Isoproterenol accelerates apoptosis through the over-expression of the sodium/calcium exchanger in HeLa cells

General Physiology and Biophysics

Volumn 32, Issue 3, 2013, Pages 311-323

  Hudecova, Sona ^a   Lencesova, Lubomira ^a   Csaderova, Lucia ^b   Sedlak, Jan ^c   Bohacova, Viera ^a   Laukova, Marcela ^a   Krizanova, Olga ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

^b INSTITUTE OF VIROLOGY   (Slovakia)

^c CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Endoplasmic reticulum stress; Na+ Ca2+ exchanger Apoptosis Isoproterenol hydrochloride

Indexed keywords

CALNEXIN; CAMPTOTHECIN; CASPASE 3; CYCLOHEXIMIDE; DEXAMETHASONE; ISOPRENALINE; PROTEIN BAX; PROTEIN BCL 2; SODIUM CALCIUM EXCHANGE PROTEIN;

ADRENERGIC STIMULATION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL;

ADRENERGIC BETA-AGONISTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CAMPTOTHECIN; CASPASE 3; CYCLOHEXIMIDE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; ISOPROTERENOL; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SODIUM-CALCIUM EXCHANGER;

EID: 84883625299     PISSN: 02315882     EISSN: 13384325     Source Type: Journal    
DOI: 10.4149//gpb-2013044     Document Type: Article

References (42)

1. Barman P., Choisy S. C. M., Hancox J. C., James A. F. (2011): Adrenoceptor/PKA-stimulation, Na+-Ca2+ exchange and PKA-activated Cl-currents in rabbit cardiomyocytes: A conundrum. Cell Calcium 49, 233-239 http://dx.doi.org/10.1016/j.ceca.2011.02.006
2. Basset O., Boittin F. X., Cognard C., Constantin B., Ruegg U. T. (2006): Bcl-2 overexpression prevents calcium overload and subsequent apoptosis in dystrophic myotubes. Biochem. J. 395, 267-276 http://dx.doi.org/10.1042/ BJ20051265
3. Caba O., Rodríguez-Serrano F., Díaz-Gavilán M., Conejo-García A., Ortiz R., Martínez-Amat A., Alvarez P., Gallo M. A., Campos J. M., Marchal J. A., Aránega A. (2012): The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetate is mediated by endoplasmic reticulum stress-induced apoptosis. Eur. J. Med. 50, 376-382 http://dx.doi.org/10.1016/j. ejmech.2012.02.017
4. Canova C., Baudet C., Chevalier G., Brachet P., Wion D. (1997): Noradrenaline inhibits the programmed cell death induced by 1,25- dihydroxyvitamin D3 in glioma. Eur. J. Pharmacol. 319, 365-368 http://dx.doi.org/10.1016/S0014-2999(96)00942-9
5. Danial N. N. (2007): BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin. Cancer. Res. 137, 254-7263
6. Diaz-Horta O., Kamagate A., Herchuelz A., Van Eylen F. (2002): Na+/Ca2+ exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diabetes 511, 815-1824
7. Eigel B. N., Gursahani H., Hadley R. V. (2004): Na+/Ca2+ exchanger plays a key role in inducing apoptosis after hypoxia in cultured guinea pig ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 287, H1466-1475 http://dx.doi.org/10.1152/ajpheart.00874.2003
8. Entschladen F., Drell T. L. 4th, Lang K., Joseph J., Zaenker K. S. (2005): Neurotransmitters and chemokines regulate tumor cell migration: Potential for a new pharmacological approach to inhibit invasion and metastasis development. Curr. Pharm. Des. 11, 403-411 http://dx.doi.org/10.2174/ 1381612053382197
9. Fendri A., Kontos CH. K., Khabir A., Mokdad-Gargouri R., Scorilas A. (2011): BCL2L12 is a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. Mol. Med. 17, 163-171 http://dx.doi.org/10.2119/ molmed.2010.00056
10. Garcia-Prieto C., Riaz Ahmed K. B., Chen Z., Zhou Y., Hammoudi N., Kang Y., Lou C., Mei Y., Jin Z., Huang P. (2012): Effective killing of leukemia cells by the natural product osw-1 through disruption of cellular calcium homeostasis. J. Biol. Chem. 288, 3240-3250 http://dx.doi.org/10.1074/jbc.M112. 384776
11. Gu C., Ma Y. C., Benjamin J., Littman D., Chao M. V., Huang X. Y. (2000): Apoptotic signaling through the beta-adrenergic receptor, A new Gs effector pathway. J. Biol. Chem. 275, 20726-20733 http://dx.doi.org/10.1074/jbc. M000152200
12. Hanahan D., Weinberg R. A. (2000): The hallmarks of cancer. Cell 100, 57-70 http://dx.doi.org/10.1016/S0092-8674(00)81683-9
13. Herchuelz A., Diaz-Horta O., van Eylen F. (2002): Na/Ca exchange and Ca2+ homeostasis in the pancreatic beta-cell. Diabetes Metab. 28, S54-60
14. Hudecova S., Kubovcakova L., Kvetnansky R., Kopacek J., Pastorekova S., Novakova M., Knezl V., Tarabova B., Lacinova L., Sulova Z., Breier A., Jurkovicova D., Krizanova O. (2007): Modulation of expression of Na+/Ca2+ exchanger in heart of rat and mouse under stress. Acta Physiol. (Oxf) 190, 127-136 http://dx.doi.org/10.1111/j.1748-1716.2007.01673.x
15. Hudecova S., Lencesova L., Csaderova L., Sirova M., Cholujova D., Cagala M., Kopacek J., Dobrota D., Pastorekova S., Krizanova O. (2011): Chemically mimicked hypoxia modulates gene expression and protein levels of the sodium calcium exchanger in HEK 293 cell line via HIF-1α. Gen. Physiol. Biophys. 30, 196-206 http://dx.doi.org/10.4149//gpb-2011-02-196
16. Chiu S. C., Chen S. P., Huang S. Y., Wang M. J., Lin S. Z., Harn H. J., Pang C. Y. (2012): Induction of apoptosis, coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. PLoS One 7, e33742 http://dx.doi.org/10.1371/journal.pone.0033742
17. Iwai-Kanai E., Hasegawa K., Araki M., Kakita T., Morimoto T., Sasayama S. (1999): α- and β-adrenergic Pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytes. Circulation 100, 305-311 http://dx.doi.org/10.1161/01.CIR.100.3.305
18. Jakubikova J., Bao Y., Sedlak J. (2005): Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL/60 and multidrug - resistant cell lines. Anticancer Res. 25, 3375-3386
19. Juhaszova M., Shimizu H., Borin M. L., Yip R. K., Santiago E. M., Lindenmayer G. E., Blaustein M. P. (1996): Localization of the Na+-Ca2+ exchanger in vascular smooth muscle, and in neurons and astrocytes. Ann. N Y Acad. Sci. 779, 318-335 http://dx.doi.org/10.1111/j.1749-6632.1996.tb44804.x
20. Lederer W. J., Berlin J. R., Cohen N. M., Hadley R. W., Bers D. M., Cannell M.B. (1990): Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum. Ann. N. Y. Acad. Sci. 588, 190-206 http://dx.doi.org/10.1111/j.1749- 6632.1990.tb13210.x
21. Lin X., Luo K., Lv Z., Huang J. (2012): Beta-adrenoceptor action on pancreatic cancer cell proliferation and Tumor growth in mice. Hepatogastroenterology 59, 584-588
22. Liu K. C., Yen C.Y., Wu R. S., Yang J. S., Lu H. F., Lu K. W., Lo C., Chen H. Y., Tang N. Y., Wu C. C., Chung J. G. (2012): The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells. Environ. Toxicol. (in press) http://dx.doi.org/10.1002/tox.21769
23. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
24. Maier L. S. (2012): New treatment options for late Na current, arrhythmias, and diastolic dysfunction. Curr Heart Fail Rep. 9, 183-191 http://dx.doi.org/10.1007/s11897-012-0099-3
25. Mamani-Matsuda M., Moynet D., Molimard M., Ferry-Dumazet H., Marit G., Reiffers J., Mossalayi M. D. (2004): Long-acting beta2-adrenergic formoterol and salmeterol induce the apoptosis of B-chronic lymphocytic leukaemia cells. Br. J. Haematol. 124, 141-150 http://dx.doi.org/10.1046/j.1365-2141.200
26. Mani S. K., Egan E. A., Addy B. K., Grimm M., Kasiganesan H., Thiyagarajan T., Renaud L., Heller Brown J., Kern C. H. B., Donald R., Menick D. R. (2010): β-adrenergic receptor stimulated NCX1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes. J. Mol. Cell. Cardiol. 48, 342-351 http://dx.doi.org/10.1016/j.yjmcc.2009.11.007
27. Miyamoto S., Howes A. L., Adams J. W. 2nd, Dorn G. W., Brown J. H. (2005): Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. J. Biol. Chem. 280, 38505-38512 http://dx.doi.org/10.1074/jbc.M505223200
28. Moore E. D., Etter E. F., Philipson K. D., Carrington W. A., Fogarty K. E., Lifshitz L. M., Fay F. S. (1993) Coupling of the Na+/Ca2+ exchanger, Na+/K+ pump and sarcoplasmic reticulum in smooth muscle. Nature 365, 657-660 http://dx.doi.org/10.1038/365657a0
29. Oakes S.A., Lin S. S., Bassik M. C. (2006): The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr. Mol. Med. 6, 99-109 http://dx.doi.org/10.2174/156652406775574587
30. Orchard C., Brette F. (2008): t-Tubules and sarcoplasmic reticulum function in cardiac ventricular myocytes. Cardiovasc Res. 77, 237-244 http://dx.doi.org/10.1093/cvr/cvm002
31. Pacak K., Sirova M., Giubellino A., Lencesova L., Csaderova L., Laukova M., Hudecova S., Krizanova O. (2012): NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model. Int. J. Canc. 131, 2445-2455 http://dx.doi.org/10.1002/ijc.27524
32. Papageorgiou S. G., Kontos CH. K., Pappa V., Thomadaki H., Kontsioti F., Dervenoulas J., Papageorgiou E., Economopoulos T., Scorillas A. (2011): The novel member of the BCL2 gene family, BCL2L12, is substantially elevated in chronic lymphocytic leukemia patients, supporting its value as a significant biomarker. The Oncologist 161, 1280-1291 http://dx.doi.org/10.1634/ theoncologist.2010-0349
33. Park I. J., Kim M. J., Park O. J., Choe W., Kang I., Kim S. S., Ha J. (2012): Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells. Apoptosis 17, 248-257 http://dx.doi.org/10.1007/s10495-011-0680-3
34. Roberts-Thomson S. J., Curry M. C. (2010): Monteith G.R. Plasma membrane calcium pumps and their emerging roles. World J. Biol. Chem. 1, 248-253 http://dx.doi.org/10.4331/wjbc.v1.i8.248
35. Rodriguez D., Rojas-Rivera D., Hetz C. (2011): Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat. Biochim. Biophys. Acta 181, 3564-574
36. Singh K., Xiao L., Remondino A., Sawyer D. B., Colucci W. S. (2011): Adrenergic regulation of cardiac myocyte apoptosis. J. Cell. Physiol. 89, 257-265
37. Teijido O., Dejean L. (2010): Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria. FEBS Letters 584, 3305-3310 http://dx.doi.org/10.1016/j.febslet.2010.07.002
38. Zha L., Fan L., Sun G., Wang H., Ma T., Zhong F., Wei W. (2012): Melatonin sensitizes human hepatoma cells to endoplasmic reticulum stress-induced apoptosis. J. Pineal. Res. 52, 322-331 http://dx.doi.org/10.1111/ j.1600-079X.2011.00946.x
39. Zhang D., Ma Q. Y., Hu H. T. and Zhang M. (2010): β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NFκB and AP-1. Cancer Biol. Ther. 10, 19-29 http://dx.doi.org/10.4161/cbt. 10.1.11944
40. Wang J. Y., Chen B. K., Wang Y. S., Tsai Y. T., Chen W. Ch., Chang W. Ch., Hou M. F., Wu W. Ch., Chang W. Ch. (2011): Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells. Cell. Signal. 24, 162-169 http://dx.doi.org/10.1016/j.cellsig.2011.08.017
41. Yan L., Herrmann V., Hofer J. K., Insel P. A. (2000): beta-adrenergic receptor/cAMP-mediated signaling and apoptosis of S49 lymphoma cells. Am. J. Physiol. Cell Physiol. 279, C1665-1674
42. Youle R. J., Strasser A. (2008): The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev.Mol. Cell. Biol. 9, 47-59 http://dx.doi.org/10.1038/nrm2308