메뉴 건너뛰기




Volumn 25, Issue 5, 2013, Pages 1595-1606

Purification and identification of novel angiotensin-I converting enzyme (ACE) inhibitory peptides from cultured marine microalgae (Nannochloropsis oculata) protein hydrolysate

Author keywords

ACE inhibition; Microalgae; Nannochloropsis oculata; Nitric oxide; Peptides

Indexed keywords

NANNOCHLOROPSIS OCULATA;

EID: 84883653291     PISSN: 09218971     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10811-013-9994-6     Document Type: Article
Times cited : (95)

References (53)
  • 1
    • 0030010035 scopus 로고    scopus 로고
    • Beneficial actions of nitrates in cardiovascular disease
    • Abrams J (1996) Beneficial actions of nitrates in cardiovascular disease. Am J Cardiol 77: 31-37.
    • (1996) Am J Cardiol , vol.77 , pp. 31-37
    • Abrams, J.1
  • 3
    • 84874736603 scopus 로고    scopus 로고
    • Mono-and digalactosyldiacylglycerols: potent nitric oxide inhibitors from the marine microalga Nannochloropsis granulata
    • doi: 10. 1007/s1081101298692
    • Banskota AH, Stefanova R, Gallant P, McGinn PT (2012) Mono-and digalactosyldiacylglycerols: potent nitric oxide inhibitors from the marine microalga Nannochloropsis granulata. J Appl Phycol. doi: 10. 1007/s1081101298692.
    • (2012) J Appl Phycol
    • Banskota, A.H.1    Stefanova, R.2    Gallant, P.3    McGinn, P.T.4
  • 4
    • 33846502109 scopus 로고    scopus 로고
    • Micro algae as a source of protein
    • Becker EW (2007) Micro algae as a source of protein. Biotechnol Adv 25: 207-210.
    • (2007) Biotechnol Adv , vol.25 , pp. 207-210
    • Becker, E.W.1
  • 5
    • 79952312700 scopus 로고    scopus 로고
    • Purification of angiotensin I-converting enzyme inhibitory peptides from a cowpea (Vigna unguiculata) enzymatic hydrolystae
    • Campos MRS, Guerrero LAC, Ancona DAB (2011) Purification of angiotensin I-converting enzyme inhibitory peptides from a cowpea (Vigna unguiculata) enzymatic hydrolystae. Process Biochem 46: 864-872.
    • (2011) Process Biochem , vol.46 , pp. 864-872
    • Campos, M.R.S.1    Guerrero, L.A.C.2    Ancona, D.A.B.3
  • 7
    • 66849112031 scopus 로고    scopus 로고
    • Effect of temperature and nitrogen concentration in the growth and lipid content of Nannchloropsis oculata and Chlorella vulgaris for biodiesel production
    • Converti A, Casazza AC, Ortiz YE, Perego P, Borghi DM (2009) Effect of temperature and nitrogen concentration in the growth and lipid content of Nannchloropsis oculata and Chlorella vulgaris for biodiesel production. Chem Eng Proess 48: 1146-1151.
    • (2009) Chem Eng Proess , vol.48 , pp. 1146-1151
    • Converti, A.1    Casazza, A.C.2    Ortiz, Y.E.3    Perego, P.4    Borghi, D.M.5
  • 8
    • 33644785987 scopus 로고    scopus 로고
    • ACE inhibitors or angiotensin II receptors antagonist attenuates diabetic neuropathy in streptoztocin-induced diabetic rats
    • Coppey LJ, Davidson EP, Rinehart TW, Gallett JS, Oltman CL, Lund DD et al (2006) ACE inhibitors or angiotensin II receptors antagonist attenuates diabetic neuropathy in streptoztocin-induced diabetic rats. Diabetes 55: 341-348.
    • (2006) Diabetes , vol.55 , pp. 341-348
    • Coppey, L.J.1    Davidson, E.P.2    Rinehart, T.W.3    Gallett, J.S.4    Oltman, C.L.5    Lund, D.D.6
  • 9
    • 0015083353 scopus 로고
    • Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
    • Cushman DW, Cheung HS (1970) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20: 1637-1648.
    • (1970) Biochem Pharmacol , vol.20 , pp. 1637-1648
    • Cushman, D.W.1    Cheung, H.S.2
  • 10
    • 79960035945 scopus 로고    scopus 로고
    • Heart health peptides from macroalgae and their potential use in functional foods
    • Fitzgerald C, Gallagher E, Tasdemir D, Hayes M (2011) Heart health peptides from macroalgae and their potential use in functional foods. J Agric Food Chem 59: 6829-6836.
    • (2011) J Agric Food Chem , vol.59 , pp. 6829-6836
    • Fitzgerald, C.1    Gallagher, E.2    Tasdemir, D.3    Hayes, M.4
  • 11
    • 33645983664 scopus 로고    scopus 로고
    • Bioactive peptides and lactic fermentations
    • FitzGerald JR, Murray AB (2007) Bioactive peptides and lactic fermentations. Int J Diary Technol 59: 118-125.
    • (2007) Int J Diary Technol , vol.59 , pp. 118-125
    • FitzGerald, J.R.1    Murray, A.B.2
  • 12
    • 0032760778 scopus 로고    scopus 로고
    • LKPNM: a prodrug-type ACE inhibitory peptide derived from fish protein
    • Fujita H, Yoshikawa M (1999) LKPNM: a prodrug-type ACE inhibitory peptide derived from fish protein. Immunopharmacology 44: 123-127.
    • (1999) Immunopharmacology , vol.44 , pp. 123-127
    • Fujita, H.1    Yoshikawa, M.2
  • 13
    • 80053940389 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme inhibitory activity in a hydrolysate of proteins from Northern shrimp (Pandalus borealis) and identification of two novel inhibitory tri-peptides
    • Gildberg A, Arnesen JA, Saether BS, Rauo J, Stenberg E (2011) Angiotensin I-converting enzyme inhibitory activity in a hydrolysate of proteins from Northern shrimp (Pandalus borealis) and identification of two novel inhibitory tri-peptides. Process Biochem 46: 2205-2209.
    • (2011) Process Biochem , vol.46 , pp. 2205-2209
    • Gildberg, A.1    Arnesen, J.A.2    Saether, B.S.3    Rauo, J.4    Stenberg, E.5
  • 14
    • 20544460150 scopus 로고    scopus 로고
    • Antioxidant activities of enzymatic extracts from brown seaweeds
    • Heo SJ, Park EJ, Lee KW, Jeon YJ (2005) Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour Technol 96: 1613-1623.
    • (2005) Bioresour Technol , vol.96 , pp. 1613-1623
    • Heo, S.J.1    Park, E.J.2    Lee, K.W.3    Jeon, Y.J.4
  • 15
    • 43049107998 scopus 로고    scopus 로고
    • The antihypertensive effect of peptides: a novel alternative to drugs?
    • Hong F, Ming L, Yi S, Zhanxia L, Yongquan W, Chi L (2008) The antihypertensive effect of peptides: a novel alternative to drugs? Peptides 29: 1062-1071.
    • (2008) Peptides , vol.29 , pp. 1062-1071
    • Hong, F.1    Ming, L.2    Yi, S.3    Zhanxia, L.4    Yongquan, W.5    Chi, L.6
  • 16
    • 0033062397 scopus 로고    scopus 로고
    • Current trends in the development of nitric oxide donors
    • Hou YC, Janczuk A, Wang PG (1999) Current trends in the development of nitric oxide donors. Curr Pharm Des 5: 417-41.
    • (1999) Curr Pharm Des , vol.5 , pp. 417-441
    • Hou, Y.C.1    Janczuk, A.2    Wang, P.G.3
  • 17
    • 84872500587 scopus 로고    scopus 로고
    • Effects of nitrogen supplementation of the culture medium on the growth, total lipid content and fatty acid profiles of three microalgae (Tetraselmis subcordiformis, Nannochloropsis oculata and Pavlova viridis)
    • doi: 10. 1007/s1081101298469
    • Huang X, Huang Z, Wen W, Yan J (2012) Effects of nitrogen supplementation of the culture medium on the growth, total lipid content and fatty acid profiles of three microalgae (Tetraselmis subcordiformis, Nannochloropsis oculata and Pavlova viridis). J Appl Phycol. doi: 10. 1007/s1081101298469.
    • (2012) J Appl Phycol.
    • Huang, X.1    Huang, Z.2    Wen, W.3    Yan, J.4
  • 18
    • 68349157539 scopus 로고    scopus 로고
    • Antioxidant and antihypertensive protein hydrolysates produced from tuna liver by enzymatic hydrolysis
    • Je JY, Lee KH, Lee MH, Ahn CB (2009) Antioxidant and antihypertensive protein hydrolysates produced from tuna liver by enzymatic hydrolysis. Food Res Int 42: 1266-1272.
    • (2009) Food Res Int , vol.42 , pp. 1266-1272
    • Je, J.Y.1    Lee, K.H.2    Lee, M.H.3    Ahn, C.B.4
  • 19
    • 20544449674 scopus 로고    scopus 로고
    • Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis
    • Je JY, Park PJ, Byun HG, Jung WK, Kim SK (2005a) Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresource Technol 96: 1624-1629.
    • (2005) Bioresource Technol , vol.96 , pp. 1624-1629
    • Je, J.Y.1    Park, P.J.2    Byun, H.G.3    Jung, W.K.4    Kim, S.K.5
  • 20
    • 7044274319 scopus 로고    scopus 로고
    • Isolation of angiotensin I converting enzyme (ACE) inhibitor from fermented oyster sauce, Crassostrea gigas
    • Je YJ, Park JY, Jung WK, Kim SK (2005b) Isolation of angiotensin I converting enzyme (ACE) inhibitor from fermented oyster sauce, Crassostrea gigas. Food Chem 90: 809-814.
    • (2005) Food Chem , vol.90 , pp. 809-814
    • Je, Y.J.1    Park, J.Y.2    Jung, W.K.3    Kim, S.K.4
  • 21
    • 77952100977 scopus 로고    scopus 로고
    • Arachin derived peptides as selective angiotensin I-converting enzyme (ACE) inhibitors: structure-activity relationship
    • Jimsheena VK, Govada LR (2010) Arachin derived peptides as selective angiotensin I-converting enzyme (ACE) inhibitors: structure-activity relationship. Peptides 31: 1165-1176.
    • (2010) Peptides , vol.31 , pp. 1165-1176
    • Jimsheena, V.K.1    Govada, L.R.2
  • 22
    • 21544467786 scopus 로고    scopus 로고
    • Angiotensin I converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats
    • Jung WK, Mendis E, Je JY, Park PJ, Son BW, Kim HC et al (2006) Angiotensin I converting enzyme inhibitory peptide from yellowfin sole (Limanda aspera) frame protein and its antihypertensive effect in spontaneously hypertensive rats. Food Chem 94: 26-32.
    • (2006) Food Chem , vol.94 , pp. 26-32
    • Jung, W.K.1    Mendis, E.2    Je, J.Y.3    Park, P.J.4    Son, B.W.5    Kim, H.C.6
  • 23
    • 12344282783 scopus 로고    scopus 로고
    • Global burden of hypertension: analysis of worldwide data
    • Kearney PM, Whelton M, Reynolds K, Muntner P, He J (2005) Global burden of hypertension: analysis of worldwide data. Lancet 365: 217-223.
    • (2005) Lancet , vol.365 , pp. 217-223
    • Kearney, P.M.1    Whelton, M.2    Reynolds, K.3    Muntner, P.4    He, J.5
  • 24
    • 77349090649 scopus 로고    scopus 로고
    • Development and biological activities of marine-derived bioactive peptides: a review
    • Kim SK, Wijesekara I (2010) Development and biological activities of marine-derived bioactive peptides: a review. J Funct Foods 2: 1-9.
    • (2010) J Funct Foods , vol.2 , pp. 1-9
    • Kim, S.K.1    Wijesekara, I.2
  • 25
    • 83655184787 scopus 로고    scopus 로고
    • Purification and characterization of angiotensin I-converting enzyme inhibitory peptide from enzymatic hydrolysates of Stylea clava flesh tissue
    • Ko SC, Lee JK, Byun HG, Lee SC, Jeon YJ (2012a) Purification and characterization of angiotensin I-converting enzyme inhibitory peptide from enzymatic hydrolysates of Stylea clava flesh tissue. Process Biochem 47: 34-40.
    • (2012) Process Biochem , vol.47 , pp. 34-40
    • Ko, S.C.1    Lee, J.K.2    Byun, H.G.3    Lee, S.C.4    Jeon, Y.J.5
  • 26
    • 84870800946 scopus 로고    scopus 로고
    • A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats
    • doi: 10. 1016/j. procbio. 2012. 07. 015
    • Ko SK, Nalae K, Kim EA, Kang MC, Lee SH, Kang SM et al (2012b) A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats. Process Biochem. doi: 10. 1016/j. procbio. 2012. 07. 015.
    • (2012) Process Biochem
    • Ko, S.K.1    Nalae, K.2    Kim, E.A.3    Kang, M.C.4    Lee, S.H.5    Kang, S.M.6
  • 27
    • 33747503962 scopus 로고    scopus 로고
    • Bioactive peptides: production and functionality
    • Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16: 945-960.
    • (2006) Int Dairy J , vol.16 , pp. 945-960
    • Korhonen, H.1    Pihlanto, A.2
  • 28
    • 69249208492 scopus 로고    scopus 로고
    • Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus
    • Kuba M, Tanaka K, Sesoko M, Inoue F, Yasuda M (2009) Angiotensin I-converting enzyme inhibitory peptides in red-mold rice made by Monascus purpureus. Process Biochem 44: 1139-1143.
    • (2009) Process Biochem , vol.44 , pp. 1139-1143
    • Kuba, M.1    Tanaka, K.2    Sesoko, M.3    Inoue, F.4    Yasuda, M.5
  • 29
    • 78049417145 scopus 로고    scopus 로고
    • Effect of angiotensin I converting enzyme inhibitory peptide purified from skate skin hydrolysate
    • Lee JK, Jeon JK, Byun HG (2011) Effect of angiotensin I converting enzyme inhibitory peptide purified from skate skin hydrolysate. Food Chem 125: 495-499.
    • (2011) Food Chem , vol.125 , pp. 495-499
    • Lee, J.K.1    Jeon, J.K.2    Byun, H.G.3
  • 30
    • 67650269402 scopus 로고    scopus 로고
    • Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, Brachionus rotundiformis
    • Lee JW, Hong S, Jeon JK, Kim SK, Byun HG (2009) Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, Brachionus rotundiformis. Bioresource Technol 100: 5255-5259.
    • (2009) Bioresource Technol , vol.100 , pp. 5255-5259
    • Lee, J.W.1    Hong, S.2    Jeon, J.K.3    Kim, S.K.4    Byun, H.G.5
  • 31
    • 79951783064 scopus 로고    scopus 로고
    • Microalgae for "Healthy" foods-possibilities and challenges
    • Lee TLC, Marino GEG (2010) Microalgae for "Healthy" foods-possibilities and challenges. Compr Rev Food Sci F 9: 655-675.
    • (2010) Compr Rev Food Sci F , vol.9 , pp. 655-675
    • Lee, T.L.C.1    Marino, G.E.G.2
  • 32
    • 0027619613 scopus 로고
    • Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolyzates derived from sardine muscle
    • Matsui T, Matsufuji H, Seki E, Osajima K, Nakashima M, Osajima Y (1993) Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolyzates derived from sardine muscle. Biosci Biotechnol Biochem 57: 922-925.
    • (1993) Biosci Biotechnol Biochem , vol.57 , pp. 922-925
    • Matsui, T.1    Matsufuji, H.2    Seki, E.3    Osajima, K.4    Nakashima, M.5    Osajima, Y.6
  • 33
    • 34147167071 scopus 로고    scopus 로고
    • Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: effect of a simulated intestinal digestion
    • Miguel M, Alonso MJ, Salaices M, Aleixandre A, López-Fandiño R (2007) Antihypertensive, ACE-inhibitory and vasodilator properties of an egg white hydrolysate: effect of a simulated intestinal digestion. Food Chem 104: 163-168.
    • (2007) Food Chem , vol.104 , pp. 163-168
    • Miguel, M.1    Alonso, M.J.2    Salaices, M.3    Aleixandre, A.4    López-Fandiño, R.5
  • 34
    • 77949498230 scopus 로고    scopus 로고
    • Nitrogen content, dietary fiber, and digestibility in algal food products
    • Misurcova L, Kracmar S, Klejdus B, Vacek J (2010) Nitrogen content, dietary fiber, and digestibility in algal food products. Czech J Food Sci 28: 27-35.
    • (2010) Czech J Food Sci , vol.28 , pp. 27-35
    • Misurcova, L.1    Kracmar, S.2    Klejdus, B.3    Vacek, J.4
  • 35
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 36
    • 70349333712 scopus 로고    scopus 로고
    • Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties
    • Quirós A, del Mar CM, Amigo L, Recio I (2009) Stability to gastrointestinal enzymes and structure-activity relationship of β-casein-peptides with antihypertensive properties. Peptides 30: 1848-1853.
    • (2009) Peptides , vol.30 , pp. 1848-1853
    • Quirós, A.1    del Mar, C.M.2    Amigo, L.3    Recio, I.4
  • 37
    • 84864133561 scopus 로고    scopus 로고
    • Effect of oxygen concentration on the growth of Nannochloropsis sp. at low light intensity
    • Raso S, Genugten BV, Vermue M, Wijffels RH (2012) Effect of oxygen concentration on the growth of Nannochloropsis sp. at low light intensity. J Appl Phycol 24: 863-871.
    • (2012) J Appl Phycol , vol.24 , pp. 863-871
    • Raso, S.1    Genugten, B.V.2    Vermue, M.3    Wijffels, R.H.4
  • 38
    • 62049084763 scopus 로고    scopus 로고
    • Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract
    • Rho SJ, Lee JS, Chung YI, Kim YW, Lee HG (2009) Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from fermented soybean extract. Process Biochem 44: 490-493.
    • (2009) Process Biochem , vol.44 , pp. 490-493
    • Rho, S.J.1    Lee, J.S.2    Chung, Y.I.3    Kim, Y.W.4    Lee, H.G.5
  • 39
    • 0041508229 scopus 로고    scopus 로고
    • Angiotensin-I-converting enzyme and its relatives
    • Riordan JF (2003) Angiotensin-I-converting enzyme and its relatives. Genome Biol 4: 225-229.
    • (2003) Genome Biol , vol.4 , pp. 225-229
    • Riordan, J.F.1
  • 40
    • 33244454977 scopus 로고    scopus 로고
    • Action mechanism of an angiotensin I-converting enzyme inhibitory peptide derived from chicken breast muscle
    • Saiga A, Okumura T, Makihara T, Katsuda SI, Morimatsu F, Nishimura T (2006) Action mechanism of an angiotensin I-converting enzyme inhibitory peptide derived from chicken breast muscle. J Agric Food Chem 54: 942-945.
    • (2006) J Agric Food Chem , vol.54 , pp. 942-945
    • Saiga, A.1    Okumura, T.2    Makihara, T.3    Katsuda, S.I.4    Morimatsu, F.5    Nishimura, T.6
  • 41
    • 84866363079 scopus 로고    scopus 로고
    • Bio-functionalities of proteins derive from marine algae-a review
    • Samarakoon K, Jeon YJ (2012) Bio-functionalities of proteins derive from marine algae-a review. Food Res Int 48: 948-960.
    • (2012) Food Res Int , vol.48 , pp. 948-960
    • Samarakoon, K.1    Jeon, Y.J.2
  • 42
    • 60749131028 scopus 로고    scopus 로고
    • Isolation and characterization of a novel angiotensin-I converting enzyme (ACE) inhibitory peptide from the algae protein waste
    • Sheih IC, Fang TJ, Wu TK (2009) Isolation and characterization of a novel angiotensin-I converting enzyme (ACE) inhibitory peptide from the algae protein waste. Food Chem 115: 279-284.
    • (2009) Food Chem , vol.115 , pp. 279-284
    • Sheih, I.C.1    Fang, T.J.2    Wu, T.K.3
  • 44
    • 0034817211 scopus 로고    scopus 로고
    • Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis
    • Suetsuna K, Chen JR (2001) Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Mar Biotechnol 3: 305-309.
    • (2001) Mar Biotechnol , vol.3 , pp. 305-309
    • Suetsuna, K.1    Chen, J.R.2
  • 45
    • 0033695674 scopus 로고    scopus 로고
    • Identification of antihypertensive peptides from peptidic digest of wakame (Undaria pinnatifida)
    • Suetsuna K, Nakano T (2000) Identification of antihypertensive peptides from peptidic digest of wakame (Undaria pinnatifida). J Nutr Biochem 11: 450-454.
    • (2000) J Nutr Biochem , vol.11 , pp. 450-454
    • Suetsuna, K.1    Nakano, T.2
  • 46
    • 0031769256 scopus 로고    scopus 로고
    • Purification and identification of angiotensin I-converting enzyme inhibitors from the red alga Porphyra yezoensis
    • Suetsuna K (1998) Purification and identification of angiotensin I-converting enzyme inhibitors from the red alga Porphyra yezoensis. J Mar Biotechnol 6: 163-167.
    • (1998) J Mar Biotechnol , vol.6 , pp. 163-167
    • Suetsuna, K.1
  • 48
    • 56849092058 scopus 로고    scopus 로고
    • The rennin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction
    • Verdecchia P, Angeli F, Mazzotta G, Gentile G, Reboldi G (2008) The rennin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction. Vasc Health Risk Manag 4: 971-981.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 971-981
    • Verdecchia, P.1    Angeli, F.2    Mazzotta, G.3    Gentile, G.4    Reboldi, G.5
  • 49
    • 0001975364 scopus 로고
    • Large scale culture of larvae of Ostrea edulis
    • Series 2
    • Walne PR (1966) Large scale culture of larvae of Ostrea edulis. L. Fish Invest (London) Series 2: 1-51.
    • (1966) L. Fish Invest (London) , pp. 1-51
    • Walne, P.R.1
  • 50
    • 51749125991 scopus 로고    scopus 로고
    • Purification and identification of a AC inhibitory peptide from oyster proteins hydrolysate and the antihypertensive effect of hydrolysate in spontaneously hypertensive rats
    • Wang J, Hu J, Chi J, Bai X, Du Y, Miyaguchi Y, Lin B (2008) Purification and identification of a AC inhibitory peptide from oyster proteins hydrolysate and the antihypertensive effect of hydrolysate in spontaneously hypertensive rats. Food Chem 111: 302-308.
    • (2008) Food Chem , vol.111 , pp. 302-308
    • Wang, J.1    Hu, J.2    Chi, J.3    Bai, X.4    Du, Y.5    Miyaguchi, Y.6    Lin, B.7
  • 51
    • 0033386873 scopus 로고    scopus 로고
    • Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension
    • Weber MA (1999) Interrupting the renin-angiotensin system: the role of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of hypertension. Am J Hypertens 12: 189-194.
    • (1999) Am J Hypertens , vol.12 , pp. 189-194
    • Weber, M.A.1
  • 52
    • 79952363771 scopus 로고    scopus 로고
    • Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate
    • Wijesekara I, Qian ZJ, Ryu BM, Ngo DH, Kim SK (2011) Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate. Food Res Int 44: 703-707.
    • (2011) Food Res Int , vol.44 , pp. 703-707
    • Wijesekara, I.1    Qian, Z.J.2    Ryu, B.M.3    Ngo, D.H.4    Kim, S.K.5
  • 53
    • 36048952787 scopus 로고    scopus 로고
    • Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate
    • Zhao Y, Li B, Liu Z, Dong S, Zhao X, Zeng M (2007) Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochem 42: 1586-1591.
    • (2007) Process Biochem , vol.42 , pp. 1586-1591
    • Zhao, Y.1    Li, B.2    Liu, Z.3    Dong, S.4    Zhao, X.5    Zeng, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.