Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins

Gene Therapy

Volumn 7, Issue 3, 2000, Pages 232-240

  Boekstegers, P ^a   Von Degenfeld, G ^a   Giehrl, W ^a   Heinrich, D ^a   Hullin, R ^a   Kupatt, C ^a   Steinbeck, G ^a   Baretton, G ^b   Middeler, G ^b   Katus, H ^b   Franz, W M ^b  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b LMU München ^*

Author keywords

Adenoviral vector; Coronary veins; Percutaneous transluminal gene delivery; Pig; Retroinfusion

Indexed keywords

BETA GALACTOSIDASE; LUCIFERASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CORONARY VEIN; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; NONHUMAN; PRESSURE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; ROUS SARCOMA ONCOVIRUS;

EID: 0033993507     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301079     Document Type: Article

References (31)

1. Guzman RJ et al. Efficient gene transfer into myocardium by direct injection of adenovirus vectors. Circ Res 1993; 73: 1202-1207.
2. French BA, Mazur W, Geske RS, Bolli R. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors. Circulation 1994; 90: 2414-2424.
3. French BA et al. Percutaneous transluminal in vivo gene transfer by recombinant adenovirus in normal porcine coronary arteries, atherosclerotic arteries, and two models of coronary restenosis. Circulation 1994; 90: 2402-2413.
4. Hajjar RJ, Kang JX, Gwathmey JK, Rosenzweig A. Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes. Circulation 1997; 95: 423-429.
5. Franz WM, Rothmann R, Frey N, Katus HA. Analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters. Cardiovasc Res 1997; 35: 560-566.
6. Magovern CJ et al. Direct in vivo gene transfer to canine myocardium using a replication-deficient adenovirus vector. Ann Thorac Surg 1996; 62: 425-433.
7. Feldman LJ, Steg G. Optimal techniques for arterial gene transfer. Cardiovasc Res 1997; 35: 391-404.
8. Steg PG et al. Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation 1994; 90: 1648-1656.
9. Barr E et al. Efficient catheter-mediated gene transfer into the heart using replication-deficient adenovirus. Gene Therapy 1994; 1: 51-58.
10. Lamping KG et al. Intrapericardial administration of adenovirus for gene transfer. Am J Physiol 1997; 272: H310-317.
11. March KL et al. Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors. Clin Cardiol 1999; 22: 123-129.
12. Giordano FJ et al. Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients. Circulation 1997; 96: 400-403.
13. Rothmann T et al. Heart muscle-specific gene expression using replication defective recombinant adenovirus. Gene Therapy 1996; 3: 919-926.
14. Hatori N, Sjoquist PO, Regardh C, Ryden L. Pharmacokinetic analysis of coronary sinus retroinfusion in pigs. Ischemic myocardial concentrations in the left circumflex arterial area using metoprolol as a tracer. Cardiovasc Drugs Ther 1991; 5: 1005-1010.
15. Ryden L et al. Pharmacokinetic analysis of coronary venous retroinfusion: a comparison with anterograde coronary artery drug administration using metoprolol as a tracer. JACC 1991; 18: 603-612.
16. Haga Y et al. Ischemic and nonischemic tissue concentrations of felodipine after coronary venous retroinfusion during myocardial ischemia and reperfusion: an experimental study in pigs. J Cardiovasc Pharmacol 1994; 24: 296-302.
17. von Degenfeld G, Giehrl W, Boekstegers P. Targeting of dobutamine to ischemic myocardium without systemic effects by selective suction and pressure-regulated retroinfusion. Cardiovasc Res 1997; 35: 233-240.
18. Boekstegers P, von Degenfeld G, Giehrl W, Steinbeck G. Selective suction and pressure-regulated retroinfusion: an effective and safe approach to retrograde protection against myocardial ischemia in patients undergoing normal and high risk percutaneous transluminal coronary angioplasty. JACC 1998; 31: 1525-1523.
19. Boekstegers P et al. Preservation of regional myocardial function and myocardial oxygen tension during acute ischemia in pigs: comparison of selective synchronized suction and retroinfusion of coronary veins (SSR) to synchronized coronary venous retroperfusion (SRF). J Am Coll Cardiol 1994; 23: 459-469.
20. Wright MJ et al. β-Galactosidase staining following intracoronary infusion of cationic liposomes in the in vivo rabbit heart is produced by microinfarction rather than effective gene transfer: a cautionary tale. Gene Therapy 1998; 5: 301-308.
21. Donahue JK et al. Ultrarapid, highly efficient viral gene transfer to the heart. Proc Natl Acad Sci USA 1997; 94: 4664-4668.
22. Donahue JK et al. Acceleration of widespread adenoviral gene transfer to intact hearts by coronary perfusion with low calcium and serotonin. Gene Therapy 1998; 5: 630-634.
23. Pernow J et al. The protective effect of L-arginine on myocardial injury and endothelial function following ischemia and reperfusion in the pig. Eur Heart J 1994; 15: 1712-1719.
24. Franz WM et al. Heart-specific targeting of firefly luciferase by the myosin light chain-2 promoter and developmental regulation in transgenic mice. Circ Res 1993; 73: 629-638.
25. Griscelli F et al. Expression from cardiomyocyte-specific promoter after adenovirus-mediated gene transfer in vitro and in vivo. CR Acad Sci III 1997; 320: 103-112.
26. Kochanek S et al. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dysthrophin and β-galactosidase. Proc Natl Acad Sci USA 1996; 93: 5731-5736.
27. Parks RJ et al. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packing signal. Proc Natl Acad Sci USA 1996; 93: 13565-13570.
28. Fox JC. Cardiovascular gene therapy: current concepts. Ther Drug Monit 1996; 18: 410-422.
29. Melillo G et al. Gene therapy for collateral development. Cardiovasc Res 1997; 35: 480-490.
30. von Degenfeld G, Heinrich D, Giehrl W, Boekstegers P. Comparison of Pura-Vario and Palmaz-Schatz stents following implantation using normal and high pressure in pigs: immediate and late results assessed by 3-dimensional IVUS. Z Kardiol 1999 (in press).
31. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.