-
1
-
-
0032742992
-
The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes
-
Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes. J Clin Invest 104:787-794, 1999
-
(1999)
J Clin Invest
, vol.104
, pp. 787-794
-
-
Weyer, C.1
Bogardus, C.2
Mott, D.M.3
Pratley, R.E.4
-
2
-
-
0036224883
-
Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity
-
Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S: Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-1027, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1022-1027
-
-
Sinha, R.1
Dufour, S.2
Petersen, K.F.3
LeBon, V.4
Enoksson, S.5
Ma, Y.Z.6
Savoye, M.7
Rothman, D.L.8
Shulman, G.I.9
Caprio, S.10
-
3
-
-
0036318319
-
Diabetes: Lipotoxicity in human pancreatic islets and the protective effect of metformin
-
Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patane G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P: Diabetes: lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 51 (Suppl 1):S134-S117, 2002
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Lupi, R.1
Del Guerra, S.2
Fierabracci, V.3
Marselli, L.4
Novelli, M.5
Patane, G.6
Boggi, U.7
Mosca, F.8
Piro, S.9
Del Prato, S.10
Marchetti, P.11
-
4
-
-
0037303077
-
Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites
-
Lam TK, van de Werve G, Giacca A: Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am J Physiol Endocrinol Metab 284:E281-E290, 2003
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
-
-
Lam, T.K.1
Van De Werve, G.2
Giacca, A.3
-
5
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane bound transcription factor
-
Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane bound transcription factor. Cell 89:331-340, 1997
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
6
-
-
0030782416
-
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver
-
Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, Brown MS: Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc Natl Acad Sci U S A 94:12354-12359, 1997
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 12354-12359
-
-
Shimomura, I.1
Bashmakov, Y.2
Shimano, H.3
Horton, J.D.4
Goldstein, J.L.5
Brown, M.S.6
-
7
-
-
0030007427
-
ADD1/SREBP 1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
-
Kim JB, Spiegelman BM: ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 10:1096-1107, 1996
-
(1996)
Genes Dev
, vol.10
, pp. 1096-1107
-
-
Kim, J.B.1
Spiegelman, B.M.2
-
8
-
-
0036228456
-
Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-α
-
Sewter C, Berger D, Considine RV, Medina G, Rochford J, Ciaraldi T, Henry R, Dohm L, Flier JS, O'Rahilly S, Vidal-Puig AJ: Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-α. Diabetes 51:1035-1041, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1035-1041
-
-
Sewter, C.1
Berger, D.2
Considine, R.V.3
Medina, G.4
Rochford, J.5
Ciaraldi, T.6
Henry, R.7
Dohm, L.8
Flier, J.S.9
O'Rahilly, S.10
Vidal-Puig, A.J.11
-
9
-
-
0032532152
-
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
-
Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS: Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12:3182-3194, 1998
-
(1998)
Genes Dev
, vol.12
, pp. 3182-3194
-
-
Shimomura, I.1
Hammer, R.E.2
Richardson, J.A.3
Ikemoto, S.4
Bashmakov, Y.5
Goldstein, J.L.6
Brown, M.S.7
-
10
-
-
0037205433
-
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice
-
Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N: Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277:19353-19357, 2002
-
(2002)
J Biol Chem
, vol.277
, pp. 19353-19357
-
-
Yahagi, N.1
Shimano, H.2
Hasty, A.H.3
Matsuzaka, T.4
Ide, T.5
Yoshikawa, T.6
Amemiya-Kudo, M.7
Tomita, S.8
Okazaki, H.9
Tamura, Y.10
Iizuka, Y.11
Ohashi, K.12
Osuga, J.13
Harada, K.14
Gotoda, T.15
Nagai, R.16
Ishibashi, S.17
Yamada, N.18
-
11
-
-
0034682474
-
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
-
Kakuma T, Lee Y, Higa M, Wang Z, Pan W, Shimomura I, Unger RH: Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets. Proc Natl Acad Sci U S A 97:8536-8541, 2000
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 8536-8541
-
-
Kakuma, T.1
Lee, Y.2
Higa, M.3
Wang, Z.4
Pan, W.5
Shimomura, I.6
Unger, R.H.7
-
12
-
-
0037593946
-
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction
-
Wang H, Maechler P, Antinozzi PA, Herrero L, Hagenfeldt-Johansson KA, Bjorklund A, Wollheim CB: The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem 278:16622-16629, 2003
-
(2003)
J Biol Chem
, vol.278
, pp. 16622-16629
-
-
Wang, H.1
Maechler, P.2
Antinozzi, P.A.3
Herrero, L.4
Hagenfeldt-Johansson, K.A.5
Bjorklund, A.6
Wollheim, C.B.7
-
13
-
-
0036537888
-
A novel interaction between lamin A and SREBP1: Implications for partial lipodystrophy and other laminopathies
-
Lloyd DJ, Trembath RC, Shackleton S: A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies. Hum Mol Genet 11:769-777, 2002
-
(2002)
Hum Mol Genet
, vol.11
, pp. 769-777
-
-
Lloyd, D.J.1
Trembath, R.C.2
Shackleton, S.3
-
14
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso I, Gurnell M, Crowley VE, Agostini M, Schwabe JW, Soos MA, Maslen GL, Williams TD, Lewis H, Schafer AJ, Chatterjee VK, O'Rahilly S: Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402:880-883, 1999
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.11
O'Rahilly, S.12
-
15
-
-
0344972105
-
ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway
-
Kotzka J, Muller-Wieland D, Koponen A, Njamen D, Kremer L, Roth G, Munck M, Knebel B, Krone W: ADD1/SREBP-1c mediates insulin-induced gene expression linked to the MAP kinase pathway. Biochem Biophys Res Commun 249:375-379, 1998
-
(1998)
Biochem Biophys Res Commun
, vol.249
, pp. 375-379
-
-
Kotzka, J.1
Muller-Wieland, D.2
Koponen, A.3
Njamen, D.4
Kremer, L.5
Roth, G.6
Munck, M.7
Knebel, B.8
Krone, W.9
-
16
-
-
0035048503
-
Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity
-
Smith SR, Lovejoy JC, Greenway F, Ryan D, deJonge L, de la Bretonne J, Volafova J, Bray GA: Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 50:425-435, 2001
-
(2001)
Metabolism
, vol.50
, pp. 425-435
-
-
Smith, S.R.1
Lovejoy, J.C.2
Greenway, F.3
Ryan, D.4
DeJonge, L.5
De La Bretonne, J.6
Volafova, J.7
Bray, G.A.8
-
17
-
-
0030027918
-
Insulin resistance and body fat distribution
-
Yamashita S, Nakamura T, Shimomura I, Nishida M, Yoshida S, Kotani K, Kameda-Takemuara K, Tokunaga K, Matsuzawa Y: Insulin resistance and body fat distribution. Diabetes Care 19:287-291, 1996
-
(1996)
Diabetes Care
, vol.19
, pp. 287-291
-
-
Yamashita, S.1
Nakamura, T.2
Shimomura, I.3
Nishida, M.4
Yoshida, S.5
Kotani, K.6
Kameda-Takemuara, K.7
Tokunaga, K.8
Matsuzawa, Y.9
-
18
-
-
0029972402
-
The regulation of adipose tissue distribution in humans
-
Bjorntorp P: The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 20:291-302, 1996
-
(1996)
Int J Obes Relat Metab Disord
, vol.20
, pp. 291-302
-
-
Bjorntorp, P.1
-
19
-
-
0031739240
-
Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: Relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway
-
Zierath JR, Livingston JN, Thorne A, Bolinder J, Reynisdottir S, Lonnqvist F, Arner P: Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway. Diabetologia 41:1343-1354, 1998
-
(1998)
Diabetologia
, vol.41
, pp. 1343-1354
-
-
Zierath, J.R.1
Livingston, J.N.2
Thorne, A.3
Bolinder, J.4
Reynisdottir, S.5
Lonnqvist, F.6
Arner, P.7
-
20
-
-
0036310157
-
Extreme insulin resistance of the central adipose depot in vivo
-
Mittelman SD, Van Citters GW, Kirkman EL, Bergman RN: Extreme insulin resistance of the central adipose depot in vivo. Diabetes 51:755-761, 2002
-
(2002)
Diabetes
, vol.51
, pp. 755-761
-
-
Mittelman, S.D.1
Van Citters, G.W.2
Kirkman, E.L.3
Bergman, R.N.4
-
21
-
-
0028833867
-
Undiagnosed glucose intolerance in the community: The Isle of Ely Diabetes Project
-
Williams DR, Wareham NJ, Brown DC, Byrne CD, Clark PM, Cox BD, Cox LI, Day NE, Hales CN, Palmer CR, et al: Undiagnosed glucose intolerance in the community: the Isle of Ely Diabetes Project. Diabet Med 12:30-35, 1995
-
(1995)
Diabet Med
, vol.12
, pp. 30-35
-
-
Williams, D.R.1
Wareham, N.J.2
Brown, D.C.3
Byrne, C.D.4
Clark, P.M.5
Cox, B.D.6
Cox, L.I.7
Day, N.E.8
Hales, C.N.9
Palmer, C.R.10
-
22
-
-
0026755807
-
Whole genome amplification from a single cell: Implications for genetic analysis
-
Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N: Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A 89:5847-5851, 1992
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 5847-5851
-
-
Zhang, L.1
Cui, X.2
Schmitt, K.3
Hubert, R.4
Navidi, W.5
Arnheim, N.6
-
23
-
-
4243062602
-
Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
-
Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ: Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol 1:41-55, 2003
-
(2003)
PLoS Biol
, vol.1
, pp. 41-55
-
-
Barroso, I.1
Luan, J.2
Middelberg, R.P.3
Harding, A.H.4
Franks, P.W.5
Jakes, R.W.6
Clayton, D.7
Schafer, A.J.8
O'Rahilly, S.9
Wareham, N.J.10
-
24
-
-
0033058730
-
Fluorescence polarization in homogeneous nucleic acid analysis
-
Chen X, Levine L, Kwok PY: Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res 9:492-498, 1999
-
(1999)
Genome Res
, vol.9
, pp. 492-498
-
-
Chen, X.1
Levine, L.2
Kwok, P.Y.3
-
25
-
-
0032582685
-
Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
-
Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferre P, Dugail I: Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors. J Biol Chem 273:29164-29171, 1998
-
(1998)
J Biol Chem
, vol.273
, pp. 29164-29171
-
-
Boizard, M.1
Le Liepvre, X.2
Lemarchand, P.3
Foufelle, F.4
Ferre, P.5
Dugail, I.6
|