Congenital Heart Block Maternal Sera Autoantibodies Target an Extracellular Epitope on the α1G T-Type Calcium Channel in Human Fetal Hearts

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Strandberg, Linn S ^a   Cui, Xuezhi ^a   Rath, Arianna ^a   Liu, Jie ^b   Silverman, Earl D ^a   Liu, Xiaoru ^a   Siragam, Vinayakumar ^a   Ackerley, Cameron ^a   Su, Brenda Bin ^a   Yan, Jane Yuqing ^a   Capecchi, Marco ^c   Biavati, Luca ^c   Accorroni, Alice ^c   Yuen, William ^a   Quattrone, Filippo ^c   Lung, Kalvin ^a   Jaeggi, Edgar T ^a   Backx, Peter H ^b,d   Deber, Charles M ^a,e   Hamilton, Robert M ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SCUOLA SUPERIORE SANT ANNA   (Italy)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE SUBUNIT ALPHA1G; EPITOPE; MATERNAL ANTIBODY; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; CACNA1G GENE; CONGENITAL HEART BLOCK; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; FEMALE; FETUS; GENE; GENE EXPRESSION; GESTATIONAL AGE; HEART ATRIOVENTRICULAR NODE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MATERNAL SERUM; MOUSE; NEWBORN; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; RABBIT; SINUS NODE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ATRIOVENTRICULAR NODE; AUTOANTIBODIES; AUTOANTIGENS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; EPITOPE MAPPING; EPITOPES; EXTRACELLULAR SPACE; FEMALE; FETAL HEART; GENE EXPRESSION; HEART BLOCK; HUMANS; MALE; MATERNAL-FETAL EXCHANGE; MICE; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; PEPTIDES; PREGNANCY; RABBITS;

EID: 84883640008     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072668     Document Type: Article

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