DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts

Aging Cell

Volumn 12, Issue 5, 2013, Pages 923-931

  Gómez Cabello, Daniel ^a,c   Adrados, Isabel ^a   Gamarra, David ^a,d   Kobayashi, Hikaru ^a   Takatsu, Yoshihiro ^b   Takatsu, Kyoko ^b   Gil, Jesús ^b   Palmero, Ignacio ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^d CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

DGCR8; Fibroblasts; MicroRNA; P21CIP1; P53; Senescence

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; DGCR8 PROTEIN; MICRORNA; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOGENESIS; CELL CYCLE ARREST; CELLS; CONTROLLED STUDY; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA SYNTHESIS; SENESCENCE;

MURINAE;

DGCR8; FIBROBLASTS; MICRORNA; P21CIP1; P53; SENESCENCE;

CELL AGING; CELL GROWTH PROCESSES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FIBROBLASTS; GENE KNOCKOUT TECHNIQUES; HEK293 CELLS; HUMANS; MICRORNAS; PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84883765312     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12117     Document Type: Article

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