Pulmonary alveolar proteinosis is a disease of decreased availability of GM-CSF rather than an intrinsic cellular defect

Clinical Immunology

Volumn 95, Issue 2, 2000, Pages 85-92

  Thomassen, Mary Jane ^a   Yi, Taolin ^a   Raychaudhuri, Baisakhi ^a   Malur, Anagha ^a   Kavuru, Mani S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Alveolar macrophages; Anti GM CSF antibody; GM CSF; IL 10; Monocytes; Pulmonary alveolar proteinois

Indexed keywords

ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ADULT; ANTIBODY DETECTION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; MALE; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0034087493     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4859     Document Type: Article

References (26)

1. Walters L. C. Chronic alveolar filling disease. Schwarz M., King T. E. Interstitial Lung Disease. 1988;239-281 Decker, Philadelphia.
2. Dranoff G., Crawford A. D., Sadelain M., Ream B., Rashid A., Bronson R. T., Dickersin G. R., Bachurski C. J., Mark E. L., Whitsett J. A., Mulligan R. C. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis. Science. 264:1994;713-716.
3. Stanley E., Lieschke G. J., Grail D., Metcalf D., Hodgson G., Gall J. A. M., Maher D. W., Cebon J., Sinickas V., Dunn A. R. Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc. Natl. Acad. Sci. USA. 91:1994;5592-5596.
4. Reed J. A., Ikegami M., Cianciolo E. R., Lu W., Cho P. S., Hull W., Jobe A. H., Whitsett J. A. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice. Am. J. Physiol. 276:1999;L556-L563.
5. Huffman J. A., Hull W. M., Dranoff G., Mulligan R. C., Whitsett J. A. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice. J. Clin. Invest. 97:1995;649-655.
6. Reed J. A., Whitsett J. A. Granulocyte-macrophage colony-stimulating factor and pulmonary surfactant homeostasis. Proc. Assoc. Am. Physicians. 110:1998;321-332.
7. Golde D. W., Territo M., Finley T. N., Cline M. J. Defective lung macrophages in pulmonary alveolar proteinosis. Ann. Intern. Med. 85:1976;304-309.
8. Thomas E. D., Ramberg R. E., Sale G. E., Sparkes R. S., Golde D. W. Direct evidence for a bone marrow origin of the alveolar macrophage in man. Science. 192:1976;1016-1018.
9. Andreesen R., Brugger W., Scheibenbogen C., Kreutz M., Leser H.-G., Rehm A., Löhr G. W. Surface phenotype analysis of human monocyte to macrophage maturation. J. Leukocyte Biol. 47:1990;490-497.
10. Seymour J. F., Dunn A. R., Vincent J. M., Presneill J. J., Pain M. C. Efficacy of granulocyte-macrophage colony-stimulating factor in acquired alveolar proteinosis [Letter]. N. Engl. J. Med. 335:1996;1924-1925.
11. Kavuru M. S., Sullivan E. J., Piccin R., Thomassen M. J., Stoller J. K. Exogenous granulocyte-macrophage colony-stimulating factor administration for pulmonary alveolar proteinosis. Am. J. Respir. Crit. Care Med., 2000.
12. Seymour J. F., Presneill J. J., Doyle I. R., Vincent J. M., Pain M. C., Downie G. H., Schoch O. D., Moore P. E., Dunn A. R. Therapy of idiopathic acquired alveolar proteinosis with granulocyte-macrophage colony-stimulating factor (GM-CSF) [Abstract]. Am. J. Respir. Crit. Care Med. 159:1999;A705.
13. Kitamura T., Tanaka N., Watanabe J., Uchida K., Kanegasaki S., Yamada Y., Nakata K. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 190:1999;875-880.
14. Tanaka N., Watanabe J., Kitamura T., Yamada Y., Kanegasaki S., Nakata K. Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony-stimulating factor. FEBS Lett. 442:1999;246-250.
15. Thomassen M. J., Buhrow L. T., Connors M. J., Kaneko F. T., Erzurum S. C., Kavuru M. S. Nitric oxide inhibits inflammatory cytokine production by human alveolar macrophages. Am. J. Respir. Cell Mol. Biol. 17:1997;279-283.
16. Yi T. L., Hu X. S., Lin F. Q., Luo P. Characterization of antigens recognized by McAbs against promastigotes of L. donovani Xinjian strain [Chinese]. Ssu Chuan i Hsueh Yuan Hsueh Pao. 16:1985;177-180.
17. Yang W., Tabrizi M., Berrada K., Yi T. SHP-1 phosphatase C-terminus interacts with novel substrates p32/p30 during erythropoietin and interleukin-3 mitogenic responses. Blood. 91:1998;3746-3755.
18. Kitamura T., Tange T., Terasawa T., Chiba S., Kuwaki T., Miyagawa K., Piao Y. F., Miyazono K., Urabe A., Takaku F. Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell Physiol. 140:1989;323-334.
19. Jiao H., Yang W., Berrada K., Tabrizi M., Shultz L., Yi T. Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: Detection of potential HCP substrates in GM-CSF signal transduction. Exp. Hematol. 25:1997;592-600.
20. Tchou-Wong K.-M., Harkin T. J., Chi C., Bodkin M., Rom W. N. GM-CSF gene expression is normal but protein release is absent in a patient with pulmonary alveolar proteinosis. Am. J. Respir. Crit. Care Med. 156:1997;1999-2002.
21. Moore K. W., O'Garra A. de Waal Malefyt, R. Annu. Rev. Immunol. 11:1993;165-190.
22. Thomassen M. J., Divis L. T., Fisher C. J. Regulation of human alveolar macrophage inflammatory cytokine production by interleukin-10. Clin. Immunol. Immunopathol. 80:1996;321-324.
23. Llorente L., Zou W., Levy Y., Richaud-Patin Y., Wijdenes J., Alcocer-Varela J., Morel-Fourrier B., Brouet J., Alcarcon-Segovia D., Galanaud P., Emilie D. Role of interleukin-10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181:1995;839-844.
24. Seymour J. F., Begley C. G., Dirksen U., Presneill J. J., Nicola N. A., Moore P. E., Schoch O. D., van Asperen P., Roth B., Burdach S., Dunn A. R. Attenuated hemapoietic response to granulocyte-macrophage colony-stimulating factor in patients with acquired pulmonary alveolar proteinosis. Blood. 92:1998;2657-2667.
25. Thomassen M. J., Ahmad M., Barna B. P., Antal J., Wiedemann H. P., Meeker D. P., Klein J., Bauer L., Gibson V., Andresen S. Induction of cytokine messenger RNA and secretion in alveolar macrophages and blood monocytes from patients with lung cancer receiving granulocyte-macrophage colony-stimulating factor therapy. Cancer Res. 51:1991;857-862.
26. Thomassen M. J., Barna B. P., Rankin D., Wiedemann H. P., Ahmad M. Differential effect of recombinant granulocyte macrophage colony-stimulating factor on human monocytes and alveolar macrophages. Cancer Res. 49:1989;4086-4089.