Cysteines in the loop between IS5 and the pore helix of CaV3.1 are essential for channel gating

Pflugers Archiv European Journal of Physiology

Volumn 460, Issue 6, 2010, Pages 1015-1028

  Karmazinova, Maria ^a   Beyl, Stanislav ^b   Stary Weinzinger, Anna ^b   Suwattanasophon, Chonticha ^d   Klugbauer, Norbert ^c   Hering, Steffen ^b   Lacinova, Lubica ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cysteine; Modeling; Modulation; T type calcium channels; Voltage gating

Indexed keywords

5,5' DITHIOBIS(2 NITROBENZOIC ACID); ALANINE; CYSTEINE; DITHIOTHREITOL; LOW VOLTAGE ACTIVATED CALCIUM CHANNEL CAV3.1; MUTANT PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CURRENT; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; HYPERPOLARIZATION; MOLECULAR MODEL; MUTATION; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; WILD TYPE;

EID: 78549274395     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0874-5     Document Type: Article

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