Treadmill exercise alleviates aging-induced apoptosis in rat cardiac myocytes

International Journal of Gerontology

Volumn 7, Issue 3, 2013, Pages 152-157

  Ko, Il Gyu ^a,b   Kim, Sung Eun ^b   Kim, Chang Ju ^b   Jee, Yong Seok ^a  

^a Hanseo University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

aging; apoptosis; cardiomyocyte; heat shock protein 70 (HSP70); treadmill exercise

Indexed keywords

HEAT SHOCK PROTEIN 70; PROTEIN BAX; PROTEIN BCL 2; SYNAPTOPHYSIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART FAILURE; HEART MUSCLE CELL; NICK END LABELING; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREADMILL EXERCISE; WESTERN BLOTTING;

EID: 84883829002     PISSN: 18739598     EISSN: 1873958X     Source Type: Journal    
DOI: 10.1016/j.ijge.2013.01.001     Document Type: Article

References (45)

1. D. Lloyd-Jones, R. Adams, and M. Carnethon Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 19 2009 480 486
2. Y. Maejima, S. Adachi, and H. Ito Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage Aging Cell 7 2008 125 136
3. H.N. Sabbah, V.G. Sharov, and S. Goldstein Cell death, tissue hypoxia and the progression of heart failure Heart Fail Rev 5 2000 131 138
4. H. Shih, B. Lee, and R.J. Lee The aging heart and post-infarction left ventricular remodeling J Am Coll Cardiol 57 2011 9 17
5. E.S. Woodle, and S. Kulkarni Programmed cell death Transplantation 66 1998 681 691
6. K. Boengler, R. Schulz, and G. Heusch Loss of cardioprotection with ageing Cardiovas Res 83 2009 247 261
7. Y. Gavrieli, Y. Sherman, and S.A. Ben-Sasson Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J Cell Biol 119 1992 493 501
8. I.G. Ko, M.S. Shin, and B.K. Kim Tadalafil improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils Pharmacol Biochem Behav 91 2009 629 635
9. F.U. Hartl Molecular chaperones in cellular protein folding Nature 381 1996 571 579
10. R. Singh, S. Kolvraa, and S.I. Rattan Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes Front Biosci 1 2007 4504 4513
11. B. Rinaldi, G. Corbi, and S. Boccuti Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart Exp Gerontol 41 2006 764 770
12. F.G. Soufi, S. Farajnia, and N. Aslanabadi Long-term exercise training affects age-induced changes in HSP70 and apoptosis in rat heart Gen Physiol Biophys 27 2008 263 270
13. W. Peng, Y. Zhang, and M. Zheng Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70 Circ Res 106 2010 102 110
14. S.K. Powers, J.C. Quindry, and A.N. Kavazis Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury Free Radic Biol Med 44 2008 193 201
15. T. Zarubin, and J. Han Activation and signaling of the p38 MAP kinase pathway Cell Res 15 2005 11 18
16. V.L. Gabai, A.B. Meriin, and D.D. Mosser Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotolerance J Biol Chem 272 1997 18033 18037
17. J.M. Streicher, S. Ren, and H. Herschman MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart Circ Res 106 2010 1434 1443
18. R.P. Taylor, and J.W. Starnes Age, cell signalling and cardioprotection Acta Physiol Scand 178 2003 107 116
19. J. Díez, M.A. Fortuño, and S. Ravassa Apoptosis in hypertensive heart disease Curr Opin Cardiol 13 1998 317 325
20. T. Kuwana, and D.D. Newmeyer Bcl-2-family proteins and the role of mitochondria in apoptosis Curr Opin Cell Biol 15 2003 691 699
21. O.F. Almeida, G.L. Condé, and C. Crochemore Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate FASEB J 14 2000 779 790
22. S.E. Kim, I.G. Ko, and B.K. Kim Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus Exp Gerontol 45 2010 357 365
23. D. Upadhyay, V. Panduri, and A. Ghio Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria Am J Respir Cell Mol Biol 29 2003 180 187
24. I.A. Alhaddad, I. Hakim, and F. Siddiqi Early exercise after experimental myocardial infarction: effect on left ventricular remodeling Coron Artery Dis 9 1998 319 327
25. J.E. Manson, P. Greenland, and A.Z. LaCroix Walking compared with vigorous exercise for the prevention of cardiovascular events in women N Engl J Med 347 2002 716 725
26. R. Hambrecht, A. Wolf, and S. Gielen Effect of exercise on coronary endothelial function in patients with coronary artery disease N Engl J Med 342 2000 454 460
27. M. Iemitsu, S. Maeda, and S. Jesmin Exercise training improves aging-induced downregulation of VEGF angiogenic signaling cascade in hearts Am J Physiol Heart Circ Physiol 291 2006 H1290 H1298
28. P.A. Ades, and C.E. Coello Effects of exercise and cardiac rehabilitation on cardiovascular outcomes Med Clin North Am 84 2000 251 265
29. S.F. Hsieh, G.C. Hu, and Y.C. Chuang The effects and safety of exercise training in subjects with chronic heart failure - do elder subjects gain similar benefits? Int J Gerontol 4 2010 165 170
30. H.B. Kwak, W. Song, and J.M. Lawler Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart FASEP J 20 2006 791 793
31. P.M. Kang, and S. Izumo Apoptosis and heart failure: a critical review of the literature Cir Res 86 2000 1107 1113
32. J. Kajstura, Y. Liu, and A. Baldini Coronary artery constriction in rats: necrotic and apoptotic myocyte death Am J Cardiol 82 1998 30 41
33. D.T. Loo In situ detection of apoptosis by the TUNEL assay: an overview of techniques Methods Mol Biol 682 2011 3 13
34. D. Zhang, J.L. Mott, and S.W. Chang Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis Genomics 69 2000 151 161
35. S. Phaneuf, and C. Leeuwenburgh Cytochrome c release from mitochondria in the aging heart: a possible mechanism for apoptosis with age Am J Physiol Regul Integr Comp Physiol 282 2002 423 430
36. M. Pollack, S. Phaneuf, and A. Dirks The role of apoptosis in the normal aging brain, skeletal muscle, and heart Ann NY Acad Sci 959 2002 93 107
37. D. Zhang, J.L. Mott, and S.W. Chang Mitochondrial DNA mutations activate programmed cell survival in the mouse heart Am J Physiol Heart Circ Physiol 288 2005 H2476 H2483
38. J. Kajstura, W. Cheng, and R. Sarangarajan Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats Am J Physiol 271 1996 1215 1228
39. M.S. Marber, R. Mestril, and S.H. Chi Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury J Clin Invest 95 1995 1446 1456
40. N.B. Radford, M. Fina, and I.J. Benjamin Cardioprotective effects of 70-kDa heat shock protein in transgenic mice Proc Natl Acad Sci USA 93 1996 2339 2342
41. Y. Zhao, W. Wang, and L. Qian Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosis Cell Stress Chaperones 12 2007 83 95
42. M. Morán, J. Delgado, and B. González Responses of rat myocardial antioxidant defences and heat shock protein HSP72 induced by 12 and 24-week treadmill training Acta Physiol Scand 180 2004 157 166
43. H.Y. Sun, N.P. Wang, and M. Halkos Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways Apoptosis 11 2006 1583 1593
44. H. Aceros, G. Farah, and L. Cobos-Puc Moxonidine improves cardiac structure and performance in SHR through inhibition of cytokines, p38 MAPK and Akt Br J Pharmacol 164 2011 946 957
45. Z. Sun, J. Zhang, and J. Zhang Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase Biochem Biophys Res Commun 409 2011 52 57