IL-17/Th17 mediated synovial inflammation is IL-22 independent

Annals of the Rheumatic Diseases

Volumn 72, Issue 10, 2013, Pages 1700-1707

  Van Hamburg, Jan Piet ^a   Corneth, Odilia B J ^a   Paulissen, Sandra M J ^a   Davelaar, Nadine ^a   Asmawidjaja, Patrick S ^a   Mus, Adriana M C ^a   Lubberts, Erik ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 6; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; STROMELYSIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SELECTION; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVITIS; T LYMPHOCYTE; WILD TYPE;

CYTOKINES; INFLAMMATION; RHEUMATOID ARTHRITIS; SYNOVITIS; T CELLS;

ADULT; AGED; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; COCULTURE TECHNIQUES; FEMALE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; INTERLEUKIN-8; INTERLEUKINS; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE AGED; RECEPTORS, CCR6; SYNOVITIS; TH17 CELLS; UP-REGULATION; YOUNG ADULT;

EID: 84883824319     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202373     Document Type: Article

References (50)

1. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011;365:2205-19.
2. Isaacs JD. The changing face of rheumatoid arthritis: sustained remission for all? Nature Rev 2010;10:605-11.
3. McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nature Rev 2007;7:429-42. (Pubitemid 46834849)
4. Lubberts E. Th17 cytokines and arthritis. Semin Immunopathol 2010;32:43-53.
5. Lubberts E. IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis? Cytokine 2008;41:84-91.
6. McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity 2008;28:445-53. (Pubitemid 351467042)
7. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009;361:888-98.
8. Korn T, Bettelli E, Oukka M, et al. IL-17 and Th17 cells. Annu Rev Immunol 2009;27:485-517.
9. Cornelissen F, van Hamburg JP, Lubberts E. The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis. Curr Opin Investig Drugs 2009;10:452-62.
10. Annunziato F, Cosmi L, Liotta F, et al. Type 17T helper cells-origins, features and possible roles in rheumatic disease. Nature Rev 2009;5:325-31.
11. Shen H, Goodall JC, Gaston JS Hill. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum 2009;60:1647-56.
12. Leipe J, Grunke M, Dechant C, et al. Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum 2010;62:2876-85.
13. Nistala K, Moncrieffe H, Newton KR, et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 2008;58:875-87. (Pubitemid 351364887)
14. van Hamburg JP, Asmawidjaja PS, Davelaar N, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 2011;63:73-83.
15. Lubberts E, Joosten LA, Oppers B, et al. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol 2001;167:1004-13. (Pubitemid 32660858)
16. Nakae S, Nambu A, Sudo K, et al. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171:6173-7. (Pubitemid 37467240)
17. van Hamburg JP, Asmawidjaja PS, Davelaar N, et al. TNF blockade requires 1,25 (OH)2D3 to control human Th17-mediated synovial inflammation. Ann Rheum Dis 2012;71:606-12.
18. Ouyang W, Rutz S, Crellin NK, et al. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu Rev Immunol 2011;29: 71-109.
19. Eyerich S, Eyerich K, Cavani A, et al. IL-17 and IL-22: siblings, not twins. Trends Immunol 2010;31:354-61.
20. Sonnenberg GF, Fouser LA, Artis D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nature Immunol 2011;12:383-90.
21. Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007;445:648-51. (Pubitemid 46232884)
22. Akdis M, Palomares O, van de Veen W, et al. T(H)17 and T(H)22 cells: a confusion of antimicrobial response with tissue inflammation versus protection. J Allergy Clin Immunol 2012;129:1438-49.
23. Wolk K, Witte E, Witte K, et al. Biology of interleukin-22. Semin Immunopathol 2010;32:17-31.
24. Rubino SJ, Geddes K, Girardin SE. Innate IL-17 and IL-22 responses to enteric bacterial pathogens. Trends Immunol 2012;33:112-18.
25. Eyerich S, Eyerich K, Pennino D, et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009;119:3573-85.
26. Veldhoen M, Hirota K, Westendorf AM, et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 2008;453:106-9. (Pubitemid 351630329)
27. Trifari S, Kaplan CD, Tran EH, et al. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nature Immunol 2009;10:864-71.
28. Duhen T, Geiger R, Jarrossay D, et al. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nature Immunol 2009;10:857-63.
29. Colin EM, Asmawidjaja PS, van Hamburg JP, et al. 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 2010;62: 132-42.
30. Zhang L, Li YG, Li YH, et al. Increased Frequencies of Th22 Cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS One 2012;7:e31000.
31. Mitra A, Raychaudhuri SK, Raychaudhuri SP. Functional role of IL-22 in psoriatic arthritis. Arthritis Res Ther 2012;14:R65.
32. Zhang L, Li JM, Liu XG, et al. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J Clin Immunol 2011;31:606-14.
33. Leipe J, Schramm MA, Grunke M, et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann Rheum Dis 2011;70:1453-7.
34. da Rocha LF Jr, Duarte AL, Dantas AT, et al. Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity. J Rheumatol 2012;39:1320-5.
35. Ikeuchi H, Kuroiwa T, Hiramatsu N, et al. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 2005;52:1037-46. (Pubitemid 40530109)
36. Geboes L, Dumoutier L, Kelchtermans H, et al. Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum 2009;60:390-5.
37. Ouyang W. Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine Growth Factor Rev 2010;21:435-41.
38. Van Belle AB, de Heusch M, Lemaire MM, et al. IL-22 is required for imiquimodinduced psoriasiform skin inflammation in mice. J Immunol 2012;188:462-9.
39. Kreymborg K, Etzensperger R, Dumoutier L, et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J Immunol 2007;179:8098-104.
40. Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008;29:947-57.
41. van Hamburg JP, Mus AM, de Bruijn MJ, et al. GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum 2009;60:750-9.
42. Cornelissen F, Mus AM, Asmawidjaja PS, et al. Interleukin-23 is critical for full-blown expression of a non-autoimmune destructivearthritis and regulates interleukin-17A and RORgammat in gammadelta T cells. Arthritis Res Ther 2009;11:R194.
43. Marijnissen RJ, Koenders MI, Smeets RL, et al. Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis Rheum 2011;63:2939-48.
44. Kim KW, Kim HR, Park JY, et al. Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts. Arthritis Rheum 2012;64:1015-23.
45. van Hamburg JP, de Bruijn MJ, Ribeiro de Almeida C, et al. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol 2008;38:2573-86.
46. Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol 2011;23:159-63.
47. Ouyang W. Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine Growth Factor Rev 2010;21:435-41.
48. Mastelic B, do Rosario AP, Veldhoen M, et al. IL-22 protects against liver pathology and lethality of an experimental blood-stage malaria infection front immunol 2012;3:85.
49. Takahashi K, Hirose K, Kawashima S, et al. IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. J Allergy Clin Immunol 2011;128:1067-76.
50. Taube C, Tertilt C, Gyulveszi G, et al. IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease. PLoS One 2011;6:e21799.