Novel molecular mechanism involving α1D (Cav1.3) L-type calcium channel in autoimmune-associated sinus bradycardia

Circulation

Volumn 111, Issue 23, 2005, Pages 3034-3041

  Qu, Yongxia ^a,b   Baroudi, Ghayath ^a,b   Yue, Yuankun ^a   Boutjdir, Mohamed ^a,b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibodies; Calcium; Heart block; Ion channels; Sinoatrial node

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; IMMUNOGLOBULIN G; MEMBRANE PROTEIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CALCIUM CURRENT; CONGENITAL HEART BLOCK; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; FEMALE; FETUS; FETUS HEART; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RABBIT; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS BRADYCARDIA; WESTERN BLOTTING;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BRADYCARDIA; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL LINE; ELECTROPHYSIOLOGY; FETUS; HEART; HUMANS; IMMUNOGLOBULIN G; MYOCYTES, CARDIAC; RABBITS; RNA, MESSENGER; SINOATRIAL NODE; TRANSDUCTION, GENETIC;

EID: 20544472640     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.104.517326     Document Type: Article

References (34)

1. Buyon JP. Neonatal lupus syndromes. In: Lahita R. ed. Śystemic Lupus Erythematosus. New York, NY: Academic Press. 1999:337-360.
2. Buyon JP, Hiebert R, Copel J, Craft J, Friedman D, Katholi M, Lee LA, Provost TT, Reichlin M, Rider L, Rupel A, Saleeb S, Weston WL, Skovron ML. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol. 1998;31:1658-1666.
3. Stiehm ER. Fetal defense mechanisms. Am J Dis Child. 1975;129: 438-443.
4. Boutjdir M, Chen L, Zhang ZH, Tseng CE, DiDonato F, Rashbaum W, Morris A, El Sherif N, Buyon JP. Arrhythmogenicity of IgG and anti-52-kD SSA/Ro affinity-purified antibodies from mothers of children with congenital heart block. Circ Res. 1997;80:354-362.
5. Mazel A, El Sherif N, Buyon J, Boutjdir M. Electrocardiographic abnormalities in a murine model injected with IgG from mothers of children with congenital heart block. Circulation. 1999;99:1914-1918.
6. Boutjdir M, Chen L, Zhang ZH, Tseng CE, El Sherif N, Buyon JP. Serum and immunoglobulin G from the mother of a child with congenital heart block induce conduction abnormalities and inhibit L-type calcium channels in a rat heart model. Pediatr Res. 1998;44:11-19.
7. Brucato A, Cirhaz R, Catelli L, Meroni P, Anti-Ro-associated sinus bradycardia in newborns. Circulation. 2000;102:E88-E89.
8. Menon A, Silverman ED, Gow RM, Hamilton RM. Chronotropic competence of the sinus node in congenital complete heart block. Am J Cardiol. 1998;82:1119-1121, A9.
9. Qu Y, Xiao GQ, Chen L, Boutjdir M. Autoantibodies from mothers of children with congenital heart block downregulate cardiac L-type Ca channels. J Mol Cell Cardiol. 2001;33:1153-1163.
10. Xiao GQ, Hu K, Boutjdir M. Direct inhibition of expressed cardiac L-and T-type calcium channels by IgG from mothers whose children have congenital heart block. Circulation, 2001;103:1599-1604.
11. Hu K, Qu Y, Yue Y, Boutjdir M. Functional basis of sinus bradycardia in congenital heart block. Circ Res. 2004;94:e32-e38.
12. Irisawa H, Brown HF, Giles W. Cardiac pacemaking in the sinoatrial node. Physiol Rev. 1993;73:197-227.
13. Takimoto K, Li D, Nerbonne JM, Levitan ES. Distribution, splicing and glucocorticoid-induced expression of cardiac alpha 1C and alpha 1D voltage-gated Ca channel mRNAs. J Mol Cell Cardiol. 1997;29: 3035-3042.
14. Platzer J, Engel J, Schrott-Fischer A, Stephan K, Bova S, Chen H, Zheng H, Striessnig J. Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca channels. Cell. 2000;102:89-97.
15. Zhang Z, Xu Y, Song H, Rodriguez J, Tuteja D, Namkung Y, Shin HS, Chiamvimonvat N. Functional roles of Ca(v)1.3 (alpha(1D)) calcium channel in sinoatrial nodes: insight gained using gene-targeted null mutant mice. Circ Res. 2002;90:981-987.
16. Mangoni ME, Couette B, Bourinet E, Platzer J. Reimer D, Striessnig J, Nargeot J. Functional role of L-type Cav1.3 Ca channels in cardiac pacemaker activity. Proc Natl Acad Sci U S A. 2003;100:5543-5548.
17. Denyer JC, Brown HF. Rabbit sino-atrial node cells: isolation and electrophysiological properties. J Physiol. 1990;428:405-424.
18. Hancox JC, Levi AJ, Lee CO, Heap P. A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function. Am J Physiol. 1993;265:H755-H766.
19. Qu Y, Boutjdir M. Gene expression of SERCA2a and L- and T-type Ca channels during human heart development. Pediatr Res. 2001;50: 569-574.
20. Qu Y, Ghatpande A, El Sherif N, Boutjdir M. Gene expression of Na/Ca exchanger during development in human heart. Cardiovasc Res. 2000; 45:866-873.
21. Qin X, Liu B, Gick G. Low external K regulates Na, K-ATPase alpha 1 and beta 1 gene expression in rat cardiac myocytes. Am J Hypertens. 1994;7:96-99.
22. Baroudi G, Acharfi S, Larouche C, Chahine M. Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome. Circ Res. 2002;90:E11-E16.
23. Kurokawa J, Chen L, Kass RS. Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel. Proc Natl Acad Sci U S A. 2003;100:2122-2127.
24. 1D) calcium channel subunit from an insulin-secreting cell line. Mol Endocrinol. 2001;15: 1211-1221.
25. Baboonian C, Venables PJ, Booth J, Williams DG, Roffe LM, Maini RN. Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity. Clin Exp Immunol. 1989;78;454-459.
26. LeFeber WP, Norris DA, Ryan SR, Huff JC, Lee LA, Kubo M, Boyce ST, Kotzin BL, Weston WL. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest. 1984;74:1545-1551.
27. Miranda ME, Tseng CE, Rashbaum W, Ochs RL, Casiano CA, Di Donato F, Chan EK, Buyon JP. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes. J Immunol. 1998;161:5061-5069.
28. Kuhl U, Melzner B, Schafer B, Schultheiss HP, Strauer BE. The Ca-channel as cardiac autoantigen. Eur Heart J. 1991:12(suppl D):99-104.
29. Rosenfeld MR, Wong E, Dalmau J, Manley G, Egan D, Posner JB, Sher E, Furneaux HM. Sera from patients with Lambert-Eaton myasthenic syndrome recognize the beta-subunit of Ca channel complexes. Ann NY Acad Sci. 1993;681:408-411.
30. Johnston I, Lang B, Leys K, Newsom-Davis J. Heterogeneity of calcium channel autoantibodies detected using a small-cell lung cancer line derived from a Lambert-Eaton myasthenic syndrome patient. Neurology. 1994;44:334-338.
31. Delbono O, Garcia J, Appel SH, Stefani E. Calcium current' and charge movement of mammalian muscle action of amyotrophic lateral sclerosis immunoglobulins. J Physiol. 1991;444:723-742.
32. Smith RG, Hamilton S, Hofmann F, Schneider T, Nastainczyk W, Birnbaumer L, Stefani E, Appel SH. Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. N Engl J Med. 1992;327:1721-1728.
33. Waltuck J, Buyon JP. Autoantibody-associated congenital heart block: outcome in mothers and children. Ann Intern Med. 1994;120:544-551.
34. Anandakumar C, Biswas A, Chew SS, Chia D, Wong YC, Ratham SS. Direct fetal therapy for hydrops secondary to congenital atrioventricular heart block. Obstet Gynecol. 1996;87:835-837.