Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model

Annals of the Rheumatic Diseases

Volumn 71, Issue 3, 2012, Pages 448-454

  Ambrosi, Aurélie ^a   Dzikaite, Vijole ^a   Park, Jeongsook ^a   Strandberg, Linn ^a   Kuchroo, Vijay K ^b   Herlenius, Eric ^a   Wahren Herlenius, Marie ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINO ACID 200-239; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY RO52; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CALCIUM HOMEOSTASIS; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONGENITAL HEART BLOCK; CONTROLLED STUDY; ELECTROCARDIOGRAM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ATRIOVENTRICULAR BLOCK; AUTOANTIBODIES; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ELECTROCARDIOGRAPHY; EPITOPES; FEMALE; HOMEOSTASIS; MATERNAL-FETAL EXCHANGE; MYOCYTES, CARDIAC; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RIBONUCLEOPROTEINS;

EID: 84857237844     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2011-200414     Document Type: Article

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