997) 31-40
-
(1997)
Genomics
, vol.40
, pp. 31-40
-
-
Miserez, A.R.1
Cao, G.2
Probst, L.C.3
Hobbs, H.H.4
-
9
-
-
10744230909
-
A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes
-
Demenais F., Kanninen T., Lindgren C.M., Wiltshire S., Gaget S., Dandrieux C., et al. A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes. Hum. Mol. Genet. 12 (2003) 1865-1873
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1865-1873
-
-
Demenais, F.1
Kanninen, T.2
Lindgren, C.M.3
Wiltshire, S.4
Gaget, S.5
Dandrieux, C.6
-
10
-
-
10744222217
-
Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes
-
Laudes M., Barroso I., Luan J., Soos M.A., Yeo G., Meirhaeghe A., et al. Genetic variants in human sterol regulatory element binding protein-1c in syndromes of severe insulin resistance and type 2 diabetes. Diabetes 53 (2004) 842-846
-
(2004)
Diabetes
, vol.53
, pp. 842-846
-
-
Laudes, M.1
Barroso, I.2
Luan, J.3
Soos, M.A.4
Yeo, G.5
Meirhaeghe, A.6
-
11
-
-
3242809742
-
SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts
-
Eberlé D., Clément K., Meyre D., Sahbatou M., Vaxillaire M., Le Gall A., et al. SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes 53 (2004) 2153-2157
-
(2004)
Diabetes
, vol.53
, pp. 2153-2157
-
-
Eberlé, D.1
Clément, K.2
Meyre, D.3
Sahbatou, M.4
Vaxillaire, M.5
Le Gall, A.6
-
12
-
-
34250888726
-
The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population
-
Felder T.K., Oberkofler H., Weitgasser R., Mackevics V., Krempler F., Paulweber B., and Patsch W. The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population. Int. J. Obes. (Lond.) 31 7 (2007) 1099-1103
-
(2007)
Int. J. Obes. (Lond.)
, vol.31
, Issue.7
, pp. 1099-1103
-
-
Felder, T.K.1
Oberkofler, H.2
Weitgasser, R.3
Mackevics, V.4
Krempler, F.5
Paulweber, B.6
Patsch, W.7
-
13
-
-
33749851823
-
Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes
-
Harding A.H., Loos R.J., Luan J., O'Rahilly S., Wareham N.J., and Barroso I. Polymorphisms in the gene encoding sterol regulatory element-binding factor-1c are associated with type 2 diabetes. Diabetologia 49 (2006) 2642-2648
-
(2006)
Diabetologia
, vol.49
, pp. 2642-2648
-
-
Harding, A.H.1
Loos, R.J.2
Luan, J.3
O'Rahilly, S.4
Wareham, N.J.5
Barroso, I.6
-
14
-
-
18944381751
-
SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci
-
Shi Y.Y., and He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15 (2005) 97-98
-
(2005)
Cell Res.
, vol.15
, pp. 97-98
-
-
Shi, Y.Y.1
He, L.2
-
15
-
-
0034210637
-
Translational pathophysiology: a novel molecular mechanism of human disease
-
Cazzola M., and Skoda R.C. Translational pathophysiology: a novel molecular mechanism of human disease. Blood 95 (2000) 3280-3288
-
(2000)
Blood
, vol.95
, pp. 3280-3288
-
-
Cazzola, M.1
Skoda, R.C.2
-
16
-
-
79959524146
-
A haplotype map of the human genome
-
The International HapMap Consortium. A haplotype map of the human genome. Nature 437 (2005) 1299-1320
-
(2005)
Nature
, vol.437
, pp. 1299-1320
-
-
The International HapMap Consortium1
-
17
-
-
30944437450
-
Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man
-
Laaksonen R., Thelen K.M., Päivä H., Matinheikki J., Vesalainen R., Janatuinen T., et al. Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man. Atherosclerosis 185 (2006) 206-209
-
(2006)
Atherosclerosis
, vol.185
, pp. 206-209
-
-
Laaksonen, R.1
Thelen, K.M.2
Päivä, H.3
Matinheikki, J.4
Vesalainen, R.5
Janatuinen, T.6
-
18
-
-
44849113536
-
SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment
-
Berthold H.K., Laaksonen R., Lehtimäki T., Gylling H., Krone W., and Gouni-Berthold I. SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment. Clin. Endocrinol. Diabetes 116 (2008) 262-267
-
(2008)
Clin. Endocrinol. Diabetes
, vol.116
, pp. 262-267
-
-
Berthold, H.K.1
Laaksonen, R.2
Lehtimäki, T.3
Gylling, H.4
Krone, W.5
Gouni-Berthold, I.6
-
19
-
-
0142124790
-
Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
-
Heemers H., Vanderhoydonc F., Roskams T., Shechter I., Heyns W., Verhoeven G., and Swinnen J.V. Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo. Mol. Cell. Endocrinol. 205 (2003) 21-31
-
(2003)
Mol. Cell. Endocrinol.
, vol.205
, pp. 21-31
-
-
Heemers, H.1
Vanderhoydonc, F.2
Roskams, T.3
Shechter, I.4
Heyns, W.5
Verhoeven, G.6
Swinnen, J.V.7
-
20
-
-
2342483040
-
SREBPs suppress IRS-2-mediated insulin signalling in the liver
-
Ide T., Shimano H., Yahagi N., Matsuzaka T., Nakakuki M., Yamamoto T., et al. SREBPs suppress IRS-2-mediated insulin signalling in the liver. Nat. Cell Biol. 6 (2004) 351-357
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 351-357
-
-
Ide, T.1
Shimano, H.2
Yahagi, N.3
Matsuzaka, T.4
Nakakuki, M.5
Yamamoto, T.6
-
21
-
-
0037593946
-
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
-
Wang H., Maechler P., Antinozzi P.A., Herrero L., Hagenfeldt-Johansson K.A., Bjorklund A., and Wollheim C.B. The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J. Biol. Chem. 278 (2003) 16622-16629
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 16622-16629
-
-
Wang, H.1
Maechler, P.2
Antinozzi, P.A.3
Herrero, L.4
Hagenfeldt-Johansson, K.A.5
Bjorklund, A.6
Wollheim, C.B.7
-
22
-
-
19944433866
-
Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells
-
Takahashi A., Motomura K., Kato T., Yoshikawa T., Nakagawa Y., Yahagi N., et al. Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells. Diabetes 54 (2005) 492-499
-
(2005)
Diabetes
, vol.54
, pp. 492-499
-
-
Takahashi, A.1
Motomura, K.2
Kato, T.3
Yoshikawa, T.4
Nakagawa, Y.5
Yahagi, N.6
-
23
-
-
0036228456
-
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor
-
Sewter C., Berger D., Considine R.V., Medina G., Rochford J., Ciaraldi T., et al. Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor. Diabetes 51 (2002) 1035-1041
-
(2002)
Diabetes
, vol.51
, pp. 1035-1041
-
-
Sewter, C.1
Berger, D.2
Considine, R.V.3
Medina, G.4
Rochford, J.5
Ciaraldi, T.6
-
24
-
-
0032933626
-
ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
-
Foretz M., Pacot C., Dugail I., Lemarchand P., Guichard C., Le Lièpvre X., et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell Biol. 19 (1999) 3760-3768
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 3760-3768
-
-
Foretz, M.1
Pacot, C.2
Dugail, I.3
Lemarchand, P.4
Guichard, C.5
Le Lièpvre, X.6
-
25
-
-
0031963963
-
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
-
Kim J.B., Sarraf P., Wright M., Yao K.M., Mueller E., Solanes G., et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Invest. 101 (1998) 1-9
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1-9
-
-
Kim, J.B.1
Sarraf, P.2
Wright, M.3
Yao, K.M.4
Mueller, E.5
Solanes, G.6
-
26
-
-
0037144604
-
Insulin and sterol-regulatory element-binding protein-1c (SREBP-1c) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1c target
-
Le Lay S., Lefrère I., Trautwein C., Dugail I., and Krief S. Insulin and sterol-regulatory element-binding protein-1c (SREBP-1c) regulation of gene expression in 3T3-L1 adipocytes. Identification of CCAAT/enhancer-binding protein beta as an SREBP-1c target. J. Biol. Chem. 277 (2002) 35625-35634
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35625-35634
-
-
Le Lay, S.1
Lefrère, I.2
Trautwein, C.3
Dugail, I.4
Krief, S.5
-
27
-
-
34347406521
-
SREBP-1c transcription factor and lipid homeostasis: clinical perspective
-
Ferré P., and Foufelle F. SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm. Res. 68 2 (2007) 72-82
-
(2007)
Horm. Res.
, vol.68
, Issue.2
, pp. 72-82
-
-
Ferré, P.1
Foufelle, F.2
|