Beta-adrenoceptor action on pancreatic cancer cell proliferation and tumor growth in mice

Hepato-Gastroenterology

Volumn 59, Issue 114, 2012, Pages 584-588

  Lin, Xueping ^a   Luo, Kai ^b   Lv, Zhongwei ^c   Huang, Jian ^b  

^a JIAXING UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Beta adrenoreceptors; Isoproterenol; Pancreatic cancer; Propranolol; Tumor growth

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BROXURIDINE; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; PROPRANOLOL;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT;

ADENOCARCINOMA; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; ISOPROTERENOL; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, NUDE; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROPRANOLOL; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84860547537     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11271     Document Type: Article

References (31)

1. Hidalgo M: Pancreatic Cancer. N Engl J Med 2010; 362(17):1605-1617.
2. Lowenfels AB, Maisonneuve P: Risk factors for pancreatic cancer. J Cell Biochem 2005; 95(4):649-56. (Pubitemid 41420153)
3. Mancuso A, Calabro F, Sternberg CN: Current therapies and advances in the treatment of pancreatic cancer. Crit Rev Oncol Hematol 2006; 58(3):231-41. (Pubitemid 43796083)
4. Wadler S: Molecular targeting in pancreatic cancer. Rev Recent Clin Trials 2007; 2(1):69-75.
5. Maki T, Kontula K, Harkonen M: The beta-adrenergic system in man: physiological and pathophysiological response. Regulation of receptor density and functioning. Scand J Clin Lab Invest Suppl 1990; 201:25-43. (Pubitemid 20271059)
6. Maudsley S, Pierce KL, Zamah AM, et al.: The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. J Biol Chem 2000; 275(13):9572-80. (Pubitemid 30185188)
7. Schuller HM: Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer 2009; 9(3):195-205.
8. Nilsson MB, Armaiz-Pena G, Takahashi R, et al.: Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. J Biol Chem 2007; 282(41):29919-26. (Pubitemid 350035290)
9. Lutgendorf SK, Cole S, Costanzo E, et al.: Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 2003; 9(12):4514-4521. (Pubitemid 37248410)
10. Lutgendorf SK, Cole S, Costanzo E, et al.: Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 2003; 9(12):4514-21. (Pubitemid 37248410)
11. Sood AK, Bhatty R, Kamat AA, et al.: Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 2006; 12(2):369-75. (Pubitemid 43166123)
12. Lutgendorf SK, Johnsen EL, Cooper B, et al.: Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 2002; 95(4):808-15. (Pubitemid 34839673)
13. Tammela T, Enholm B, Alitalo K, Paavonen K: The biology of vascular endothelial growth factors. Cardiovasc Res 2005; 65(3):550-63. (Pubitemid 40138976)
14. Demers M, Couillard J, Belanger S, St-Pierre Y: New roles for matrix metalloproteinases in metastasis. Crit Rev Immunol 2005; 25(6):493-523. (Pubitemid 44268954)
15. Pomerantz J, Schreiber-Agus N, Liegeois NJ, et al.: The ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998; 92(6):713-23. (Pubitemid 28155311)
16. Chan C, Lin HJ, Lin J: Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. Int J Oncol 2008; 33(2):415-9.
17. Schuller HM: Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis. Prog Exp Tumor Res 2007; 39:45-63.
18. Schuller HM: Neurotransmission and cancer: implications for prevention and therapy. Anticancer drugs 2008; 19(7):655-71.
19. Wallukat G: The beta-adrenergic receptors. Herz 2002; 27(7):683-90.
20. Al-Wadei HA, Plummer HK, 3rd, Schuller HM: Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid. Carcinogenesis 2009; 30(3):506-11.
21. Schuller HM, Cole B: Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line. Carcinogenesis 1989; 10(9):1753-5. (Pubitemid 19222282)
22. Park PG, Merryman J, Orloff M, Schuller HM: Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res 1995; 55(16):3504-8.
23. Schuller HM, Al-Wadei HA, Majidi M: GABA B receptor is a novel drug target for pancreatic cancer. Cancer 2008; 112(4):767-78. (Pubitemid 351240570)
24. Shen SG, Zhang D, Hu HT, Li JH, Wang Z, Ma QY: Effects of alpha-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro. World J Gastroenterol 2008; 14(15):2358-63. (Pubitemid 351877606)
25. Wu W, Murata J, Murakami K, Yamaura T, Hayashi K, Saiki I: Social isolation stress augments angiogenesis induced by colon 26-L5 carcinoma cells in mice. Clin Exp Metastasis 2000; 18(1):1-10. (Pubitemid 32096042)
26. Wu W, Murata J, Hayashi K, Yamaura T, Mitani N, Saiki I: Social isolation stress impairs the resistance of mice to experimental liver metastasis of murine colon 26-L5 carcinoma cells. Biol Pharm Bull 2001; 24(7):772-6. (Pubitemid 32633484)
27. Wu WK, Wong HP, Luo SW, et al.: 4-(Methylnitrosamino)-1-(3-pyridyl)-1- butanone from cigarette smoke stimulates colon cancer growth via beta-adrenoceptors. Cancer Res 2005; 65(12):5272-7. (Pubitemid 40827338)
28. Masur K, Niggemann B, Zanker KS, Entschieden F: Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 2001; 61(7):2866-9. (Pubitemid 32691927)
29. Palm D, Lang K, Niggemann B, et al.: The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 2006; 118(11):2744-9. (Pubitemid 43673352)
30. Shin VY, Wu WK, Chu KM, et al.: Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells. Toxicol Sci 2007; 96(1):21-9. (Pubitemid 46323205)
31. Liao X, Che X, Zhao W, et al.: Effects of propranolol in combination with radiation on apoptosis and survival of gastric cancer cells in vitro. Radiat Oncol; 5:98.