Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride syntheses in cultured rat hepatocytes

Lipids

Volumn 36, Issue 4, 2001, Pages 395-400

  Liu, Lijuan ^a   Yeh, Yu Yan ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; ENZYME INHIBITION; FATTY ACIDS; SULFUR COMPOUNDS;

HYPOLIPIDEMIC EFFECTS;

LIPIDS;

ACETIC ACID; ALLIIN; FATTY ACID; FATTY ACID SYNTHASE; GAMMA GLUTAMYL S ALLYLCYSTEINE; GAMMA GLUTAMYL S METHYLCYSTEINE; GAMMA GLUTAMYL S PROPYLCYSTEINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ORGANOSULFUR DERIVATIVE; PHOSPHOLIPID; S ALLYL N ACETYLCYSTEINE; S ALLYLCYSTEINE; S ALLYLSULFONYLALANINE; S ETHYLCYSTEINE; S METHYLCYSTEINE; S PROPYLCYSTEINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; GARLIC; LIPID METABOLISM; LIVER CELL; MALE; METABOLIC INHIBITION; NONHUMAN; RAT; SOLUBILITY;

ALLIUM SATIVUM; ANIMALIA;

EID: 0035031160     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-001-0734-4     Document Type: Article

References (39)

1. Steiner, M., and Lin, R.S. (1998) Changes in Platelet Function and Susceptibility of Lipoproteins to Oxidation Associated with Administration of Aged Garlic Extract, J. Cardiovasc. Pharmacol. 31, 904-908.
2. Rahman, K., and Billington, D. (2000) Dietary Supplementation with Aged Garlic Extract Inhibits ADP-Induced Platelet Aggregation in Humans, J. Nutr. 130, 2662-2665.
3. Bordia, T., Mohammed, N., Thomson, M., and Ali, M. (1996) An Evaluation of Garlic and Onion as Antithrombotic Agents, Prostaglandins Leukotrienes Essent. Fatty Acids 54, 183-186.
4. Efendy, J.L., Simmons, D.L., Campbell, G.R., and Campbell, J.H. (1997) The Effect of the Aged Garlic Extract, "Kyolic," on the Development of Experimental Atherosclerosis, Atherosclerosis 132, 37-42.
5. Breithaupt-Grogler, K., Ling, M., Boudoulas, H., and Belz, G.G. (1997) Protective Effect of Chronic Garlic Intake on Elastic Properties of Aorta in the Elderly, Circulation 96, 2649-2655.
6. Munday, J.S., James, K.A., Fray, L.M., Kirkwood, S.W., and Thompson, K.G. (1999) Daily Supplementation with Aged Garlic Extract, but not Raw Garlic, Protects Low Density Lipoprotein Against in Vitro Oxidation, Atherosclerosis 143, 399-404.
7. Chi, M.S., Koh, E.T., and Stewart, T.J. (1982) Effects of Garlic on Lipid Metabolism in Rats Fed Cholesterol or Lard, J. Nutr. 112, 241-248.
8. Qureshi, A.A., Abuirmeileh, N., Din, Z.Z., Elson, C.E., and Burger, W.C. (1983) Inhibition of Cholesterol and Fatty Acid Biosynthesis in Liver Enzymes and Chicken Hepatocytes by Polar Fractions of Garlic, Lipids 18, 343-348.
9. Qureshi, A.A., Din, Z.Z., Abuirmeileh, N., Burger, W.C., Ahmad, Y., and Elson, C.E. (1983) Suppression of Avian Hepatic Lipid Metabolism by Solvent Extracts of Garlic: Impact on Serum Lipids, J. Nutr. 113, 1746-1755.
10. Yeh, Y-Y., and Yeh, S.-M. (1994) Garlic Reduces Plasma Lipids by Inhibiting Hepatic Cholesterol and Triacylglycerol Synthesis, Lipids 29, 189-193.
11. Jain, R.C. (1977) Effect of Garlic on Serum Lipids, Coagulability and Fibrinolytic Activity of Blood, Am. J. Clin. Nutr. 30, 1380-1381.
12. Steiner, M., Khan, A.H., Holbert, D., and Lin, R.I. (1996) A Double-Blind Crossover Study in Moderately Hypercholesterolemic Men That Compared the Effect of Aged Garlic Extract and Placebo Administration on Blood Lipids, Am. J. Clin. Nutr. 64, 866-870.
13. Yeh, Y.-Y., Lin, R.I., Yeh, S.-M., and Evens, S. (1997) Garlic Reduces Plasma Cholesterol in Hypercholesterolemic Men Maintaining Habitual Diets, in Food Factors for Cancer Prevention (Ohigashi, H., Osawa, T., Terao, J., Watanabe, S., and Toshikawa, T., eds.). pp. 226-230, Springer, Tokyo.
14. Bordia, A., Verma, S.K., and Srivastava, K.C. (1998) Effect of Garlic (Allium sativum) on Blood Lipids, Blood Sugar, Fibrinogen, and Fibrinolytic Activity in Patients with Coronary Artery Disease, Prostaglandins Leukotrienes Essent. Fatty Acids 58, 257-263.
15. Berthold, H.K., Sudhop, T., and von Bergmann, K. (1998) Effect of a Garlic Oil Preparation on Serum Lipoproteins and Cholesterol Metabolism: A Randomized Controlled Trial, JAMA 279, 1900-1902.
16. Isaacsohn, J.L., Moser, M., Stein, E.A., Dudley, K., Davey, J.A., Liskov, E., and Black, H.R. (1998) Garlic Powder and Plasma Lipids and Lipoproteins: A Multicenter, Randomized, Placebo-Controlled Trial, Arch. Intern. Med. 158, 1189-1194.
17. Superko, H.R., and Krauss, R.M. (2000) Garlic Powder, Effect on Plasma Lipids, Postprandial Lipemia, Low-Density Lipoprotein Particle Size, High-Density Lipoprotein Subclass Distribution and Lipoprotein(a), J. Am. Coll. Cardiol. 35, 321-326.
18. Agarwal, K.C. (1996) Therapeutic Actions of Garlic Constituents, Med. Res. Rev. 16, 111-124.
19. Lawson, L.D. (1993) Bioactive or Organosulfur Compounds of Garlic and Garlic Products: Role on Reducing Blood Lipids, in Human Medicinal Agents from Plants (Kinghorn, A.D., and Balandrin, M.F., eds.) pp. 306-330, American Chemical Society, Washington, DC.
20. Pentz, R., and Siegers, C.P. (1996) Garlic Preparations: Methods for Qualitative and Quantitative Assessment of Their Ingredients, in Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species, 2nd edn. (Koch, H.P., and Lawson, L.D., eds.) pp. 109-134, Williams and Wilkins, Baltimore.
21. Matsuura, H. (1997) Phytochemistry of Garlic Horticultural and Processing Procedures, in Nutraceuticals: Designer Foods III Garlic, Soy, and Licorice (Lachance, P.A., ed.) pp. 55-69, Food and Nutrition Press, Inc., Trumbull.
22. Liu, L., and Yeh, Y.-Y. (2000) Inhibition of Cholesterol Biosynthesis by Organosulfur Compounds Derived from Garlic, Lipids 35, 197-203.
23. Mirhadi, S.A., Ahuja, S.P., and Gupta, P.P. (1983) Effect of Garlic (Allium sativum L.) on the Lipid Composition and Lipid Biosynthesis in Tissues of Rabbits During Experimental Atherosclerosis, J. Nuclear Agric. Biol. 12, 33-37.
24. Steiner, G., and Lewis, G.F. (1996) Hyperinsulinemia and Triglyceride-Rich Lipoproteins, Diabetes 45 (Suppl. 3), S24-S26.
25. Folch, J., Lees, M., and Sloane Stanley, G.H. (1957) A Simple Method for the Isolation and Purification of Total Lipids from Animal Tissues, J. Biol. Chem. 226, 497-510.
26. Kuksis, A. (1978) Separation and Determination of Structure of Fatty Acids, in Handbook of Lipid Research (Hanahan, D.J., ed.), Fatty Acids and Glycerides (Kuksis, A., ed.), Vol. 1, pp. 1-76, Plenum Press, New York.
27. Yeh, Y.-Y., Streuli, V.L., and Zee, P. (1977) Relative Utilization of Fatty Acids for Synthesis of Ketone Bodies and Complex Lipids in the Liver of Developing Rats, Lipids 12, 367-374.
28. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein Measurement with the Folin Phenol Reagent, J. Biol. Chem. 193, 265-275.
29. Kelley, D.S., Nelson, G.J., and Hunt, J.E. (1986) Effect of Prior Nutritional Status on the Activity of Lipogenic Enzymes in Primary Monolayer Cultures of Rat Hepatocytes, Biochem. J. 235, 87-90.
30. Eder, K., and Kirchgessner, M. (1998) The Effect of Dietary Vitamin E Supply and a Moderately Oxidized Oil on Activities of Hepatic Lipogenic Enzymes in Rats, Lipids 33, 277-283.
31. Nepokroeff, C.M., Lakshmanan, M.R., and Porter, J.W. (1975) Fatty-Acid Synthase from Rat Liver, Methods Enzymol. 35, 37-44.
32. Deutsch, J. (1983) Glucose-6-phosphate Dehydrogenase, in Methods of Enzymatic Analysis, 3rd edn. (Bergmeyer, H.U., Bergmeyer, J., and Grassl, M., eds.), pp. 190-196, Verlag Chemie, Weinheim.
33. Castelli, W.P. (1986) The Triglyceride Issue: A View from Framingham, Am. Heart J. 112, 432-437.
34. Krauss, R.M. (1998) Triglycerides and Atherogenic Lipoproteins: Rationale for Lipoprotein Management, Am. J. Med. 105 (1A), 58S-62S.
35. Mader, F.H. (1990) Treatment of Hyperlipidaemia with Garlic-Powder Tablets. Evidence from the German Association of General Practitioners' Multicentric Placebo-Controlled Double-Blind Study, Arzneim. Forsch. 40, 1111-1116.
36. Jamdar, S.C., and Cao, W.F. (1995) Triacylglycerol Biosynthetic Enzymes in Lean and Obese Zucker Rats, Biochim. Biophys. Acta 1255, 237-243.
37. Lawson, L.D. (1996) The Composition and Chemistry of Garlic Cloves and Processed Garlic, in Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species, 2nd edn. (Koch, H.P., and Lawson, L.D., eds.) pp. 37-107, Williams and Wilkins, Baltimore.
38. Chait, A., Albers, J.J., and Brunzell, J.D. (1980) Very Low Density Lipoprotein Overproduction in Genetic Forms of Hypertriglyceridaemia, Eur. J. Clin. Invest. 10, 17-22.
39. Warshafsky, S., Kamer, R.S., and Sivak, S.L. (1993) Effect of Garlic on Total Serum Cholesterol. A Meta Analysis, Ann. Intern. Med. 119, 599-605.