Presynaptic dopamine modulation by stimulant self-administration

Frontiers in Bioscience - Scholar

Volumn 5 S, Issue 1, 2013, Pages 261-276

  Espana, Rodrigo A ^a   Jones, Sara R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Amphetamine; Cocaine; Dopamine; Dopamine transporter; Review; Voltammetry

Indexed keywords

AMPHETAMINE; CENTRAL STIMULANT AGENT; COCAINE; DOPAMINE; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; DOPAMINE REUPTAKE TRANSPORTER; DOPAMINE TRANSPORTER; PSYCHOSTIMULANT AGENT; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER; STREET DRUG;

AFFECT; BASOLATERAL AMYGDALA; BRAIN SLICE; CAUDATE PUTAMEN; COCAINE DEPENDENCE; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINE RELEASE; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; FRONTAL CORTEX; GLOBUS PALLIDUS; HIPPOCAMPUS; LATERAL HYPOTHALAMUS; LIMBIC SYSTEM; MEMORY; MESOLIMBIC DOPAMINERGIC SYSTEM; METHAMPHETAMINE DEPENDENCE; MICRODIALYSIS; MOTIVATION; NONHUMAN; NUCLEUS ACCUMBENS; POTENTIOMETRY; PREFRONTAL CORTEX; PUTAMEN; REINFORCEMENT; REVIEW; REWARD; STIMULUS RESPONSE; VENTRAL PALLIDUM; ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; SYNAPTIC TRANSMISSION; SYNAPTOSOME;

ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; LIMBIC SYSTEM; PRESYNAPTIC TERMINALS; SELF ADMINISTRATION; STREET DRUGS; SYNAPTIC TRANSMISSION;

EID: 84883723374     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s371     Document Type: Review

References (140)

1. WL Woolverton, KM Johnson: Neurobiology of cocaine abuse. Trends Pharmacol Sci 13, 193-200 (1992)
2. RA Wise: Neurobiology of addiction. Curr Opin Neurobiol 6, 243-251 (1996)
3. GF Koob, M Le Moal: Drug abuse: hedonic homeostatic dysregulation. Science 278, 52-58 (1997)
4. T Ljungberg, P Apicella, W Schultz: Responses of monkey midbrain dopamine neurons during delayed alternation performance. Brain Res 567, 337-341 (1991)
5. T Ljungberg, P Apicella, W Schultz: Responses of monkey dopamine neurons during learning of behavioral reactions. J Neurophysiol 67, 145-163 (1992)
6. W Schultz, P Apicella, T Ljungberg: Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task. J Neurosci 13, 900-913 (1993)
7. J Mirenowicz, W Schultz: Importance of unpredictability for reward responses in primate dopamine neurons. J Neurophysiol 72, 1024-1027 (1994)
8. JR Hollerman, W Schultz: Dopamine neurons report an error in the temporal prediction of reward during learning. Nat Neurosci 1, 304-309 (1998)
9. A Imperato, G Di Chiara: Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239, 219-228 (1986)
10. G Di Chiara, A Imperato: Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J Pharmacol Exp Ther 244, 1067-1080 (1988)
11. E Carboni, A Imperato, L Perezzani, G Di Chiara: Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats. Neuroscience 28, 653-661 (1989)
12. BW Adams, CW Bradberry, B Moghaddam: NMDA antagonist effects on striatal dopamine release: microdialysis studies in awake monkeys. Synapse 43, 12-18 (2002)
13. J Chen, W Paredes, JH Lowinson, EL Gardner: Delta 9-Tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex. Eur J Pharmacol 190, 259-262 (1990)
14. AC Riegel, A Zapata, TS Shippenberg, ED French: The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons. Neuropsychopharmacology 32, 1558-1569 (2007)
15. A Zocchi, E Girlanda, G Varnier, I Sartori, L Zanetti, GA Wildish, M Lennon, M Mugnaini, CA Heidbreder: Dopamine responsiveness to drugs of abuse: A shell-core investigation in the nucleus accumbens of the mouse. Synapse 50, 293-302 (2003)
16. DW Self, L Stein: The D1 agonists SKF 82958 and SKF 77434 are self-Administered by rats. Brain Res 582, 349-352 (1992)
17. MR Weed, WL Woolverton: The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys. J Pharmacol Exp Ther 275, 1367-1374 (1995)
18. DW Self, JD Belluzzi, S Kossuth, L Stein: Selfadministration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors. Psychopharmacology (Berl) 123, 303-306 (1996)
19. SB Caine, SS Negus, NK Mello, J Bergman: Effects of dopamine D(1-like) and D(2-like) agonists in rats that selfadminister cocaine. J Pharmacol Exp Ther 291, 353-360 (1999)
20. RD Spealman, J Bergman, BK Madras, KF Melia: Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes. J Pharmacol Exp Ther 258, 945-953 (1991)
21. RS Sinnott, RH Mach, MA Nader: Dopamine D2/D3 receptors modulate cocaine's reinforcing and discriminative stimulus effects in rhesus monkeys. Drug Alcohol Depend 54, 97-110 (1999)
22. RS Sinnott, MA Nader: Modulation of cocaine's discriminative stimulus effects by dopamine D(1) agonists in rhesus monkeys. Pharmacol Biochem Behav 68, 301-309 (2001)
23. SB Caine, GF Koob: Effects of dopamine D-1 and D-2 antagonists on cocaine self-Administration under different schedules of reinforcement in the rat. J Pharmacol Exp Ther 270, 209-218 (1994)
24. FJ White, PW Kalivas: Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend 51, 141-153 (1998)
25. PW Kalivas, BA Sorg, MS Hooks: The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol 4, 315-334 (1993)
26. CM Pennartz, HJ Groenewegen, FH Lopes da Silva: The nucleus accumbens as a complex of functionally distinct neuronal ensembles: an integration of behavioural, electrophysiological and anatomical data. Prog Neurobiol 42, 719-761 (1994)
27. S Ikemoto, J Panksepp: The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Brain Res Rev 31, 6-41 (1999)
28. DS Zahm, JS Brog: On the significance of subterritories in the "accumbens" part of the rat ventral striatum. Neuroscience 50, 751-767 (1992)
29. AJ McGeorge, RL Faull: The organization of the projection from the cerebral cortex to the striatum in the rat. Neuroscience 29, 503-537 (1989)
30. HJ Groenewegen, E Vermeulen-Van der Zee, KA te, MP Witter: Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience 23, 103-120 (1987)
31. HJ Groenewegen, HW Berendse, JG Wolters, AH Lohman: The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: evidence for a parallel organization. Prog Brain Res 85, 95-116 (1990)
32. JS Brog, A Salyapongse, AY Deutch, DS Zahm: The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J Comp Neurol 338, 255-278 (1993)
33. CI Wright, AV Beijer, HJ Groenewegen: Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized. J Neurosci 16, 1877-1893 (1996)
34. L Heimer, DS Zahm, L Churchill, PW Kalivas, C Wohltmann: Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience 41, 89-125 (1991)
35. DS Zahm, L Heimer: Specificity in the efferent projections of the nucleus accumbens in the rat: comparison of the rostral pole projection patterns with those of the core and shell. J Comp Neurol 327, 220-232 (1993)
36. I Usuda, K Tanaka, T Chiba: Efferent projections of the nucleus accumbens in the rat with special reference to subdivision of the nucleus: biotinylated dextran amine study. Brain Res 797, 73-93 (1998)
37. RM Carelli, VC King, RE Hampson, SA Deadwyler: Firing patterns of nucleus accumbens neurons during cocaine self-Administration in rats. Brain Res 626, 14-22 (1993)
38. AJ Uzwiak, FX Guyette, MO West, LL Peoples: Neurons in accumbens subterritories of the rat: phasic firing timelocked within seconds of intravenous cocaine self-infusion. Brain Res 767, 363-369 (1997)
39. WA Carlezon, Jr., DP Devine, RA Wise: Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology (Berl) 122, 194-197 (1995)
40. S Ikemoto, BS Glazier, JM Murphy, WJ McBride: Role of dopamine D1 and D2 receptors in the nucleus accumbens in mediating reward. J Neurosci 17, 8580-8587 (1997)
41. PK Hitchcott, GD Phillips: Double dissociation of the behavioural effects of R(+) 7-OH-DPAT infusions in the central and basolateral amygdala nuclei upon Pavlovian and instrumental conditioned appetitive behaviours. Psychopharmacology (Berl) 140, 458-469 (1998)
42. DL McKinzie, ZA Rodd-Henricks, CT Dagon, JM Murphy, WJ McBride: Cocaine is self-Administered into the shell region of the nucleus accumbens in Wistar rats. Ann N Y Acad Sci 877, 788791 (1999)
43. DCS Roberts, ME Corcoran, HC Fibiger: On the role of ascending catecholaminergic systems in intravenous selfadministration of cocaine. Pharmacol Biochem Behav 6, 615-620 (1977)
44. A McGregor, DCS Roberts: Effect of medial prefrontal cortex injections of SCH 23390 on intravenous cocaine self-Administration under both a fixed and progressive ratio schedule of reinforcement. Behav Brain Res 67, 75-80 (1995)
45. GD Carr, NM White: Conditioned place preference from intra-Accumbens but not intra-caudate amphetamine injections. Life Sci 33, 2551-2557 (1983)
46. SE Hemby, GH Jones, JB Justice, Jr., DB Neill: Conditioned locomotor activity but not conditioned place preference following intra-Accumbens infusions of cocaine. Psychopharmacology (Berl) 106, 330336 (1992)
47. S Schildein, A Agmo, JP Huston, RK Schwarting: Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioral activity. Brain Res 790, 185-194 (1998)
48. WH Lyness, NM Friedle, KE Moore: Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-Amphetamine self-Administration. Pharmacol Biochem Behav 11, 553-556 (1979)
49. HO Pettit, A Ettenberg, FE Bloom, GF Koob: Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin selfadministration in rats. Psychopharmacology (Berl) 84, 167-173 (1984)
50. HJ Groenewegen, FT Russchen: Organization of the efferent projections of the nucleus accumbens to pallidal, hypothalamic, and mesencephalic structures: a tracing and immunohistochemical study in the cat. J Comp Neurol 223, 347-367 (1984)
51. S Ikemoto: Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56, 27-78 (2007)
52. SM Boye, RJ Grant, PB Clarke: Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and D-Amphetamine in rats. Neuropharmacology 40, 792-805 (2001)
53. LH Sellings, PB Clarke: Segregation of amphetamine reward and locomotor stimulation between nucleus accumbens medial shell and core. J Neurosci 23, 6295-6303 (2003)
54. Y Li, MJ Acerbo, TE Robinson: The induction of behavioural sensitization is associated with cocaineinduced structural plasticity in the core (but not shell) of the nucleus accumbens. Eur J Neurosci 20, 1647-1654 (2004)
55. HL Alderson, JA Parkinson, TW Robbins, BJ Everitt: The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin selfadministration in rats. Psychopharmacology (Berl) 153, 455-463 (2001)
56. DM Hutcheson, JA Parkinson, TW Robbins, BJ Everitt: The effects of nucleus accumbens core and shell lesions on intravenous heroin self-Administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement. Psychopharmacology (Berl) 153, 464-472 (2001)
57. K McFarland, PW Kalivas: The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 21, 8655-8663 (2001)
58. ZA Rodd-Henricks, DL McKinzie, TK Li, JM Murphy, WJ McBride: Cocaine is self-Administered into the shell but not the core of the nucleus accumbens of Wistar rats. J Pharmacol Exp Ther 303, 1216-1226 (2002)
59. S Ikemoto, M Qin, ZH Liu: The functional divide for primary reinforcement of D-Amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid? J Neurosci 25, 5061-5065 (2005)
60. F Ambroggi, A Ishikawa, HL Fields, SM Nicola: Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons. Neuron 59, 648-661 (2008)
61. SM Nicola: The flexible approach hypothesis: unification of effort and cue-responding hypotheses for the role of nucleus accumbens dopamine in the activation of reward-seeking behavior. J Neurosci 30, 16585-16600 (2010)
62. P Di Ciano, BJ Everitt: Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior. Neuropsychopharmacology 25, 341-360 (2001)
63. SB Floresco, RJ McLaughlin, DM Haluk: Opposing roles for the nucleus accumbens core and shell in cueinduced reinstatement of food-seeking behavior. Neuroscience 154, 877-884 (2008)
64. N Chaudhri, LL Sahuque, WW Schairer, PH Janak: Separable roles of the nucleus accumbens core and shell in context-And cue-induced alcohol-seeking. Neuropsychopharmacology 35, 783-791 (2010)
65. JD Salamone: The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav Brain Res 61, 117-133 (1994)
66. KC Berridge, TE Robinson: What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28, 309-369 (1998)
67. JC Horvitz: Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events. Neuroscience 96, 651-656 (2000)
68. G Di Chiara, V Valentini, S Fenu: Behavioral and neurochemical pharmacology of 5-HT6 receptors related to reward and reinforcement. Int Rev Neurobiol 96, 111-139 (2011)
69. JM Richard, KC Berridge: Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fear. J Neurosci 31, 12866-12879 (2011)
70. BJ Everitt, D Belin, D Economidou, Y Pelloux, JW Dalley, TW Robbins: Review. Neural mechanisms underlying the vulnerability to develop compulsive drugseeking habits and addiction. Philos Trans R Soc Lond B Biol Sci 363, 3125-3135 (2008)
71. MR Hilario, RM Costa: High on habits. Front Neurosci 2, 208-217 (2008)
72. DC Roberts, GF Koob, P Klonoff, HC Fibiger: Extinction and recovery of cocaine self-Administration following 6-hydroxydopamine lesions of the nucleus accumbens. Pharmacol Biochem Behav 12, 781-787 (1980)
73. MC Ritz, RJ Lamb, SR Goldberg, MJ Kuhar: Cocaine receptors on dopamine transporters are related to selfadministration of cocaine. Science 237, 1219-1223 (1987)
74. MJ Kuhar, MC Ritz, JW Boja: The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14, 299-302 (1991)
75. RE Heikkila, H Orlansky, C Mytilineou, G Cohen: Amphetamine: evaluation of d-And l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H norepinephrine in slices of rat neostriatum and cerebral cortex. J Pharmacol Exp Ther 194, 47-56 (1975)
76. D Sulzer, S Rayport: Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action. Neuron 5, 797-808 (1990)
77. D Sulzer, E Pothos, HM Sung, NT Maidment, BG Hoebel, S Rayport: Weak base model of amphetamine action. Ann N Y Acad Sci 654, 525-528 (1992)
78. M Raiteri, F Cerrito, AM Cervoni, G Levi: Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine. J Pharmacol Exp Ther 208, 195202 (1979)
79. Y Schmitz, CJ Lee, C Schmauss, F Gonon, D Sulzer: Amphetamine distorts stimulation-dependent dopamine overflow: effects on D2 autoreceptors, transporters, and synaptic vesicle stores. J Neurosci 21, 5916-5924 (2001)
80. ES Ramsson, CD Howard, DP Covey, PA Garris: High doses of amphetamine augment, rather than disrupt, exocytotic dopamine release in the dorsal and ventral striatum of the anesthetized rat. J Neurochem 119, 1162-1172 (2011)
81. ES Ramsson, DP Covey, DP Daberkow, MT Litherland, SA Juliano, PA Garris: Amphetamine augments action potential-dependent dopaminergic signaling in the striatum in vivo. J Neurochem 117, 937-948 (2011)
82. DJ Michael, RM Wightman: Electrochemical monitoring of biogenic amine neurotransmission in real time. J Pharm Biomed Anal 19, 33-46 (1999)
83. SR Jones, SJ Odell, JF Marshall, RM Wightman: Functional and anatomical evidence for different dopamine dynamics in the core and shell of the nucleus accumbens in slices of rat brain. Synapse 23, 224-231 (1996)
84. EA Budygin, CE John, Y Mateo, SR Jones: Lack of cocaine effect on dopamine clearance in the core and shell of the nucleus accumbens of dopamine transporter knock-out mice. J Neurosci 22, RC222 (2002)
85. Y Mateo, EA Budygin, D Morgan, DCS Roberts, SR Jones: Fast onset of dopamine uptake inhibition by intravenous cocaine. Eur J Neurosci 20, 2838-2842 (2004)
86. CE John, SR Jones: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology 52, 1596-1605 (2007)
87. WJ Wieczorek, ZL Kruk: Differential action of (+)-Amphetamine on electrically evoked dopamine overflow in rat brain slices containing corpus striatum and nucleus accumbens. Br J Pharmacol 111, 829836 (1994)
88. SR Jones, RR Gainetdinov, RM Wightman, MG Caron: Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci 18, 1979-1986 (1998)
89. MM Iravani, ZL Kruk: Effects of amphetamine on carrier-mediated and electrically stimulated dopamine release in slices of rat caudate putamen and nucleus accumbens. J Neurochem 64, 1161-1168 (1995)
90. YL Hurd, U Ungerstedt: Cocaine: an in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum. Synapse 3, 48-54 (1989)
91. B Moghaddam, BS Bunney: Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: comparison to amphetamine. Synapse 4, 156-161 (1989)
92. R Kuczenski, DS Segal, ML Aizenstein: Amphetamine, Cocaine, and Fencamfamine-Relationship Between Locomotor and Stereotypy Response Profiles and Caudate and Accumbens-Dopamine Dynamics. Journal of Neuroscience 11, 2703-2712 (1991)
93. F Weiss, MP Paulus, MT Lorang, GF Koob: Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration. J Neurosci 12, 4372-4380 (1992)
94. RC Pierce, PW Kalivas: Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine. J Pharmacol Exp Ther 275, 1019-1029 (1995)
95. D King, MJ Zigmond, JM Finlay: Effects of dopamine depletion in the medial prefrontal cortex on the stress-induced increase in extracellular dopamine in the nucleus accumbens core and shell. Neuroscience 77, 141-153 (1997)
96. C Heidbreder, J Feldon: Amphetamine-induced neurochemical and locomotor responses are expressed differentially across the anteroposterior axis of the core and shell subterritories of the nucleus accumbens. Synapse 29, 310-322 (1998)
97. CR McKittrick, ED Abercrombie: Catecholamine mapping within nucleus accumbens: differences in basal and amphetamine-stimulated efflux of norepinephrine and dopamine in shell and core. J Neurochem 100, 1247-1256 (2007)
98. PW Kalivas, P Duffy: Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress. Brain Res 675, 325-328 (1995)
99. FE Pontieri, G Tanda, CG Di: Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens. Proc Natl Acad Sci U S A 92, 12304-12308 (1995)
100. JD Sokolowski, AN Conlan, JD Salamone: A microdialysis study of nucleus accumbens core and shell dopamine during operant responding in the rat. Neuroscience 86, 1001-1009 (1998)
101. C Cadoni, M Solinas, CG Di: Psychostimulant sensitization: differential changes in accumbal shell and core dopamine. Eur J Pharmacol 388, 69-76 (2000)
102. M Barrot, M Marinelli, DN Abrous, F Rouge-Pont, MM Le, PV Piazza: The dopaminergic hyperresponsiveness of the shell of the nucleus accumbens is hormone-dependent. Eur J Neurosci 12, 973-979 (2000)
103. FE Pontieri, G Tanda, F Orzi, CG Di: Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 382, 255-257 (1996)
104. JF Marshall, SJ O'Dell, R Navarrete, AJ Rosenstein: Dopamine high-Affinity transport site topography in rat brain: major differences between dorsal and ventral striatum. Neuroscience 37, 11-21 (1990)
105. NS Pilotte, LG Sharpe, SD Rountree, MJ Kuhar: Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse 22, 87-92 (1996)
106. MJ Nirenberg, J Chan, A Pohorille, RA Vaughan, GR Uhl, MJ Kuhar, VM Pickel: The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. J Neurosci 17, 6899-6907 (1997)
107. GF Koob, FE Bloom: Cellular and molecular mechanisms of drug dependence. Science 242, 715723 (1988)
108. RA Wise, P Newton, K Leeb, B Burnette, D Pocock, JB Justice, Jr.: Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine selfadministration in rats. Psychopharmacology (Berl) 120, 10-20 (1995)
109. ND Volkow, GJ Wang, MW Fischman, RW Foltin, JS Fowler, NN Abumrad, S Vitkun, J Logan, SJ Gatley, N Pappas, R Hitzemann, CE Shea: Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386, 827-830 (1997)
110. EA Kiyatkin, DE Kiyatkin, GV Rebec: Phasic inhibition of dopamine uptake in nucleus accumbens induced by intravenous cocaine in freely behaving rats. Neuroscience 98, 729-741 (2000)
111. DK Pitts, J Marwah: Cocaine modulation of central monoaminergic neurotransmission. Pharmacol Biochem Behav 26, 453-461 (1987)
112. LC Einhorn, PA Johansen, FJ White: Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area. J Neurosci 8, 100-112 (1988)
113. K Batsche, MI Granoff, RY Wang: 5-HT3 receptor antagonists fail to block the suppressant effect of cocaine on the firing rate of A10 dopamine neurons in the rat. Brain Res 592, 273-277 (1992)
114. MA Hinerth, HA Collins, M Baniecki, RN Hanson, BL Waszczak: Novel in vivo electrophysiological assay for the effects of cocaine and putative "cocaine antagonists" on dopamine transporter activity of substantia nigra and ventral tegmental area dopamine neurons. Synapse 38, 305-312 (2000)
115. SH Ahmed, D Lin, GF Koob, LH Parsons: Escalation of cocaine self-Administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. J Neurochem 86, 102-113 (2003)
116. RA España, DCS Roberts, SR Jones: Short-Acting cocaine and long-Acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Neuroscience 155, 250-257 (2008)
117. AN Samaha, N Mallet, SM Ferguson, F Gonon, TE Robinson: The rate of cocaine administration alters gene regulation and behavioral plasticity: implications for addiction. J Neurosci 24, 6362-6370 (2004)
118. ML Heien, AS Khan, JL Ariansen, JF Cheer, PE Phillips, KM Wassum, RM Wightman: Real-Time measurement of dopamine fluctuations after cocaine in the brain of behaving rats. Proceedings of the National Academy of Sciences of the United States of America 102, 10023-10028 (2005)
119. SR Jones, JD Joseph, LS Barak, MG Caron, RM Wightman: Dopamine neuronal transport kinetics and effects of amphetamine. J Neurochem 73, 2406-2414 (1999)
120. R Seecof, FS Tennant, Jr: Subjective perceptions to the intravenous "rush" of heroin and cocaine in opioid addicts. Am J Drug Alcohol Abuse 12, 79-87 (1986)
121. SM Evans, EJ Cone, JE Henningfield: Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects. J Pharmacol Exp Ther 279, 1345-1356 (1996)
122. G Zernig, S Giacomuzzi, Y Riemer, G Wakonigg, K Sturm, A Saria: Intravenous drug injection habits: drug users' self-reports versus researchers' perception. Pharmacology 68, 49-56 (2003)
123. Y Mateo, CM Lack, D Morgan, DCS Roberts, SR Jones: Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self administration and deprivation. Neuropsychopharmacology 30, 1455-1463 (2005)
124. MJ Ferris, Y Mateo, DC Roberts, SR Jones: Cocaineinsensitive dopamine transporters with intact substrate transport produced by self-Administration. Biol Psychiatry 69, 201-207 (2011)
125. DCS Roberts, K Brebner, M Vincler, WJ Lynch: Patterns of cocaine self-Administration in rats produced by various access conditions under a discrete trials procedure. Drug Alcohol Depend 67, 291299 (2002)
126. K Brebner, R Phelan, DCS Roberts: Effect of baclofen on cocaine self-Administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules. Psychopharmacology (Berl) 148, 314-321 (2000)
127. MA Smith, DL Yancey, D Morgan, Y Liu, W Froestl, DCS Roberts: Effects of positive allosteric modulators of the GABAB receptor on cocaine self-Administration in rats. Psychopharmacology (Berl) 173, 105-111 (2004)
128. RA España, EB Oleson, JL Locke, BR Brookshire, DCS Roberts, SR Jones: The hypocretin-orexin system regulates cocaine self-Administration via actions on the mesolimbic dopamine system. Eur J Neurosci 31, 336-348 (2010)
129. RA España, JR Melchior, DCS Roberts, SR Jones: Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-Administration. Psychopharmacology (Berl) 214, 415-426 (2011)
130. LH Parsons, AD Smith, JB Justice, Jr.: Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse 9, 60-65 (1991)
131. MA Gerrits, P Petromilli, HG Westenberg, CG Di, JM van Ree: Decrease in basal dopamine levels in the nucleus accumbens shell during daily drug-seeking behaviour in rats. Brain Res 924, 141-150 (2002)
132. VI Chefer, TS Shippenberg: Changes in basal and cocaine-evoked extracellular dopamine uptake and release in the rat nucleus accumbens during early abstinence from cocaine: quantitative determination under transient conditions. Neuroscience 112, 907-919 (2002)
133. A Teixeira, LG Muller, P Reckziegel, N Boufleur, CS Pase, JG Villarinho, R Fachinetto, J Ferreira, JB Rocha, ME Burger: Beneficial effects of an innovative exercise model on motor and oxidative disorders induced by haloperidol in rats. Neuropharmacology 60, 432-438 (2011)
134. AM Novick, GL Forster, SM Tejani-Butt, MJ Watt: Adolescent social defeat alters markers of adult dopaminergic function. Brain Res Bull 86, 123-128 (2011)
135. SB Flagel, SJ Watson, TE Robinson, H Akil: Individual differences in the propensity to approach signals vs goals promote different adaptations in the dopamine system of rats. Psychopharmacology (Berl) 191, 599-607 (2007)
136. S Ramamoorthy, TS Shippenberg, LD Jayanthi: Regulation of monoamine transporters: Role of transporter phosphorylation. Pharmacol Ther 129, 220-238 (2011)
137. LB Li, N Chen, S Ramamoorthy, L Chi, XN Cui, LC Wang, ME Reith: The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. J Biol Chem 279, 21012-21020 (2004)
138. GE Torres, A Carneiro, K Seamans, C Fiorentini, A Sweeney, WD Yao, MG Caron: Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter. J Biol Chem 278, 2731-2739 (2003)
139. N Chen, ME Reith: Substrates dissociate dopamine transporter oligomers. J Neurochem 105, 910-920 (2008)
140. Y Li, SY Cheng, N Chen, ME Reith: Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine. J Neurochem 114, 873-885 (2010)