Preventive effect of garlic (Allium sativum L.) on serum biochemical factors and histopathology of pancreas and liver in streptozotocin-induced diabetic rats

Iranian Journal of Pharmaceutical Research

Volumn 12, Issue 3, 2013, Pages 325-338

  Masjedi, Fatemeh ^a   Gol, Ali ^b   Dabiri, Shahriar ^c  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

^c KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes; Garlic; Hepatic enzymes; Histopathology; Serum lipids

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GARLIC EXTRACT; GLUCOSE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLORIMETRY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG HYDROLYSIS; GARLIC; HISTOPATHOLOGY; LIVER; LYMPHOCYTIC INFILTRATION; MALE; NONHUMAN; PANCREAS; RAT; STREPTOZOCIN DIABETES;

EID: 84883800283     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. American Association of Diabetes Educators. Intensive diabetes management: implications of the DCCT and UKPDS. Diabetes Educator (2002) 28: 735-740.
2. Nathan DM. Long-term complications of diabetes mellitus. N. Engl. J. Med. (1993) 328: 1676-1685.
3. Kar A, Choudhary BK and Bandyopadhyay NG. Preliminary studies on the inorganic constituents of some indigenous hypoglycaemic herbs on oral glucose tolerance test. J. Ethnopharmacol. (1999) 64: 179-184.
4. nd ed. International Diabetes Federation, Brussels (2003) 15-71.
5. Marix J. Unravelling the causes of diabetes. Science (2002) 295: 686-689.
6. Kasiviswanath R, Ramesh A and Kumar KE. Hypoglycemic and antihyperglycemic effect of Gmelina asiatica Linn. in normal and in alloxan induced diabetic rats. Biol. Pharm. Bull. (2005) 28: 729-732.
7. Mazloom Z, Yousefnejad A and Dabbaghmanesh MH. Effect of probiotics on lipid profle, glycemic control, insulin action, oxidative stress, and infammatory markers in patients with type 2 diabetes: a clinical trial. Iranian J. Med. Sci. (2013) 38: 38-43.
8. Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA and Inge KE. Health benefts of herbs and spices: the past, the present, the future. Med. J. Aust. (2006) 185: 4-24.
9. Reaven E, Wright D, Mondon CE, Solomon R, Ho H and Reaven GM. Effect of age and diet on insulin secretion and insulin action in the rat. Diabetes (1983) 32: 175-180.
10. Rajani Kanth V, Uma Maheswara Reddy P and Raju TN. Attenuation of streptozotocin-induced oxidative stress in hepatic and intestinal tissues of Wistar rat by methanolic-garlic extract. Acta Diabetol. (2008) 45: 243-251.
11. Agarwal KC. Therapeutic actions of garlic constituents. Med. Res. Rev. (1996) 16: 111-124.
12. Augusti KT. Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). Indian J. Exp. Biol. (1996) 34: 634-640.
13. Jain RC, Vyas CR and Mahatma OP. Hypoglycemic action of onion and garlic. Lancet (1973) 2: 1491.
14. Jain RC and Vyas CR. Garlic in alloxan-induced diabetic rabbits. Am. J. Clin. Nutr. (1975) 28: 684-685.
15. Augusti KT and Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Exprientia (1996) 52: 115-120.
16. Sheela CG and Augusti KT. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. (1992) 30: 523-526.
17. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council (NRC). Guide for the Care and Use of Laboratory Animals. National Academy Press, Washington DC. (1985).
18. El-Demerdash FM, Yousef MI and Abou El-Naga NI. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem. Toxicol. (2005) 43: 57-63.
19. Yamatani K, Marubashi S, Wakasugi K, Saito K, Sato N, Takahashi K and Sasaki H. Catecholamine-induced cAMP response in Streptozotocin-induced diabetic rat liver. Tohoku J. Exp. Med. (1994) 173: 311-320.
20. Sorg DA and Buckner B. A simple method of obtaining venous blood from small animals. Proc. Sec. Exp. Med. (1964) 115: 1131-1132.
21. Soudamani S, Yuvaraj S, Malini T and Balasubramanian K. Experimental diabetes has adverse effects on the differentiation of ventral prostate during sexual maturation of rats. Anat. Rec. Part A (2005) 287: 1281-1289.
22. Anwar MM and Meki AR. Oxidative stress in Streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp. Biochem. Physiol. (2003) 135: 539-547.
23. Swanston-Flatt SK, Day C, Bailey CJ and Flatt PR. Traditional plant treatments for diabetes. Studies in normal and Streptozotocin diabetic mice. Diabetologia (1990) 33: 462-464.
24. Baluchnejadmojarad T and Roghani M. Endothelium-dependent and-independent effect of aqueous extract of garlic on vascular reactivity on diabetic rats. Fitoterapia (2003) 74: 630-637.
25. Baluchnejadmojarad T and Roghani M. Garlic extract attenuates time-dependent changes in the reactivity of isolated aorta in Streptozotocin-diabetic rats. Life Sci. (2003) 73: 2281-2289.
26. Mathew PT and Augusti KT. Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes. I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. Indian J. Biochem. Biophys. (1973) 10: 209-212.
27. Augusti KT and Mathew PT. Effect of allicin on certain enzymes of liver after a short term feeding to normal rats. Experientia (1975) 31: 148-149.
28. Fehresti Sani M, Montasser Kouhsari Sh and Moradabadi L. Effects of three medicinal plants extracts in experimental diabetes: antioxidant enzymes activities and plasma lipids profles in comparison with Metformin. Iran. J. Pharm. Res. (2012) 11: 897-903.
29. Schwartz CJ, Valente AJ and Sprague EA. A modern view of atherogenesis. Am. J. Cardiol. (1993) 71: 9-14.
30. Khalili A, Nekooeian AA, Khosravi MB and Fakher S. Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. Int. J. Exp. Pathol. (2012) 93: 210-217.
31. Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV and Orekhov AN. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol. (2008) 45: 1-6.
32. Basheeruddin Asdaqa SM and Inamdarb MN. Interaction of Propranolol with garlic on biochemical and histological changes in rat. Iran. J. Pharm. Res. (2009) 8: 201-207.
33. Watala C and Winocour PD. The relationship of chemical modifcation of membrane proteins and lipoproteins to reduced membrane fuidity of erythrocytes from diabetic subjects. Eur. J. Clin. Chem. Clin. Biochem. (1992) 30: 513-519.
34. Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab. Rev. (1998) 14: 263-283.
35. nd ed. Williams and Wilkins, Baltimore (1996) 135-212.
36. Lawson LD and Hughes BG. Characterization of the formation of allicin and other thiosulfnates from garlic. Planta Med. (1992) 58: 345-350.
37. Plengvidhya C, Chinayon S, Sitprija S, Pasatrat S and TunkYoon M. Effects of spray dried garlic preparation on primary hyperlipoproteinaemia. J. Med. Assoc. Thailand (1988) 71: 248-252.
38. Bordia A, Verma SK and Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fbrinogen, and fbrinolytic activity in patients with coronary artery disease. Prostag. Leukotr. Ess. (1998) 58: 257-263.
39. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the german association of general practitioners' multicentric placebo-controlled double-blind study. Arzneim. Forsch. Drug Res. (1990) 40: 1111-1116.
40. Yeh YY and Yeh SM. Garlic reduce plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids (1994) 29: 189-193.
41. Yeh YY, Lin RI, Yeh SM and Evens S. Garlic reduce plasma cholesterol in hypercholesterolemic men maintaining habitual diets. In: Ohigashi H, Osawa T, Terao J, Watanabe S and Toshikawa T. (eds.) Food Factors for Cancer Prevention. Springer, Tokyo (1997) 226-230.
42. Liu L and Yeh YY. Water-Soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride syntheses in cultured rat hepatocytes. Lipids (2001) 36: 395-400.
43. Isaacsohn JL, Moser M, Stein EA, Dudley K, Davey JA, Liskov E and Black HR. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Arch. Intern. Med. (1998) 158: 1189-1194.
44. Superko HR and Krauss RM. Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein (a). J. Am. Coll. Cardiol. (2000) 35: 321-326.
45. rd ed. Williams and Wilkins, Philadelphia (2001) 1870-1885.
46. Doi K, Yamanouchi J, Kume E and Yasoshima A. Morphologic changes in hepatocyte nuclei of Streptozotocin (SZ)-induced diabetic mice. Exp. Toxicol. Pathol. (1997) 49: 295-299.
47. rd ed. Churchill Livingston, Edinburgh (1993).
48. Jamshidzadeh A, Khoshnood MJ, Dehghani Z and Niknahad H. Hepatoprotective activity of Cichorium intybus L. leaves extract against carbon tetrachloride induced toxicity. Iran. J. Pharm. Res. (2006) 1: 41-46.
49. th ed. McGraw-Hill, New York (2001) 1399.
50. Noorafshan A, Esmail-Zadeh B, Bahmanpour S and Poost-Pasand A. Early stereological changes in liver of Sprague-Dawley rats after streptozotocin injection. Indian J. Gastroenterol. (2005) 24: 104-107.
51. Damasceno DC, Volpato GT, Paranhos-Calderon M and Cunha-Rudge MV. Oxidative stress and diabetes in pregnant rats. Anim. Reprod. Sci. (2002) 15: 235-544.
52. Gul M, Laaksonen DE, Atalay M, Vider L and Hanninen O. Effects of endurance training on tissue glutathione homeostasis and lipid peroxidation in streptozotocin-induced diabetic rats. Scand. J. Med. Sci. Sports (2002) 12: 163-170.
53. Ahn T, Yun CH and Oh DB. Tissue-specifc effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats. Toxicol. Lett. (2006) 166: 27-36.
54. Raza H, Prabu SK, Robin MA and Avadhani NG. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in Streptozotocin-induced diabetic rats: Tissue-specifc variations and roles in oxidative stress. Diabetes (2004) 53: 185-194.
55. Liu CT, Wong PL, Lii CK, Hse H and Sheen LY. Antidiabetic effect of garlic oil but not diallyl disulfde in rats with streptozotocin induced diabetes. Food Chem. Toxicol. (2006) 44: 1377-1384.
56. Borek C. Antioxidant health effects of aged garlic extract. J. Nutr. (2001) 131: 1010-1015.
57. Prakasam A, Sethupathy S and Pugalendi KV. Infuence of Casearia esculenta root extract on protein metabolism and marker enzymes in streptozotocin-induced diabetic rats. Pol. J. Pharmacol. (2004) 56: 587-593.
58. Bopanna KN, Kannan J, Godgil S, Balaraman R and Rathod SP. Antidiabetic and antihyperlipidemic effects of neem seed kernel powder on alloxan diabetic rabbits. Indian J. Pharmacol. (1997) 29: 162-172.
59. Eskander EF, Jun HW, Ibrahim KA and Abdelal WE. Hypoglycaemic effect of a herbal formulation in alloxan induced diabetic rats. Egypt J. Pharm. Sci. (1995) 36: 253-270.
60. Ohaeri OC. Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Biosci. Reprod. (2001) 21: 19-24.
61. Nakagawa S, Yoshida S, Hirao Y, Kasuga S and Fuwa T. Cytoprotective activity of components of garlic, ginseng and ciuwjia on hepatocyte injury induced by carbon tetrachloride in-vitro. Hiroshima J. Med. Sci. (1985) 34: 303-309.
62. Bonnevie-Nielsen V, Steffes MW and Lernmark AA. Major loss in islet mass and B-cells function precedes hyperglycemia in mice given multiple low doses of streptozotocin. Diabetes (1981) 30: 424-429.